LOCUS       NM_001137667            6792 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript
            variant 2, mRNA.
ACCESSION   NM_001137667
VERSION     NM_001137667.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6792)
  AUTHORS   Jin,F.F., Wang,C.J., Cui,L., Liu,F.F., Wang,K.L., Li,W.J. and
            Li,Z.G.
  TITLE     Interaction of E2F3a and CASP8AP2 Regulates Histone Expression and
            Chemosensitivity of Leukemic Cells
  JOURNAL   J Pediatr Hematol Oncol 45 (3), e339-e344 (2023)
   PUBMED   36162009
  REMARK    GeneRIF: Interaction of E2F3a and CASP8AP2 Regulates Histone
            Expression and Chemosensitivity of Leukemic Cells.
REFERENCE   2  (bases 1 to 6792)
  AUTHORS   Myacheva,K., Walsh,A., Riester,M., Pelos,G., Carl,J. and
            Diederichs,S.
  TITLE     CRISPRi screening identifies CASP8AP2 as an essential viability
            factor in lung cancer controlling tumor cell death via the AP-1
            pathway
  JOURNAL   Cancer Lett 552, 215958 (2023)
   PUBMED   36252816
  REMARK    GeneRIF: CRISPRi screening identifies CASP8AP2 as an essential
            viability factor in lung cancer controlling tumor cell death via
            the AP-1 pathway.
REFERENCE   3  (bases 1 to 6792)
  AUTHORS   Wang,C.J., Jia,M.Z., Deng,L.P., Li,W.J., Zhang,Q., Zhang,T.J.,
            Li,S.Y., Cui,L. and Li,Z.G.
  TITLE     Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the
            Expression of LEF1
  JOURNAL   Pediatr Hematol Oncol 39 (6), 549-560 (2022)
   PUBMED   35139734
  REMARK    GeneRIF: Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the
            Expression of LEF1.
REFERENCE   4  (bases 1 to 6792)
  AUTHORS   Abaandou,L., Sharma,A.K. and Shiloach,J.
  TITLE     Knockout of the caspase 8-associated protein 2 gene improves
            recombinant protein expression in HEK293 cells through
            up-regulation of the cyclin-dependent kinase inhibitor 2A gene
  JOURNAL   Biotechnol Bioeng 118 (1), 186-198 (2021)
   PUBMED   32910455
  REMARK    GeneRIF: Knockout of the caspase 8-associated protein 2 gene
            improves recombinant protein expression in HEK293 cells through
            up-regulation of the cyclin-dependent kinase inhibitor 2A gene.
REFERENCE   5  (bases 1 to 6792)
  AUTHORS   Cui,L., Gao,C., Wang,C.J., Liu,S.G., Wu,M.Y., Zhang,R.D. and
            Li,Z.G.
  TITLE     Low expression of CTBP2 and CASP8AP2 predicts risk of relapse in
            childhood B-cell precursor acute lymphoblastic leukemia: a
            retrospective cohort study
  JOURNAL   Pediatr Hematol Oncol 37 (8), 732-746 (2020)
   PUBMED   32804017
  REMARK    GeneRIF: Low expression of CTBP2 and CASP8AP2 predicts risk of
            relapse in childhood B-cell precursor acute lymphoblastic leukemia:
            a retrospective cohort study.
REFERENCE   6  (bases 1 to 6792)
  AUTHORS   Jun,J.I., Chung,C.W., Lee,H.J., Pyo,J.O., Lee,K.N., Kim,N.S.,
            Kim,Y.S., Yoo,H.S., Lee,T.H., Kim,E. and Jung,Y.K.
