LOCUS       NM_001079843            7934 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens castor zinc finger 1 (CASZ1), transcript variant 1,
            mRNA.
ACCESSION   NM_001079843
VERSION     NM_001079843.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7934)
  AUTHORS   Droll,S.H., Zhang,B.J., Levine,M.C., Xue,C., Ho,P.J. and Bao,X.
  TITLE     CASZ1 Is Essential for Skin Epidermal Terminal Differentiation
  JOURNAL   J Invest Dermatol 144 (9), 2029-2038 (2024)
   PUBMED   38458428
  REMARK    GeneRIF: CASZ1 Is Essential for Skin Epidermal Terminal
            Differentiation.
REFERENCE   2  (bases 1 to 7934)
  AUTHORS   Cardoso,B.A., Duque,M., Girio,A., Fragoso,R., Oliveira,M.L.,
            Allen,J.R., Martins,L.R., Correia,N.C., Silveira,A.B., Veloso,A.,
            Kimura,S., Demoen,L., Matthijssens,F., Jeha,S., Cheng,C., Pui,C.H.,
            Grosso,A.R., Neto,J.L., De Almeida,S.F., Van Vlieberghe,P.,
            Mullighan,C.G., Yunes,J.A., Langenau,D.M., Pflumio,F. and
            Barata,J.T.
  TITLE     CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute
            lymphoblastic leukemia
  JOURNAL   Haematologica 109 (6), 1713-1725 (2024)
   PUBMED   38058200
  REMARK    GeneRIF: CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes
            T-cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7934)
  AUTHORS   Liu,T., Li,T. and Ke,S.
  TITLE     Role of the CASZ1 transcription factor in tissue development and
            disease
  JOURNAL   Eur J Med Res 28 (1), 562 (2023)
   PUBMED   38053207
  REMARK    GeneRIF: Role of the CASZ1 transcription factor in tissue
            development and disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7934)
  AUTHORS   Kato,N., Takeuchi,F., Tabara,Y., Kelly,T.N., Go,M.J., Sim,X.,
            Tay,W.T., Chen,C.H., Zhang,Y., Yamamoto,K., Katsuya,T., Yokota,M.,
            Kim,Y.J., Ong,R.T., Nabika,T., Gu,D., Chang,L.C., Kokubo,Y.,
            Huang,W., Ohnaka,K., Yamori,Y., Nakashima,E., Jaquish,C.E.,
            Lee,J.Y., Seielstad,M., Isono,M., Hixson,J.E., Chen,Y.T., Miki,T.,
            Zhou,X., Sugiyama,T., Jeon,J.P., Liu,J.J., Takayanagi,R., Kim,S.S.,
            Aung,T., Sung,Y.J., Zhang,X., Wong,T.Y., Han,B.G., Kobayashi,S.,
            Ogihara,T., Zhu,D., Iwai,N., Wu,J.Y., Teo,Y.Y., Tai,E.S., Cho,Y.S.
            and He,J.
  TITLE     Meta-analysis of genome-wide association studies identifies common
            variants associated with blood pressure variation in east Asians
  JOURNAL   Nat Genet 43 (6), 531-538 (2011)
   PUBMED   21572416
REFERENCE   5  (bases 1 to 7934)
  AUTHORS   Takeuchi,F., Isono,M., Katsuya,T., Yamamoto,K., Yokota,M.,
            Sugiyama,T., Nabika,T., Fujioka,A., Ohnaka,K., Asano,H., Yamori,Y.,
            Yamaguchi,S., Kobayashi,S., Takayanagi,R., Ogihara,T. and Kato,N.
  TITLE     Blood pressure and hypertension are associated with 7 loci in the
            Japanese population
  JOURNAL   Circulation 121 (21), 2302-2309 (2010)
   PUBMED   20479155
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 7934)
  AUTHORS   Igarashi,J., Muroi,S., Kawashima,H., Wang,X., Shinojima,Y.,
            Kitamura,E., Oinuma,T., Nemoto,N., Song,F., Ghosh,S., Held,W.A. and
            Nagase,H.
