LOCUS       NM_198137               1867 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cation channel sperm associated 4 (CATSPER4), mRNA.
ACCESSION   NM_198137 XM_371237
VERSION     NM_198137.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Soranzo,N., Rivadeneira,F., Chinappen-Horsley,U., Malkina,I.,
            Richards,J.B., Hammond,N., Stolk,L., Nica,A., Inouye,M., Hofman,A.,
            Stephens,J., Wheeler,E., Arp,P., Gwilliam,R., Jhamai,P.M.,
            Potter,S., Chaney,A., Ghori,M.J., Ravindrarajah,R., Ermakov,S.,
            Estrada,K., Pols,H.A., Williams,F.M., McArdle,W.L., van Meurs,J.B.,
            Loos,R.J., Dermitzakis,E.T., Ahmadi,K.R., Hart,D.J., Ouwehand,W.H.,
            Wareham,N.J., Barroso,I., Sandhu,M.S., Strachan,D.P., Livshits,G.,
            Spector,T.D., Uitterlinden,A.G. and Deloukas,P.
  TITLE     Meta-analysis of genome-wide scans for human adult stature
            identifies novel Loci and associations with measures of skeletal
            frame size
  JOURNAL   PLoS Genet 5 (4), e1000445 (2009)
   PUBMED   19343178
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Qi,H., Moran,M.M., Navarro,B., Chong,J.A., Krapivinsky,G.,
            Krapivinsky,L., Kirichok,Y., Ramsey,I.S., Quill,T.A. and
            Clapham,D.E.
  TITLE     All four CatSper ion channel proteins are required for male
            fertility and sperm cell hyperactivated motility
  JOURNAL   Proc Natl Acad Sci U S A 104 (4), 1219-1223 (2007)
   PUBMED   17227845
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Clapham,D.E. and Garbers,D.L.
  TITLE     International Union of Pharmacology. L. Nomenclature and
            structure-function relationships of CatSper and two-pore channels
  JOURNAL   Pharmacol Rev 57 (4), 451-454 (2005)
   PUBMED   16382101
  REMARK    Review article
REFERENCE   6  (bases 1 to 1867)
  AUTHORS   Lobley,A., Pierron,V., Reynolds,L., Allen,L. and Michalovich,D.
  TITLE     Identification of human and mouse CatSper3 and CatSper4 genes:
            characterisation of a common interaction domain and evidence for
            expression in testis
  JOURNAL   Reprod Biol Endocrinol 1, 53 (2003)
   PUBMED   12932298
  REMARK    GeneRIF: Catsper4 has a single channel-forming domain, a pore-loop
            with the consensus sequence TxDxW, & a coiled-coil protein-protein
            interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may
            interact directly or indirectly to form a functional tetramer.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355877.25.
            
            On Nov 27, 2019 this sequence version replaced NM_198137.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128139.1, BN000273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456354.7/ ENSP00000390423.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AL355877.25        2090-2328
            240-383             AL355877.25        2775-2918
            384-485             AL355877.25        5275-5376
            486-583             AL355877.25        9174-9271
            584-704             AL355877.25        9445-9565
            705-838             AL355877.25        9774-9907
            839-1013            AL355877.25        11372-11546
            1014-1225           AL355877.25        12318-12529
            1226-1391           AL355877.25        12842-13007
            1392-1867           AL355877.25        13977-14452
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1867
                     /gene="CATSPER4"
                     /note="cation channel sperm associated 4"
                     /db_xref="GeneID:378807"
                     /db_xref="HGNC:HGNC:23220"
                     /db_xref="MIM:609121"
     exon            1..239
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1445
                     /gene="CATSPER4"
                     /note="ion channel CatSper4"
                     /codon_start=1
                     /product="cation channel sperm-associated protein 4"
