LOCUS       NM_001367721            8833 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent serine protein kinase
            (CASK), transcript variant 4, mRNA.
ACCESSION   NM_001367721
VERSION     NM_001367721.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8833)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 8833)
  AUTHORS   Patel,P.A., LaConte,L.E.W., Liang,C., Cecere,T., Rajan,D.,
            Srivastava,S. and Mukherjee,K.
  TITLE     Genetic evidence for splicing-dependent structural and functional
            plasticity in CASK protein
  JOURNAL   J Med Genet 61 (8), 759-768 (2024)
   PUBMED   38670634
  REMARK    GeneRIF: Genetic evidence for splicing-dependent structural and
            functional plasticity in CASK protein.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8833)
  AUTHORS   Mori,T., Zhou,M. and Tabuchi,K.
  TITLE     Diverse Clinical Phenotypes of CASK-Related Disorders and Multiple
            Functional Domains of CASK Protein
  JOURNAL   Genes (Basel) 14 (8), 1656 (2023)
   PUBMED   37628707
  REMARK    GeneRIF: Diverse Clinical Phenotypes of CASK-Related Disorders and
            Multiple Functional Domains of CASK Protein.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8833)
  AUTHORS   Stevenson,D., Laverty,H.G., Wenwieser,S., Douglas,M. and
            Wilson,J.B.
  TITLE     Mapping and expression analysis of the human CASK gene
  JOURNAL   Mamm Genome 11 (10), 934-937 (2000)
   PUBMED   11003712
REFERENCE   5  (bases 1 to 8833)
  AUTHORS   Dimitratos,S.D., Stathakis,D.G., Nelson,C.A., Woods,D.F. and
            Bryant,P.J.
  TITLE     The location of human CASK at Xp11.4 identifies this gene as a
            candidate for X-linked optic atrophy
  JOURNAL   Genomics 51 (2), 308-309 (1998)
   PUBMED   9722958
REFERENCE   6  (bases 1 to 8833)
  AUTHORS   Cohen,A.R., Woods,D.F., Marfatia,S.M., Walther,Z., Chishti,A.H. and
            Anderson,J.M.
  TITLE     Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to
            the basolateral membrane of epithelial cells
  JOURNAL   J Cell Biol 142 (1), 129-138 (1998)
   PUBMED   9660868
  REMARK    Erratum:[J Cell Biol 1998 Aug 24;142(4):following 1156. Wood DF
            [corrected to Woods DF]]
REFERENCE   7  (bases 1 to 8833)
  AUTHORS   Daniels,D.L., Cohen,A.R., Anderson,J.M. and Brunger,A.T.
  TITLE     Crystal structure of the hCASK PDZ domain reveals the structural
            basis of class II PDZ domain target recognition
  JOURNAL   Nat Struct Biol 5 (4), 317-325 (1998)
   PUBMED   9546224
REFERENCE   8  (bases 1 to 8833)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   9  (bases 1 to 8833)
  AUTHORS   Hata,Y., Butz,S. and Sudhof,T.C.
  TITLE     CASK: a novel dlg/PSD95 homolog with an N-terminal
            calmodulin-dependent protein kinase domain identified by
            interaction with neurexins
  JOURNAL   J Neurosci 16 (8), 2488-2494 (1996)
   PUBMED   8786425
REFERENCE   10 (bases 1 to 8833)
  AUTHORS   Moog,U. and Kutsche,K.