  TITLE     Role of FLASH in caspase-8-mediated activation of NF-kappaB:
            dominant-negative function of FLASH mutant in NF-kappaB signaling
            pathway
  JOURNAL   Oncogene 24 (4), 688-696 (2005)
   PUBMED   15592525
  REMARK    GeneRIF: endogenous caspase-8 mediates tumor necrosis
            factor-alpha-induced activation of NF-kappaB via FLASH
REFERENCE   7  (bases 1 to 6792)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J Biol Chem 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   8  (bases 1 to 6792)
  AUTHORS   Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
            Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
  TITLE     FLASH coordinates NF-kappa B activity via TRAF2
  JOURNAL   J Biol Chem 276 (27), 25073-25077 (2001)
   PUBMED   11340079
REFERENCE   9  (bases 1 to 6792)
  AUTHORS   Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
  TITLE     Apoptosis. Searching for FLASH domains
  JOURNAL   Nature 401 (6754), 662 (1999)
   PUBMED   10537104
REFERENCE   10 (bases 1 to 6792)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353692.14, BC132828.1 and AF164678.2.
            
            On Aug 1, 2019 this sequence version replaced NM_001137667.1.
            
            Summary: This protein is highly similar to FLASH, a mouse apoptotic
            protein identified by its interaction with the death-effector
            domain (DED) of caspase 8. Studies of FLASH protein suggested that
            this protein may be a component of the death-inducing signaling
            complex that includes Fas receptor, Fas-binding adapter FADD, and
            caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
            Alternative splicing results in multiple transcript variants
            encoding the same protein.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132828.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000671703.3/ ENSP00000518371.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL353692.14        25325-25497
            174-6692            BC132828.1         1-6519
            6693-6792           AF164678.2         6477-6576
FEATURES             Location/Qualifiers
     source          1..6792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..6792
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:HGNC:1510"
                     /db_xref="MIM:606880"
     exon            1..188
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            189..271
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..6165
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="FLICE associated huge; FLICE-associated huge
                     protein; human FLASH; FLASH homolog RIP25"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001131139.1"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:HGNC:1510"
                     /db_xref="MIM:606880"
                     /translation="MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSA
                     SKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNF
                     SLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVK
                     TKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSV
                     EKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPR
                     ILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSR
                     VDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPH
                     SKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKE
                     VDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTT
                     TDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTL
