LOCUS       NM_001145064            8100 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cytosolic arginine sensor for mTORC1 subunit 2
            (CASTOR2), mRNA.
ACCESSION   NM_001145064 NM_001145063 XM_001715774 XM_001715901 XM_001717397
            XM_001721738 XM_935555
VERSION     NM_001145064.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8100)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8100)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 8100)
  AUTHORS   Chantranupong,L., Scaria,S.M., Saxton,R.A., Gygi,M.P., Shen,K.,
            Wyant,G.A., Wang,T., Harper,J.W., Gygi,S.P. and Sabatini,D.M.
  TITLE     The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
  JOURNAL   Cell 165 (1), 153-164 (2016)
   PUBMED   26972053
  REMARK    GeneRIF: Study establishes the CASTOR1 homodimer and
            CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1
            pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245150.3 and BC147030.1.
            
            On May 17, 2019 this sequence version replaced NM_001145064.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.325632.1,
                                           SRR1803611.387443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616305.2/ ENSP00000484732.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC245150.3         59550-59827
            279-1368            BC147030.1         1-1090
            1369-8100           AC245150.3         119642-126373
FEATURES             Location/Qualifiers
     source          1..8100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..8100
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /note="cytosolic arginine sensor for mTORC1 subunit 2"
                     /db_xref="GeneID:729438"
                     /db_xref="HGNC:HGNC:37073"
                     /db_xref="MIM:617033"
     exon            1..394
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1271
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /note="GATS-like protein 2; GATS-like protein 1; GATS
                     protein-like 1; cellular arginine sensor for mTORC1
                     protein 2; GATS protein like 2; cytosolic arginine sensor
                     for mTORC1 subunit 1"
                     /codon_start=1
                     /product="cytosolic arginine sensor for mTORC1 subunit 2"
                     /protein_id="NP_001138536.1"
                     /db_xref="CCDS:CCDS75620.1"
                     /db_xref="GeneID:729438"
                     /db_xref="HGNC:HGNC:37073"
                     /db_xref="MIM:617033"
                     /translation="MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSL
                     TETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKS
                     VIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLG
                     ITNGFVKPKLVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMA
                     TGDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGF
                     DECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENINGVISALKVSQAEKH"
     exon            395..465
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..659
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..792
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..916
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1027
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1110
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1205
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..8100
