LOCUS       NM_032992               1367 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens caspase 6 (CASP6), transcript variant beta, mRNA.
ACCESSION   NM_032992
VERSION     NM_032992.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Sheng,M., Huo,S., Jia,L., Weng,Y., Liu,W., Lin,Y. and Yu,W.
  TITLE     NUAK1 promotes metabolic dysfunction-associated steatohepatitis
            progression by activating Caspase 6-driven pyroptosis and
            inflammation
  JOURNAL   Hepatol Commun 8 (7), e0479 (2024)
   PUBMED   38967580
  REMARK    GeneRIF: NUAK1 promotes metabolic dysfunction-associated
            steatohepatitis progression by activating Caspase 6-driven
            pyroptosis and inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Lin,Y., Sheng,M., Qin,H., Zhang,P., Wang,C., Fu,W., Meng,X.,
            Wang,D. and Hou,Y.
  TITLE     Caspase 6 promotes innate immune activation by functional crosstalk
            between RIPK1-IkappaBalpha axis in liver inflammation
  JOURNAL   Cell Commun Signal 21 (1), 282 (2023)
   PUBMED   37828624
  REMARK    GeneRIF: Caspase 6 promotes innate immune activation by functional
            crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1367)
  AUTHORS   Qi,L., Wang,L., Jin,M., Jiang,M., Li,L. and Li,Y.
  TITLE     Caspase-6 is a key regulator of cross-talk signal way in PANoptosis
            in cancer
  JOURNAL   Immunology 169 (3), 245-259 (2023)
   PUBMED   36814103
  REMARK    GeneRIF: Caspase-6 is a key regulator of cross-talk signal way in
            PANoptosis in cancer.
            Review article
REFERENCE   4  (bases 1 to 1367)
  AUTHORS   Zhu,J., Shi,Y., Lan,S., Wang,J., Jiang,F., Tang,C., Cai,Y., Pan,Z.,
            Jian,H., Fang,H., Zhang,Y. and Zhong,F.
  TITLE     Dissection of pyroptosis-related prognostic signature and
            CASP6-mediated regulation in pancreatic adenocarcinoma: new sights
            to clinical decision-making
  JOURNAL   Apoptosis 28 (5-6), 769-782 (2023)
   PUBMED   36882663
  REMARK    GeneRIF: Dissection of pyroptosis-related prognostic signature and
            CASP6-mediated regulation in pancreatic adenocarcinoma: new sights
            to clinical decision-making.
REFERENCE   5  (bases 1 to 1367)
  AUTHORS   Ocal,E., Alkan Akalin,S. and Asir,F.
  TITLE     Role of cited-1 and caspase-6 expression in HELLP syndrome
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (7), 3082-3087 (2023)
   PUBMED   37070911
  REMARK    GeneRIF: Role of cited-1 and caspase-6 expression in HELLP
            syndrome.
REFERENCE   6  (bases 1 to 1367)
  AUTHORS   Bullrich,F., Fernandes-Alnemri,T., Litwack,G., Alnemri,E.S. and
            Croce,C.M.
  TITLE     Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3
  JOURNAL   Genomics 36 (2), 362-365 (1996)
   PUBMED   8812467
REFERENCE   7  (bases 1 to 1367)
  AUTHORS   Tiso,N., Pallavicini,A., Muraro,T., Zimbello,R., Apolloni,E.,
            Valle,G., Lanfranchi,G. and Danieli,G.A.
  TITLE     Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and
            Ich-1, involved in cellular apoptosis
  JOURNAL   Biochem Biophys Res Commun 225 (3), 983-989 (1996)
   PUBMED   8780721
REFERENCE   8  (bases 1 to 1367)
  AUTHORS   Takahashi,A., Alnemri,E.S., Lazebnik,Y.A., Fernandes-Alnemri,T.,
            Litwack,G., Moir,R.D., Goldman,R.D., Poirier,G.G., Kaufmann,S.H.
            and Earnshaw,W.C.
  TITLE     Cleavage of lamin A by Mch2 alpha but not CPP32: multiple
            interleukin 1 beta-converting enzyme-related proteases with
            distinct substrate recognition properties are active in apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8395-8400 (1996)
   PUBMED   8710882
REFERENCE   9  (bases 1 to 1367)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease
            gene family
  JOURNAL   Cancer Res 55 (13), 2737-2742 (1995)
   PUBMED   7796396
REFERENCE   10 (bases 1 to 1367)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     CPP32, a novel human apoptotic protein with homology to
            Caenorhabditis elegans cell death protein Ced-3 and mammalian
            interleukin-1 beta-converting enzyme
  JOURNAL   J Biol Chem 269 (49), 30761-30764 (1994)
   PUBMED   7983002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U20536.1, U20537.1, BM837197.1
            and AC004067.1.
