LOCUS       NM_001226               1634 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens caspase 6 (CASP6), transcript variant alpha, mRNA.
ACCESSION   NM_001226
VERSION     NM_001226.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Sheng,M., Huo,S., Jia,L., Weng,Y., Liu,W., Lin,Y. and Yu,W.
  TITLE     NUAK1 promotes metabolic dysfunction-associated steatohepatitis
            progression by activating Caspase 6-driven pyroptosis and
            inflammation
  JOURNAL   Hepatol Commun 8 (7), e0479 (2024)
   PUBMED   38967580
  REMARK    GeneRIF: NUAK1 promotes metabolic dysfunction-associated
            steatohepatitis progression by activating Caspase 6-driven
            pyroptosis and inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Lin,Y., Sheng,M., Qin,H., Zhang,P., Wang,C., Fu,W., Meng,X.,
            Wang,D. and Hou,Y.
  TITLE     Caspase 6 promotes innate immune activation by functional crosstalk
            between RIPK1-IkappaBalpha axis in liver inflammation
  JOURNAL   Cell Commun Signal 21 (1), 282 (2023)
   PUBMED   37828624
  REMARK    GeneRIF: Caspase 6 promotes innate immune activation by functional
            crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Qi,L., Wang,L., Jin,M., Jiang,M., Li,L. and Li,Y.
  TITLE     Caspase-6 is a key regulator of cross-talk signal way in PANoptosis
            in cancer
  JOURNAL   Immunology 169 (3), 245-259 (2023)
   PUBMED   36814103
  REMARK    GeneRIF: Caspase-6 is a key regulator of cross-talk signal way in
            PANoptosis in cancer.
            Review article
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Zhu,J., Shi,Y., Lan,S., Wang,J., Jiang,F., Tang,C., Cai,Y., Pan,Z.,
            Jian,H., Fang,H., Zhang,Y. and Zhong,F.
  TITLE     Dissection of pyroptosis-related prognostic signature and
            CASP6-mediated regulation in pancreatic adenocarcinoma: new sights
            to clinical decision-making
  JOURNAL   Apoptosis 28 (5-6), 769-782 (2023)
   PUBMED   36882663
  REMARK    GeneRIF: Dissection of pyroptosis-related prognostic signature and
            CASP6-mediated regulation in pancreatic adenocarcinoma: new sights
            to clinical decision-making.
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Ocal,E., Alkan Akalin,S. and Asir,F.
  TITLE     Role of cited-1 and caspase-6 expression in HELLP syndrome
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (7), 3082-3087 (2023)
   PUBMED   37070911
  REMARK    GeneRIF: Role of cited-1 and caspase-6 expression in HELLP
            syndrome.
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Bullrich,F., Fernandes-Alnemri,T., Litwack,G., Alnemri,E.S. and
            Croce,C.M.
  TITLE     Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3
  JOURNAL   Genomics 36 (2), 362-365 (1996)
   PUBMED   8812467
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Tiso,N., Pallavicini,A., Muraro,T., Zimbello,R., Apolloni,E.,
            Valle,G., Lanfranchi,G. and Danieli,G.A.
  TITLE     Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and
            Ich-1, involved in cellular apoptosis
  JOURNAL   Biochem Biophys Res Commun 225 (3), 983-989 (1996)
   PUBMED   8780721
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Takahashi,A., Alnemri,E.S., Lazebnik,Y.A., Fernandes-Alnemri,T.,
            Litwack,G., Moir,R.D., Goldman,R.D., Poirier,G.G., Kaufmann,S.H.
            and Earnshaw,W.C.
  TITLE     Cleavage of lamin A by Mch2 alpha but not CPP32: multiple
            interleukin 1 beta-converting enzyme-related proteases with
            distinct substrate recognition properties are active in apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8395-8400 (1996)
   PUBMED   8710882
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease
            gene family
  JOURNAL   Cancer Res 55 (13), 2737-2742 (1995)
   PUBMED   7796396
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     CPP32, a novel human apoptotic protein with homology to
            Caenorhabditis elegans cell death protein Ced-3 and mammalian
            interleukin-1 beta-converting enzyme
  JOURNAL   J Biol Chem 269 (49), 30761-30764 (1994)
   PUBMED   7983002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U20536.1, BC000305.2 and
            AC004067.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001226.3.
