LOCUS       NM_024764               3699 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cation channel sperm associated auxiliary subunit beta
            (CATSPERB), mRNA.
ACCESSION   NM_024764
VERSION     NM_024764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3699)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   2  (bases 1 to 3699)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3699)
  AUTHORS   Koller,D.L., Ichikawa,S., Lai,D., Padgett,L.R., Doheny,K.F.,
            Pugh,E., Paschall,J., Hui,S.L., Edenberg,H.J., Xuei,X., Peacock,M.,
            Econs,M.J. and Foroud,T.
  TITLE     Genome-wide association study of bone mineral density in
            premenopausal European-American women and replication in
            African-American women
  JOURNAL   J Clin Endocrinol Metab 95 (4), 1802-1809 (2010)
   PUBMED   20164292
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3699)
  AUTHORS   Liu,J., Xia,J., Cho,K.H., Clapham,D.E. and Ren,D.
  TITLE     CatSperbeta, a novel transmembrane protein in the CatSper channel
            complex
  JOURNAL   J Biol Chem 282 (26), 18945-18952 (2007)
   PUBMED   17478420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI559703.1, AK126034.1, AL133373.5 and BC126214.1.
            
            On May 17, 2019 this sequence version replaced NM_024764.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126034.1, BC126214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256343.8/ ENSP00000256343.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BI559703.1         6-22
            18-2352             AK126034.1         2-2336
            2353-2353           AL133373.5         55306-55306
            2354-2493           AK126034.1         2338-2477
            2494-2494           AL133373.5         59318-59318
            2495-3568           BC126214.1         2449-3522
            3569-3623           AK126034.1         3553-3607
            3624-3699           AL133373.5         96205-96280
FEATURES             Location/Qualifiers
     source          1..3699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..3699
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /note="cation channel sperm associated auxiliary subunit
                     beta"
                     /db_xref="GeneID:79820"
                     /db_xref="HGNC:HGNC:20500"
                     /db_xref="MIM:611169"
     exon            1..157
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3508
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /note="cation channel, sperm associated beta; cation
                     channel sperm-associated protein subunit beta;
                     catSper-beta; catsper channel auxiliary subunit beta"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit beta precursor"
                     /protein_id="NP_079040.2"
                     /db_xref="CCDS:CCDS32142.1"
                     /db_xref="GeneID:79820"
                     /db_xref="HGNC:HGNC:20500"
                     /db_xref="MIM:611169"
                     /translation="MESPLIYVSVLLLNIFEFSSGIVYNKDDTEKRFACSNKGFPQEN
                     EIIKLYLFLENLKIQCFFQTENEIASKAMLSVFTSGGLAPSLGIMNSTYNGIFHFNLT
                     LFSDRILWLVDIPRENITQSTDIAAVEEWLVRITLHHGLNIYATEGTLLDVIREPILQ
                     WTPGDVIPESEISKLYPHVVDLKVTKCPCANDVALLGFIVDTIVDGVYIGITFGGFWH
                     DYDTTWFNMTQTIYSQLQEEYEDLSLVDMVLTNHFLVILTSLGLFVSEDLRYPSRHSL
                     SFSRADFCGFERVDYVKGKLWYNERCFANREHFEVDYVTVTFERNRTLSESSSCFYSQ
                     EPFLEWVPCLPHIFKGIKIFPTVLTFLVDQERGTGVYLFYNKVRKTAIASVSTLRNNE
                     PNSQSKFPIFRFPSSFSSPVGMVFHPRSHFLYAYGNQIWLSVDGGNTFQLIANFHDDI
                     IKKTFHSFYTSAITFVSQRGKVYSTKAGMGRYSAVGSVTERIFTLYYDHLGFLHKLTL