  TITLE     Quantitative analysis of human tissue-specific differences in
            methylation
  JOURNAL   Biochem Biophys Res Commun 376 (4), 658-664 (2008)
   PUBMED   18805397
REFERENCE   7  (bases 1 to 7934)
  AUTHORS   Caren,H., Fransson,S., Ejeskar,K., Kogner,P. and Martinsson,T.
  TITLE     Genetic and epigenetic changes in the common 1p36 deletion in
            neuroblastoma tumours
  JOURNAL   Br J Cancer 97 (10), 1416-1424 (2007)
   PUBMED   17940511
REFERENCE   8  (bases 1 to 7934)
  AUTHORS   Fransson,S., Martinsson,T. and Ejeskar,K.
  TITLE     Neuroblastoma tumors with favorable and unfavorable outcomes:
            Significant differences in mRNA expression of genes mapped at
            1p36.2
  JOURNAL   Genes Chromosomes Cancer 46 (1), 45-52 (2007)
   PUBMED   17044048
REFERENCE   9  (bases 1 to 7934)
  AUTHORS   Liu,Z., Yang,X., Tan,F., Cullion,K. and Thiele,C.J.
  TITLE     Molecular cloning and characterization of human Castor, a novel
            human gene upregulated during cell differentiation
  JOURNAL   Biochem Biophys Res Commun 344 (3), 834-844 (2006)
   PUBMED   16631614
  REMARK    GeneRIF: CASZ1 is expressed in a number of human tumors and
            localizes to a chromosomal region frequently lost in tumors of
            neuroectodermal origin.
REFERENCE   10 (bases 1 to 7934)
  AUTHORS   Yuan,Z.R., Wang,R., Solomon,J., Luo,X., Sun,H., Zhang,L. and Shi,Y.
  TITLE     Identification and characterization of survival-related gene, a
            novel cell survival gene controlling apoptosis and tumorigenesis
  JOURNAL   Cancer Res 65 (23), 10716-10724 (2005)
   PUBMED   16322216
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK092289.1, BC051883.2,
            BC004410.1, DQ217660.1, AA449398.1 and AL139423.25.
            
            On Nov 22, 2018 this sequence version replaced NM_001079843.2.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor. The encoded protein may function as a tumor
            suppressor, and single nucleotide polymorphisms in this gene are
            associated with blood pressure variation. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ217660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377022.8/ ENSP00000366221.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AK092289.1         5-466
            463-2664            BC051883.2         163-2364
            2665-3813           BC004410.1         694-1842
            3814-4205           DQ217660.1         3816-4207
            4206-4206           AA449398.1         325-325
            4207-4816           DQ217660.1         4209-4818
            4817-7934           AL139423.25        45186-48303         c
FEATURES             Location/Qualifiers
     source          1..7934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..7934
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /note="castor zinc finger 1"
                     /db_xref="GeneID:54897"
                     /db_xref="HGNC:HGNC:26002"
                     /db_xref="MIM:609895"
     exon            1..83
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            84..240
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            241..293
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            294..332
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..5596
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /note="isoform a is encoded by transcript variant 1;
                     survival-related; zinc finger protein 693; zinc finger
                     protein castor homolog 1; castor-related protein; castor