                     SPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTM
                     GETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFP
                     SPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYC
                     GISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVES
                     KSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEA
                     ISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIY
                     KSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRR
                     GKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIA
                     VPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKI
                     SKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKL
                     KKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVH
                     YKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTP
                     KSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG
                     SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDN
                     WSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSIL
                     LEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIH
                     LALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPST
                     SSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKS
                     THEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSM
                     EEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILD
                     NSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANR
                     PLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDL
                     NHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGI
                     KDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKL
                     DKNPNQVSERFQQLMKLFEKSKCR"
     exon            272..340
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            341..441
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            442..516
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            517..632
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            633..2878
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..6008
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            6009..6108
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            6109..6161
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
     exon            6162..6792
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggagacct cggtgggcag aaaggaaccg ggttgtcttg ggccgggcag ggcgggtaag
       61 ttgtcgtagg ggcccggtcc gtgagggact gctaaggaag aggctgcatg gcgcggtagt
      121 cccccgagtg gaggtcggct gcccctggga aaccagagag tcggagggag tccatctgga
      181 gcggccaagt ggtgactctc aaaaggaaat aggatcatgg cagcagatga tgacaatggt
      241 gatggaacaa gtttatttga tgtcttttct gcttctcctc ttaagaacaa tgatgaaggc
      301 tcactggaca tatacgctgg gttggacagt gctgtttctg acagcgcttc caaatcctgt
      361 gtaccatcaa gaaattgttt ggacttatat gaagagatcc tgactgaaga aggaactgca
      421 aaggaggcaa catataatga tttgcaagta gaatatggaa aatgtcaact acaaatgaaa
      481 gagctgatga aaaaatttaa agaaatacag acacagaatt tcagcttaat aaacgaaaac
      541 cagtctctta agaagaatat ttcagcactt atcaaaactg ccagagtgga aataaaccgc
      601 aaggatgaag aaataagtaa tcttcaccaa agattgtctg agtttccaca ttttcgaaat
      661 aatcataaaa ctgcaaggac atttgataca gttaaaacaa aagatcttaa atctagatct
      721 ccacatttgg atgattgttc aaagactgat cacagagcta aaagtgatgt ttctaaagat
      781 gtacatcata gcacttcact gccaaatctg gaaaaggaag gaaaaccaca ttctgataaa
      841 aggagtactt cacatttacc tacatctgtt gagaaacact gcactaatgg tgtttggtca
