LOCUS       NM_012114               3145 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens caspase 14 (CASP14), mRNA.
ACCESSION   NM_012114
VERSION     NM_012114.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   Markiewicz,A., Sigorski,D., Markiewicz,M., Owczarczyk-Saczonek,A.
            and Placek,W.
  TITLE     Caspase-14-From Biomolecular Basics to Clinical Approach. A Review
            of Available Data
  JOURNAL   Int J Mol Sci 22 (11), 5575 (2021)
   PUBMED   34070382
  REMARK    GeneRIF: Caspase-14-From Biomolecular Basics to Clinical Approach.
            A Review of Available Data.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3145)
  AUTHORS   Handa,T., Katayama,A., Yokobori,T., Yamane,A., Horiguchi,J.,
            Kawabata-Iwakawa,R., Rokudai,S., Bao,P., Gombodorj,N., Altan,B.,
            Kaira,K., Asao,T., Kuwano,H., Nishiyama,M. and Oyama,T.
  TITLE     Caspase14 expression is associated with triple negative phenotypes
            and cancer stem cell marker expression in breast cancer patients
  JOURNAL   J Surg Oncol 116 (6), 706-715 (2017)
   PUBMED   28570747
  REMARK    GeneRIF: High CASP14 expression is a marker of breast cancer
            aggressiveness in association with proliferation, TNBC phenotype,
            and cancer stemness.
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   Li,T., Qi,Z., Kong,F., Li,Y., Wang,R., Zhang,W., Shang,Y.,
            Huang,L., He,D. and Xiao,X.
  TITLE     S100A7 acts as a dual regulator in promoting proliferation and
            suppressing squamous differentiation through GATA-3/caspase-14
            pathway in A431 cells
  JOURNAL   Exp Dermatol 24 (5), 342-348 (2015)
   PUBMED   25651379
  REMARK    GeneRIF: overexpression of S100A7 in A431 skin squamous carcinoma
            cells significantly promoted cell proliferation in vitro and tumor
            growth in vivo, whereas it suppressed the expression of GATA-3 and
            caspase-14
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Jung,M., Choi,J., Lee,S.A., Kim,H., Hwang,J. and Choi,E.H.
  TITLE     Pyrrolidone carboxylic acid levels or caspase-14 expression in the
            corneocytes of lesional skin correlates with clinical severity,
            skin barrier function and lesional inflammation in atopic
            dermatitis
  JOURNAL   J Dermatol Sci 76 (3), 231-239 (2014)
   PUBMED   25315296
  REMARK    GeneRIF: Caspase-14 was decreased in inflammatory lesions compared
            to non-lesion in atopic dermatitis. The amount of caspase-14 in the
            lesions correlated with clinical severity as determined by eczema
            area and severity index score and the skin barrier functions.
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Beasley,S., El-Sherbiny,M., Megyerdi,S., El-Shafey,S., Choksi,K.,
            Kaddour-Djebbar,I., Sheibani,N., Hsu,S. and Al-Shabrawey,M.
  TITLE     Caspase-14 expression impairs retinal pigment epithelium barrier
            function: potential role in diabetic macular edema
  JOURNAL   Biomed Res Int 2014, 417986 (2014)
   PUBMED   25121097
  REMARK    GeneRIF: caspase-14 contributes to retinal pigment epithelium cell
            barrier disruption under hyperglycemic conditions.
REFERENCE   6  (bases 1 to 3145)
  AUTHORS   Ahmad,M., Srinivasula,S.M., Hegde,R., Mukattash,R.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     Identification and characterization of murine caspase-14, a new
            member of the caspase family
  JOURNAL   Cancer Res 58 (22), 5201-5205 (1998)
   PUBMED   9823333
REFERENCE   7  (bases 1 to 3145)
  AUTHORS   Hu,S., Snipas,S.J., Vincenz,C., Salvesen,G. and Dixit,V.M.
  TITLE     Caspase-14 is a novel developmentally regulated protease
  JOURNAL   J Biol Chem 273 (45), 29648-29653 (1998)
   PUBMED   9792675
REFERENCE   8  (bases 1 to 3145)
  AUTHORS   Van de Craen,M., Van Loo,G., Pype,S., Van Criekinge,W., Van den
            brande,I., Molemans,F., Fiers,W., Declercq,W. and Vandenabeele,P.
