LOCUS       NM_001257118            1996 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens caspase 1 (CASP1), transcript variant 6, mRNA.
ACCESSION   NM_001257118
VERSION     NM_001257118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Gao,K., Liu,Y., Sun,C., Wang,Y., Bao,H., Liu,G., Ou,J. and Sun,P.
  TITLE     TNF-a induces mitochondrial dysfunction to drive
            NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells
  JOURNAL   Sci Rep 14 (1), 25880 (2024)
   PUBMED   39468189
  REMARK    GeneRIF: TNF-a induces mitochondrial dysfunction to drive
            NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Yu,C., Li,J., Kuang,W., Ni,S., Cao,Y. and Duan,Y.
  TITLE     PRDM1 promotes nucleus pulposus cell pyroptosis leading to
            intervertebral disc degeneration via activating CASP1 transcription
  JOURNAL   Cell Biol Toxicol 40 (1), 89 (2024)
   PUBMED   39432156
  REMARK    GeneRIF: PRDM1 promotes nucleus pulposus cell pyroptosis leading to
            intervertebral disc degeneration via activating CASP1
            transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Enan,E.T., Abd El Hafez,A., Hussin,E. and Hany,H.S.E.D.I.
  TITLE     Immunohistochemical Expression of Caspase1 and Epidermal Growth
            Factor Receptor in Invasive Breast Carcinoma and Their Biological
            and Prognostic Associations
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2529-2537 (2024)
   PUBMED   39068588
  REMARK    GeneRIF: Immunohistochemical Expression of Caspase1 and Epidermal
            Growth Factor Receptor in Invasive Breast Carcinoma and Their
            Biological and Prognostic Associations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Li,Y., Du,L., Meng,L., Lv,C. and Tian,X.
  TITLE     High expression of CASP1 induces atherosclerosis
  JOURNAL   Medicine (Baltimore) 103 (16), e37616 (2024)
   PUBMED   38640260
  REMARK    GeneRIF: High expression of CASP1 induces atherosclerosis.
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Chen,L., Yu,H., Li,Z., Wang,Y., Jin,S., Yu,M., Zhu,L., Ding,C.,
            Wu,X., Wu,T., Xun,C., Zhou,Y., He,D. and Liu,Y.
  TITLE     Force-induced Caspase-1-dependent pyroptosis regulates orthodontic
            tooth movement
  JOURNAL   Int J Oral Sci 16 (1), 3 (2024)
   PUBMED   38221531
  REMARK    GeneRIF: Force-induced Caspase-1-dependent pyroptosis regulates
            orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Kronheim,S.R., Mumma,A., Greenstreet,T., Glackin,P.J., Van Ness,K.,
            March,C.J. and Black,R.A.
  TITLE     Purification of interleukin-1 beta converting enzyme, the protease
            that cleaves the interleukin-1 beta precursor
  JOURNAL   Arch Biochem Biophys 296 (2), 698-703 (1992)
   PUBMED   1321594
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Thornberry,N.A., Bull,H.G., Calaycay,J.R., Chapman,K.T.,
            Howard,A.D., Kostura,M.J., Miller,D.K., Molineaux,S.M.,
            Weidner,J.R., Aunins,J. et al.
  TITLE     A novel heterodimeric cysteine protease is required for
            interleukin-1 beta processing in monocytes
  JOURNAL   Nature 356 (6372), 768-774 (1992)
   PUBMED   1574116
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Cerretti,D.P., Kozlosky,C.J., Mosley,B., Nelson,N., Van Ness,K.,
            Greenstreet,T.A., March,C.J., Kronheim,S.R., Druck,T.,
            Cannizzaro,L.A. et al.
  TITLE     Molecular cloning of the interleukin-1 beta converting enzyme
  JOURNAL   Science 256 (5053), 97-100 (1992)
   PUBMED   1373520
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Howard,A.D., Kostura,M.J., Thornberry,N., Ding,G.J., Limjuco,G.,
            Weidner,J., Salley,J.P., Hogquist,K.A., Chaplin,D.D., Mumford,R.A.
            et al.
  TITLE     IL-1-converting enzyme requires aspartic acid residues for
            processing of the IL-1 beta precursor at two distinct sites and
            does not cleave 31-kDa IL-1 alpha
  JOURNAL   J Immunol 147 (9), 2964-2969 (1991)
   PUBMED   1919001
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Kostura,M.J., Tocci,M.J., Limjuco,G., Chin,J., Cameron,P.,
            Hillman,A.G., Chartrain,N.A. and Schmidt,J.A.
  TITLE     Identification of a monocyte specific pre-interleukin 1 beta
            convertase activity
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5227-5231 (1989)
   PUBMED   2787508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290114.1, AP001153.5,
            KF455483.1 and AA737419.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001257118.2.