  TITLE     CASK Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24278995
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158144.15, AL353691.12,
            AL627402.10, AL603754.5 and AL445239.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a calcium/calmodulin-dependent serine
            protein kinase. The encoded protein is a MAGUK (membrane-associated
            guanylate kinase) protein family member. These proteins are
            scaffold proteins and the encoded protein is located at synapses in
            the brain. Mutations in this gene are associated with FG syndrome
            4, intellectual disability and microcephaly with pontine and
            cerebellar hypoplasia, and a form of X-linked intellectual
            disability. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000378163.7/ ENSP00000367405.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-625               AL158144.15        81352-81976         c
            626-738             AL158144.15        11537-11649         c
            739-844             AL353691.12        52105-52210         c
            845-922             AL353691.12        10451-10528         c
            923-995             AL353691.12        4311-4383           c
            996-1098            AL627402.10        66645-66747         c
            1099-1274           AL627402.10        60494-60669         c
            1275-1397           AL627402.10        55656-55778         c
            1398-1481           AL627402.10        31795-31878         c
            1482-1581           AL627402.10        21821-21920         c
            1582-1599           AL627402.10        17834-17851         c
            1600-1721           AL627402.10        5121-5242           c
            1722-1799           AL603754.5         18637-18714         c
            1800-1880           AL603754.5         16029-16109         c
            1881-2069           AL603754.5         7462-7650           c
            2070-2148           AL445239.8         72467-72545         c
            2149-2234           AL445239.8         64358-64443         c
            2235-2303           AL445239.8         62578-62646         c
            2304-2372           AL445239.8         59831-59899         c
            2373-2408           AL445239.8         58399-58434         c
            2409-2605           AL445239.8         56518-56714         c
            2606-2721           AL445239.8         45490-45605         c
            2722-2802           AL445239.8         37692-37772         c
            2803-2883           AL445239.8         37505-37585         c
            2884-3086           AL445239.8         33806-34008         c
            3087-3170           AL445239.8         26750-26833         c
            3171-8833           AL445239.8         17733-23395         c
FEATURES             Location/Qualifiers
     source          1..8833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..8833
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /note="calcium/calmodulin dependent serine protein kinase"
                     /db_xref="GeneID:8573"
                     /db_xref="HGNC:HGNC:1497"
                     /db_xref="MIM:300172"
     exon            1..625
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..3347
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     trinucleotide repeat containing 8; peripheral plasma
                     membrane protein CASK; calcium/calmodulin-dependent serine
                     protein kinase (MAGUK family);
                     calcium/calmodulin-dependent serine protein kinase
                     membrane-associated guanylate kinase; protein lin-2
                     homolog; calcium/calmodulin-dependent serin protein
                     kinase"
                     /codon_start=1
                     /product="peripheral plasma membrane protein CASK isoform
                     4"
                     /protein_id="NP_001354650.1"
                     /db_xref="CCDS:CCDS94598.1"
                     /db_xref="GeneID:8573"
                     /db_xref="HGNC:HGNC:1497"
                     /db_xref="MIM:300172"
                     /translation="MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVD
                     VAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFE
                     IVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKL
                     GGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLP
                     FYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
                     KERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSED
                     PTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINT
                     KSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHE
                     VYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMN
                     ELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFK
                     IVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYD
                     PAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRV
                     ACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRK
                     TLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQ
                     DISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVF
                     IAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVC
                     TAPQWVPVSWVY"
     exon            626..738
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            739..844
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            845..922
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            923..995
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1098
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1274
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1397
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1481
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1581
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1599
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1721
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1799
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1880
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2069
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2148
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2234
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2303
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2372
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2408
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2605
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2721
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2802
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2883
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3086
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3170
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..8833
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4531..4536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /note="hexamer: AATATA"
     polyA_site      4558
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /note="major polyA site"
     regulatory      8810..8815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /note="hexamer: AATAAA"
     polyA_site      8833
                     /gene="CASK"
                     /gene_synonym="CAGH39; CAMGUK; CMG; FGS4; hCASK; LIN2;
                     MICPCH; MRXSNA; TNRC8"
                     /note="major polyA site"
ORIGIN      
        1 actcccgggc gggcggtggc ggctgcggga ggaggagaaa gaggagggag cgtctctgcc
       61 gccgcctcct ggtccccagc gccgatccgc cgccgccgcc acctccctcc gcggcgatcc
      121 tcgctccatg gtcctgccgc ggccccctct gtagcccgag ctgctccgcg acgcgacgga
      181 gccggcctcg gacagaggga gcggtcgcgg cctcgcggcc cgcgcgggct gacgagcgga
      241 gagcgcgacg ccgcgcggtc cccgaggatc cgcacgccgg gcagcgcggc ccgagcagcg
      301 cgagaagcag cgggcgggcg ggcggcgccg ggcccgggcc gccctcgctc ccgcgccccg
      361 gccccgccgc ccgcgccggg gcggtcgcct gcagaggaag gcgccgcagt ctctgggcct
      421 cgcggcccca ctcgagcgtc ctcggcaccg agggctcgcg ggtcctgagg ggaggaggcg
      481 atcccggggc tgggcactga gctcttgggc gcccccaccc ccgttttcga agccctccac
      541 gctgcggccg ctatcccctc cggaccatgg ccgacgacga cgtgctgttc gaggatgtgt
      601 acgagctgtg cgaggtgatc ggaaagggtc ccttcagtgt tgtacgacga tgtatcaaca
      661 gagaaactgg gcaacaattt gctgtaaaaa ttgttgatgt agccaagttc acatcaagtc