  TITLE     Identification of a new caspase homologue: caspase-14
  JOURNAL   Cell Death Differ 5 (10), 838-846 (1998)
   PUBMED   10203698
REFERENCE   9  (bases 1 to 3145)
  AUTHORS   Richard,G.
  TITLE     Autosomal Recessive Congenital Ichthyosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301593
REFERENCE   10 (bases 1 to 3145)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313992.1, AC004699.1 and
            BM840054.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012114.2.
            
            Summary: This gene encodes a member of the cysteine-aspartic acid
            protease (caspase) family. Sequential activation of caspases plays
            a central role in the execution-phase of cell apoptosis. Caspases
            exist as inactive proenzymes which undergo proteolytic processing
            at conserved aspartic residues to produce two subunits, large and
            small, that dimerize to form the active enzyme. This caspase has
            been shown to be processed and activated by caspase 8 and caspase
            10 in vitro, and by anti-Fas agonist antibody or TNF-related
            apoptosis inducing ligand in vivo. The expression and processing of
            this caspase may be involved in keratinocyte terminal
            differentiation, which is important for the formation of the skin
            barrier. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU502748.1, AK313992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427043.4/ ENSP00000393417.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-941               AK313992.1         1-941
            942-2868            AC004699.1         16787-18713
            2869-3145           BM840054.1         1-277
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..3145
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /note="caspase 14"
                     /db_xref="GeneID:23581"
                     /db_xref="HGNC:HGNC:1502"
                     /db_xref="MIM:605848"
     exon            1..166
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     exon            167..239
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..941
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /EC_number="3.4.22.-"
                     /note="caspase 14, apoptosis-related cysteine protease;
                     CASP-14; caspase 14, apoptosis-related cysteine peptidase;
                     mini-ICE"
                     /codon_start=1
                     /product="caspase-14 precursor"
                     /protein_id="NP_036246.1"
                     /db_xref="CCDS:CCDS12323.1"
                     /db_xref="GeneID:23581"
                     /db_xref="HGNC:HGNC:1502"
                     /db_xref="MIM:605848"
                     /translation="MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFR
                     QLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEM
                     VKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIP
                     TYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAEL
                     VQEGKARKTNPEIQSTLRKRLYLQ"
     exon            240..389
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     exon            390..615
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     exon            616..732
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     exon            733..836
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     exon            837..3145
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /note="hexamer: AATAAA"
     polyA_site      3145
                     /gene="CASP14"
                     /gene_synonym="ARCI12; caspase-14"
                     /note="major polyA site"
ORIGIN      
        1 atagaccagg cttctcagga gaaaccccgg gagattccac actgtcagcc ccttctccaa
       61 gatcagtacg tgggcctgac tcctcctcgg tgcccagctc agtattggca actaggagag
