LOCUS       NM_001227               2344 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens caspase 7 (CASP7), transcript variant a, mRNA.
ACCESSION   NM_001227
VERSION     NM_001227.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Wang,Z., Huang,Y., Zhu,M., Cao,J. and Xiong,Z.
  TITLE     TLR2 and CASP7 as the biomarkers associated with non-alcoholic
            fatty liver disease and chronic kidney disease
  JOURNAL   Biochem Biophys Res Commun 667, 50-57 (2023)
   PUBMED   37209562
  REMARK    GeneRIF: TLR2 and CASP7 as the biomarkers associated with
            non-alcoholic fatty liver disease and chronic kidney disease.
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   He,K., Wan,T., Wang,D., Hu,J., Zhou,T., Tao,W., Wei,Z., Lu,Q.,
            Zhou,R., Tian,Z., Flavell,R.A. and Zhu,S.
  TITLE     Gasdermin D licenses MHCII induction to maintain food tolerance in
            small intestine
  JOURNAL   Cell 186 (14), 3033-3048 (2023)
   PUBMED   37327784
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Desroches,A. and Denault,J.B.
  TITLE     Characterization of caspase-7 interaction with RNA
  JOURNAL   Biochem J 478 (13), 2681-2696 (2021)
   PUBMED   34156061
  REMARK    GeneRIF: Characterization of caspase-7 interaction with RNA.
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Riedl,S.J., Fuentes-Prior,P., Renatus,M., Kairies,N., Krapp,S.,
            Huber,R., Salvesen,G.S. and Bode,W.
  TITLE     Structural basis for the activation of human procaspase-7
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 14790-14795 (2001)
   PUBMED   11752425
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Tiso,N., Pallavicini,A., Muraro,T., Zimbello,R., Apolloni,E.,
            Valle,G., Lanfranchi,G. and Danieli,G.A.
  TITLE     Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and
            Ich-1, involved in cellular apoptosis
  JOURNAL   Biochem Biophys Res Commun 225 (3), 983-989 (1996)
   PUBMED   8780721
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Lippke,J.A., Gu,Y., Sarnecki,C., Caron,P.R. and Su,M.S.
  TITLE     Identification and characterization of CPP32/Mch2 homolog 1, a
            novel cysteine protease similar to CPP32
  JOURNAL   J Biol Chem 271 (4), 1825-1828 (1996)
   PUBMED   8567622
REFERENCE   8  (bases 1 to 2344)
  AUTHORS   Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J.,
            Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G.
            et al.
  TITLE     Mch3, a novel human apoptotic cysteine protease highly related to
            CPP32
  JOURNAL   Cancer Res 55 (24), 6045-6052 (1995)
   PUBMED   8521391
REFERENCE   9  (bases 1 to 2344)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     CPP32, a novel human apoptotic protein with homology to
            Caenorhabditis elegans cell death protein Ced-3 and mammalian
            interleukin-1 beta-converting enzyme
  JOURNAL   J Biol Chem 269 (49), 30761-30764 (1994)
   PUBMED   7983002
REFERENCE   10 (bases 1 to 2344)
  AUTHORS   Olson,R.E., Morello,J.A. and Kieff,E.D.
  TITLE     Antibiotic treatment of oral anaerobic infections
  JOURNAL   J Oral Surg 33 (8), 619-621 (1975)
   PUBMED   1056466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627395.14, U37448.1,
            BC015799.1 and BM976488.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001227.4.
            
            Summary: This gene encodes a member of the cysteine-aspartic acid
            protease (caspase) family. Sequential activation of caspases plays
            a central role in the execution-phase of cell apoptosis. Caspases
            exist as inactive proenzymes which undergo proteolytic processing
            at conserved aspartic residues to produce two subunits, large and
            small, that dimerize to form the active enzyme. The precursor of
            the encoded protein is cleaved by caspase 3 and 10, is activated
            upon cell death stimuli and induces apoptosis. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (a, also known as alpha) differs
            in the 5' UTR, lacks a portion of the 5' coding region and
            initiates translation at a downstream, in-frame start codon,
            compared to variant d. Variants a, c and e encode the same isoform
            (alpha), which has a shorter N-terminus compared to isoform delta.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.182938.1,
                                           SRR1803616.89798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369318.8/ ENSP00000358324.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL627395.14        7840-7863
            25-1162             U37448.1           1-1138
            1163-1788           BC015799.1         1174-1799
            1789-2344           BM976488.1         17-572              c
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..2344
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /note="caspase 7"
