LOCUS       NM_021185               3691 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cation channel sperm associated auxiliary subunit
            gamma (CATSPERG), transcript variant 1, mRNA.
ACCESSION   NM_021185
VERSION     NM_021185.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3691)
  AUTHORS   Wang,H., Liu,J., Cho,K.H. and Ren,D.
  TITLE     A novel, single, transmembrane protein CATSPERG is associated with
            CATSPER1 channel protein
  JOURNAL   Biol Reprod 81 (3), 539-544 (2009)
   PUBMED   19516020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060889.1, AK128220.1, BC109035.1 and AW072458.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021185.4.
            
            Summary: CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM
            606389) sperm calcium channel, which is required for sperm
            hyperactivated motility and male fertility (Wang et al., 2009
            [PubMed 19516020]).[supplied by OMIM, Jul 2010].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409235.8/ ENSP00000386962.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1255              BC060889.1         13-1267
            1256-2887           AK128220.1         1066-2697
            2888-3440           BC109035.1         2314-2866
            3441-3690           AK128220.1         3251-3500
            3691-3691           AW072458.1         10-10               c
FEATURES             Location/Qualifiers
     source          1..3691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3691
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /note="cation channel sperm associated auxiliary subunit
                     gamma"
                     /db_xref="GeneID:57828"
                     /db_xref="HGNC:HGNC:25243"
                     /db_xref="MIM:613452"
     exon            1..46
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            47..330
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..3540
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cation channel sperm-associated protein subunit
                     gamma; catsper channel auxiliary subunit gamma"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit gamma isoform 1 precursor"
                     /protein_id="NP_067008.3"
                     /db_xref="CCDS:CCDS12514.2"
                     /db_xref="GeneID:57828"
                     /db_xref="HGNC:HGNC:25243"
                     /db_xref="MIM:613452"
                     /translation="MCGPAMFPAGPPWPRVRVVQVLWALLAVLLASWRLWAIKDFQEC
                     TWQVVLNEFKRVGESGVSDSFFEQEPVDTVSSLFHMLVDSPIDPSEKYLGFPYYLKIN
                     YSCEEKPSEDLVRMGHLTGLKPLVLVTFQSPVNFYRWKIEQLQIQMEAAPFRSKEPCM
                     AEEVCSMSWYTPMPIKKGSVVMRVDISSNGLGTFIPDKRFQMNINGFLKRDRDNNIQF
                     TVGEELFNLMPQYFVGVSSRPLWHTVDQSPVLILGGIPNEKYVLMTDTSFKDFSLVEL
                     SIDSCWVGSFYCPHSGFTATIYDTIATESTLFIRQNQLVYYFTGTYTTLYERNRGSGS
                     WIRVLASECIKKLCPVYFHSNGSEYIMALTTGKHEGYVHFGTIRDGQVSFEMLPRQWS
                     VCEQIGVTTCSIIWSEYIAGEYTLLLLVESGYGNASKRFQVVSYNTASDDLELLYHIP
                     EFIPEARGLEFLMILGTESYTSTAMAPKGIFCNPYNNLIFIWGNFLLQSSNKENFIYL
                     ADFPKELSIKYMARSFRGAVAIVTETEEIWYLLEGSYRVYQLFPSKGWQVHISLKLMQ
                     QSSLYASNETMLTLFYEDSKLYQLVYLMNNQKGQLVKRLVPVEQLLMYQQHTSHYDLE
                     RKGGYLMLSFIDFCPFSVMRLRSLPSPQRYTRQERYRARPPRVLERSGFHNENSLAIY
                     QGLVYYLLWLHSVYDKPYADPVHDPTWRWWANNKQDQDYYFFLASNWRSAGGVSIEMD
                     SYEKIYNLESAYELPERIFLDKGTEYSFAIFLSAQGHSFRTQSELGTAFQLHSQVDVG