                     homolog 1, zinc finger"
                     /codon_start=1
                     /product="zinc finger protein castor homolog 1 isoform a"
                     /protein_id="NP_001073312.1"
                     /db_xref="CCDS:CCDS41246.1"
                     /db_xref="GeneID:54897"
                     /db_xref="HGNC:HGNC:26002"
                     /db_xref="MIM:609895"
                     /translation="MDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVV
                     EKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAP
                     TPVLGRIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDS
                     GPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAA
                     TSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGL
                     RLPSSTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYK
                     KPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPT
                     PSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGL
                     PTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDV
                     IRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTS
                     DVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNK
                     CDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTST
                     SQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLSA
                     SPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTP
                     TPYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLVASGAGDSAPVAAASVP
                     APPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPG
                     ESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLL
                     NIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCDGQCDFLHKAH
                     FHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPP
                     VPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLAT
                     TSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAESHCL
                     DHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWH
                     IKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSH
                     ARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSST
                     PVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRR
                     FDLYEDCKDAACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKR
                     FKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFS
                     SSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAP
                     GPPISLDGSLSLGAEPGSLLFLQSAAAGLGLALGDAGDPGPPDAAAPGPREGAAAAAA
                     AAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEA
                     AAEAAGAGARTPALAALAALGAPGPAPTAASSP"
     exon            333..821
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1656
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1725
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1816
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1981
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2154
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2996
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3132
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3196
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3351
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3474
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3813
