LOCUS       NM_001233               2953 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens caveolin 2 (CAV2), transcript variant 1, mRNA.
ACCESSION   NM_001233
VERSION     NM_001233.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Gorospe,B., Moura,J.J.G., Gutierrez-Merino,C. and Samhan-Arias,A.K.
  TITLE     Biochemical and Biophysical Characterization of the Caveolin-2
            Interaction with Membranes and Analysis of the Protein Structural
            Alteration by the Presence of Cholesterol
  JOURNAL   Int J Mol Sci 23 (23), 15203 (2022)
   PUBMED   36499524
  REMARK    GeneRIF: Biochemical and Biophysical Characterization of the
            Caveolin-2 Interaction with Membranes and Analysis of the Protein
            Structural Alteration by the Presence of Cholesterol.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2953)
  AUTHORS   Zhu,Y., Tian,J., Peng,X., Wang,X., Yang,N., Ying,P., Wang,H.,
            Li,B., Li,Y., Zhang,M., Cai,Y., Lu,Z., Niu,S., Li,Y., Zhong,R.,
            Chang,J. and Miao,X.
  TITLE     A genetic variant conferred high expression of CAV2 promotes
            pancreatic cancer progression and associates with poor prognosis
  JOURNAL   Eur J Cancer 151, 94-105 (2021)
   PUBMED   33975060
  REMARK    GeneRIF: A genetic variant conferred high expression of CAV2
            promotes pancreatic cancer progression and associates with poor
            prognosis.
REFERENCE   3  (bases 1 to 2953)
  AUTHORS   Bai,R., Rebelo,A., Kleeff,J. and Sunami,Y.
  TITLE     Identification of prognostic lipid droplet-associated genes in
            pancreatic cancer patients via bioinformatics analysis
  JOURNAL   Lipids Health Dis 20 (1), 58 (2021)
   PUBMED   34078402
  REMARK    GeneRIF: Identification of prognostic lipid droplet-associated
            genes in pancreatic cancer patients via bioinformatics analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2953)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2953)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2953)
  AUTHORS   Fujimoto,T., Kogo,H., Ishiguro,K., Tauchi,K. and Nomura,R.
  TITLE     Caveolin-2 is targeted to lipid droplets, a new 'membrane domain'
            in the cell
  JOURNAL   J Cell Biol 152 (5), 1079-1085 (2001)
   PUBMED   11238462
REFERENCE   7  (bases 1 to 2953)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
REFERENCE   8  (bases 1 to 2953)
  AUTHORS   Murata,M., Peranen,J., Schreiner,R., Wieland,F., Kurzchalia,T.V.
            and Simons,K.
  TITLE     VIP21/caveolin is a cholesterol-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10339-10343 (1995)
   PUBMED   7479780
REFERENCE   9  (bases 1 to 2953)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 2953)
  AUTHORS   Glenney,J.R. Jr.
  TITLE     The sequence of human caveolin reveals identity with VIP21, a
            component of transport vesicles
  JOURNAL   FEBS Lett 314 (1), 45-48 (1992)
   PUBMED   1360410
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY353255.1, BC005256.1,
            AC006159.3, BX350116.2 and AK024513.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001233.4.
            
            Summary: The protein encoded by this gene is a major component of
            the inner surface of caveolae, small invaginations of the plasma
            membrane, and is involved in essential cellular functions,
            including signal transduction, lipid metabolism, cellular growth
            control and apoptosis. This protein may function as a tumor
            suppressor. This gene and related family member (CAV1) are located
            next to each other on chromosome 7, and express colocalizing
            proteins that form a stable hetero-oligomeric complex.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified for this gene. Additional isoforms
            resulting from the use of alternate in-frame translation initiation
            codons have also been described, and shown to have preferential
            localization in the cell (PMID:11238462). [provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (1) encodes two isoforms resulting
            from the use of alternate in-frame, translation initiation codons.
