LOCUS       NM_001039496             780 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens catsper channel auxiliary subunit zeta (CATSPERZ),
            mRNA.
ACCESSION   NM_001039496
VERSION     NM_001039496.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Sinha,A., Singh,V., Singh,S. and Yadav,S.
  TITLE     Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2
            proteins related to calcium ion entry and acrosomal acidification
            in asthenozoospermic males
  JOURNAL   Life Sci 218, 81-88 (2019)
   PUBMED   30550884
  REMARK    GeneRIF: Low TEX40 expression is associated with asthenozoospermia.
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Chung,J.J., Miki,K., Kim,D., Shim,S.H., Shi,H.F., Hwang,J.Y.,
            Cai,X., Iseri,Y., Zhuang,X. and Clapham,D.E.
  TITLE     CatSperzeta regulates the structural continuity of sperm Ca2+
            signaling domains and is required for normal fertility
  JOURNAL   Elife 6, e23082 (2017)
   PUBMED   28226241
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Micci,F., Panagopoulos,I., Thorsen,J., Davidson,B., Trope,C.G. and
            Heim,S.
  TITLE     Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas
  JOURNAL   PLoS Biol 12 (2), e1001784 (2014)
   PUBMED   24504521
  REMARK    GeneRIF: The frequency of the ESRRA/C11orf20 gene fusion in serous
            ovarian carcinomas of stages III and IV must be very low.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Salzman,J., Marinelli,R.J., Wang,P.L., Green,A.E., Nielsen,J.S.,
            Nelson,B.H., Drescher,C.W. and Brown,P.O.
  TITLE     ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian
            carcinoma
  JOURNAL   PLoS Biol 9 (9), e1001156 (2011)
   PUBMED   21949640
  REMARK    GeneRIF: ESRRA-C11orf20, a gene fusion between ESRRA and C11orf20
            (TEX40) is recurrent serous ovarian carcinoma.
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001453.6 and AL117564.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039496.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.170070.1,
                                           SRR5189667.254049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328404.8/ ENSP00000491717.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AP001453.6         72540-72572
            34-777              AL117564.1         4-747
            778-780             AP001453.6         76950-76952
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..780
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /note="catsper channel auxiliary subunit zeta"
                     /db_xref="GeneID:25858"
                     /db_xref="HGNC:HGNC:19231"
                     /db_xref="MIM:617511"
     exon            1..74
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..656
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /note="testis-expressed sequence 40 protein;
                     testis-expressed protein 40; testis expressed 40;
                     catSperzeta; catSper-zeta; cation channel sperm-associated
                     protein subunit zeta"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit zeta"
                     /protein_id="NP_001034585.1"
                     /db_xref="GeneID:25858"
                     /db_xref="HGNC:HGNC:19231"
                     /db_xref="MIM:617511"
                     /translation="MEEKPSKVSLKSSDRQGSDEESVHSDTRDLWTTTTLSQAQLNMP
                     LSEVCEGFDEEGRNISKTRGWHSPGRGSLDEGYKASHKPEELDEHALVELELHRGSSM
                     EINLGEKDTASQIEAEKSSSMSSLNIAKHMPHRAYWAEQQSRLPLPLMELMENEALEI
                     LTKALRSYQLGIGRDHFLTKELQRYIEGLKKRRSKRLYVN"
     exon            75..405
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /inference="alignment:Splign:2.1.0"
     exon            406..485
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /inference="alignment:Splign:2.1.0"
     exon            486..552
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /inference="alignment:Splign:2.1.0"
     exon            553..780
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      760..765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /note="hexamer: AATAAA"
     polyA_site      780
                     /gene="CATSPERZ"
                     /gene_synonym="C11orf20; TEX40"
                     /note="major polyA site"
ORIGIN      
        1 gactcccttc tcgtctcgag gcctgtggcg tctgggtccg ttggggcaga accatggagg
       61 aaaagccttc gaaagtgtcg ctcaagtctt ccgaccgcca aggctcggac gaggagagcg
      121 tgcatagcga cactcgggac ctgtggacca cgaccacgct gtcccaggca cagctgaaca
      181 tgccgctgtc cgaggtctgc gagggcttcg acgaggaggg ccgcaacatt agcaagaccc
      241 gcgggtggca cagcccgggg cggggctcgt tggacgaggg gtacaaggcc agccacaagc
      301 cggaggaact ggacgagcac gcgctggtgg agctggagtt gcaccgcggc agctccatgg
      361 aaatcaatct gggggagaag gacactgcat cccagatcga ggccgaaaag tcttcctcaa
      421 tgtcatcact caatattgcg aagcacatgc cccatcgagc ctactgggca gagcagcaga
      481 gcaggctgcc actgcccctg atggaactca tggagaatga agctctggaa atcctcacca
      541 aagccctccg gagctaccag ttagggatcg gcagggacca cttcctgact aaggagctgc
      601 agcgatacat cgaagggctc aagaagcgcc ggagcaagag gctgtacgtg aattaaaaac
      661 gccaccttgg gctcgagcag cgacccgaac cagccccgtg ccagcccggt ccccagaccc
      721 aagcctgacc ccatccgagt ggaatttgag tcctaaagaa ataaaagagt cgatgcatgg
//
