LOCUS       NM_020764               5839 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens CASK interacting protein 1 (CASKIN1), mRNA.
ACCESSION   NM_020764
VERSION     NM_020764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5839)
  AUTHORS   Wahbeh,M.H., Peng,X., Bacharaki,S., Hatzimanolis,A.,
            Dimitrakopoulos,S., Wohler,E., Yang,X., Yovo,C., Maher,B.J.,
            Sobreira,N., Stefanis,N.C. and Avramopoulos,D.
  TITLE     A Missense Variant in CASKIN1's Proline-Rich Region Segregates with
            Psychosis in a Three-Generation Family
  JOURNAL   Genes (Basel) 14 (1), 177 (2023)
   PUBMED   36672919
  REMARK    GeneRIF: A Missense Variant in CASKIN1's Proline-Rich Region
            Segregates with Psychosis in a Three-Generation Family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5839)
  AUTHORS   Toke,O., Koprivanacz,K., Radnai,L., Mero,B., Juhasz,T., Liliom,K.
            and Buday,L.
  TITLE     Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates
            the Lack of a Typical Peptide Binding Groove and Supports a Role in
            Lipid Mediator Binding
  JOURNAL   Cells 10 (1), 173 (2021)
   PUBMED   33467043
  REMARK    GeneRIF: Solution NMR Structure of the SH3 Domain of Human Caskin1
            Validates the Lack of a Typical Peptide Binding Groove and Supports
            a Role in Lipid Mediator Binding.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5839)
  AUTHORS   Koprivanacz,K., Toke,O., Besztercei,B., Juhasz,T., Radnai,L.,
            Mero,B., Mihaly,J., Peter,M., Balogh,G., Vigh,L., Buday,L. and
            Liliom,K.
  TITLE     The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting
            a direct role for the lipid in intracellular signaling
  JOURNAL   Cell Signal 32, 66-75 (2017)
   PUBMED   28104445
  REMARK    GeneRIF: the SH3 domain of human Caskin1 is a lipid-binding domain
            rather than a proline-rich motif interacting domain.
REFERENCE   4  (bases 1 to 5839)
  AUTHORS   Stafford,R.L., Hinde,E., Knight,M.J., Pennella,M.A., Ear,J.,
            Digman,M.A., Gratton,E. and Bowie,J.U.
  TITLE     Tandem SAM domain structure of human Caskin1: a presynaptic,
            self-assembling scaffold for CASK
  JOURNAL   Structure 19 (12), 1826-1836 (2011)
   PUBMED   22153505
  REMARK    GeneRIF: SAM domains of Caskin1 form a new type of SAM helical
            polymer.
REFERENCE   5  (bases 1 to 5839)
  AUTHORS   Stafford,R.L., Ear,J., Knight,M.J. and Bowie,J.U.
  TITLE     The molecular basis of the Caskin1 and Mint1 interaction with CASK
  JOURNAL   J Mol Biol 412 (1), 3-13 (2011)
   PUBMED   21763699
  REMARK    GeneRIF: Study shows that a short linear EEIWVLRK peptide motif
            from Caskin1 is necessary and sufficient for binding CASK.
REFERENCE   6  (bases 1 to 5839)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   7  (bases 1 to 5839)
  AUTHORS   Tabuchi,K., Biederer,T., Butz,S. and Sudhof,T.C.
  TITLE     CASK participates in alternative tripartite complexes in which Mint
            1 competes for binding with caskin 1, a novel CASK-binding protein
  JOURNAL   J Neurosci 22 (11), 4264-4273 (2002)
   PUBMED   12040031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009065.8 and AF451977.1.