            This RefSeq represents the longer isoform (a, also known as alpha)
            derived from the use of the upstream AUG (at nt 182-184). Isoform
            alpha has been shown to localize mostly in the golgi
            (PMID:11238462).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1194190.1, BC005256.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222693.5/ ENSP00000222693.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AY353255.1         138-350
            214-1068            BC005256.1         351-1205
            1069-1069           AC006159.3         11853-11853
            1070-1323           BC005256.1         1207-1460
            1324-1763           BX350116.2         18-457              c
            1764-2933           AC006159.3         12548-13717
            2934-2953           AK024513.1         408-427
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..2953
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /note="caveolin 2"
                     /db_xref="GeneID:858"
                     /db_xref="HGNC:HGNC:1528"
                     /db_xref="MIM:601048"
     exon            1..194
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..533
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /note="isoform a is encoded by transcript variant 1;
                     caveolae protein, 20-kD"
                     /codon_start=1
                     /product="caveolin-2 isoform a"
                     /protein_id="NP_001224.1"
                     /db_xref="CCDS:CCDS5766.1"
                     /db_xref="GeneID:858"
                     /db_xref="HGNC:HGNC:1528"
                     /db_xref="MIM:601048"
                     /translation="MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSDQDRDPHR
                     LNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGI
                     LFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRCFSSVSLQLS
                     QD"
     exon            195..382
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            383..2953
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2933..2938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /note="hexamer: AATAAA"
     polyA_site      2953
                     /gene="CAV2"
                     /gene_synonym="CAV"
                     /note="major polyA site"
ORIGIN      
        1 gcaccgcgcc agccgggctg cagcggccgc gcaccaaggc tgcgatgggg ctggagacgg
       61 agaaggcgga cgtacagctc ttcatggacg acgactccta cagccaccac agcggcctcg
      121 agtacgccga ccccgagaag ttcgcggact cggaccagga ccgggatccc caccggctca
      181 actcgcatct caagctgggc ttcgaggatg tgatcgcaga gccggtgact acgcactcct
      241 ttgacaaagt gtggatctgc agccatgccc tctttgaaat cagcaaatac gtaatgtaca
      301 agttcctgac ggtgttcctg gccattcccc tggccttcat tgcgggaatt ctctttgcca
      361 ccctcagctg tctgcacatc tggattttaa tgccttttgt aaagacctgc ctaatggttc
      421 tgccttcagt gcagacaata tggaagagtg tgacagatgt tatcattgct ccattgtgta
      481 cgagcgtagg acgatgcttc tcttctgtca gcctgcaact gagccaggat tgaatacttg
      541 gaccccaggt ctggagattg ggatactgta atacttcttt gttattataa cataaaagca
      601 ccactgttct gttcatttcc tagctgttct aattaagaaa actattaaga tgagcaacca
      661 catttagaaa tgtttattga caggtctttt caaataatgc ttttctaatt aatagccaaa
      721 gatttcatat ctaactttgt aaccagaatt atacagtaag ttgacaccac ttagatttaa
      781 aggcagacag ttttgcttta gtacaatagt atacatttta taatgatgaa cttataatga
      841 ttaagggaca tttctataaa aatactacaa tagttttatg cacaacttcc cattaaaaat
      901 gagatttctt atttgtttgt ctgtttttac tctgggagta atacttttta aattaccttt
      961 acatatatag tcactggcat actgagaata tacaatgatc ctggaaattg cagtaacaaa
     1021 agcacacaac gattatagta actataagat acaataaaac aaataaatat gaaagtagat
     1081 tcatgaaaat gtattccttt aaaatattgt tttcctacag gcctatttaa caagatgttt
     1141 cattttactg tatattttgt agttaatata aatgttgctc taatcagatt gcttaaaagc
     1201 atttttatta tatttatgtt gttgaactaa tatatgaaat aagtaaatgt agctcccaca
     1261 aggtaaactt cattggtaag attgcactgt tctgattatg taagcatttg tacatcttct
     1321 ttggaaataa aagataaaag agcgatacac aaagctttct tttctaactt ttccaagcaa
     1381 aatctaaaat gttttatgac atttttctgg ctgtgatctt aaaataattc atatctaaat
     1441 agtattttgt ctaggagatg ctttctctct agtagttaga aattaaatct gtgtcagcat
     1501 tcctattaat gtctcacttt actttcaagt aatattggtg ctatttaaca ttttacagta
     1561 aatgttactt ctgatacttt agtacaattt caactacagt gattcatgta gagagacagg
     1621 ggagttgtca acttgggcta ctgaactaca tgcataaact aaaaactaac agctacaaac
     1681 ttttaagatt tctctaatat tggtatgtaa cacaggataa agttattctt gtcattttga
     1741 actgtagagt cctatttcag tgtgatgaat cactgttgct ttgaaaaatc tcattatttc
     1801 tgggccgggc atggtggctc acccctgtaa tcccagcact ttgggaggcc aaggcgggtg
     1861 gatcatgagg tcaggagatc aagaccatcc tggccaacat ggtgataccc cgtctctact
     1921 aaaaatacaa aaaaattagt tgggcatggt ggcatgcacc tgtagtccca gctacctggg
     1981 aggctgaggc aggagaattg cttgaacctg ggaggcagag gttgcagtga gccaaaatca
     2041 tgccactgca ctcccgcctg gcaacagagc aagagtctgt ctcaaaaaaa aaaagaaaaa
     2101 aagaaaaaaa gaaaaaagaa aaatctcatt atttcaaaat gatagacata taccaaaaac
     2161 aagtctataa tgtgagtagt tactaaaatt tacacatctt aaaagtgtgt aaatgcttaa
     2221 atttcagaat taccatcaga acctcaattg acattccttt gaatacgcta ataagtgaca
     2281 aataagatta ataagatttt tcaaaatcgc caggactggt gaatataaat gatgattgaa
     2341 ctggaataat attggggacc aaatcaaatg aatgattaaa ttatgaagct catatccttt
     2401 tgaaggtagt tgcaaagaga catttcaaaa ctgccctagg ccattgcagc atccttagat
     2461 gggacgcata atcattacct taaagcatca ccactcattt tgaccatata gattttatta
     2521 tgttagttta aaaggtcaat cagcctcatg actttatagt tatgtcttgt atttaaaaac
     2581 attttttata catttggtta tgttgataaa ccaaaaacat ttgattaata aaatatctat
     2641 ttgaataaat tatgagctat cctttcaaac agctattggc aagttttaaa cccaaaatat
     2701 atacacatag ttctgtaata aaactgtttg acttctcaag taacatgact tccttatttc
     2761 tgaacagtac tggttacttt caaaatgaat ttttattgag attttccatt aactattttt
     2821 ttcaaagact caaattttgt accaagtaaa tccaggcttt atgtacaaac atgttgtttg
     2881 ttttatttgg ggctggggga ggtatatgat gagcagactt ctcggaattc ataataaatt
     2941 ttctaaaagc cta
//
