LOCUS       NM_001037666            1501 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1
            (CASTOR1), mRNA.
ACCESSION   NM_001037666
VERSION     NM_001037666.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Li,T., Wang,X., Ju,E., da Silva,S.R., Chen,L., Zhang,X., Wei,S. and
            Gao,S.J.
  TITLE     RNF167 activates mTORC1 and promotes tumorigenesis by targeting
            CASTOR1 for ubiquitination and degradation
  JOURNAL   Nat Commun 12 (1), 1055 (2021)
   PUBMED   33594058
  REMARK    GeneRIF: RNF167 activates mTORC1 and promotes tumorigenesis by
            targeting CASTOR1 for ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   Sun,L., Li,X., Pan,J., Mao,J., Yuan,Y., Wang,D., Sun,W.,
            Krueger,G.R.F. and Wang,G.
  TITLE     Seeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of
            Arginine Analogs Inhibiting CASTOR1
  JOURNAL   Cancer Genomics Proteomics 16 (6), 465-479 (2019)
   PUBMED   31659101
  REMARK    GeneRIF: The binding free energy calculations revealed that
            Nalpha-acetyl-arginine, citrulline, and norarginine have sufficient
            binding affinity with CASTOR1 to compete with arginine. The
            hydrogen bond analysis revealed that norarginine,
            Nalpha-acetyl-arginine and D-arginine have proficient H-bonds that
            can facilitate their entering the narrow binding pocket.
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Li,T., Ju,E. and Gao,S.J.
  TITLE     Kaposi sarcoma-associated herpesvirus miRNAs suppress
            CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis
  JOURNAL   J Clin Invest 129 (8), 3310-3323 (2019)
   PUBMED   31305263
  REMARK    GeneRIF: the KSHV-encoded miRNA miR-K4-5p, and probably miR-K1-5p,
            directly targeted CASTOR1 to inhibit its expression. Knockdown of
            miR-K1-5p and -K4-5p restored CASTOR1 expression and thereby
            attenuated mTORC1 activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Chantranupong,L., Scaria,S.M., Saxton,R.A., Gygi,M.P., Shen,K.,
            Wyant,G.A., Wang,T., Harper,J.W., Gygi,S.P. and Sabatini,D.M.
  TITLE     The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
  JOURNAL   Cell 165 (1), 153-164 (2016)
   PUBMED   26972053
  REMARK    GeneRIF: Study establishes the CASTOR1 homodimer and
            CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1
            pathway.
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Orozco,G., Viatte,S., Bowes,J., Martin,P., Wilson,A.G.,
            Morgan,A.W., Steer,S., Wordsworth,P., Hocking,L.J., Barton,A.,
            Worthington,J. and Eyre,S.
  CONSRTM   UK Rheumatoid Arthritis Genetics Consortium; Wellcome Trust Case
            Control Consortium; Biologics in Rheumatoid Arthritis Genetics and
            Genomics Study Syndicate Consortium
  TITLE     Novel rheumatoid arthritis susceptibility locus at 22q12 identified
            in an extended UK genome-wide association study
  JOURNAL   Arthritis Rheumatol 66 (1), 24-30 (2014)
   PUBMED   24449572
  REMARK    GeneRIF: This genome wide association study identified a new
            rheumatoid arthritis susceptibility locus mapping to 22q12 in the
            GATSL3 gene.
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Kapranov,P., Drenkow,J., Cheng,J., Long,J., Helt,G., Dike,S. and
            Gingeras,T.R.