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..4012
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4184
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4336
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            4337..4478
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..7934
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7397
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
     regulatory      7916..7921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /note="hexamer: AATAAA"
     polyA_site      7934
                     /gene="CASZ1"
                     /gene_synonym="CAS11; CST; dJ734G22.1; SRG; ZNF693"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcccgc ggcgctccat cccaaacaca cacacatttt tcccccggac ttggaaagtc
       61 acccaaagcc gccccaagtg caggcaaaca gaccttgctg actgaaggca aagactcctc
      121 catcccacct gccctcccag ctgccacggc catcgacccc tcctttacaa ggggctcctg
      181 caactcccca gcagcacgtg ttggaatgga cttcggaccc tggcctcttg ggatgcaaag
      241 gatgaagtga cacccccagc tacatccgag gaggttctag gacctgctac gagagtttgg
      301 gaccaaggag aagagaatgg atcttggaac agctgagggc acccggtgca cggacccgcc
      361 tgcaggcaag cccgccatgg cgcccaaacg caagggtggc ctgaagctga acgccatctg
      421 cgccaagctg agccgccagg tggtggtgga gaagcgagct gacgccggct cccacacgga
      481 gggcagccca tcgcagcccc gggaccaaga gcgcagtggc cctgagtctg gggcagcccg
      541 ggccccccgc agcgaggaag acaagagacg ggcagtgatc gagaagtggg tgaacgggga
      601 gtacagcgag gagccggcac ccacacccgt gttggggcgg attgcccgcg agggcctgga
      661 gctgcctccc gagggtgtct acatggtgca gccccagggg tgcagcgatg aggaagacca
      721 cgcggaggag ccctccaagg acggcggtgc cctggaggag aaggattcgg acggggcagc
      781 ctccaaggag gacagcggcc ccagcaccag gcaggcttca ggagaggcct cctcgctgcg
      841 ggactacgcg gcctccacca tgaccgagtt cctcggcatg tttggctatg atgaccagaa
      901 cacgcgggac gagctggcca ggaagatcag ctttgagaag ctgcacgcgg gctccacccc
      961 ggaggcagcc acctcctcca tgctgcccac ctccgaggat accctcagca agcgggcgcg
     1021 gttctctaag tatgaggagt acatccgcaa gctcaaggct ggcgagcagc tctcctggcc
     1081 ggcccccagc accaagaccg aggagcgggt gggcaaggag gtggtgggca ccctgcccgg
     1141 cctgcggctg cccagcagca cggcccacct ggagaccaag gccaccatcc tgcccctgcc
     1201 gtcgcacagc agtgtccaga tgcagaacct ggtagcccgg gcctccaagt acgacttctt
     1261 catccaaaaa ctgaagaccg gcgagaatct gcggccccag aacgggagca cctacaagaa
     1321 gccatccaag tacgacctgg agaatgtcaa gtacctgcac ctcttcaaac ccggggaggg
     1381 cagccccgac atgggcgggg ccatcgcctt caagacaggc aaggtggggc gcccttccaa
     1441 gtacgacgtc cggggcatcc agaagccagg ccccgccaag gttccgccca cccccagcct
     1501 ggctcccgca cccctcgcca gcgtgcccag tgcccccagc gcccccgggc cagggccaga
     1561 gcctcctgcc tccctgtcct tcaacactcc cgagtacctg aagtcaacct tctccaaaac
     1621 agactccatc accacgggga ccgtctccac tgtcaagaac ggactgccca cagataaacc
     1681 agccgtcact gaagatgtaa acatttacca gaaatatatt gccaggttct cgggcagcca
     1741 gcactgtggc cacatccact gtgcctacca gtaccgcgag cactaccact gccttgaccc
     1801 tgagtgtaac taccagaggt tcacgagtaa gcaggacgtg atccgccact acaacatgca
     1861 caagaagcgc gacaactccc tgcagcacgg cttcatgcgt ttcagcccgc tggacgactg
     1921 cagcgtctac taccacggct gccacctcaa tgggaagagc acccactatc actgcatgca
     1981 ggtgggctgt aacaaggtgt acacgagcac gtctgacgtg atgacccacg agaacttcca
     2041 caagaagaat acccagctca ttaacgacgg cttccagcgc ttccgagcca ccgaagactg
     2101 tggcacagcc gactgccagt tctacggaca gaagaccacg cacttccact gcaggcgccc
     2161 cggctgcaca ttcactttca agaacaagtg tgacatcgag aagcacaaga gctaccacat
     2221 caaggacgat gcctacgcca aggacggctt caagaagttc tacaagtacg aggagtgcaa