            
            On Jun 1, 2019 this sequence version replaced NM_032992.2.
            
            Summary: This gene encodes a member of the cysteine-aspartic acid
            protease (caspase) family of enzymes. Sequential activation of
            caspases plays a central role in the execution-phase of cell
            apoptosis. Caspases exist as inactive proenzymes which undergo
            proteolytic processing at conserved aspartic acid residues to
            produce two subunits, large and small, that dimerize to form the
            active enzyme. This protein is processed by caspases 7, 8 and 10,
            and is thought to function as a downstream enzyme in the caspase
            activation cascade. Alternative splicing of this gene results in
            multiple transcript variants that encode different isoforms.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (beta) lacks several exons in the
            coding region but maintains the reading frame, compared to variant
            alpha. It encodes isoform beta which is shorter than isoform alpha.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.100513.1, U20537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                U20536.1           29-78
            51-261              U20537.1           1-211
            262-706             BM837197.1         236-680
            707-1366            AC004067.1         116153-116812       c
            1367-1367           AC004067.1         116152-116152       c
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..1367
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="caspase 6"
                     /db_xref="GeneID:839"
                     /db_xref="HGNC:HGNC:1507"
                     /db_xref="MIM:601532"
     exon            1..90
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..665
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /EC_number="3.4.22.59"
                     /note="isoform beta is encoded by transcript variant beta;
                     caspase 6, apoptosis-related cysteine protease; caspase 6,
                     apoptosis-related cysteine peptidase; apoptotic protease
                     MCH-2; mammalian Ced-3 homologue 2"
                     /codon_start=1
                     /product="caspase-6 isoform beta"
                     /protein_id="NP_116787.1"
                     /db_xref="CCDS:CCDS3685.1"
                     /db_xref="GeneID:839"
                     /db_xref="HGNC:HGNC:1507"
                     /db_xref="MIM:601532"
                     /translation="MSSASGLRRGHPAVSTVSHADADCFVCVFLSHGEGNHIYAYDAK
                     IEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE
                     VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL
                     TLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN"
     exon            91..266
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..426
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1367
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1250
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="major polyA site"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1367
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
ORIGIN      
        1 gtggcttcag gaagaggagg gcaaggtgtc tggctgcgcg tttggctgca atgagctcgg
       61 cctcggggct ccgcaggggg cacccggcag tgtcaactgt tagccacgca gatgccgatt
      121 gctttgtgtg tgtcttcctg agccatggcg aaggcaatca catttatgca tatgatgcta
      181 aaatcgaaat tcagacatta actggcttgt tcaaaggaga caagtgtcac agcctggttg
      241 gaaaacccaa gatatttatc attcaggcat gtcggggaaa ccagcacgat gtgccagtca
      301 ttcctttgga tgtagtagat aatcagacag agaagttgga caccaacata actgaggtgg
      361 atgcagcctc cgtttacacg ctgcctgctg gagctgactt cctcatgtgt tactctgttg
      421 cagaaggata ttattctcac cgggaaactg tgaacggctc atggtacatt caagatttgt
      481 gtgagatgtt gggaaaatat ggctcctcct tagagttcac agaactcctc acactggtga
      541 acaggaaagt ttctcagcgc cgagtggact tttgcaaaga cccaagtgca attggaaaga
      601 agcaggttcc ctgttttgcc tcaatgctaa ctaaaaagct gcatttcttt ccaaaatcta
      661 attaattaat agaggctatc taattttaca ctctgtattg aaaatggctt tctcagccag
      721 gcgtggttac tcacacctgt aatcccagca ctttgggagt ccaaggtggg cggatcacct
      781 gaggtcggga gttcgagacc agcctgacca acatggagaa gccccgtctc tactaaaaat
      841 gcaaaaaaaa atttagctag gcatggcggc gcatgcctgc aatcccagct acttggaagg
      901 ctgaggcagg agaatcactt gaacccagga ggtggaggct gcggtgagcc gagattgcgc
      961 cattgcactc cagcctgggc aacgagtgaa actccgtctc aaaaaaaaga aaatgtcttt
     1021 ctcttccttt tatataaata tcgttagggt gaagcattat ggtctaatga ttcaaatgtt
     1081 ttaaagttta atgcctagca gagaactgcc ttaaaaaaaa aaaaaaaaag ttcatgttgg
     1141 ccatggtgaa agggtttgat atggagaaac aaaatcctca ggaaattaga taaataaaaa
     1201 tttataagca tttgtattat tttttaataa actgcagggt tacacaaaaa tctagctgat
     1261 ttaacttgta ttttgtcact tttttataaa agtttattgt ttgatgtttt taaaggtttt
     1321 tgaaatccag gaattaaatc atcccttaat aaaatattcg aaattca
//