      121 tagtgagatt gaacttggcc ttgaggaaca gctgcctcta gagttggatc agacaagggt
      181 gctgagagcc gggactcaca accaaaggag aaatgagcaa tccgcggtct ttggaagagg
      241 agaaatatga tatgtcaggt gcccgcctgg ccctaatact gtgtgtcacc aaagcccggg
      301 aaggttccga agaagacctg gatgctctgg aacacatgtt tcggcagctg agattcgaaa
      361 gcaccatgaa aagagacccc actgccgagc aattccagga agagctggaa aaattccagc
      421 aggccatcga ttcccgggaa gatcccgtca gttgtgcctt cgtggtactc atggctcacg
      481 ggagggaagg cttcctcaag ggagaagatg gggagatggt caagctggag aatctcttcg
      541 aggccctgaa caacaagaac tgccaggccc tgcgagctaa gcccaaggtg tacatcatac
      601 aggcctgtcg aggagaacaa agggaccccg gtgaaacagt aggtggagat gagattgtga
      661 tggtcatcaa agacagccca caaaccatcc caacatacac agatgccttg cacgtttatt
      721 ccacggtaga gggatacatc gcctaccgac atgatcagaa aggctcatgc tttatccaga
      781 ccctggtgga tgtgttcacg aagaggaaag gacatatctt ggaacttctg acagaggtga
      841 cccggcggat ggcagaagca gagctggttc aagaaggaaa agcaaggaaa acgaaccctg
      901 aaatccaaag caccctccgg aaacggctgt atctgcagta gaagtagaaa gaccaggagg
      961 agctttcctt ccagcattct ttctgtctca cagaaattta gaggcagctc ttacctctcc
     1021 ccaagatctt ctgttcccaa ggccaaatgg cacccagttt cttttccatc acacccttca
     1081 tgcaggtcct cctgtcctta ttagagcaag ccagccaaaa cttagcacaa ggcatggtgg
     1141 caacattaac atcacctccc tcaggctgga ctttctatct ttattaatgc aaccgaagag
     1201 acctaagagt gcattcactt atcccacttt ctgttcctgt ggtcttcttt ctcccatgaa
     1261 gcagaaactg gataaagctc aagattttcc atagacaaac caaagcccac tcatcccctc
     1321 ctaccccaat ccaacctctg ctggctcctg catctcactt ggaggtcaaa cctcctcctg
     1381 aggccaatgc attcccaact tccagttctt tcctttaccc tggagagtta gtaaggtaag
     1441 aaccattctt tctctccaaa accactcctc cttggctggc aagttggtgt cctaactccg
     1501 ttctcttcct agctcatggc ctctctagat aataaagttg tctcctcctt tctggatctc
     1561 ttcctcctaa cacccctccc ctgaaaccct ggactctgcc ctctctccaa gaaaatccat
     1621 ctattcaact attcttgcat tcaattactc taaatgagag cgtgttggag ctatggcaaa
     1681 ttccctgttg tcaccttgct attttgcaga caacataata tttaacctct cataaccaga
     1741 gaggttaaat aatttgtcaa atgcaataca gtaagacaga ggcaaggaca aggtttgact
     1801 tccagcccag cctcttttcc acaacctgct aaatcctgat ccatctgaaa acttttctaa
     1861 ttagtgaaga tgactaataa aaattttccc tatctccaag gtaggagctt tctggaagtt
     1921 tctagaaatt ttcaataacc accagccaag gttacctcca ggtaaccttg cagcaccagg
     1981 ctggaagtca gatcggcttc actatcttcc aactctacag cctgtatctc tccatcccca
     2041 gctttgacct ttcctgctca agtaacctac gggcacatcc agcgtcacta aaaactcagg
     2101 gcttttcttc ccggttactc ctccaagcgt tccctggtat cctcaacctc agatcccagg
     2161 ttcagatttc tgcagtcaat ctatgacccc tctcttcttg catccttcat atgccaccag
     2221 acaccatgcc cagtccagcc tgattttgaa acaactttca tgccggtctt ctcttccctg
     2281 acatgttact gtccaggctc aagtcctcag cttctcatat ctgcatcttt gcaaccaact
     2341 tcctcccttg cctctctgct tttccatccc acttttcatg tgtcctccat accatctata
     2401 acagtgatct ccctggaaca ctcaagaaga cacaacatac catattattt aaagaccagg
     2461 gtactggaca gtggctcaca cctgtattcc cgactttgag agtctgaagc gggaggatca
     2521 cttgaggcca ggagttaaga gaccagcctg ggcaacacag caagaccctg tctctaaaaa
     2581 aaaaaattaa ttaactgggt atggtggcac atgcctgtag tcccagctac tcaggaggct
     2641 gaggtgggag gatgacttga gcccaggagt ttgaggctgc aaggagctat gatcatgcca
     2701 gtgcatccca gctctaggtg agacagtgag atccggtctc caaaataaat caatcaatca
     2761 aataaagacc aaagtcaaac cgcacatcag gatctctcac acccttccaa ttttgccatc
     2821 taccagcact tagctaaacc catctcccat ctcttccacc atgaattcac tctttcaaaa
     2881 aggctaatgt cttcttactc acccttgcct ctaagccttt gctatcacca tttcccccaa
     2941 gctggagggc cctccctctc cctttacccc tcttccacta cctcccaccc ctactttttc
     3001 cagaaagcca tttcctctct tttttctgat tgatccttcc ctctcaccca ggattagatg
     3061 ctggaaatga ccacttctgg agggcaggga acaagccctt aatctgcata atgagtgttc
     3121 aataaacagt tgtcaaactt tgaaa
//