     2281 gtacgagggc tgcgtgtaca gcaaggctac caaccacttc cactgcatcc gcgccggctg
     2341 cggcttcacc ttcacctcca ccagccagat gacctctcac aagcgcaagc atgagcgccg
     2401 gcacatccgc tcctcgggcg cgctggggct gccgccctcg ctgctgggcg ccaaggacac
     2461 ggagcacgag gagtccagca acgacgacct tgttgacttc tccgccctga gcagcaagaa
     2521 ctccagcctg agcgcctccc ctaccagcca gcagtcctct gcgtccctgg ctgccgccac
     2581 tgccgccacc gaggctgggc ccagtgccac caaacctccc aacagcaaga tctcggggct
     2641 gctgccccag ggcctgcctg gctcaatccc cctggccctg gccctctcca actcgggcct
     2701 gcccaccccc acgccctact tccccatact ggctggccgt gggagcacct ccctgcctgt
     2761 gggcaccccc agcctcctgg gtgccgtgtc gtctgggtca gcagcctcag ccacccctga
     2821 cacacccacg ctggtcgcct cgggagctgg agactcagcc cccgtggctg ccgcctctgt
     2881 cccggcacca cccgcctcca tcatggagag gatctctgca agcaagggcc tcatctcgcc
     2941 catgatggcc aggctggctg cagctgccct caagccctct gccacctttg acccaggaag
     3001 cgggcagcag gtcaccccag ccaggttccc cccggcccaa gtgaagccgg aacccggtga
     3061 gagcaccggc gccccaggcc cccacgaagc ctcccaggac cgcagtctag acctgactgt
     3121 gaaggagccc agcaacgaat caaatggcca cgcagtcccg gcaaattcat ctcttttatc
     3181 ctcgcttatg aataagatgt ctcagggcaa ccctggcctg ggcagcctgc tgaacatcaa
     3241 ggcggaagcg gaggggagcc ccgctgcgga gccctcgccc ttcctaggca aggccgtgaa
     3301 ggcgctggtt caggagaagt tggcagagcc ctggaaggtg tacctgcgca ggtttggtac
     3361 aaaggacttc tgtgacggcc agtgtgactt cctccacaag gcccacttcc actgcgtggt
     3421 ggaggaatgc ggcgcgctct tcagcacctt ggacggggcc atcaagcacg caaacttcca
     3481 cttccggaca gagggaggag cagcaaaagg aaacacagag gctgcctttc cggcctcggc
     3541 cgccgagacc aaacctccca tggccccctc gtcccctccg gtccctcctg tcaccacggc
     3601 cacggtgtcc tctctggagg ggcccgctcc cagcccggcc tccgtgccct ccacccccac
     3661 cctgctcgcc tggaagcagc tggcttccac cataccccag atgcctcaga tcccagcgtc
     3721 agtgcctcac ctgcccgcct cgcccttggc aacgacttct ctagagaacg ccaagcccca
     3781 ggtcaaaccc ggattcctcc agttccagga gaacgatcct tgcctcgcca cggactgcaa
     3841 gtacgccaac aagttccact tccactgtct ctttgggaac tgcaagtacg tctgcaaaac
     3901 gtctggcaag gccgaatccc actgcctgga ccacatcaac cccaacaaca acctggtgaa
     3961 cgtgcgagac cagtttgcat actactctct gcagtgtctc tgtcccaacc agcactgcga
     4021 gttccgaatg cgtgggcact accactgcct ccgcaccggc tgctattttg tgaccaacat
     4081 caccaccaag ctcccctggc acatcaagaa gcatgagaag gcggagcggc gggcagccaa
     4141 tggcttcaaa tacttcacca agcgcgagga gtgtggcagg ctaggttgca agtacaacca
     4201 ggtgaacagc cacttccact gcatccggga gggctgccag ttctccttcc tcctcaagca
     4261 ccagatgacc tcccacgcgc ggaagcacat gcggaggatg ctggggaaga acttcgaccg
     4321 cgtgcccccc tcccagggcc ccccaggcct gatggatgct gagacagatg agtgcatgga
     4381 ctacactggc tgcagcccag gcgccatgtc ctctgagtca tccaccatgg accggagctg
     4441 ctccagcacc cccgtgggta acgagagcac cgcggcaggg aacaccatct ctatgccgac
     4501 agcctcgggg gccaaaaagc gcttctggat catcgaggac atgtcgccct tcggcaagcg
     4561 gcggaagacg gcgtcctccc ggaagatgct ggacgagggc atgatgctgg agggcttccg
     4621 gcgcttcgac ctttacgagg actgcaagga cgcagcttgt cagttctcgc tcaaggtcac
     4681 ccactaccac tgcacgcgcg agaactgcgg ctacaagttc tgcgggcgca cgcacatgta
     4741 caagcacgcg cagcaccacg accgcgtgga caacctggtg ctggacgact tcaagcgctt
     4801 caaggcctca ctcagctgcc acttcgccga ctgccccttc tcgggcacca gcacgcactt
     4861 ccactgcctg cgctgccgct tccgctgcac cgacagcacc aaggtcacgg cgcatcgcaa
     4921 gcaccacggc aaacaggacg tgatcagcgc cgcgggcttc tgccagttca gctccagcgc
     4981 cgactgcgcc gtgcccgact gcaagtacaa gctcaagtgc tcgcacttcc actgcacctt
     5041 cccgggctgc cgccacacgg tggtgggcat gtcgcagatg gactcgcaca agcgcaagca