      721 cagggttaag tacagaagat ctaaagcggg aagccagtat ctgtcatatg ctgaaacatc
      781 cacacattgt agagttattg gagacatata gctcagatgg aatgctttac atggttttcg
      841 aatttatgga tggagcagat ctgtgttttg aaatcgtaaa gcgagctgac gctggttttg
      901 tgtacagtga agctgtagcc agccattata tgagacagat actggaagct ctacgctact
      961 gccatgataa taacataatt cacagggatg tgaagcccca ctgtgttctc cttgcctcaa
     1021 aagaaaactc ggcacctgtt aaacttggag gctttggggt agctattcaa ttaggggagt
     1081 ctggacttgt agctggagga cgtgttggaa cacctcattt tatggcacca gaagtggtca
     1141 aaagagagcc ttacggaaag cctgtagacg tctgggggtg cggtgtgatc ctttttatcc
     1201 tgctcagtgg ttgtttgcct ttttacggaa ccaaggaaag attgtttgaa ggcattatta
     1261 aaggaaaata taagatgaat ccaaggcagt ggagccatat ctctgaaagt gccaaagacc
     1321 tagtacgtcg catgctgatg ctggatccag ctgaaaggat cactgtttat gaagcactga
     1381 atcacccatg gcttaaggag cgggatcgtt acgcctacaa gattcatctt ccagaaacag
     1441 tagagcagct gaggaaattc aatgcaagga ggaaactaaa gggtgcagta ctagccgctg
     1501 tgtcaagtca caaattcaac tcattctatg gggatccccc tgaagagtta ccagatttct
     1561 ccgaagaccc tacctcctca ggacttctag cagcagaaag agcagtctca caggtgctgg
     1621 acagcctgga agagattcat gcgcttacag actgcagtga aaaggaccta gattttctac
     1681 acagtgtttt ccaggatcag catcttcaca cactactaga tctgtatgac aaaattaaca
     1741 caaagtcttc accacaaatc aggaatcctc caagcgatgc agtacagaga gccaaagagg
     1801 tattggaaga aatttcatgt taccctgaga ataacgacgc aaaggaacta aagcgtattt
     1861 taacacaacc tcatttcatg gccttacttc agactcacga cgtagtggca catgaagttt
     1921 acagtgatga agcattgagg gtcacacctc ctcccacctc tccctattta aacggcgatt
     1981 ctccagaaag tgctaacgga gacatggata tggagaatgt gaccagagtt cggctggtac
     2041 agtttcaaaa gaacacagat gaaccaatgg gaatcacttt aaaaatgaat gaactaaatc
     2101 attgtattgt tgcaagaatt atgcatgggg gcatgattca caggcaaggt acacttcatg
     2161 ttggtgatga aattcgagaa atcaatggca tcagtgtggc taaccaaaca gtggaacaac
     2221 tgcaaaaaat gcttagggaa atgcggggga gtattacctt caagattgtg ccaagttacc
     2281 gcactcagtc ttcgtcctgt gagagagatt ccccttccac ttccagacag tccccagcta
     2341 atggtcatag cagcactaac aattctgttt cggacttgcc atcaactacc caaccaaaag
     2401 gacgacagat ctatgtaaga gcacaatttg aatatgatcc agccaaggat gacctcatcc
     2461 cctgtaaaga agctggcatt cgattcagag ttggtgacat catccagatt attagtaagg
     2521 atgatcataa ttggtggcag ggtaaactgg aaaactccaa aaatggaact gcaggtctca
     2581 ttccttctcc tgaacttcag gaatggcgag tagcttgcat tgccatggag aagaccaaac
     2641 aggagcagca ggccagctgt acttggtttg gcaagaaaaa gaagcagtac aaagataaat
     2701 atttggcaaa gcacaatgca gtgtttgatc aattagatct tgtcacatat gaagaagtag
     2761 taaaactgcc agcattcaag aggaaaacac tagtcttatt aggcgcacat ggtgttggga
     2821 gaagacacat aaaaaacact ctcatcacaa agcacccaga ccggtttgcg taccctattc
     2881 cacatacaac cagacctcca aagaaagacg aagaaaatgg aaagaattat tactttgtat
     2941 ctcatgacca aatgatgcaa gacatctcta ataacgagta cttggagtac ggcagccacg
     3001 aggatgcgat gtatgggaca aaactggaga ccatccggaa gatccacgag caggggctga
     3061 ttgcaatact ggacgtggag cctcaggcac tgaaggtcct gagaactgca gagtttgctc
     3121 cttttgttgt tttcattgct gcaccaacta ttactccagg tttaaatgag gatgaatctc
     3181 ttcagcgtct gcagaaggag tctgacatct tacagagaac atatgcacac tacttcgatc
     3241 tcacaattat caacaatgaa attgatgaga caatcagaca tctggaggaa gctgttgagc
     3301 tcgtgtgcac agccccacag tgggtccctg tctcctgggt ctattaggcc tctccccaga
     3361 tatctgagca taactgggag cacctcattt gtggaaaagc ctctttgtta tcggccttgt
     3421 gtcagcaggt catggtccct agagactacc tagttgtagt gtgacctaca tttataatta
     3481 ttgtcatgtc cgaatagata ggaggagaaa aacaattaca cactaattta aagagacagt
     3541 atctttttta atcagttctc ctaaacttta ataaaatgta tctttaaatg tatgtattat
     3601 tcaatccttt ggaatgttat atttttggaa atcatagctt tttatttcca aggcccctaa
     3661 aaactgcaca aaatagatgc tgctttctat aatctatttt aataataata aacaatgatt
     3721 ctgttacctt gactgggggt ggaacactac attcttttta gagtctgatt ttatggattg
     3781 gaatattggg atatctttct ttcctttatt tatttgaaat aattagtgta gtgattacaa
     3841 aacagtcata aatttttaaa ggcctttttt ctctcttttt ttttttttag aatagtattt
     3901 ttttttaagt cctttatgta acatccagat aatgtgatac tgtctctttg aagcaccctg
     3961 taaacctttt agagatttga agttgggtct tgactcttaa tgcatgtgga cagtcgcgag
     4021 cgtttatgct gtcggtgtgt ctgtgttgga caaaacaatc tgtaatctac agcaaagtac