            
            On May 17, 2019 this sequence version replaced NM_020764.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF451977.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343516.8/ ENSP00000345436.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC009065.8         80807-80947
            142-172             AF451977.1         67-97
            173-173             AC009065.8         80979-80979
            174-319             AF451977.1         99-244
            320-320             AC009065.8         87242-87242
            321-5836            AF451977.1         246-5761
            5837-5839           AC009065.8         100230-100232
FEATURES             Location/Qualifiers
     source          1..5839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5839
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /note="CASK interacting protein 1"
                     /db_xref="GeneID:57524"
                     /db_xref="HGNC:HGNC:20879"
                     /db_xref="MIM:612184"
     exon            1..267
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..4469
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /codon_start=1
                     /product="caskin-1"
                     /protein_id="NP_065815.1"
                     /db_xref="CCDS:CCDS42103.1"
                     /db_xref="GeneID:57524"
                     /db_xref="HGNC:HGNC:20879"
                     /db_xref="MIM:612184"
                     /translation="MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNF
                     QDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL
                     KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR
                     VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ
                     TKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQL
                     LREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRV
                     GYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSIS
                     GMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPV
                     AHAGQVYGEQPPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTP
                     EDLTAIGVTKPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNG
                     YENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQ
                     SLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHL
                     PPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPR
                     EARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPA
                     PATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPV
                     PTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRV
                     GRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEP
                     EDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTP
                     RPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPG
                     PFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESD
                     TVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTD
                     LAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKR
                     AHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS
                     LGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSA
                     CLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE"
     exon            268..319
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            320..417
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            418..563
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            564..659
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            660..790
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            791..899
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1008
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1103
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1221
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1323