     5101 cgagaagcag gagcgcggcg agcccgcggc agagggcccc gcgcccgggc ctcccatcag
     5161 tctggacggc tccctgtcgc tgggcgccga gccgggctcg ctgctcttcc tgcagtcggc
     5221 ggccgccggc ctgggcctgg cgctgggcga cgcgggcgac cccggcccgc ccgacgccgc
     5281 cgcccccggg ccgcgcgagg gcgccgccgc cgccgccgcc gcagctgggg agtcctcgca
     5341 ggaggacgag gaggaggagc tggagctgcc ggaggaggag gccgaagacg acgaggacga
     5401 ggacgacgac gaggacgacg acgacgagga cgacgacgag gacgacgacg acgaggacct
     5461 gcgcaccgac tcggaggagt cgctgcccga ggcggcggcg gaggcggcgg gcgcgggcgc
     5521 gcggaccccg gccttggcgg cgctggcggc cctgggcgcc cccggccccg cgcccactgc
     5581 agcctcctcg ccctagcggc gcccgcgggt ggccctggcg gcggcctcgg cctcggcctc
     5641 gggagcggcg ccgccccgcg cgaagcggcc cctgggcaga gccccgcgcc ccgccggtgc
     5701 ttccggaccc cgagtccgtc tcaggacaga ggcggggacc cctctggtgc tccgcggccg
     5761 aggacacagg cggcggcggt ggccctgctc tagggaggcc gggtctcttc agggaaacag
     5821 aaggtgctct tgtcccgggg tagggaacct aggagcaggg gtcccgggcg aatgcggcgc
     5881 agctcccggc cgctgccccg gcgcccctcc ccgcggccga ttcggccccg cgaccattgc
     5941 tcaggactgg gacgggcgct gggggccacc gggaccccca ccgcgcgcca ccagggcggg
     6001 gtggctcctg gagccgctgg cggggcctcc ctcatgcagc taggatcctc ccccctgccc
     6061 agggggagac gggcagaagg cagtcagcac gggtgacact acagggaccg tggaggaagc
     6121 ctcacgggag tagcagccgc ggagctccag ctcagcccca ccccagggcc cggctgctcc
     6181 cccaggcctg ggtcgggtct gtttggcgac tccctggccc cagcctccgc cccagggaaa
     6241 ccgaggctgc gtccaaaacc cagagtagcc cgctgggggc cggggcgggg tctcggccac
     6301 cctggtggtg caaacaggaa ggatgcgcct ggttttggct ttaatgttca aaatggaaaa
     6361 aaatacaaga aagttgtaca gtatttttcc tgtaaaggtt attattctac atagaacaaa
     6421 aaggaagaaa gcaggcgtgg tgagagtgca gacccgcctg ggcccggcct gaggttggag
     6481 gctcagtccc gtttatcctg tgggatttgg tccagggttt ttgtagaggc cttaactgtt
     6541 tgaggctgtc tgtcttcaca atagcactga tgggagctgc gtgattccaa ctcttaactt
     6601 gaattttgta gagacaagaa aaaaggacta ttactgttga tccaagtttg tagttaattt
     6661 aacatttgag ttctctcttg gtgatgcgtg tggctttata gggctttttt ttttttccag
     6721 tttgttttat tactttgttt gggatgcttc ttcgctggtg cagtctaccc agattgggtt
     6781 ccctttgcaa aacatccccc ttcctggaga tgatgatgcc atcgaagccc gggccagggc
     6841 ctgacctggc aggcacacac ctggccagtg gctctgaggt ccccggggac cgagtcccct
     6901 gcgagggcag gctgcccgag gccacacctg cccaccttcc ctactccagg ccaccagctg
     6961 gtgtcagatt gggccaccgg gagagaacag gcctaggagg gaatggaagg ctggcgggga
     7021 ggctgtcatc cagaagcctc ctccccagag gtctccagga ggaacctggc tcaactgggg
     7081 ggcagtggtt tacttttccc ttttttcttc ctttcttttg tcctctcagc tgcccacagc
     7141 cagaaagcca ggaccacccg aactggacag ggagcaggga gggaggagtg gtcgcacgga
     7201 gcgtacctga ttcaacagga aatcagttat tttctaaaac agcccctacc agagcctcct
     7261 gaactctgtg ggcaccacgt gctgctgtga gcatctgccc agacagtgac ccgccacagg
     7321 ccccgggcgt ctgtggaagg agttttgtaa aggaaaaaaa aacacacaca cacaaacatt
     7381 ttttcaatgt agcaaaatca aacttaaaaa aaaaaaagaa gaaaagaaga agatgccgac
     7441 agtgcggagt ctagcctttt gtaaacttca tattgcacac taggactata agccattgct
     7501 agctcatttt gaattttaac gtgtaatttt tgttttattt tctttctgtg gggaaacaat
     7561 gcttgatcca ccaatgctct ttttaatgtt ttataactat gtatgtgtat atatataaat
     7621 atcaaataat atgtatgcac atatgtgtgt gtatatatct atatgtatat acatatatag
     7681 atatatagag atatatagag aggttttgag acaaaaaaaa tacagaacgt gaaacccgag
     7741 ctgaacagcg tgtgctctga ttacttgaat ctggtctcct cggcacctgg ttattaagaa
     7801 ctgaatattt ttccacttga atttagtgct attagaaatt taatatatgt gttttattta
     7861 tttgattttt tttttttttt ttgcatgact gatgcaaggt ttgacatttt cactcaataa
     7921 aaactggaaa aaaa
//