                     /db_xref="GeneID:840"
                     /db_xref="HGNC:HGNC:1508"
                     /db_xref="MIM:601761"
     exon            1..67
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..979
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /EC_number="3.4.22.60"
                     /note="isoform alpha precursor is encoded by transcript
                     variant a; caspase 7, apoptosis-related cysteine protease;
                     ICE-like apoptotic protease 3; apoptotic protease MCH-3;
                     caspase 7, apoptosis-related cysteine peptidase"
                     /codon_start=1
                     /product="caspase-7 isoform alpha precursor"
                     /protein_id="NP_001218.1"
                     /db_xref="CCDS:CCDS7581.1"
                     /db_xref="GeneID:840"
                     /db_xref="HGNC:HGNC:1508"
                     /db_xref="MIM:601761"
                     /translation="MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVT
                     MRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFR
                     SLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIK
                     DLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEAD
                     FLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQ
                     SDDPHFHEKKQIPCVVSMLTKELYFSQ"
     exon            68..177
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            178..314
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..443
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            444..619
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..749
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..2344
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /note="hexamer: ATTAAA"
     polyA_site      2344
                     /gene="CASP7"
                     /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3"
                     /note="major polyA site"
ORIGIN      
        1 agacccttgc tgcggagcga cggagagaga ctgtgccagt cccagccgcc ctaccgccgt
       61 gggaacgatg gcagatgatc agggctgtat tgaagagcag ggggttgagg attcagcaaa
      121 tgaagattca gtggatgcta agccagaccg gtcctcgttt gtaccgtccc tcttcagtaa
      181 gaagaagaaa aatgtcacca tgcgatccat caagaccacc cgggaccgag tgcctacata
      241 tcagtacaac atgaattttg aaaagctggg caaatgcatc ataataaaca acaagaactt
      301 tgataaagtg acaggtatgg gcgttcgaaa cggaacagac aaagatgccg aggcgctctt
      361 caagtgcttc cgaagcctgg gttttgacgt gattgtctat aatgactgct cttgtgccaa
      421 gatgcaagat ctgcttaaaa aagcttctga agaggaccat acaaatgccg cctgcttcgc
      481 ctgcatcctc ttaagccatg gagaagaaaa tgtaatttat gggaaagatg gtgtcacacc
      541 aataaaggat ttgacagccc actttagggg ggatagatgc aaaacccttt tagagaaacc
      601 caaactcttc ttcattcagg cttgccgagg gaccgagctt gatgatggca tccaggccga
      661 ctcggggccc atcaatgaca cagatgctaa tcctcgatac aagatcccag tggaagctga
      721 cttcctcttc gcctattcca cggttccagg ctattactcg tggaggagcc caggaagagg
      781 ctcctggttt gtgcaagccc tctgctccat cctggaggag cacggaaaag acctggaaat
      841 catgcagatc ctcaccaggg tgaatgacag agttgccagg cactttgagt ctcagtctga
      901 tgacccacac ttccatgaga agaagcagat cccctgtgtg gtctccatgc tcaccaagga
      961 actctacttc agtcaatagc catatcaggg gtacattcta gctgagaagc aatgggtcac
     1021 tcattaatga atcacatttt tttatgctct tgaaatattc agaaattctc caggatttta
     1081 atttcaggaa aatgtattga ttcaacaggg aagaaacttt ctggtgctgt cttttgttct
     1141 ctgaattttc agagactttt tttataatgt tattcatttg gtgactgtgt aactttctct
     1201 taagattaat tttctctttg tatgtctgtt accttgttaa tagacttaat acatgcaaca
     1261 gaagtgactt ctggagaaag ctcatggctg tgtccactgc aattggtggt aacagtggta
     1321 gagtcatgtt tgcacttggc aaaaagaatc ccaatgtttg acaaaacaca gccaagggga
     1381 tatttactgc tctttattgc agaatgtggg tattgagtgt gatttgaatg atttttcatt
     1441 ggcttagggc agattttcat gcaaaagttc tcatatgagt tagaggagaa aaagcttaat
     1501 gattctgata tgtatccatc aggatccagt ctggaaaaca gaaaccattc taggtgtttc
     1561 aacagaggga gtttaataca ggaaattgac ttacatagat gataaaagag aagccaaaca
     1621 gcaagaagct gttaccacac ccagggctat gaggataatg ggaagaggtt tggtttcctg
     1681 tgtccagtag tgggatcatc cagaggagct ggaaccatgg tgggggctgc ctagtgggag
     1741 ttaggaccac caatggattg tggaaaatgg agccatgaca agaacaaagc cactgactga
     1801 gatggagtga gctgagacag ataagagaat accttggtct cacctatcct gccctcacat
     1861 cttccaccag caccttactg cccaggccta tctggaagcc acctcaccaa ggaccttgga
     1921 agagcaaggg acagtgaggc aggagaagaa caagaaatgg atgtaagcct ggcccataat
     1981 gtgaacataa gtaatcacta atgctcaaca atttatccat tcaatcattt attcattggg
     2041 ttgtcagata gtctatgtat gtgtaaaaca atctgttttg gctttatgtg caaaatctgt
     2101 tatagcttta aaatatatct ggaacttttt agattattcc aagccttatt ttgagtaaat
     2161 atttgttact tttagttcta taagtgagga agagtttatg gcaaagattt ttggcacttt
     2221 gttttcaaga tggtgttatc ttttgaattc ttgataaatg actgtttttt tctgcctaat
     2281 agtaactggt taaaaaacaa atgttcatat ttattgatta aaaatgtggt tgcttaattc
     2341 ctaa
//
