LOCUS       NM_004657               3054 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens caveolae associated protein 2 (CAVIN2), mRNA.
ACCESSION   NM_004657
VERSION     NM_004657.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Shui,Y.B., Liu,Y., Huang,A.J.W. and Siegfried,C.J.
  TITLE     SDPR expression in human trabecular meshwork and its potential role
            in racial disparities of glaucoma
  JOURNAL   Sci Rep 14 (1), 10258 (2024)
   PUBMED   38704467
  REMARK    GeneRIF: SDPR expression in human trabecular meshwork and its
            potential role in racial disparities of glaucoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Chen,X., Ma,W., Yao,Y., Zhang,Q., Li,J., Wu,X., Mei,C., Jiang,X.,
            Chen,Y., Wang,G., Wang,K., Liu,Y., Guo,Y., Liu,Z. and Yuan,Y.
  TITLE     Serum deprivation-response protein induces apoptosis in
            hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways
  JOURNAL   Cell Death Dis 12 (5), 425 (2021)
   PUBMED   33931585
  REMARK    GeneRIF: Serum deprivation-response protein induces apoptosis in
            hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Li,Y. and Wu,C.
  TITLE     LINC00261/microRNA-550a-3p/SDPR axis affects the biological
            characteristics of breast cancer stem cells
  JOURNAL   IUBMB Life 73 (1), 188-201 (2021)
   PUBMED   33274565
  REMARK    GeneRIF: LINC00261/microRNA-550a-3p/SDPR axis affects the
            biological characteristics of breast cancer stem cells.
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Peng,M., Ye,L., Yang,L., Liu,X., Chen,Y., Huang,G., Jiang,Y.,
            Wang,Y., Li,D., He,J., Qiu,Z., Xiang,T. and Guo,S.
  TITLE     CAVIN2 is frequently silenced by CpG methylation and sensitizes
            lung cancer cells to paclitaxel and 5-FU
  JOURNAL   Epigenomics 12 (20), 1793-1810 (2020)
   PUBMED   33016107
  REMARK    GeneRIF: CAVIN2 is frequently silenced by CpG methylation and
            sensitizes lung cancer cells to paclitaxel and 5-FU.
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Gustincich,S., Vatta,P., Goruppi,S., Wolf,M., Saccone,S., Della
            Valle,G., Baggiolini,M. and Schneider,C.
  TITLE     The human serum deprivation response gene (SDPR) maps to 2q32-q33
            and codes for a phosphatidylserine-binding protein
  JOURNAL   Genomics 57 (1), 120-129 (1999)
   PUBMED   10191091
REFERENCE   7  (bases 1 to 3054)
  AUTHORS   Mineo,C., Ying,Y.S., Chapline,C., Jaken,S. and Anderson,R.G.
  TITLE     Targeting of protein kinase Calpha to caveolae
  JOURNAL   J Cell Biol 141 (3), 601-610 (1998)
   PUBMED   9566962
REFERENCE   8  (bases 1 to 3054)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
REFERENCE   9  (bases 1 to 3054)
  AUTHORS   Gustincich,S. and Schneider,C.
  TITLE     Serum deprivation response gene is induced by serum starvation but
            not by contact inhibition
  JOURNAL   Cell Growth Differ 4 (9), 753-760 (1993)
   PUBMED   8241023
REFERENCE   10 (bases 1 to 3054)
  AUTHORS   Burgener,R., Wolf,M., Ganz,T. and Baggiolini,M.
  TITLE     Purification and characterization of a major
            phosphatidylserine-binding phosphoprotein from human platelets
  JOURNAL   Biochem J 269 (3), 729-734 (1990)
   PUBMED   2390065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA561006.1, BC016475.1,
            R55388.1, BM971534.1 and BQ025694.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004657.5.
            
            Summary: This gene encodes a calcium-independent
            phospholipid-binding protein whose expression increases in
            serum-starved cells. This protein is a substrate for protein kinase
            C (PKC) phosphorylation and recruits polymerase I and transcript
            release factor (PTRF) to caveolae. Removal of this protein causes
            caveolae loss and its over-expression results in caveolae
            deformation and membrane tubulation.[provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.138824.1,
                                           SRR1660803.99200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304141.5/ ENSP00000305675.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DA561006.1         193-216
            25-2350             BC016475.1         1-2326
            2351-2524           R55388.1           147-320
            2525-3010           BM971534.1         63-548              c
            3011-3054           BQ025694.1         20-63               c
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.3"
     gene            1..3054
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /note="caveolae associated protein 2"
                     /db_xref="GeneID:8436"
                     /db_xref="HGNC:HGNC:10690"
                     /db_xref="MIM:606728"
     exon            1..646
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1441
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /note="serum deprivation-response protein;
                     phosphatidylserine-binding protein; serum deprivation
                     response"