            
            Summary: This gene encodes a member of the cysteine-aspartic acid
            protease (caspase) family of enzymes. Sequential activation of
            caspases plays a central role in the execution-phase of cell
            apoptosis. Caspases exist as inactive proenzymes which undergo
            proteolytic processing at conserved aspartic acid residues to
            produce two subunits, large and small, that dimerize to form the
            active enzyme. This protein is processed by caspases 7, 8 and 10,
            and is thought to function as a downstream enzyme in the caspase
            activation cascade. Alternative splicing of this gene results in
            multiple transcript variants that encode different isoforms.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (alpha) represents the longer
            transcript and encodes the longer isoform (alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1083565.1,
                                           SRR5189661.121761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265164.7/ ENSP00000265164.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                U20536.1           29-52
            25-1329             BC000305.2         1-1305
            1330-1634           AC004067.1         116152-116456       c
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..1634
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="caspase 6"
                     /db_xref="GeneID:839"
                     /db_xref="HGNC:HGNC:1507"
                     /db_xref="MIM:601532"
     exon            1..90
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..932
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /EC_number="3.4.22.59"
                     /note="isoform alpha precursor is encoded by transcript
                     variant alpha; caspase 6, apoptosis-related cysteine
                     protease; caspase 6, apoptosis-related cysteine peptidase;
                     apoptotic protease MCH-2; mammalian Ced-3 homologue 2"
                     /codon_start=1
                     /product="caspase-6 isoform alpha precursor"
                     /protein_id="NP_001217.2"
                     /db_xref="CCDS:CCDS3684.1"
                     /db_xref="GeneID:839"
                     /db_xref="HGNC:HGNC:1507"
                     /db_xref="MIM:601532"
                     /translation="MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRR
                     GIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE
                     VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFII
                     QACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYS
                     HRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP
                     CFASMLTKKLHFFPKSN"
     exon            91..133
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..280
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..357
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..533
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..693
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1634
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1517
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="major polyA site"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="CASP6"
                     /gene_synonym="caspase-6; CSP-6; MCH2"
ORIGIN      
        1 gtggcttcag gaagaggagg gcaaggtgtc tggctgcgcg tttggctgca atgagctcgg
       61 cctcggggct ccgcaggggg cacccggcag gtggggaaga aaacatgaca gaaacagatg
      121 ccttctataa aagagaaatg tttgatccgg cagaaaagta caaaatggac cacaggagga
      181 gaggaattgc tttaatcttc aatcatgaga ggttcttttg gcacttaaca ctgccagaaa
      241 ggcggggcac ctgcgcagat agagacaatc ttacccgcag gttttcagat ctaggatttg
      301 aagtgaaatg ctttaatgat cttaaagcag aagaactact gctcaaaatt catgaggtgt
      361 caactgttag ccacgcagat gccgattgct ttgtgtgtgt cttcctgagc catggcgaag
      421 gcaatcacat ttatgcatat gatgctaaaa tcgaaattca gacattaact ggcttgttca
      481 aaggagacaa gtgtcacagc ctggttggaa aacccaagat atttatcatt caggcatgtc
      541 ggggaaacca gcacgatgtg ccagtcattc ctttggatgt agtagataat cagacagaga
      601 agttggacac caacataact gaggtggatg cagcctccgt ttacacgctg cctgctggag
      661 ctgacttcct catgtgttac tctgttgcag aaggatatta ttctcaccgg gaaactgtga
      721 acggctcatg gtacattcaa gatttgtgtg agatgttggg aaaatatggc tcctccttag
      781 agttcacaga actcctcaca ctggtgaaca ggaaagtttc tcagcgccga gtggactttt
      841 gcaaagaccc aagtgcaatt ggaaagaagc aggttccctg ttttgcctca atgctaacta
      901 aaaagctgca tttctttcca aaatctaatt aattaataga ggctatctaa ttttacactc
      961 tgtattgaaa atggctttct cagccaggcg tggttactca cacctgtaat cccagcactt
     1021 tgggagtcca aggtgggcgg atcacctgag gtcgggagtt cgagaccagc ctgaccaaca
     1081 tggagaagcc ccgtctctac taaaaatgca aaaaaaaatt tagctaggca tggcggcgca
     1141 tgcctgcaat cccagctact tggaaggctg aggcaggaga atcacttgaa cccaggaggt
     1201 ggaggctgcg gtgagccgag attgcgccat tgcactccag cctgggcaac gagtgaaact
     1261 ccgtctcaaa aaaaagaaaa tgtctttctc ttccttttat ataaatatcg ttagggtgaa
     1321 gcattatggt ctaatgattc aaatgtttta aagtttaatg cctagcagag aactgcctta
     1381 aaaaaaaaaa aaaaaagttc atgttggcca tggtgaaagg gtttgatatg gagaaacaaa
     1441 atcctcagga aattagataa ataaaaattt ataagcattt gtattatttt ttaataaact
     1501 gcagggttac acaaaaatct agctgattta acttgtattt tgtcactttt ttataaaagt
     1561 ttattgtttg atgtttttaa aggtttttga aatccaggaa ttaaatcatc ccttaataaa
     1621 atattcgaaa ttca
//