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1412
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1497
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1589
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1700
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1802
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1941
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..3948
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4372
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..5839
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5820..5825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /note="hexamer: AATAAA"
     polyA_site      5839
                     /gene="CASKIN1"
                     /gene_synonym="ANKS5A"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgggag cccgagccca agccggagcc cgaggagggc gaaggggcgg cgggcggcga
       61 ggaggcggcg ggggaggcgg cgggggaggc ggccggtgcc gcggggccgc cgccgcctct
      121 gagccgcgcc gagctcacga gcgcagccgc gtcgctgcgg ccccggccgc gccatgggga
      181 aggagcagga gctggtgcag gcggtgaagg cggaggacgt agggaccgcg cagaggctgc
      241 tgcagaggcc gcggcccggg aaggccaagc tcctgggttc caccaagaag atcaatgtca
      301 acttccagga cccggatggc ttctcggctc tgcaccatgc ggccctgaac ggcaacacgg
      361 aattgatcag cctgctgctg gaggcccagg ccgctgtgga catcaaggac aacaaaggca
      421 tgcggccgct gcactatgcg gcctggcagg gccggaagga gcccatgaag ctggtgctga
      481 aggcgggctc ggccgtgaac atcccgtctg atgagggcca catccccctg cacctggcgg
      541 cccagcatgg tcactatgat gtgtctgaga tgctgctaca gcaccagtct aacccgtgca
      601 tggtggacaa ctcggggaag acgcccctgg acctggcctg cgagttcggc cgcgttgggg
      661 tggtccagct gctcctcagc agcaatatgt gtgcggcgct gctggagccc cggccgggag
      721 acgccaccga ccccaacggc accagccctt tgcacctcgc agctaaaaac ggccacatcg
      781 acatcatcag gctcctcctc caagccggca tcgacattaa ccgccagacc aagtccggca
      841 cggccctgca cgaggctgcg ctctgcggaa agacagaggt ggtgcggctg ctgctggata
      901 gcgggatcaa tgcccacgtg aggaacacct acagccagac agccctggac atcgtgcacc
      961 agttcaccac gtcccaggcc agcagggaga tcaagcagct gttgcgagag gcctcagcgg
     1021 ccctgcaggt ccgggcgacc aaggattatt gcaacaatta cgacctgacc agcctcaacg
     1081 tgaaggcagg ggacatcatc acagtcctcg agcagcatcc ggatggccgg tggaagggct
     1141 gcatccatga caaccggacg ggcaatgacc gggtgggcta cttcccgtcc tccctgggcg
     1201 aggccattgt caagcgagca ggttcccgag caggcactga accaagcctg ccccagggaa
     1261 gcagctcatc gggaccctct gcacccccag aggagatctg ggtgctgagg aagccttttg
     1321 caggtgggga ccgaagcggc agcattagcg gcatggctgg cggccggggc agcgggggtc
     1381 acgccctaca cgcgggctct gaaggcgtca agctcctggc aacggtgctt tcccagaagt
     1441 ccgtctctga gtccggcccg ggggacagcc ccgccaagcc tccggaaggc tctgcaggtg
     1501 tggcccggtc ccagcctcca gtggcccacg ccgggcaggt ctatggggag cagccgccca
     1561 agaagctgga gccagcatcg gagggcaaga gctctgaggc cgtgagccag tggctcaccg
     1621 cgttccagct gcagctctac gcccccaact tcatcagcgc cggctacgac ctgcccacca
     1681 tcagccgcat gactcccgag gacctcacgg ccattggtgt caccaagccg ggccaccgga
     1741 agaagatcgc ggcagagatc agcggcctaa gcatccctga ctggctgcct gagcacaaac
     1801 ccgctaacct ggccgtgtgg ctgtccatga tcggcctggc ccagtactac aaggtgttgg
     1861 tggacaatgg ctacgagaac attgatttca tcaccgacat cacctgggag gacctgcagg
     1921 agatcggcat caccaagctg gggcaccaga agaagctgat gctcgctgtg aggaagctgg
     1981 cagagctgca gaaggctgaa tacgccaagt atgagggggg ccccctgcgc cggaaggcgc
     2041 cccagtctct tgaagtgatg gccatcgagt cgccgccccc gcctgagccc acaccggccg
     2101 actgccagtc ccctaaaatg accaccttcc aggacagcga gctcagtgac gagctgcagg
     2161 ctgccatgac tggcccggct gaggtggggc ccaccactga gaagccctcc agccacctgc
     2221 cacccacccc gagggccacc acgcggcagg actccagcct gggtggtcgg gcacggcaca
     2281 tgagcagctc gcaggagctg ctgggagatg ggccccctgg gcccagcagc cccatgtctc
     2341 gaagccagga gtacctcctg gatgagggcc ccgcccccgg caccccgccc agggaggccc
     2401 ggcccggccg ccacggccac agcatcaaga gggccagcgt gccccccgtg cctggcaagc
     2461 cacggcaggt cctcccacca ggcactagcc acttcacgcc cccccagacg cccaccaaaa
     2521 cccgaccagg ctctccccag gcccttgggg gacctcatgg tccagcccca gctacggcca