                     /protein_id="NP_937770.1"
                     /db_xref="CCDS:CCDS30645.1"
                     /db_xref="GeneID:378807"
                     /db_xref="HGNC:HGNC:23220"
                     /db_xref="MIM:609121"
                     /translation="MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSP
                     LQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLL
                     VINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILN
                     FIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIM
                     VLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKRE
                     YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEE
                     EEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQENLRQYK
                     EIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSAL
                     VSMEKVHDSSSQILLKKHKSSH"
     exon            240..383
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            384..485
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..583
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..704
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..838
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1013
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1225
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1391
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1867
                     /gene="CATSPER4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CATSPER4"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="CATSPER4"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaagg aagagactga gcaaacatga gggataatga aaaggcctgg tggcagcaat
       61 ggacctccca tacaggcctc gaggggtggg gcgggactca ggaggaccgt atggggtttg
      121 gaggggcagt agctgcactg aggggccgcc cctctcccct gcagagtacc attcacgagt
      181 cctacggtcg gccagaggag caagtgctca tcaaccgcca ggaaatcacg aacaaagcgg
      241 acgcctggga catgcaggag ttcatcactc acatgtacat caagcagctg ctccgacacc
      301 ccgccttcca actgctgctg gccctgctgc tggtgatcaa tgccatcacc atcgctctcc
      361 gtaccaactc ctacctggac cagaaacact atgagttgtt ctctaccata gatgacattg
      421 tgctgaccat ccttctttgt gaggttctcc ttggctggct caatggcttc tggattttct
      481 ggaaggacgg ctggaacatc ctcaacttca ttatcgtctt tatcttgctc ttgcggttct
      541 tcattaatga aatcaatatt ccctccatca actacactct cagggcgctt cgtctggtgc
      601 atgtgtgcat ggcggtggag cccctcgccc ggatcatccg cgtcatcctg cagtcggtgc
      661 ctgacatggc caatatcatg gtcctcatcc tcttcttcat gctggttttt tccgtgtttg
      721 gagtaacact ctttggtgca ttcgtgccca agcatttcca gaacatacag gttgcgctgt
      781 acaccctctt catctgcatc acccaggacg gctgggtgga catctacagt gacttccaga
      841 cagagaagag ggaatatgca atggagattg ggggtgccat ctactttacc atcttcatca
      901 ccatcggtgc cttcattggc atcaacctgt tcgtcatcgt ggtgaccacc aacctggagc
      961 aaatgatgaa ggcaggagag cagggacaac agcaacgaat aacctttagt gagacaggcg
     1021 cagaggaaga ggaggagaat gaccagctgc cactggtgca ttgtgtggtc gcccgctcgg
     1081 agaaatctgg tctcctccag gaaccccttg cgggaggccc cctgtcgaac ctctcagaaa
     1141 acacgtgtga caacttttgc ttggtgcttg aggcaataca ggagaacctg aggcagtaca
     1201 aggagatccg agatgaactc aacatgattg tggaggaggt gcgcgcaatc cgcttcaacc
     1261 aggagcagga gtcagaggtg ttgaacaggc gctcgtcgac gagcgggtcg ttggagacta
     1321 cgtcatccaa ggacatccgc cagatgtctc aacagcaaga cttgctcagt gcgctcgtta
     1381 gcatggaaaa ggttcatgac tctagctcac aaatactcct taaaaaacac aagagcagcc
     1441 actgagaggc caggatggga gccaaggggc ctgcacacac acacccagcc gctgcgtctt
     1501 cctgtgtcct tagtgtggct tggcagagcc tggccagagc ccatcctctc ccttatacct
     1561 gggcagaggc caggggctgt gaaggtggca gcacctgcag gtctggtgcc tgtgagcccc
     1621 aggtccggtg gagcaaggag agaggaggat gctggatgat gagagtggga accctagcag
     1681 caaggatgag cacagaaggg ggtgctggcc aacgcagcca ggatttgacc taaggatggg
     1741 gatccctggc cccctgctct tgcccagagc tggtgggggg cctcagtggg ccccagaacc
     1801 aagaagagaa aggcaaggcc agtggggcca gacatctgtg tgttgacaat aaagttttgt
     1861 gttggaa
//
