LOCUS       NM_004347               1446 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens caspase 5 (CASP5), transcript variant a, mRNA.
ACCESSION   NM_004347
VERSION     NM_004347.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Hisama,F.M., Pillai,R.K., Sidorova,J., Patterson,K., Gokingco,C.,
            Yacobi-Bach,M. and Oshima,J.
  TITLE     Caspase 5 depletion is linked to hyper-inflammatory response and
            progeroid syndrome
  JOURNAL   Geroscience 46 (2), 2771-2775 (2024)
   PUBMED   37603195
  REMARK    GeneRIF: Caspase 5 depletion is linked to hyper-inflammatory
            response and progeroid syndrome.
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and
            Shao,F.
  TITLE     Recognition and maturation of IL-18 by caspase-4 noncanonical
            inflammasome
  JOURNAL   Nature 624 (7991), 442-450 (2023)
   PUBMED   37993714
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Pan,J., Zhao,L., Liu,J. and Wang,G.
  TITLE     Inhibition of circular RNA circ_0138959 alleviates pyroptosis of
            human gingival fibroblasts via the microRNA-527/caspase-5 axis
  JOURNAL   Bioengineered 13 (1), 1908-1920 (2022)
   PUBMED   35030963
  REMARK    GeneRIF: Inhibition of circular RNA circ_0138959 alleviates
            pyroptosis of human gingival fibroblasts via the
            microRNA-527/caspase-5 axis.
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Rahmati,Y., Mollanoori,H., Najafi,S., Esmaeili,S. and Alivand,M.R.
  TITLE     CASP5 and CR1 as potential biomarkers for Kawasaki disease: an
            Integrated Bioinformatics-Experimental Study
  JOURNAL   BMC Pediatr 21 (1), 566 (2021)
   PUBMED   34895171
  REMARK    GeneRIF: CASP5 and CR1 as potential biomarkers for Kawasaki
            disease: an Integrated Bioinformatics-Experimental Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Eckhart,L., Kittel,C., Gawlas,S., Gruber,F., Mildner,M., Jilma,B.
            and Tschachler,E.
  TITLE     Identification of a novel exon encoding the amino-terminus of the
            predominant caspase-5 variants
  JOURNAL   Biochem Biophys Res Commun 348 (2), 682-688 (2006)
   PUBMED   16893518
  REMARK    GeneRIF: novel exon was present in six alternatively spliced
            caspase-5 mRNA variants expressed in human peripheral blood
            mononuclear cells (PBMC) and encoded the previously unknown
            amino-terminus of caspase-5.
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Waterhouse,N.J., Finucane,D.M., Green,D.R., Elce,J.S., Kumar,S.,
            Alnemri,E.S., Litwack,G., Khanna,K., Lavin,M.F. and Watters,D.J.
  TITLE     Calpain activation is upstream of caspases in radiation-induced
            apoptosis
  JOURNAL   Cell Death Differ 5 (12), 1051-1061 (1998)
   PUBMED   9894612
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Caulin,C., Salvesen,G.S. and Oshima,R.G.
  TITLE     Caspase cleavage of keratin 18 and reorganization of intermediate
            filaments during epithelial cell apoptosis
  JOURNAL   J Cell Biol 138 (6), 1379-1394 (1997)
   PUBMED   9298992
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Nasir,J., Theilmann,J.L., Vaillancourt,J.P., Munday,N.A., Ali,A.,
            Scherer,S., Beatty,B., Nicholson,D.W. and Hayden,M.R.
  TITLE     Interleukin-1beta-converting enzyme (ICE) and related cell death
            genes ICErel-II and ICErel-III map to the same PAC clone at band
            11q22.2-22.3
  JOURNAL   Mamm Genome 8 (8), 611-613 (1997)
   PUBMED   9250871
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Faucheu,C., Blanchet,A.M., Collard-Dutilleul,V., Lalanne,J.L. and
            Diu-Hercend,A.
  TITLE     Identification of a cysteine protease closely related to
            interleukin-1 beta-converting enzyme
  JOURNAL   Eur J Biochem 236 (1), 207-213 (1996)
   PUBMED   8617266
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Munday,N.A., Vaillancourt,J.P., Ali,A., Casano,F.J., Miller,D.K.,
            Molineaux,S.M., Yamin,T.T., Yu,V.L. and Nicholson,D.W.
  TITLE     Molecular cloning and pro-apoptotic activity of ICErelII and
            ICErelIII, members of the ICE/CED-3 family of cysteine proteases
  JOURNAL   J Biol Chem 270 (26), 15870-15876 (1995)
   PUBMED   7797592
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296660.1, DQ228672.1,
            DR005081.1 and X94993.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004347.4.