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /note="hexamer: TATAAA"
     polyA_site      3541
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /note="hexamer: AATATA"
     polyA_site      3588
                     /gene="CASTOR2"
                     /gene_synonym="GATSL1; GATSL2"
                     /note="major polyA site"
ORIGIN      
        1 agctgctccc cgcgccgggc gccgcgcgcc gctgctccgc cgctcggccc ctcggctgct
       61 gctccgccgg cgctgcctcc ctcgccccgc ggctccccct tgcaacttgg cgggcctcct
      121 cccttttgtc cggcccggcc cggccgccgc cgccccccgc gcccggcgcc gagctcccgg
      181 gtctccgggc cggctgtcgg tgccggcagg gcgcggaggg ggcgggggcc gcggctcgtc
      241 cccccgcgga tgagccgccg cggacggggc gcgggcggac gatggaactc cacatcctgg
      301 agcaccggct gcaagttgcc agcgtcgcca aggagagtat cccgctgttc acctacggcc
      361 tgatcaaact tgccttcctg tcctccaaga ccaggtgcaa gttcttcagt ctgactgaga
      421 cgccagagga ttacactatc attgtcgatg aggaaggatt cctagagctg ccctcctcgg
      481 agcacctgag tgtggcagat gccacctggc tggccctgaa cgtggtgtcc ggcggtggca
      541 gcttctccag ctcccagccc atcggcgtga ccaagatcgc caagtcagtc atcgccccac
      601 tggctgacca gaacatatcc gtgttcatgc tgtccacgta tcagacagac ttcatcctgg
      661 tgcgcgagcg ggacctgccc tttgtcaccc acacattgtc atcagagttc accatcctgc
      721 gggtcgtcaa tggcgagacc gtggcagccg agaacctcgg catcaccaat ggcttcgtga
      781 agcccaagct ggtccagagg ccagtcatcc acccactgtc cagcccgagc aacaggttct
      841 gtgtcaccag cctggaccct gacacgctgc ctgctgttgc cacactcctc atggatgtca
      901 tgttctactc caatggagtg aaggacccca tggccactgg ggatgactgc ggccacatcc
      961 gcttcttctc cttctccctc atcgagggct acatctccct ggtgatggac gtgcagacgc
     1021 agcagaggtt tcctagtaac ttgctgttca caagcgcatc cggagagctc tggaagatgg
     1081 tccggattgg aggacagccc ctggggtttg atgagtgtgg catcgtggcc cagatctcag
     1141 agcccttggc tgctgcagac atcccagcct actacatcag tactttcaag tttgatcatg
     1201 cacttgtccc cgaagagaac atcaatggtg tcatcagtgc cctgaaggtc agccaagcag
     1261 agaagcacta gaagggtctc ttctgctcct ccctgccgcc gcccgggccc agccctaacc
     1321 ctgaagattg atcttgcagt atttctctac agactggaaa atcagcctgg ggaccctgag
     1381 gaaggggcct ctgtgggaga ctccctcgat tgccaatccc tccagggcag gggcccacgc
     1441 caaggcctct ccatgccctc ctgccttccc ggagcccccc gaccctccag agaacgacct
     1501 ttctcttccc tacctccccc accccggaaa atgctttcgg aggcccaggg agcttgtgag
     1561 ctgatccgcc ttctcatccg gcctcaccca cggccagggg cagatgccga gggaagccgg
     1621 tccctcctgc gagacaccgg tgtgccagct gtcatgtcac cttgcagggc tggggctggc
     1681 ggggtggggc cgagtttggg gtgccctgga gggtttgggg gtgagtactg tggtcactgg
     1741 tctctgcttc catcagctca gggctggttc cctcggagtg gaggccagcg tggccccctc
     1801 aggtcatcgg ggctggtgag gctcagacag gaacccaggt gggatccccg agctgggaag
     1861 gacccagact ccccctgtac ctcgcctgcc aaccacaggg cctgggcccg actcccagca
     1921 agactgccaa gagggccctg tccagaccct cccccacaag cactcagtcc ttgggggagg
     1981 agggagggtc ccaggagacc caccagcctg gagcaccagc tcctgtcccc tcggctctcc
     2041 ctggacccga cttgggcagg tagagcctca gcttccccca gtagggacat ccctggcttt
     2101 ccaggcctga ggtttcttag gtggtgtccc acctccccaa cagacaacta gaccagcata
     2161 ggactccccg ccgtcctcct ccctcctctg cccccaagtc acctgcctgc ccacccgccc
     2221 cttggctggg ggctgtggca ttcatgagta cttgacccag gaggcagctt aactgagcct
     2281 taatagagaa aaccatactt tgttttagtt ttttatttaa tgtatttgca cccagggtgc
     2341 tcttggcggt agtttctgtt tggcagggat aggacctgtt tgagttctgt caagggagcc
     2401 tggaggctct gtgtcactaa gctggtgctc tgtggctcca gggacaggca gtgggaatcg
     2461 ggagatgtca caggagcctg ggccctctct tctgaaggga agctaggagc agagatctgt