                     VVLADPGCIEASVKQEVLINRNSVLFSITLKDKKLCYDQGISGHHLMETSMTVNVVGS
                     SGLCFQETHLGPHMQGNLMVPVFIGCPPGKRLAFDITYTLEYSRLKNKHYFDCVNVNP
                     EMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLLVVGGGPTLDSLKDYSEDEIYRFN
                     SPLDKTNSLIWTTRTTRTTKDSAFHIMSHESPGIEWLCLENAPCYDNVPQGIFAPEFF
                     FKVLVSNRGVDTSTYCNYQLTFLLHIHGLPLSPKRALFIIMVSASVFVGLVIFYIAFC
                     LLWPLVVKGCTMIRWKINNLIASESYYTYASISGISSMPSLRHSRMGSMFSSRMTEDR
                     AEPKEAVERQLMT"
     exon            331..384
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            385..529
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            530..656
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            657..729
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            730..885
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1057
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1195
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1255
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1375
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1426
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1556
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1668
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1827
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1940
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2154
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2217
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2416
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2535
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2616
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2673
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2830
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2894
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2990
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3080
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3173
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3273
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3691
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3672..3677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /note="hexamer: AATAAA"
     polyA_site      3691
                     /gene="CATSPERG"
                     /gene_synonym="C19orf15"
                     /note="major polyA site"
ORIGIN      
        1 actggtgcgg ccgagtgaca gttgaccggt tttaaccaag tgactggttc tagccacgtt
       61 atgtgcggcc cagccatgtt ccctgccggt cctccgtggc ccagagtccg agtcgtgcag
      121 gtgctgtggg ccctgctggc agtgctcctg gcgtcgtgga ggctgtgggc gatcaaggat
      181 ttccaggaat gcacctggca ggttgtcctg aacgagttta agagggtagg cgagagtggt
      241 gtgagcgaca gcttctttga gcaagagccc gtggacacag tgagcagctt gtttcacatg
      301 ctggtggact cacccatcga cccgagcgag aaatacctgg gcttccctta ctacctgaag
      361 atcaactact cctgcgagga aaagccctct gaggacctgg tgcgcatggg ccacctgacg
      421 gggctaaagc ccctggtgct ggtcaccttc cagtccccag tcaacttcta ccgctggaag
      481 atagagcagc tgcagatcca gatggaggct gcccccttcc gcagcaaaga gccatgcatg
      541 gcagaagaag tgtgtagcat gagctggtac acgcccatgc ccatcaagaa aggcagtgtg
      601 gtcatgcgtg tggacatcag cagcaatggc ctggggacct tcattccaga taaaaggttc
      661 cagatgaata tcaacggctt cctgaagaga gaccgggaca ataacatcca attcactgtg
      721 ggagaggagc tcttcaacct gatgccccag tactttgtgg gtgtctcatc gaggcccttg
      781 tggcacactg tggaccagtc acctgtgctt atcctgggag gcattcccaa tgagaagtac
      841 gtcctgatga ctgacaccag cttcaaggac ttctctctcg tggagctgag cattgacagt