      901 cgttctcatt atcaggttgg cgagggtagc tcaaatgagg atagtagaag aggaagaaaa
      961 gatattagac atagccagtt taacagagga actgaaagag tacgaaaaga cttaagtact
     1021 ggctgtggtg atggtgaacc aaggatattg gaggctagtc aaaggctaca aggacatcct
     1081 gagaaatatg gtaaaggtga accaaagact gaaagcaaaa gttcgaagtt taaaagtaac
     1141 tcagattctg actataaagg tgaacgcatt aactcttctt gggagaaaga gacccctgga
     1201 gaaaggtcac acagtcgagt agactctcaa agtgacaaaa aactagaaag acaaagtgaa
     1261 agatcacaaa atataaatag gaaagaagtt aaatcacaag acaaagaaga aagaaaagtt
     1321 gatcaaaaac ctaaatcagt agtaaaggac caagatcact ggagaagatc tgaacgagca
     1381 tcacttcctc attccaagaa tgaaataaca ttttctcata attcaagtaa ataccatcta
     1441 gaagagagaa gaggatggga agattgtaaa agagacaaga gtgtaaacag tcatagtttt
     1501 caagatggaa gatgtccatc ttctctttca aacagtagaa ctcacaaaaa cattgactct
     1561 aaggaagttg atgccatgca tcagtgggaa aatacacctt taaaagcaga aagacataga
     1621 actgaagata agaggaaaag agaacaagaa agcaaagaag aaaataggca tattagaaat
     1681 gaaaaaagag tacctacaga acatttgcag aagactaata aggaaactaa gaaaaccact
     1741 actgatttaa agaaacagaa tgaaccaaag actgataagg gagaagtcct tgataatggt
     1801 gtttctgaag gagcagataa taaagagctt gcaatgaaag ctgagagtgg tccaaatgaa
     1861 acaaaaaaca aggacctaaa attgagtttt atgaaaaaat tgaacttaac tctttctcct
     1921 gctaaaaagc aacctgtttc ccaggataat cagcataaaa taactgatat tcccaagtcc
     1981 agtggtgtat gtgattcaga gtcttcaatg caagttaaaa cagtggcata tgttccctcc
     2041 ataagtgaac atatcttggg ggaagcagct gtcagtgaac ataccatggg ggaaaccaag
     2101 tcaacgttat tggaaccaaa ggttgctctt ctagcagtga ctgaacccag gatcggtatc
     2161 tcagaaacca acaaggaaga cgaaaatagt ttgttagtta ggtctgttga caatactatg
     2221 cattgtgaag agcccatttg tggtacagag acttccttcc catctcctat ggaaatacaa
     2281 cagacagaat ccttgtttcc atcaacagga atgaaacaaa ccattaataa tggaagggca
     2341 gcagctcctg tggtaatgga tgtattacaa acagatgtgt ctcaaaactt tggcttggaa
     2401 ttggatacca aaagaaatga taattcagat tattgtggta tttctgaagg tatggagatg
     2461 aaggtggcac tttcaacaac agtgagtgaa accactgaaa gcattttgca gccttcaatt
     2521 gaggaagctg atattttgcc aataatgctt tcagaagata ataacccaaa atttgagcct
     2581 tctgttatag ttacaccact ggttgagagt aagtcgtgtc atctggagcc ttgcttacct
     2641 aaagagactc tagattcttc acttcagcag actgagttaa tggaccacag aatggcaact
     2701 ggtgaaacaa actcagtata tcatgatgat gataactcgg ttttgagcat tgaccttaat
     2761 cacctgagac ctattccaga agccatcagt cctctgaata gtccagtgag acctgtagca
     2821 aaagttctta gaaatgaaag cccacctcaa gttccagtgt ataataacag tcataaagat
     2881 gtgtttttac caaattcagc tcattctacc tctaagagtc agtctgatct caataaggaa
     2941 aatcaaaagc caatttacaa atctgacaaa tgtacagaag cagacacatg taagaattca
     3001 ccattagatg aattagaaga aggagaaatt agaagtgata gtgaaacatc taaaccacaa
     3061 gaaagttttg aaaaaaattc caaacgtaga gtgtcagctg atgtgcggaa gtcaaagact
     3121 atcccacgac gtgggaaaag tactgtgtgt ttagataaag acagtaggaa aacacatgta
     3181 agaatccatc agaccaataa caaatggaat aaaagacctg ataaatctag cagatcttca
     3241 aaaacagaga agaaagataa agtgatgagc acttccagct tggaaaaaat agttccaatt
     3301 attgctgtac cctcttctga acaagagatc atgcacatgt tacgaatgat aagaaaacat
     3361 gtaagaaaaa attatatgaa attcaaggca aaattttcat taatacaatt tcacagaatt
     3421 attgagtcag caattttgag ttttacatct ttaattaaac atctcaactt acacaaaatc
     3481 tctaagtcag tgactacctt acagaagaat ctctgtgata ttatagagtc taaacttaag
     3541 caagttaaaa agaatggcat agttgatcgt ttatttgaac agcaactacc agatatgaaa
     3601 aaaaaattgt ggaagtttgt agatgaccaa cttgattatt tgtttgcaaa gcttaagaaa
     3661 atcttagtat gtgattccaa aagctttgga agagatagtg atgaaggcaa acttgaaaaa
     3721 acaagtaaac agaatgcaca gtattcaaat agtcagaaaa ggagtgtgga caactccaac
     3781 agagaattgc tgaaagaaaa attatcaaaa tcagaagacc ctgttcatta taagtcttta