     2581 aggtgaagcc caccccgcag ctgctgccgc cgacagagcg ccccatgtca ccccgctccc
     2641 tgcctcagtc accgacgcac cgcggctttg cctacgtgct gccccagccc gtggagggcg
     2701 aggtggggcc ggctgccccg gggcctgcgc ccccacccgt gccgacggct gtgcccacac
     2761 tgtgcctgcc ccctgaggcc gacgcggagc cggggcggcc caagaagcgg gcccacagcc
     2821 tgaatcgcta tgcggcgtcc gacagcgagc cggagcggga cgagctgctg gtgcctgcgg
     2881 ctgccggccc ctatgccacg gtccagcggc gcgtgggccg cagccactca gtgagggcgc
     2941 ccgcaggtgc cgacaagaac gtcaaccgca gccagtcctt tgccgtgcgg ccccgaaaga
     3001 aggggccccc gccgccccca cccaagcgct ccagctcggc cctggctagt gccaacctgg
     3061 cggatgagcc ggtgcctgac gccgagcctg aggatggcct gctgggggtc cgggcacagt
     3121 gccggcgggc cagtgacctg gccggcagcg tggacacggg tagtgccggc agtgtgaaga
     3181 gcatcgcggc catgctggag ctgtcctcca ttgggggtgg gggccgggct gcccgcaggc
     3241 ctcctgaggg ccaccccact ccccgccctg ccagcccaga gccgggccgg gtggccaccg
     3301 tgctggcctc agtgaaacac aaagaggcca tcgggcctgg cggggaggtg gtgaaccggc
     3361 gccgcacgct cagcgggcca gtcaccggac ttctggccac tgcccgccgg gggcctgggg
     3421 agtcggcaga cccaggcccc tttgtggagg atggcactgg ccggcagcgg cctcggggtc
     3481 cctccaaggg cgaggcgggt gtcgaaggcc cgcccttggc caaggtggaa gccagcgcca
     3541 cactcaagag gcgcatccgg gccaagcaga accagcagga gaacgtcaag ttcatcctga
     3601 ccgagtctga cacggtcaag cgcaggccca aggccaagga gcgggaggcc gggcctgagc
     3661 caccaccgcc actgtccgtg taccataatg gcactggcac cgtgcgccgc cgaccggcct
     3721 cggagcaggc tgggcctccg gagctgcctc caccgccccc gcctgccgaa cccccgccca
     3781 ccgacctggc gcacctaccc ccattgcccc cgcccgaggg cgaagcccgg aagccggcca
     3841 agccgcctgt ctctcccaag cccgtcctga cgcagcctgt gcccaagctc cagggctcgc
     3901 ccacacccac ctccaagaag gtgccgctgc caggccctgg cagcccagag gtgaagcgcg
     3961 cccacggcac gccaccgccc gtgtctccca agccgccgcc gccgcccaca gcgcccaagc
     4021 ccgtcaaggc ggtcgcgggg ctgccttcgg gcagcgccgg cccttcaccc gcaccctcgc
     4081 ccgcgcgaca gccgcccgcc gccctcgcca agccgcccgg tacgccgccc tcgctgggcg
     4141 ccagccccgc caagcccccg tcccccggcg cgcccgcgct gcacgtgccc gccaagcccc
     4201 cgcgagccgc cgccgccgcc gccgccgccg ccgccgcgcc ccccgccccg cccgaaggcg
     4261 cctcgccagg ggacagcgcc cggcagaaac tggaggagac aagcgcgtgc ctggccgcgg
     4321 cgctgcaggc ggtggaggag aagatccggc aggaggacgc gcagggcccg cgcgactcgg
     4381 cggcggaaaa gagcactggc agcatcctgg acgacatcgg cagcatgttc gacgacctgg
     4441 ccgaccagct ggatgccatg ctggagtgaa cgccgcctgg ccgggccctc ccgcgccgcc
     4501 cgggccctcc ccgcacactg acctatacct caggatgggc gcgtctgggc gcggcgcgag
     4561 cggccgggca gggccctgca gaagcacaac tccggcccct ggacccgggc cggggcgccc
     4621 accggggacc gcctggccgg gggctccaag ggctctaggc agaccctgcg cccgcgggtc
     4681 ctccccacct gctgctcccc gtgcaatacc tgctgggcct cctgcccgcg cgggagggga
     4741 gggcgccccg ggaccaggga tggggcagcg cacaggcccg ggcccagcac agaactgccc
     4801 atcgggacgc ccggccagcc gctcgggcgc agcacaaggg acaggggacc aaggtcaggg
     4861 cccccctgcc ccaccgcacc cccagaatat aagctatcaa gagtattaat ttattgggaa
     4921 tgagctgagg cggatttccc cagagaaaca aaaaggtata actttaacaa atatatattt
     4981 aaagaaagaa atattattga ttctatagaa aaccatttac caactgaaag gacacgaagt
     5041 ctagctccgg acaaaagctg ttagaggccc aggctgtctg cctgcggtcc ttcctccggc
     5101 cagagtggag gccccaggct gctagcacag gtggaaggct ggggcccggg ggcgggtgct
     5161 ctgccggggg ctcctccgtg cttctctcct aagttctctg cgccccaaga actcgaggtt
     5221 gtgccttgct ctcggcggcc gtgtcctcct cctggcgtgg ctgcgtccca gggcgcgggt
     5281 gggtttggtg aatgtgggtg tgtcagcgtg gcagccacgt ggaagcaggg catgtagcag
     5341 gccaggccac gggcttgcag ctcctctgag ggtgtgcctg gccccctctc caggggctgt
     5401 gcaggcagcc catccacccc agtggagttc ccacggacgc ttctgctcat ggtccaaggc
     5461 tgtgttgtgt ggtcattctc gccctccctt ttcctctctc ctcctgcccc ctccaagaag
     5521 tactgactgg tctcctctat cgtgtttgct gatccacagt gttgggcaca actttgacgt
     5581 ttcttaaaaa aaaaatttaa aaaatgccga aaaccagcga ttgtggtgtg gggcgggtgg
     5641 aggcggctgg cggaggtggc gtcccggcgt gcagggcccc ttcctgctgt ctcaccccgt
     5701 gtttccctgc gagtggacgt gcccagctgt ccccccaggc ctctcctcag agggcggcac
     5761 aggctgggct ccagcaggtg ggcaggggag gtctgggcaa ggcgctgccg tcggctgtca
     5821 ataaacagca ggaaacaga
//
