LOCUS       NM_001130957            3436 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens catsper channel auxiliary subunit epsilon (CATSPERE),
            transcript variant 1, mRNA.
ACCESSION   NM_001130957
VERSION     NM_001130957.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Chung,J.J., Miki,K., Kim,D., Shim,S.H., Shi,H.F., Hwang,J.Y.,
            Cai,X., Iseri,Y., Zhuang,X. and Clapham,D.E.
  TITLE     CatSperzeta regulates the structural continuity of sperm Ca2+
            signaling domains and is required for normal fertility
  JOURNAL   Elife 6, e23082 (2017)
   PUBMED   28226241
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591594.9, DB462258.1, BC032859.1, BX648685.1, BC028392.1 and
            AC099757.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001130957.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028392.1, AK302609.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366534.9/ ENSP00000355492.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AL591594.9         41533-41630
            99-515              DB462258.1         56-472
            516-693             BC032859.1         403-580
            694-2426            BX648685.1         297-2029
            2427-3127           BC028392.1         2305-3005
            3128-3292           BC032859.1         2860-3024
            3293-3436           AC099757.2         106718-106861
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3436
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /note="catsper channel auxiliary subunit epsilon"
                     /db_xref="GeneID:257044"
                     /db_xref="HGNC:HGNC:28491"
                     /db_xref="MIM:617510"
     exon            1..222
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3013
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C1orf101;
                     catSperepsilon; catSper-epsilon; cation channel
                     sperm-associated protein subunit epsilon; cation channel
                     sperm-associated auxiliary subunit epsilon"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit epsilon isoform 1 precursor"
                     /protein_id="NP_001124429.1"
                     /db_xref="CCDS:CCDS44340.1"
                     /db_xref="GeneID:257044"
                     /db_xref="HGNC:HGNC:28491"
                     /db_xref="MIM:617510"
                     /translation="MSAREVAVLLLWLSCYGSALWRYSTNSPNYRIFSTRSTIKLEYE
                     GTLFTEWSVPETCFVLNKSSPTTELRCSSPGVHAIKPIVTGPDEEERYLFVESSHTCF
                     LWYYRVRHFFNNFTQLITVWAYDPESADPDELLGNAEEPSINSIVLSTQMATLGQKPV
                     IHTVLKRKVYSSNEKMRRGTWRIVVPMTKDDALKEIRGNQVTFQDCFIADFLILLTFP
                     LLTIPEIPGYLPISSPRGSQLMASWDACVVASAVLVTDMETFHTTDSFKSWTRIRVPP
                     DILSDDERRSVAHVILSRDGIVFLINGVLYIKSFRGFIRLGGIVNLPDGGITGISSRK
                     WCWVNYLLKAKGRRSTFAVWTENEIYLGSILLKFARLVTTTELKNILSLSVTATLTID
                     RVEYTGHPLEIAVFLNYCTVCNVTKKIFLVIYNEDTKQWVSQDFTLDAPIDSVTMPHF
                     TFSALPGLLLWNKHSIYYCYHNFTFTGILQTPAGHGNLSMLSNDSIIHEVFIDYYGDI
                     LVKMENNVIFYSKINTRDAVKLHLWTNYTTRAFIFLSTSGQTYFLYALDDGTIQIQDY
                     PLHLEAQSIAFTTKDKCPYMAFHNNVAHVFYFLDKGEALTVWTQIVYPENTGLYVIVE
                     SYGPKILQESHEISFEAAFGYCTKTLTLTFYQNVDYERISDYFETQDKHTGLVLVQFR
                     PSEYSKACPIAQKVFQIAVGCDDKKFIAIKGFSKKGCHHHDFSYVIEKSYLRHQPSKN
                     LRVRYIWGEYGCPLRLDFTEKFQPVVQLFDDNGYVKDVEANFIVWEIHGRDDYSFNNT
                     MAQSGCLHEAQTWKSMIELNKHLPLEEVWGPENYKHCFSYAIGKPGDLNQPYEIINSS
                     NGNHIFWPMGHSGMYVFRVKILDPNYSFCNLTAMFAIETFGLIPSPSVYLVASFLFVL
                     MLLFFTILVLSYFRYMRIYRRYIYEPLHKPQRKRKKN"
     exon            223..271
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            272..345
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            346..415
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            416..483
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            484..508
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            509..586
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            587..693
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1186
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1664
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2107
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2166
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2242
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2295
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2346
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2380
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2460
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2560
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2647
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2805