     3841 gtgggatgta aaaaatctga ggaaaattat caagaccaaa ataactccag tattaacact
     3901 gtaaagcatg acattaaaaa aaattttaac atctgctttg ataatataaa gaactctcaa
     3961 tccgaagagc gctccttgga agtacactgt ccaagcaccc caaagtcaga aaaaaacgaa
     4021 ggaagcagca tagaggatgc acagacatcc cagcatgcaa ctttgaagcc agaacgaagt
     4081 ttcgagattc ttaccgaaca gcaagcatcg agccttactt ttaatttagt gagtgatgca
     4141 caaatgggtg aaatatttaa aagtttgttg caaggttctg atcttttaga cagcagtgtt
     4201 aactgtactg aaaaaagtga gtgggagtta aagactccag agaagcagct gctagagact
     4261 cttaagtgcg agtctatacc agcttgtaca acagaagagc tagtttcagg ggtggcttct
     4321 ccatgtccta aaatgattag tgatgataat tggtcattat tatcatctga aaaaggtcca
     4381 tctctgtctt cagggctttc attgccggtt catcctgatg tgttggatga aagttgtatg
     4441 tttgaagtgt ctactaacct acctttaagt aaagataatg tgtgtagtgt agaaaagagc
     4501 aagccctgcg tttcttccat acttcttgaa gatctagcag tctctttaac agtaccatcg
     4561 cctctgaagt cagatggtca tctcagtttt ttaaagcctg atatgtcgtc cagttcaact
     4621 cctgaagaag tcattagtgc tcattttagt gaagatgcct tacttgagga agaggatgca
     4681 tctgagcaag atattcattt agctctggag tctgataatt caagcagtaa atcaagttgt
     4741 tcttcttcct ggacaagccg atctgttgct ccaggctttc agtaccaccc taatctacct
     4801 atgcatgccg tcataatgga aaagtccaat gatcatttca ttgtgaaaat acgacgtgca
     4861 acaccatcta cctcttctgg ccttaaacag agtatgatgc ctgatgaatt attgacatct
     4921 ttgcccagac atggaaagga agctgatgaa ggaccagaga aagaatatat ttcatgtcag
     4981 aacacagttt ttaaatctgt ggaggaattg gaaaactcca acaaaaatgt tgatggcagc
     5041 aagtcaactc atgaagaaca gagctctatg atacaaacac aggttcctga tatatatgaa
     5101 tttcttaaag atgcttcaga taagatgggt catagtgatg aagtggctga tgaatgtttc
     5161 aaattgcatc aagtatggga aacaaaagtg cctgaaagca ttgaagaatt gccttcaatg
     5221 gaagaaatct cacactctgt tggggaacat cttccaaaca catacgtaga tctaacgaaa
     5281 gatccagtca ctgaaaccaa aaacttgggg gaattcatag aagtaacagt tttacatatt
     5341 gatcagttgg gatgttctgg aggcaattta aatcagagtg ctcaaatatt agacaattct
     5401 ttgcaggctg atactgtagg tgcttttatt gatttgacac aagatgcttc aagtgaggct
     5461 aaaagtgaag gtaatcatcc tgcattagct gtggaagact tgggatgtgg ggtgatacag
     5521 gtagatgaag ataattgtaa ggaagaaaag gcacaagtgg caaacaggcc tttaaaatgc
     5581 attgttgagg aaacctatat cgacttgacc acagaatctc ccagttcatg tgaagtaaaa
     5641 aaagatgagt taaaatcaga gccaggatca aattgtgata actcggagtt gcctgggact
     5701 ttgcataatt ctcacaaaaa gagaagaaac atttctgatc taaatcatcc tcataaaaaa
     5761 caaagaaagg aaacagactt aactaataag gaaaagacca agaaacctac ccaagattct
     5821 tgtgagaata ctgaagctca ccaaaagaaa gccagtaaga agaaggcccc tcctgtgact
     5881 aaagatccct catcattaaa ggcaacccca gggattaagg attcatcagc agcacttgcc
     5941 acttctacaa gtctttctgc aaaaaatgtt attaaaaaga agggagaaat tatcatttta
     6001 tggacaagaa atgatgaccg ggaaatttta ttggagtgtc agaaaagagg gccatcattt
     6061 aaaacatttg catatttagc cgccaagttg gataaaaatc caaatcaggt ctcagaaaga
     6121 ttccagcagc taatgaagct ctttgaaaag tcaaaatgca gataagttgc tgaattcctg
     6181 ggactcttaa ctgatattgc atactacaca gaagcttcaa attcctcatg ttttaaatga
     6241 gcactagagg gaggtttatc acctttttgg ttaccagatg ataatctata tttgttatta
     6301 ctcagtgact ctctaatttc acatcagcat gttcagcttg tgctagtcat cattctgatt
     6361 tgcttatctg tttttggtca aaatatttat ttttaaacat gttagaactt accaaaatga
     6421 aagcaacagt gatgtattga aatcttagtt ttgatatttt aaagaaatga ctttctagat
     6481 taaaaaaata gttttgtagc attttaaact tagtgactat ttagttcaat tgttcatcca
     6541 ttttttattt gcttttataa ttgcctcctt gttttggtat attgtaaaat aatttaaata
     6601 atgtatttat aaatatgtat aattatgatg taaaataccg tgtgtatatg tatgtatgtg
     6661 tgtttctgta tatgcacaca cataaacggc tttgcctagc caaggatttt ttttatctgt
     6721 ataaaacttt ttgtataaag tttgctttca ataacagtaa tgtataataa aaccatgtaa
     6781 agttttgttg ta
//