                     /codon_start=1
                     /product="caveolae-associated protein 2"
                     /protein_id="NP_004648.1"
                     /db_xref="CCDS:CCDS2313.1"
                     /db_xref="GeneID:8436"
                     /db_xref="HGNC:HGNC:10690"
                     /db_xref="MIM:606728"
                     /translation="MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTE
                     EAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSK
                     YQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIF
                     QEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDS
                     AEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLT
                     SNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFA
                     EGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQK
                     VRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS"
     exon            647..3054
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /note="hexamer: AATAAA"
     polyA_site      3054
                     /gene="CAVIN2"
                     /gene_synonym="cavin-2; PS-p68; SDPR; SDR"
                     /note="major polyA site"
ORIGIN      
        1 gatcagcgta gccagttgtt gcctgtctga acctctgcca gtcctggaga ctggtgccct
       61 gagctccaac cagcgggcct catcctacac cctcaccacc gcaacttctc acccgagcaa
      121 gaagcagctc ccagagagaa agaacgttcc cacctgccta gccatgggag aggacgctgc
      181 acaggccgaa aagttccagc accctgggtc tgacatgcgg caggaaaagc cctcgagccc
      241 cagcccgatg ccttcctcca caccaagccc cagcctgaac ctagggaaca cagaggaggc
      301 catccgggac aactcacagg tgaacgcagt cacggtgctc acgctcctgg acaagctggt
      361 gaacatgcta gacgctgtgc aggagaacca gcacaagatg gagcagcgac agatcagttt
      421 ggagggctcc gtgaagggca tccagaatga cctcaccaag ctctccaagt accaggcctc
      481 caccagcaac acggtgagca agctgctgga gaagtcccgc aaggtcagcg cccacacgcg
      541 cgcggtcaaa gagcgcatgg ataggcagtg cgcacaggtg aagcggctgg agaacaacca
      601 cgcccagctc ctccgacgca accatttcaa agtgctcatc ttccaggagg aaaatgagat
      661 ccctgccagc gtgtttgtga aacagcccgt ttccggtgcc gtggaaggga aggaggagct
      721 tccggatgaa aacaaatccc tggaggaaac cctgcacacc gtggacctct cctcagatga
      781 tgatttgccc cacgatgagg aggccctgga agacagtgcc gaggaaaagg tggaagaaag
      841 tagggcagag aaaataaaaa gatccagcct gaagaaagtg gatagcctca agaaagcatt
      901 ttctcgccag aacatcgaga aaaagatgaa caagctgggg acaaagatcg tatctgtaga
      961 gaggagagag aagattaaga aatctctcac gtcaaatcac cagaaaatat cctcaggaaa
     1021 aagctccccc ttcaaggttt ctcccctcac tttcgggcgg aagaaagtcc gagagggaga
     1081 aagccatgca gaaaatgaga ccaagtcaga agacctgcct agcagtgagc agatgccaaa
     1141 tgaccaggaa gaggagtcct ttgcagaggg tcattccgaa gcgtccctcg ccagcgctct
     1201 ggtggaaggg gaaattgcag aggaggctgc tgagaaggcg acctccaggg ggagtaactc
     1261 ggggatggac agcaacatcg acttgactat tgtggaagat gaagaggagg agtcagtggc
     1321 cctggaacag gcacagaagg tacgctatga gggtagctac gcgctaacat ccgaggaggc
     1381 ggagcgctcc gatggggacc ccgtgcagcc cgccgtgctc caggtgcacc agacctcctg
     1441 agcttagagc caccgtgcca tcctgtgctg tgctcaagcg ggcagccagg gctgaagaac
     1501 aaactcttgc acatctccag cacgactcac ccactcctgc gttcctgtcc aggcagtaat
     1561 cattgaccat atagtcatag taagacacac gagaccaggc tttaccatga aagcgacctg
     1621 tcacggactc cacttttaat ttgctcttag gttctatctc tgtagaatgt ctccaagatt
     1681 gaagaagaaa ctgagcagtt gaaaaatgct aatctctttg acttagtcag aaaaaaacag
     1741 aggataatta agatactagt catgaaaagt gattcattct tttttgtcat tccataagct
     1801 tgctgaatag tgtaccggta atatattgta tttccaccgt actctgtgaa tctaattatt
     1861 attctttaag tgttgatata taatatacat aaatatgtaa gctaaacata taactatatg
     1921 ttttaagaag aaaacatcta cgaaaggtaa aaagagatga tcagttggtt gtttacttgc
     1981 tagaaaccat tgttttattg caaacgaagg aaaaatgaag agattataaa agtcagctaa
     2041 tgaagtaaga tacgtagtaa agtcaggact attcaaaaag taagaaagaa aatttggaaa
     2101 atgagagaaa caggaaacaa agaatgccga aaagaatgaa aacagagaaa aaatgtatgt
     2161 gcttgaaagt aaaatactta caatagtagc ttaactattt cactctttaa ataaaaatac
     2221 taaagaagtt cgtatatcct ggaataacat gtcatcttca aaatattttt attttctaat
     2281 atttttaata ataaacattt tatagtgtta aagctgtatt tttcttaata aataaaggac
     2341 attacaaata tttctttaag gaagttcaaa aggatgttgt cttgttaaca ctggaacgaa
     2401 tataaatctt caaaatacaa ttaatatata ctgttttgtg gaaacttagc tcatactatt
     2461 ctttaatgct cttcaaattt aaactaaccc ttacattcca tgtgatgtga tgtaggctta
     2521 taagatgcta aaatctatag gttttggaag tgaaagattc tattttttct ttttttgtac
     2581 ataatgggaa tttcattcca gattatattt tatttacata ttaatttcac agaatattaa
     2641 tatttcttaa cttcttaaag catgctagcg ttttatgtat atgtacacat atattcagac
     2701 agggtaattt tatctgctgc ctaacattgt actaaaatat tgctttatct gtttttaatt
     2761 acaaaatgct aatgatttct taaattatag tttaaagaca attggcccag gaagcaaatc
     2821 ccctgccttt agtatgaacc actataagta accttacaaa tagagttaat ccaagacaat
     2881 attaacaaac tgtgctttgt ctttaataaa agggatagga ttaacaaaca tattgatggc
     2941 ataacctatt cagctatgtc cttatttttg caataatgta acctcaaata ttggattgtt
     3001 gaaccaacaa tggctgtgtt aaagaagatt aaataaaccg aaaaataaaa agca
//