                     GRFEASGPPTAFGNSRNLFGQPPDMGFETALAPQHTSLDEIIFFAYVPENEPQETIYS
                     KKFGNIHYGKVIHSGKTGRAYIRKVLQHTTPKGFLSSVIAEMKEPFGLEEVNESSCLS
                     SSLLINKAGNVYKLTLDSQVVQALFEDTDIEKTVVLPGYSSFLITSILDNKNALAIAT
                     MPESAPNNMTFLKSTWFLYNFGQRNGRTWKIYSKPCNYWFQHDDSPSLNIVKYIDLGN
                     SYVLKAKVIRNAKGFRMLEIPLLTVFVGNPNLLEVTAEVTFDDTDSYVITISAASKVL
                     HQGSTSLAFIMWSASTECFVTTMVPTLKSSCSYLRSMHHIPSKFIPFEDWISGVHKDS
                     QGFNLIKTLPINYRPPSNMGIAIPLTDNFYHADPSKPIPRNMFHMSKKTGKFKQCANV
                     STREECNCTKDQKFSHAVAFSDCREKVPRFKFPITQYPVSLEIINEDGRVPLQSPYLV
                     TVTEVNMRHNWKLKHTVPENIKRMKQLVEPILGAAVYNPSGLNLSIKGSELFHFRVTV
                     ISGVTFCNLIEEFQIYVDEAPLPFPGHTLIAVATAVVLGGLIFIAFMFQLQGIHPWRT
                     FQRWIRRNQEKFSSISLSELIHRSKSEE"
     exon            158..236
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            237..325
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            326..466
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            467..527
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            528..623
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            624..773
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            774..869
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            870..988
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1021
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1088
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1135
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1285
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1444
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1589
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1744
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1899
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2087
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2417
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2557
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2755
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2866
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2977
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3113
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3214
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3289
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3699
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /note="hexamer: CATAAA"
     polyA_site      3625
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /note="major polyA site"
     regulatory      3675..3680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
                     /note="hexamer: AATACA"
     polyA_site      3699
                     /gene="CATSPERB"
                     /gene_synonym="C14orf161; CatSper(beta)"
ORIGIN      
        1 gctgattggc tgttaccaaa ggtgactaga gtgctaagcc agtcaacagg gaaaacttgg
       61 ctcctgactt tgggtctttc ttctcagtct atatggaaga aaactgagaa aaaatataaa
      121 aaagaagaac acaactagtt gcgcatctcc taaagagatg gaatcgccac ttatatatgt
      181 ttcagttttg cttttgaaca tatttgaatt ttcatcagga atagtatata ataaagatga
      241 tacagagaaa cgctttgcat gttctaacaa agggttccct caagagaatg aaataatcaa
      301 gttgtatctt ttcttagaaa acttgaaaat ccagtgtttc ttccaaactg aaaatgaaat
      361 tgcatcaaaa gcaatgctaa gtgtgttcac atcaggagga cttgctccca gcttgggaat
      421 catgaatagt acatataatg gcatcttcca ctttaattta acgttgttca gtgatcggat
      481 tttgtggttg gttgatattc ctagagaaaa catcacacaa agcacagata ttgcagctgt
      541 agaagaatgg ttagtaagaa tcactttaca tcatggacta aatatttatg ctactgaagg
      601 aactctattg gatgttattc gagaaccgat tcttcagtgg actcctgggg atgtgattcc
      661 agaaagtgaa atcagtaaat tatatccaca tgtggtagat ctcaaagtga caaaatgccc
