LOCUS       NM_152784               2556 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cation channel sperm associated auxiliary subunit
            delta (CATSPERD), mRNA.
ACCESSION   NM_152784
VERSION     NM_152784.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Chung,J.J., Navarro,B., Krapivinsky,G., Krapivinsky,L. and
            Clapham,D.E.
  TITLE     A novel gene required for male fertility and functional CATSPER
            channel formation in spermatozoa
  JOURNAL   Nat Commun 2, 153 (2011)
   PUBMED   21224844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011499.5, AK128088.1 and BC043005.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152784.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381624.4/ ENSP00000371037.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC011499.5         94014-94053
            41-59               AK128088.1         1-19
            60-1607             BC043005.1         6-1553
            1608-1864           AK128088.1         1576-1832
            1865-2553           BC043005.1         1811-2499
            2554-2556           AC011499.5         152109-152111
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2556
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /note="cation channel sperm associated auxiliary subunit
                     delta"
                     /db_xref="GeneID:257062"
                     /db_xref="HGNC:HGNC:28598"
                     /db_xref="MIM:617490"
     exon            1..172
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2498
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /note="transmembrane protein 146; catSperdelta;
                     catSper-delta; cation channel sperm-associated protein
                     subunit delta; catsper channel auxiliary subunit delta"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit delta precursor"
                     /protein_id="NP_689997.3"
                     /db_xref="CCDS:CCDS12149.2"
                     /db_xref="GeneID:257062"
                     /db_xref="HGNC:HGNC:28598"
                     /db_xref="MIM:617490"
                     /translation="MLMLMLVAAVTMWLRPLVTAQLCRSRTVRTGKVFNLIQDVQGDR
                     LYFHPTTTRLIKHPCEKNIALYLGKQVFFTMDNFETSLLPFTIPTSMQVGVPEVTSAH
                     FAGSLLLLVVDQKVYIYDYENNSWSMSLGIKHPVTHVSGDNCCYTGSLFCVHVSNLVF
                     AYFRGDQISQTYIYYSNTGGFSFWKYHYDRQAEIIGSLGGIFHFFSLSQVAMLVVNQG
                     KGMFKYSDHPLNRSFGLSFDYNGTLDILIAPGQRGILLLWFENSLLFSHNAGQLVDTV
                     RVKKGDQTLFSSIFEAKITIHNIAVTENELAVITREDNLYYGNLGIVPSSIIKFADQY
                     IWSEDVALMFRSPGTLEILTPLRDTAFPAFDFQKCLVNIQALLMDPELHVGKCKIEFL
                     TGEFIYRMYTIDMHSQLELTASLIPQPGTSLIPLVMVSNPHSLGFQATFYENGYTSDG
                     NTKYKLDIFLKQQQHWGRTDSNFTSSLKKATMSTLTVDIANKEISCVDIKPLSTLISV
                     GCDLDKKIVIQNKVSACSMGILDPLTLQDNYSFIIEKEFYDPGFQGQQSSEDLHVFYS
                     YQQLGCPLLVYYDTLWKPVVELWRKDSFQEVIDAEYVLLEVNGQFSYSYSLTAQSAMC
                     TSQPQNWTTMIKEFGGPFFWNRENYVSCHDPNNNAPLRWPDVQYQILGGRTANQIIFG
                     HNGFYVFYISIVDPYYSYCQLETIFSIYVYGAFPVQLVSAGVVILLIISSILGSVWLA
                     YKTPKLLRTARGRRIKKCATQLCRRCKTVCQFRASATARAGTEPPGRHRTPHGGRSDH
                     "
     exon            173..227
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            228..304
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            305..377
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            378..492
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            493..560
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            561..674
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            675..758
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            759..909
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1005
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1088
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1265