      901 tgctgggtgg gctccttcta ctgcccccat tctggcttca cagccaccat ctatgacact
      961 attgccaccg agagcaccct cttcattcgg cagaaccagc tggtctacta ttttacaggc
     1021 acctatacca cactctatga gagaaaccgc ggcagtggca gttggattcg tgtcctggcc
     1081 agcgagtgca tcaagaagct gtgccctgtg tatttccata gcaatggctc tgagtacata
     1141 atggccctca ccacgggcaa gcatgagggt tatgtacact tcgggaccat cagagatggc
     1201 caggtgtcct ttgagatgct gcccaggcag tggtctgtgt gcgagcagat aggagttacc
     1261 acctgctcca taatttggtc tgaatacatc gcgggtgagt atactctact gctgctggtg
     1321 gagagtggat atggtaatgc aagtaaacgt ttccaggtgg tcagctacaa cacagctagt
     1381 gatgacctgg aacttctcta ccacatccca gaattcatcc ctgaagctcg aggattggag
     1441 ttcctgatga tcctagggac agagtcctac accagcactg caatggcccc caagggcatc
     1501 ttctgtaacc cgtacaacaa tctgatcttc atctggggca acttcctcct gcagagctct
     1561 aacaaggaaa acttcatcta cctggcagac ttccccaagg aactgtccat caaatacatg
     1621 gccagatcgt tccgtggggc tgtggctatt gtcacagaga cggaggagat ctggtacctc
     1681 ctggagggca gctaccgggt ctaccagctg ttcccttcca agggctggca ggtgcacatc
     1741 agcttaaagc tgatgcaaca gtcctctctc tacgcatcca atgagaccat gctgaccctc
     1801 ttctacgaag acagcaaact gtaccagctg gtgtacctta tgaacaacca gaagggccag
     1861 ctggtcaaga ggctcgtgcc cgtggagcag cttctgatgt atcaacagca caccagccac
     1921 tatgacttgg agcggaaagg gggctacttg atgctctcct tcatcgactt ctgccccttc
     1981 tcggtgatgc gcctgcggag cctgcccagt ccgcagagat acacgcgcca ggagcgctac
     2041 cgggcgcggc cgccgcgcgt cctggagcgc tcgggcttcc acaacgagaa ctcgctcgcc
     2101 atctaccagg gcctggtcta ctacctgctg tggctgcact ccgtgtacga caagccgtac
     2161 gcggacccgg tgcacgaccc cacctggcgc tggtgggcga acaacaaaca agaccaggat
     2221 tactacttct tcttggcgag caattggcga agcgcgggcg gcgtgtccat agaaatggac
     2281 agctacgaaa agatctacaa cctcgagtcc gcgtacgagc tgccggagcg cattttcctg
     2341 gacaagggca ctgagtacag cttcgccatc ttcctgtcgg cgcagggcca ctcgttccgg
     2401 acgcagtcag aactcggcac cgccttccag ctgcatagcc aggtggacgt gggcgtggtg
     2461 ctggccgacc ccggctgcat cgaggcctcg gtgaagcagg aggtcctgat taatcgcaac
     2521 tcggtgctat tttcgattac gctcaaggat aaaaagcttt gctatgacca aggcattagt
     2581 ggacatcacc ttatggagac ttccatgacg gtcaatgtgg tgggttcatc cgggctctgc
     2641 ttccaggaaa cacacctggg gccccatatg caaggcaacc tgatggtgcc agtgttcatt
     2701 ggctgccccc caggcaagcg cctggccttc gacatcacct acacgctgga atacagccgc
     2761 ctgaagaaca aacactactt tgactgcgtt aacgtgaacc cggagatgcc ctgctttctc
     2821 ttccgggaca ttttctaccc cttcttcttg attcaagatt tggtgacagg agactccggc
     2881 agtttccagg gcagctatgt tctgctggtg gtgggtggcg ggcccacact ggacagcctc
     2941 aaggactaca gtgaggacga aatctaccgc ttcaacagcc ccctggacaa gaccaacagc
     3001 cttatctgga ccacgaggac cacaaggacc accaaagact cagcctttca catcatgtcc
     3061 cacgagagcc caggcatcga gtggctctgt ctggagaatg ccccatgcta tgacaatgtt
     3121 ccccaaggca tctttgcccc tgaattcttc ttcaaggtgt tggtgagcaa tagaggagtg
     3181 gacacgagca cctactgcaa ctaccagctc accttcctgc tgcacatcca cgggctgcca
     3241 ctcagtccca agcgggccct tttcatcatc atggtgtcag ctagcgtgtt tgtgggcctg
     3301 gtgatcttct acatcgcctt ctgcctcctg tggcccctcg tggtgaaggg ctgcacgatg
     3361 atccggtgga agataaacaa cctcattgcc tcagaatcct actacaccta cgcctccatt
     3421 tccggaatct cgagcatgcc gtctctgaga cattccagga tgggctccat gttcagctcc
     3481 aggatgacag aggacagggc tgaacccaag gaagccgtgg agagacagtt gatgacctga
     3541 gtgtcccacc tgccccagcc cccagttact gtcacgcctc tcttatgagg cccatcttga
     3601 agatgcaacc tgtcacccag cccaggcctc tctttctgtt ttgcttgatg tttacttctc
     3661 gttcagactc aaataaagcc ttttttcagg a
//