            
            Summary: This gene encodes a protein which is a member of the
            cysteine-aspartic acid protease (caspase) family. Sequential
            activation of caspases plays a central role in the execution-phase
            of cell apoptosis. Caspases exist as inactive proenzymes which
            undergo proteolytic processing at conserved aspartic residues to
            produce 2 subunits, large and small, that dimerize to form the
            active enzyme. This gene was identified by its ability to
            proteolytically cleave and activate the inactive precursor of
            interleukin-1, a cytokine involved in the processes such as
            inflammation, septic shock, and wound healing. This gene has been
            shown to induce cell apoptosis and may function in various
            developmental stages. Studies of a similar gene in mouse suggest a
            role in the pathogenesis of Huntington disease. Alternative
            splicing results in transcript variants encoding distinct isoforms.
            [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (6) differs in the 3' UTR compared
            to variant alpha. Variant alpha and variant 6 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223503.1, AK290114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533400.6/ ENSP00000433138.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-968               AK290114.1         5-972
            969-969             AP001153.5         67131-67131         c
            970-1508            AK290114.1         974-1512
            1509-1665           AP001153.5         63778-63934         c
            1666-1865           KF455483.1         1-200
            1866-1996           AA737419.1         11-141              c
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..1996
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /note="caspase 1"
                     /db_xref="GeneID:834"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="MIM:147678"
     exon            1..38
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            39..305
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            306..368
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            369..484
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            485..658
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            659..893
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1037
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1147
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1996
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /note="major polyA site"
ORIGIN      
        1 cagtcacaca agaagggagg agagaaaagc catggccgac aaggtcctga aggagaagag
       61 aaagctgttt atccgttcca tgggtgaagg tacaataaat ggcttactgg atgaattatt
      121 acagacaagg gtgctgaaca aggaagagat ggagaaagta aaacgtgaaa atgctacagt
      181 tatggataag acccgagctt tgattgactc cgttattccg aaaggggcac aggcatgcca
      241 aatttgcatc acatacattt gtgaagaaga cagttacctg gcagggacgc tgggactctc
      301 agcagatcaa acatctggaa attaccttaa tatgcaagac tctcaaggag tactttcttc
      361 ctttccagct cctcaggcag tgcaggacaa cccagctatg cccacatcct caggctcaga
      421 agggaatgtc aagctttgct ccctagaaga agctcaaagg atatggaaac aaaagtcggc
      481 agagatttat ccaataatgg acaagtcaag ccgcacacgt cttgctctca ttatctgcaa
      541 tgaagaattt gacagtattc ctagaagaac tggagctgag gttgacatca caggcatgac
      601 aatgctgcta caaaatctgg ggtacagcgt agatgtgaaa aaaaatctca ctgcttcgga
      661 catgactaca gagctggagg catttgcaca ccgcccagag cacaagacct ctgacagcac
      721 gttcctggtg ttcatgtctc atggtattcg ggaaggcatt tgtgggaaga aacactctga
      781 gcaagtccca gatatactac aactcaatgc aatctttaac atgttgaata ccaagaactg
      841 cccaagtttg aaggacaaac cgaaggtgat catcatccag gcctgccgtg gtgacagccc
      901 tggtgtggtg tggtttaaag attcagtagg agtttctgga aacctatctt taccaactac
      961 agaagagttt gaggatgatg ctattaagaa agcccacata gagaaggatt ttatcgcttt
     1021 ctgctcttcc acaccagata atgtttcttg gagacatccc acaatgggct ctgtttttat
     1081 tggaagactc attgaacata tgcaagaata tgcctgttcc tgtgatgtgg aggaaatttt
     1141 ccgcaaggtt cgattttcat ttgagcagcc agatggtaga gcgcagatgc ccaccactga
     1201 aagagtgact ttgacaagat gtttctacct cttcccagga cattaaaata aggaaactgt
     1261 atgaatgtct gtgggcaggt acatgtgtat ggtcgggagt gtgggaaggt tgaggaaagg
     1321 gtactgaaag tccatttgag tcaagaactc taggtttaca ggctgagaat ccttaatcca
     1381 aaaatttgaa ttttgaaatg ctctaaaatc caacactgtg tgagcgccca catgatattc
     1441 aaaggaaatg tttattgaaa catttcaaat tataggtttt tggattaggg atgctaaacc
     1501 agtaagtata cagctgaatt ccaatataca aaaatatctg aaatttgaaa tacttctggt
     1561 agcatgcatt ttggataagg gataatcaag ccatatacag aaaatactga agtaatgcct
     1621 ttcttctggt cagtgcagag cacgttgctc ttctcccaaa gtttttcatt tagacccctt
     1681 ttgagattca tctgatattg gcctagaagt ggccgtaaga ctacaaaccc tcacttttgg
     1741 atgtttctct ccttcacctc agcagggtat atttaaacat agcatgtggt ctttcctttt
     1801 aaaattgtgt atgttcccat tggtggtata actttataac ttgcatgtct ttaacaaaat
     1861 tctttcctat gttttttttt ttaattattt ctttttctca taggaagtga agagatcctt
     1921 ctgtaaaggt ttttggaatt atgtctgctg aataataaac ttttttgaaa taataaatct
     1981 ggtagaaaaa tgaaaa
//