     2521 tacaagacgc tggagccgct ggcaccccac atgggaactc ccaccaacca gctgtagttc
     2581 tatctgagca ccggaggggg tgagggaacc cgagggccat ggggaggtgg acagccaggt
     2641 ggcaggccag ctgagtggtc atgtccagga ggcatggggt tagccgtggt gtcccttcca
     2701 gtggggtggt tttctgaatg agcaggacca agggcccctg tggttttggc tctggcgggg
     2761 gttttttttt ttttttttga gatgggagtc tggctctgtt gcctaggctg gaatgcagtg
     2821 gcacgatctt ggctcactac accctcctcc tcccaggttc aagtgattct cctgcctcgg
     2881 cctcccaagt agctgggatt acaggcacgc accaccacgt ctggctagtt attgtatttt
     2941 ttaatagaga cgggatttcg taacattgct caggctggtc ttgaactcct gagttaagtg
     3001 atccgcctgc ctcggcctcc caaaatgccg ggattacagg cgtgagccac cacacccagc
     3061 cgagttgtgc tgtttctgtg gtcagaggag aagggatatt ttctagtcct gacaaagtgt
     3121 tccctgcttc tctgagtggg accctctgag ccctggaagc ccaccagaag gagaagctgt
     3181 tctttaaaat ccttgtgggt gttgaaggcc caccacatta attagaaacc aacttttttt
     3241 tttttaagtt aatttgtttt gcacaaaact ccagaacaaa actcgtacat tgctggtccc
     3301 aaaagggagg tggccaagtg gggcagggct gtggtggaag ccctgagtcc cctttctgac
     3361 cttgcaaggc cttgattttc ctttctgtca tttccccctg acggtgtcac ttctctgcct
     3421 ttccttcccg ccgtgcaagt gtgtcggccc cgtgacccca gagtcgtgtg tcccctagac
     3481 ttcctaggac gtatctattg tacacaccta taaatacctg tgttttatgt tgatagagat
     3541 atatactgta aatagcatat atacttgagc aatatatatg ttaatatata ctgtgtgcgc
     3601 agtccgtgga cacagccccc cgctgtgtgt gcacacgtgt atgggcgtga tggcctccac
     3661 cccgcaccgt ctgccataca cgcgggcaca tttgagccac catatatttt taattcaagt
     3721 atataggcaa tacgattatt acagaagccg atgggttccc tcagacctga cttgagagaa
     3781 caaagccagc agctcaaaga gcctgtgaca tgggacgtgg gaagggtgct gagagcccgc
     3841 tgtggcgtgg gtcatgcctt ctgcacccca ctttccccag gcaagatccc tgggcgccct
     3901 tatttggggg gatgttgatc ccgagggagg agtatttgga atttcttgct tttaaccaga
     3961 atgccccctc tcccctgccc tcgccagcag cctcaccctg aagacctggg cctgctgaat
     4021 gggccacacg ctgcctgtgt cctgcctccg tgggtggcac tttttacgca ggcagcttct
     4081 ctgttttttt tgttttttgt aacctgcaag cttagaaatc tcaggttgtg ctcctggggc
     4141 tgctcctggg gactggcctc gtgtcatgga gaaaagcatg tgtgtcgggg cgcgctgggg
     4201 ccagggtatg gctctccgcc ctggctggct ctgcaggggt ggtccctgtt caagcccgct
     4261 ccgtgggagc tgccccctgg ggaccctgct cctcggtcac agggggcccc tttagttttc
     4321 ccatccccat cctgctcgtg taaagcttgg tttatcttct cggcgttctg tgtgtagcgt
     4381 agtcttggtt tggtctccac agctcttcgg ggtggggtgt gagtgtggtt tttcccaggc
     4441 aggggccgtc tgcccttgtc ccccagctat ctcctggtct gctgggtggg agggtctctc
     4501 caggccccag accccacttg gaggggcatg tgtttctcag aggggctcca tccgcagttg
     4561 catggaactc cttacctgtt tgccgtccat cccccggagg taatcagagg agtgggcctg
     4621 ttgtcttggc gctggcggat ggggcaggtg cctggcgggg gaggaagagg gctctctatg
     4681 atgtggaatt tttttttttt tttttttgag acggagtctt gctctgtcgc ccaggctgga
     4741 gtgctgtggc atgatctcag ctcactgcag caacctccac ttcctgggtt caagcgagtc
     4801 tcctacattg gcctcccaag taggtgagat tacaggcact caccaccaca cgcggctaat
     4861 ttttgtattt ttggtagaga cggggtttca ccatgttggc cacgctggtc ttgaactcct
     4921 gacctcaagt gatccaccca ccttggcctc ccgaagtgct gggattacag gcatgagcca
     4981 ccgtgcccgg cctcatggaa tttctagggg tgagcaggtg accctggggc tgccacttga
     5041 gctcctggag tgtgtgtctt ggcccctgtg tggttctcca ttaagaaaag ctcagatagt
     5101 ctcaacccca ccctctcccc ttgctgcact cagagtacca gtgggagctg aaggatgggg
     5161 aggaacagag cagtgaccac ccctccctgc cactgataag ttctgcctcg tcgtggggct
     5221 cccctggttc ccaagacacc ccttcctccc tcagcccgtc gtcctaaccc agcaaagatc
     5281 tgggcattgc tgactctgca cctccttcct ccatgggcat ctccaggacc gccctccttc