            
            Summary: This gene encodes a member of the cysteine-aspartic acid
            protease (caspase) family. Sequential activation of caspases plays
            a central role in the execution-phase of cell apoptosis. Caspases
            exist as inactive proenzymes which undergo proteolytic processing
            at conserved aspartic residues to produce two subunits, large and
            small, that dimerize to form the active enzyme. Overexpression of
            the active form of this enzyme induces apoptosis in fibroblasts.
            Max, a central component of the Myc/Max/Mad transcription
            regulation network important for cell growth, differentiation, and
            apoptosis, is cleaved by this protein; this process requires
            Fas-mediated dephosphorylation of Max. The expression of this gene
            is regulated by interferon-gamma and lipopolysaccharide.
            Alternatively spliced transcript variants have been identified for
            this gene. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (a) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142348,
                              SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000260315.8/ ENSP00000260315.3
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK296660.1         1-39
            40-347              DQ228672.1         8-315
            348-556             DR005081.1         402-610
            557-1446            X94993.1           418-1307
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..1446
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /note="caspase 5"
                     /db_xref="GeneID:838"
                     /db_xref="HGNC:HGNC:1506"
                     /db_xref="MIM:602665"
     exon            1..39
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1337
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /EC_number="3.4.22.58"
                     /note="isoform a precursor is encoded by transcript
                     variant a; caspase 5, apoptosis-related cysteine protease;
                     TY protease; protease TY; protease ICH-3; caspase 5,
                     apoptosis-related cysteine peptidase"
                     /codon_start=1
                     /product="caspase-5 isoform a precursor"
                     /protein_id="NP_004338.3"
                     /db_xref="CCDS:CCDS8328.2"
                     /db_xref="GeneID:838"
                     /db_xref="HGNC:HGNC:1506"
                     /db_xref="MIM:602665"
                     /translation="MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTS
                     IQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKK
                     YYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAEST
                     NILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVG
                     MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT
                     AHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLAL
                     ISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSC
                     CCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN"
     exon            40..213
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            214..465
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..575
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            576..749
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..984
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1128
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1238
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1341
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1446
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /note="hexamer: AATAAA"
     polyA_site      1446
                     /gene="CASP5"
                     /gene_synonym="ICE(rel)III; ICEREL-III; ICH-3"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgtac aaagagacag aggctgttag ctatggctga agacagtggc aaaaaaaaaa
       61 ggcgtaagaa ttttgaagct atgttcaaag gtatccttca gagtggattg gataacttcg
      121 tgataaacca catgctaaag aacaacgtgg ctggacaaac atctatccag accctagtac
      181 ctaatacgga tcaaaagtcg accagtgtaa aaaaagacaa ccacaaaaaa aaaacagtta
      241 agatgttgga atacctgggc aaagatgttc ttcatggtgt ttttaattat ttggcaaaac
      301 acgatgttct gacattgaag gaagaggaaa agaaaaaata ttatgatacc aaaattgaag
      361 acaaggccct gatcttggta gactctttgc gaaagaatcg cgtggctcat caaatgttta
      421 cccaaacact tctcaatatg gaccaaaaga tcaccagtgt aaaacctctt ctgcaaatcg
      481 aggctggacc acctgagtca gcagaatcta caaatatact caaactttgt cctcgtgaag
      541 aattcctgag actgtgtaaa aaaaatcatg atgagatcta tccaataaaa aagagagagg
      601 accgcagacg cctggctctc atcatatgca atacaaagtt tgatcacctg cctgcaagga
      661 atggggctca ctatgacatc gtggggatga aaaggctgct tcaaggcctg ggctacactg
      721 tggttgacga aaagaatctc acagccaggg atatggagtc agtgctgagg gcatttgctg
      781 ccagaccaga gcacaagtcc tctgacagca cgttcttggt actcatgtct catggcatcc
      841 tagagggaat ctgcggaact gcgcataaaa agaaaaaacc ggatgtgctg ctttatgaca
      901 ccatcttcca gatattcaac aaccgcaact gcctcagtct aaaggacaaa cccaaggtca
      961 tcattgtcca ggcctgcaga ggtgaaaaac atggggaact ctgggtcaga gactctccag
     1021 catccttggc actcatctct tcacagtcat ctgagaacct ggaggcagat tctgtttgca
     1081 agatccacga ggagaaggac ttcattgctt tctgttcttc aacaccacat aacgtgtcct
     1141 ggagagaccg cacaaggggc tccatcttca ttacggaact catcacatgc ttccagaaat
     1201 attcttgctg ctgccaccta atggaaatat ttcggaaggt acagaaatca tttgaagttc
     1261 cacaggctaa agcccagatg cccaccatag aacgagcaac cttgacaaga gatttctacc
     1321 tctttcctgg caattgaaaa tgaaaccaca ggcagcccag ccctcctctg tcaacatcaa
     1381 agagcacatt taccagtata gcttgcatag tcaatatttg gtatttcaat aaaagtaaag
     1441 actgta
//