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2859
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3436
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3273..3278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /note="hexamer: ACTAAA"
     polyA_site      3292
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /note="major polyA site"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="CATSPERE"
                     /gene_synonym="C10orf101; C1orf101"
ORIGIN      
        1 acacttctcc ctcgctggtc ttcaggcccg gcccgccctg tccagaggcg ccgggaccca
       61 ggcgcctgca gccgcccgcc gggccgacgt cccacgggaa tgcgcgaggc ctggacggga
      121 gtggccgagg cggttgggcg gaggcggagc aggcgccatg tcagcccggg aagtggccgt
      181 gctgctgctg tggctgagct gctatggctc cgccctttgg aggtattcca ctaacagccc
      241 aaactatcgc atttttagta ccagaagtac tattaagtta gagtatgaag gaacattatt
      301 tactgagtgg agtgtgccag aaacttgttt tgtgctaaat aaaagctcac ccacgacaga
      361 attgcgttgt tcctcacctg gtgttcacgc tataaaacca attgttactg gcccagatga
      421 agaagaacgc tatttatttg tggaaagttc tcatacttgc tttctgtggt actatagagt
      481 tagacatttc tttaacaact ttacccagct tatcactgtg tgggcatatg atccagaaag
      541 tgcagatcct gatgagttgc tggggaatgc agaagaacct tcaataaatt ccatagtact
      601 cagcacacag atggccacat tgggacagaa gcctgtcata catacagttc tgaagagaaa
      661 agtttattct tcaaatgaga aaatgagaag ggggacctgg cgtattgtag taccaatgac
      721 aaaagatgat gcactaaagg agattagagg aaaccaagtt acttttcagg attgctttat
      781 tgcagatttt cttattctgt tgacttttcc tttgttgacc atacctgaaa ttcctggtta
      841 tttaccaatc tcctcaccac gtggtagtca attaatggct tcctgggatg cttgtgtagt
      901 tgcatctgct gttttggtga cagatatgga gacctttcac acaactgatt cattcaaatc
      961 ttggaccaga atcagagtgc ctccagacat tctgagtgat gatgaaagac ggagtgtggc
     1021 tcatgtgatc ttatcgcggg atggaatcgt ttttcttata aatggtgttc tttacataaa
     1081 gagttttcgt ggatttataa gactgggagg aattgtaaat cttcctgatg gtggaattac
     1141 tggcatttca tcaagaaaat ggtgttgggt caattattta ttaaaggcta aaggaagaag
     1201 aagcaccttt gcagtctgga cagaaaatga aatttacctc ggatccattc ttcttaagtt
     1261 tgccagatta gtaactacca cagaactgaa aaacatccta agtctatcgg tgactgctac
     1321 tctgaccata gacagggttg agtatacagg acaccctctg gagattgctg tgtttttaaa
     1381 ttattgcact gtatgtaacg tcaccaaaaa gattttctta gtgatatata atgaagatac
     1441 aaaacagtgg gtttcccaag actttacatt agatgcccct attgacagtg ttaccatgcc
     1501 acattttaca ttttcagcac tgccaggatt actgctatgg aacaagcata gtatctacta
     1561 ttgttaccat aatttcacct ttactgggat tttacagaca cctgcaggac atggaaatct
     1621 atcaatgcta tcaaatgaca gcattattca tgaagttttc atagattatt atggagatat
     1681 tttggtaaaa atggaaaata atgtaatatt ttattccaag attaatacta gagatgcagt
     1741 aaagctgcat ttatggacaa attacacaac aagagcattc attttcttaa gtacatctgg
     1801 tcaaacatat ttcctgtatg ctttggatga tggcacaata caaatacagg actatccctt
     1861 acatctggaa gcacaaagta tagctttcac aacaaaagac aaatgcccat acatggcatt
     1921 tcataacaat gttgctcatg ttttttactt tttggacaag ggagaggctc tgacagtttg
     1981 gactcagatc gtctatccag aaaacactgg tctgtatgtt attgtggaat cttatggccc
     2041 aaaaatatta caagagagtc atgagatttc ctttgaagct gcctttggat actgcaccaa
     2101 aactctgaca ctaacatttt atcagaatgt agattatgag agaatatctg attactttga
     2161 gacacaagac aagcacacgg gtcttgtgct ggttcagttt cgacctagtg aatattcaaa
     2221 agcatgtcca atagcccaaa aggtgttcca aatagctgtt ggctgtgatg ataaaaaatt
     2281 cattgcaatt aaaggattta gtaaaaaagg atgtcatcac catgattttt catacgtgat
     2341 tgaaaagtca tatctgaggc atcagccatc gaaaaacttg agagtaaggt atatttgggg
     2401 agaatatggc tgccctctga ggcttgactt cacagaaaag tttcaacctg tggttcaact
     2461 atttgatgat aatggctatg ttaaagacgt tgaagcaaat ttcatagtgt gggaaataca
     2521 cggcagggat gactatagct ttaataatac tatggcacag agtggttgtt tacatgaagc
     2581 acagacatgg aagtcaatga ttgaacttaa caagcacctc ccactagaag aagtctgggg
     2641 acctgagaac tataaacact gtttttctta tgctattgga aaaccaggag acttaaatca
     2701 accatacgag attatcaaca gttctaatgg taaccatata ttttggccca tgggccattc
     2761 tggaatgtat gtatttcgtg tgaagatcct ggatccaaac tatagtttct gtaacctaac
     2821 agctatgttt gcaatagaga catttggact gattcccagt ccaagtgtct acctggtagc
     2881 ttctttcctc ttcgtcctga tgctgctctt cttcactatt cttgttttga gctactttcg
     2941 gtacatgagg atttatagac gatatattta tgaaccactt cacaaacctc aaagaaaacg
     3001 taagaagaat taggaaaact gaaagtttgt ttattacaga tatatgcata tagagaaaca
     3061 gtgtattaca tagtgatatt gagagtgtgt gtttgaccaa gaaatactaa atataagctc
     3121 gtagtaggca tcaccaaatt caagatctga aaaatattct tgaactatct ccaaaataga
     3181 aatgttttca tatatattgt tattaaatta atcctttgtt tgccttcatt ttaaagatac
     3241 tctatgtact ctcacatggc atgaaaaaat aaactaaatt tgactattac aatcctttgt
     3301 aagaatgaaa gtgaattttt gaaaatatat ctatgtgtca agtatcattt tgcatgaaac
     3361 ttttcacatg aaaccttata tgactgtagt taatttatat ataaaggatt taataaaggt
     3421 gtgtggattt aaataa
//