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1379
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1528
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1607
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1660
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1735
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1864
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2042
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2197
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2556
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="CATSPERD"
                     /gene_synonym="TMEM146"
                     /note="major polyA site"
ORIGIN      
        1 attgatgcgc atgcgcaggg cttcagcctg cacgtactcg gattgtgcag cgactccccg
       61 tggcggttga ggggcagtgg tggcggcgga agcccaagtc gatgctgatg ttgatgctgg
      121 tggcggctgt gaccatgtgg ctccgaccgc tggtcacagc tcagctctgt cgttctcgca
      181 cagtgaggac aggaaaagtg tttaatctga tacaggacgt tcaaggggac cgcctgtatt
      241 ttcatcctac aacaacacgc ttgattaaac atccttgcga gaaaaatata gcactatatc
      301 tagggaaaca agtttttttc acaatggata actttgagac tagtctcctt ccatttacca
      361 tccctacatc aatgcaggtc ggcgtaccag aagtgacatc agcacatttt gctggttcgt
      421 tattgctgtt agtagtggat caaaaagtct atatttatga ttatgaaaat aattcttgga
      481 gcatgtcttt aggtataaaa caccctgtta cacatgtctc tggtgataat tgttgttata
      541 ctggaagttt gttttgtgtg catgtcagta atttggtttt tgcatatttc cgtggagatc
      601 agatatccca gacttatata tattattcaa atactggggg attcagtttt tggaagtatc
      661 actatgacag acaggcagaa atcattgggt ctttaggcgg aatcttccac tttttttctt
      721 tgtcacaggt tgcgatgctt gtagtgaatc aagggaaggg catgttcaag tactcagatc
      781 accccctcaa ccggagtttc gggctgtctt ttgactataa tgggactcta gacatcctca
      841 tcgcccccgg ccagagaggc atcctgctcc tatggtttga gaacagcctg ttgttttccc
      901 ataatgcagg tcagctcgtc gacaccgtcc gggtgaaaaa aggagaccag accttgtttt
      961 cttccatttt tgaagccaag atcaccatcc acaacattgc tgtcactgaa aatgaactgg
     1021 cagttataac tcgggaggat aatttgtatt atggcaatct gggcatcgtg ccaagttcca
     1081 taatcaaatt tgcagaccaa tacatctggt cagaagacgt ggccctgatg ttcaggagcc
     1141 cagggactct ggaaatactg accccactgc gtgacacagc ctttccagct tttgatttcc
     1201 agaagtgcct cgtgaatatc caggcgcttc tcatggaccc tgaactccac gttggaaagt
     1261 gcaagataga gtttctgaca ggagaattta tatacaggat gtataccatt gacatgcaca
     1321 gccagctgga attgactgct tcgttgatac cccagccagg cacatccctg attcctctgg
     1381 tgatggtgag caacccccac tccctggggt tccaggccac cttctacgag aacggttaca
     1441 catcagatgg gaacaccaag tacaaactgg atattttcct aaaacagcag cagcactggg
     1501 gcaggaccga ctccaacttc acttccagtt taaagaaagc caccatgtct accttaactg
     1561 tggacatagc aaacaaggaa atttcatgtg tggatatcaa gccactgtcg acactgattt
     1621 cagttggctg cgacctggat aaaaagatcg tcatccagaa caaagtttcc gcctgttcca
     1681 tgggcatcct ggaccccttg accctgcaag acaattacag cttcatcatc gagaaggaat
     1741 tctacgaccc cggcttccag gggcagcagt cctccgagga cctgcacgtg ttttactcct
     1801 accagcagct gggctgtcct ctcctcgtct actatgacac cctatggaag cccgtggtgg
     1861 agctgtggcg aaaagacagt ttccaggagg tcatcgacgc cgagtatgtg ttactggagg
     1921 tgaacgggca gttctcatac tcctattccc tgacggccca gtcggccatg tgtacctccc
     1981 agccgcagaa ctggaccacc atgataaagg aattcggggg gcccttcttc tggaacagag
     2041 agaactatgt gagctgccac gaccccaaca acaatgcccc tttgaggtgg ccagacgtcc
     2101 agtatcagat cttgggcggc cggacagcaa accagatcat tttcggccac aatggctttt
     2161 atgtcttcta catttcgatc gtggatccgt actacagcta ctgtcaactg gagaccatct
     2221 ttagcatcta cgtgtatgga gcattccccg tgcagctggt ctctgctgga gtcgtcatcc
     2281 tactgatcat ctccagcatc ctggggtccg tttggctggc ctacaagacc cccaagctgc
     2341 tacgcacagc acgcggccgc aggatcaaga agtgtgcgac acagctgtgt aggagatgca
     2401 agacggtctg ccagttcagg gcctcagcca cagccagggc aggcacagag cccccgggac
     2461 gccaccgcac tcctcacgga ggcaggtctg accactgagg ccggtccaca gggtcccaac
     2521 cccttgtctt caaataaagt ataatgtaac atagca
//