      721 ctgtgccaat gatgtggcat tactaggctt cattgtggat acaatagttg atggtgttta
      781 cataggcata acctttggtg gattctggca tgattatgat accacatggt ttaacatgac
      841 acagactatc tattcccaac ttcaagaaga atatgaagac ctttcattgg tggatatggt
      901 tttaacgaat cattttttag ttatcctcac ctctttgggc ctttttgtaa gtgaagatct
      961 tcgttatcca tcacgccaca gcttatcgtt ttccagggca gacttttgtg gttttgaaag
     1021 ggttgactat gtgaaaggaa aactgtggta taatgaaaga tgttttgcta acagagagca
     1081 ctttgaagtt gattatgtta cagttacctt tgagagaaac agaaccctaa gtgagtcaag
     1141 ctcttgtttt tatagtcagg aaccatttct tgaatgggta ccctgcttac ctcacatttt
     1201 taaaggaata aaaatttttc caactgtgct aacatttctt gttgaccaag agcgtggtac
     1261 tggagtttac ctcttctata acaaggtcag gaaaactgcc attgcctctg tgagcaccct
     1321 gagaaataat gaaccaaatt cacaatcaaa atttccaatt tttcggtttc cttcatcatt
     1381 ctcttctccc gttggaatgg tatttcatcc ccgaagccac tttttgtatg cttatggcaa
     1441 tcagatatgg ctttcagttg atggcggcaa cacctttcaa ttaatagcta actttcatga
     1501 tgatatcata aagaagactt ttcatagttt ttatacatca gctattactt ttgtttctca
     1561 acgtggaaag gtttactcga caaaggcagg aatgggaaga tacagtgcag tcggaagtgt
     1621 tactgagaga attttcacat tatactatga tcacttggga ttcctacata agctgactct
     1681 gggtcgcttt gaagctagtg gaccacccac agcctttgga aattctagaa atctttttgg
     1741 acagcctcca gatatgggct ttgagactgc gcttgcccca cagcacacct ccttagatga
     1801 aattatcttt tttgcatatg tacctgagaa cgaaccccag gaaacgatct acagcaagaa
     1861 gttcggcaat atacactatg gaaaagtgat acactctggg aaaactggaa gagcttacat
     1921 aagaaaggta ttgcaacata cgactcctaa aggatttttg tcctcagtta ttgcagaaat
     1981 gaaagagccc tttggattag aagaagtgaa tgagagctct tgtttgtcta gttccctttt
     2041 gattaataaa gctggaaatg tctataaact cactcttgat tcacaagttg ttcaggcctt
     2101 gtttgaagat acagatatag agaagactgt agtgcttccc gggtacagca gcttcctcat
     2161 cacaagcatt ttagataata agaatgcatt agccattgct accatgcctg aaagtgcacc
     2221 caacaatatg acctttctaa agagcacatg gttcttatac aactttgggc aaaggaatgg
     2281 acgaacatgg aaaatatatt caaaaccatg taattattgg tttcaacatg atgattcacc
     2341 atccctcaac atcgtgaaat acattgatct gggaaactct tatgttttaa aagctaaggt
     2401 catacggaat gcaaaaggtt ttcgaatgct tgaaatacca ctactgactg tgtttgttgg
     2461 aaaccctaat ttgttggaag ttacagctga agtgactttt gatgatactg acagttatgt
     2521 aataacaatt tctgcagcta gcaaagtttt acatcagggt tcaacttcac tggcatttat
     2581 tatgtggtca gcctctactg agtgctttgt tacgacaatg gtgccaacac tgaaaagcag
     2641 ctgtagttat ctcagatcta tgcatcacat tcctagcaaa tttatcccat ttgaagactg
     2701 gattagtgga gttcataaag acagtcaggg ttttaacctc atcaaaactt tgccgataaa
     2761 ctacaggcct ccatctaata tgggaattgc tattccactc acagataatt tttatcatgc
     2821 agatcctagc aaacccatac caagaaacat gtttcacatg tcaaagaaaa ccggtaaatt
     2881 caaacagtgt gctaatgttt ccactcggga ggagtgtaac tgcacaaagg atcagaagtt
     2941 ttcacatgct gttgctttct cggattgcag ggaaaaagtt cctcgcttta agtttccaat
     3001 tacacaatat ccagtttctt tggaaattat caacgaggat ggacgtgtcc cattgcaatc
     3061 tccatatctg gttactgtga ctgaagtgaa catgaggcac aactggaaac tgaaacacac
     3121 tgtgccagaa aatattaaaa gaatgaaaca attagtagaa ccaattcttg gtgctgcagt
     3181 gtataatcct tcaggtctca acttaagcat aaagggctct gaacttttcc actttagagt
     3241 gaccgtcatt tcaggagtaa ctttttgtaa cttaattgaa gaatttcaga tttatgttga
     3301 tgaggcacca ttgccattcc caggacacac gcttattgcc gtggcaacag cggtagtgct
     3361 agggggatta atttttatag catttatgtt tcaactgcaa ggcatccatc cgtggaggac
     3421 attccaaaga tggattagaa gaaaccaaga gaagttttca agtatctctc tcagtgagct
     3481 gattcataga tcaaagtctg aagagtgaac acatggtgat cataatttct ctttattttc
     3541 tagttttatc agccaattcc tagaacaata tatttaaatg ttaaatatgc aagctacata
     3601 aaatcctaaa gaattgtcat tataattcaa attgctactt gtcaatatat tcaccatttc
     3661 cttttcttat tttgaataca tagaaaatgt cttatgcca
//