  TITLE     Examples of the complex architecture of the human transcriptome
            revealed by RACE and high-density tiling arrays
  JOURNAL   Genome Res 15 (7), 987-997 (2005)
   PUBMED   15998911
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   10 (bases 1 to 1501)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA343534.1, AC004997.2 and BC021927.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001037666.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055587.1, BC021927.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407689.8/ ENSP00000384183.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DA343534.1         123-163
            42-121              AC004997.2         7100-7179           c
            122-192             AC004997.2         6421-6491           c
            193-380             AC004997.2         5088-5275           c
            381-513             AC004997.2         4870-5002           c
            514-637             AC004997.2         4540-4663           c
            638-751             AC004997.2         3978-4091           c
            752-834             AC004997.2         3731-3813           c
            835-929             AC004997.2         3547-3641           c
            930-1471            AC004997.2         2862-3403           c
            1472-1500           BC021927.1         1482-1510
            1501-1501           AC004997.2         2832-2832           c
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1501
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /note="cytosolic arginine sensor for mTORC1 subunit 1"
                     /db_xref="GeneID:652968"
                     /db_xref="HGNC:HGNC:34423"
                     /db_xref="MIM:617034"
     exon            1..121
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..998
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /note="GATS-like protein 3; cellular arginine sensor for
                     mTORC1 protein 1; GATS protein like 3"
                     /codon_start=1
                     /product="cytosolic arginine sensor for mTORC1 subunit 1"
                     /protein_id="NP_001032755.1"
                     /db_xref="CCDS:CCDS43001.1"
                     /db_xref="GeneID:652968"
                     /db_xref="HGNC:HGNC:34423"
                     /db_xref="MIM:617034"
                     /translation="MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSL
                     TETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVI
                     APLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSS
                     NGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASS
                     SPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFD
                     ECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS"
     exon            122..192
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..380
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..513
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..637
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..751
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..834
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..929
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1501
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /note="hexamer: AATAAA"
     polyA_site      1501
                     /gene="CASTOR1"
                     /gene_synonym="GATSL3"
                     /note="major polyA site"
ORIGIN      
        1 gagccgcgat ggagctgcac atcctagaac accgggtgcg ggtgctgagc gtcgcccgtc
       61 ccggtctctg gctctacacc cacccgctca tcaagctgct cttcctgccc cgccgcagcc
      121 ggtgcaagtt cttcagcctg acggagaccc ctgaggatta cacgcttatg gtggacgagg
      181 agggctttaa agagctgccc ccatctgagt tcctgcaagt agctgaggcc acatggctgg
      241 tgctgaacgt gtcgtctcac agcggtgcgg cagtgcaggc tgctggggtc accaagatcg
      301 cccgttcggt catcgcgcca ctggccgagc accacgtgtc tgtgctgatg ctgtccactt
      361 accagacgga cttcatcctg gtgcgggagc aggacctgtc cgtggtgatc cacacgctgg
      421 cccaggagtt cgacatttac cgcgaggtgg gcggagagcc tgtgcctgtg acgagggatg
      481 attccagcaa tggctttccc cgcactcagc atgggcccag ccccacggtg catcccatcc
      541 agagcccaca gaaccgcttc tgtgtcctca cactggaccc tgagacgctt ccagccatcg
      601 ccaccaccct catagatgtc ctcttctact cgcacagcac ccccaaggag gcagcctcta
      661 gcagtcctga acccagctcc atcacgttct ttgccttctc cctcatcgag ggttatatct
      721 ccattgtcat ggatgctgaa acacagaaaa agttccccag tgacctcctg ctgaccagct
      781 cctcggggga gctgtggagg atggtgcgca tcggtggaca gcccctgggc tttgatgaat
      841 gtggcatcgt ggcacagatt gcaggtcccc tggctgccgc tgacatctct gcctactaca
      901 tcagcacctt caacttcgac cacgccctgg tgcccgagga cggtatcggc agcgtcatcg
      961 aggtcctcca gcggcggcag gaaggcctgg cttcctgagg cccatgggca acagagcagc
     1021 ctccctgctc tcccctcgac ccaggcttcc aaagacttct ctaagctatt tccttaagct
     1081 ctggaacgag ccccctgttc tgctggggac cctcgttccg ctctctgtat gtaagctgcg
     1141 tgcaggcacc ggcttttacg cggacacctg tgtacactca caggtggagt gggcaggtgc
     1201 tagcctgact gcgtgtctgc ccatgcaggg gaacacggtg ctcggggctt aagcccccaa
     1261 cccatcactc cctgcgcagc ctcggcgttt gcacagtccc tgcctgaggc ctgagccatt
     1321 ccccaaaggc ttcctgggcc agctgccccg ctgacctccg ttctgcctct ggtggggttg
     1381 ccttccctgg ccaggtgagt cctgacagtg cctctccctc ctggggcctc caaggaaagt
     1441 attttgacat ctctctctct tctgttttta ttgacttgtt aataaaggac tttgtagtga
     1501 c
//