     5341 aaggggcact gcccacacca ctgtcctcag cccgaggcat gcatctgagc tggagaggct
     5401 tgcaggcctg accctggtag cttcccctcc ccaagattca gaggcgggga cccaaagcct
     5461 cactccaaac cactggcatt ctcacctcct ctcacctcca ggcaccaggc tgctggtggg
     5521 aaaggaagga gctgggggat cagaggcttc cagtgtggcc tccggaagca gcagcgtagc
     5581 cagggtgaca tttgttcagc aggaggaggc ttggtctgga ggggcttgcc cctctgaggt
     5641 gacagaggat gccctggagg tcaggagaga agactgggaa gacaggaagg gccaggcccc
     5701 tgttaaagcc cagggcacta tttggtgatc ttcaaaggtg aacacaggcc acctcccact
     5761 ggccccctcc tcctggccac attttccagg gataccctgg ggagtcctaa ggccaccctg
     5821 ggcccctttc tgagcctaga gatctggatg tggtgacaac cagggctttt cccagcccca
     5881 gctaagagag ggggctttag ggcaagagca cctcagccct gcaatggggg gatctttttt
     5941 tttttttttt tttgagacag gctggagtgc agtggtgcga tctcggttcg ctgcaacctc
     6001 tgcttcccag gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gattacaggc
     6061 acccaccacc acgctcggct aatttttgta tttttagtag agacagggtt tcactatgtt
     6121 ggccaggctg ttcttgaact cctgacctca ggtgatccgc ccaccttggc ctcccaaagt
     6181 gctgggatta caggcatgag ataccccgcc tggccaatgg gatttttgac gccacttcct
     6241 gagtgaagcg ctttgcatgg ggatgggaag aagcaccccc aaccttctag tccgctccga
     6301 gcagggcctg gagcattgga gacattggtt agtgtaatag gcagagcctg agtgaggccg
     6361 gggggcttct ccaacagaga aaagacattg gctttgggta ccatgctgag ggagggggtt
     6421 aggcctggtg ggggcccatt caaaggaggc cgggctcggt ggcttaggcc tgtcatccca
     6481 gcactttggg agaccaaggt gggaggatag cttgaggcca agatagcaag accaacctgg
     6541 tcaacatagc aagaccctgc ctctacaaga aaataacgaa agaggcccca gggaaggaag
     6601 ccagccagga gcagcctgga gcagaggcag gagcctgagg cctgagccat ggcatccagg
     6661 gacagcctgg tggccgagag agcttgtggc tgtcactata agggaagagg agctatggaa
     6721 attggaagtg cagggtggcc tgtgtgctag gagtgggggt gcaggcctag gtgtgtttat
     6781 gcacacgttt gtgcatgtac ctgtgagcgt ggatgtgttc ctatgcatta gagtgtgtgc
     6841 gtgcacgtgt gcagagccca cacctgagat atgggactgg ctcttggagt attttgagtt
     6901 ctcagtagca gtcttgttgt caggccttga gtgcagaaat gattaggtga gtgagggcag
     6961 gactcgaatg cagaccctgg ctccagggga gagggtgggg cgtctctggt aggacggcct
     7021 caccccactt gtcagaacta ctctggaggg gggcaaaggt gtcaggaaca gtttgagcag
     7081 ttctggctca gggtcattca tgaggttgct gttgtctgaa atcttagcta aggattggag
     7141 gatgcacttc taagtgaggc ctggctgtag gcaggaggcc tcagtccttc cccaggtggg
     7201 ccaacccaca gggctgcttg agtgtcttca caatatggcg ctcggcttcc ccccagagca
     7261 agagattcaa gggcccaggg taaaagccaa cgtgttattt ttatccctag cctcagaatt
     7321 cacacgccgt tgcctccacc atgctctggt ttgatacagc ccagctctga ttggaagggg
     7381 ctggggctgc ccgtgctgac tcttcaaagg catcccatcc tgcagatggt gttcacaggg
     7441 agagtttgtg ggggccggca ctccctcatc tactggggct cattctggaa gaaggtccag
     7501 aagaattgga gacccctgcc cctcacccaa actttggagg tggcagggtg aacagcaggc
     7561 caagttcagg tcccaagaca ggccaaggcc agtgcggttt cccttccact gcctcagttt
     7621 acctgtattc agaagacagt ctaggaagag ttgagcagag ttccctctaa aagagtaggg
     7681 agctgataac agtcccaagc cctcctcttt ctctatgcca aaatcatttc cgttatcctg
     7741 agatgggggt gagtggatgg atggtgtact gaggggcctc tgccctgccc agagccccca
     7801 ccatcgtagt gggggcaggg gacttcctgc ccacaacccc ctccaaccct cacctggcgt
     7861 gcccgggtca ccagcagcag cagcggcgtt ccatcgctcc caagatctgg gtgaagggga
     7921 gaacctgcca tcttatccct acccccccgg ggccctcaag cttattttct tgttgaagaa
     7981 acacaaaacc ctcgagattc atgtactgta tgttggagaa aaaaaattac ctaatgttcc
     8041 cccaaaaaag acagtatatt ttgtactttg taaagtgtta attaaaatga aaaaaaaaaa
//