     4081 attctacatt ccgttcatgg ggcacaccca ggggaataag aataaaatgc tattatgact
     4141 aagttgtaaa cctatgcaca tcccttgcat tttgggcaac tttataaaaa aaaagaaact
     4201 gatttttatt aataataatc atgtagtgaa atgtgtttgt aattttgtct caatttaatt
     4261 tgttgtaagg tggggtgggg ggaattgctg gtttcaccat ttcagatctg tgttgtctaa
     4321 gagtattaac gttttaatta agcaaagaaa tgatttttaa tctgtatgta attgttttaa
     4381 agcacccatt ttaagagaaa atactgtgca atgaagaaac cagtttaggc atttgctata
     4441 aactgaaata ttccaaaaga atcatctata acagccctgt aaattccttt aaaatgataa
     4501 ctaacaggac agtttgacca atttttttta aatatacttc cttttatgtg ttcaataatt
     4561 aaatgccttt gggtccttca tttcattata gatttgttca ggcttccaag ctgataatct
     4621 ttacaattgt ataatttgtt agatgctcat tgaacctttg aaggcccagg agtgagtatc
     4681 agttggcagg gtgacaaagt agcctgccag agcacagctg gaccacgtct gactcgcaca
     4741 gagccatgcg cccaagggcc acgggtgtac tggaggccac ctgtggtctc tccttcctct
     4801 tgctgtatcc cttggcacag gggaatcatc tgtccttgtt gctttagaga cattaaccat
     4861 ctcataactc ttccatgaag tcacattctt ccaatacagg agattcgggc tggggttctc
     4921 agactctttg ccagaggtca gtagaatgtt tttcattagc atgtgagggt gtgaagtgct
     4981 tatattaacc tgtgatcctt gaaaacatac catcattttt tgcttcttgt aggttagatg
     5041 gccttgtcac tttgtgcctt ggcaggatgt gcagggtgtg ttctgagctg aacagctcct
     5101 cttaaaggac caaacagaga aggcattagt atacttcttt tacattgtca acaccatacc
     5161 cgcctccgcc ccccaccgcc tattattaaa tggtggcgat tttttttttt ctgatgttgt
     5221 tctttgccag tgaccagatg agtctgcaac ttactaacaa ggtattgagt gaactacttc
     5281 tgtatgggcc ccacagtggg gtgaccaagc caccaaacca gagataagct caacagtggt
     5341 ctcacactag atagagagag aaaccttcaa agagttgggt agggctgtgt tagaactgat
     5401 tcgaatctga tagatgccaa ggccagacag tcgttcctgg tatggtactg accacaattt
     5461 cgggctctta gtgtgaaggt gcgcactcta cctcttttct ggtgaagcac aaagacaact
     5521 acaactaaca catgggaaac agaaacttcc ctccctctag tggaaacccc cacgccccca
     5581 cttgcccttt gagcccacat ctccagagat gctgatgatg cctgtcttaa gccatctgcc
     5641 atatttataa aggtggatta agcagaggag gagaaaagca atgccaactt aaatgtctgt
     5701 ggccccacaa ttcacaagca ctgtagcact catcctcagt ggctttatac gtcctctgag
     5761 aagcacacag gcaggcatca ttcttgccat cattccgatg gtgaaatccc tgcatgcaga
     5821 actcattgac ttctcaaaga tgttacctgt tccattccac taatacatgt cttctctaaa
     5881 gcagtgtctt tatgacctag ctgcatatac ttacatttct gaattcagag taatttcagt
     5941 acattgctgc tgctgctgct gctgctgctg ctgctgctgc tgctgctgct gctgctactg
     6001 ctacattaca attgtccact aagcaatcag agaaaattgc taaaagcttc tttactgctt
     6061 ccattccatc agcagaacct ttttttttct ttctttcttt taaagaccag aatgaatgtt
     6121 tagagtacta aatcttatta gtggtcaatt gaagtattgg agagccacat tttgaaggtt
     6181 ctctccccca cccaactcca ttccccacag caagaaaggg agtgttttta tatgttgaat
     6241 tctttgttaa aaagatgaaa tgtcctgatt ttccagtcac aagacagtaa ttactttgca
     6301 catacagcat atcccatttt aatgctaaaa agggaaatgt cactcaattt aattcatctg
     6361 gaagtttccc agtgtcaaga taacattgta gcctttttaa atgcaattaa atgtatctct
     6421 tgtcaggtga gatgatttaa aatctttgct cagagaggaa aacaaatggt tgacctactt
     6481 cttgctattt gcattcagaa ggcatcgtcc cagcccatcc tattggtggc agaatatcta
     6541 aagatgtcgc aaagtccccc actgcagtag aaatgcagga ggtgttcctg ttccccgtcc
     6601 aattccttct taggctgcta gagacagcca gtgggccaag ccttcccctg tgctccaggc
     6661 aggcctgggc tgcagctact gttacctttt tacagccttt gatctgatcg ctgcagagtt
     6721 cttttgtttt taaatcactt gtatttgtct cttcattaag gcttcaagtt tatttcttga
     6781 aaaagtttag tcaattgaac caccctccag gaagattccc agcgtggaaa ctgcccctga
     6841 aaaacaaggc agcccaaagc cagctctctt ttgtccccca ctgatgtcat gtcctttttt
     6901 tttttcattt caggccagtt tcttaacttg gggcaaagag aatgtgttgc taaagctacc
     6961 aagaaaactg cttgattaac aaattcttaa tagaaatgcc tcccacactg tctctttgaa
     7021 aagagaaggc accttggaat cggcattcca aaaccaagct ccttgtcatc ctcatccctc
     7081 ctccttcttg cttcctatta tcaaactcgt gtgtgtttct tgttttctca gaactgaaca
     7141 cagcctccta attccatcct cttgactagg gcttacaata ctgagagcga ttacaggctg
     7201 taataagtta aaggtccctg agcgtggctt tcttgttctg cgcctctaat taattcttct
     7261 attaaaagat gctttccttc tcactgcagc ttacagaaag gctacaagct ttaatcacag
     7321 atcatttcat ttgccagagc ctttcctttt ctaactcctt tagaaataag atttccctct
     7381 ctgtttggaa tctctggata caggactctc ctccaagctc atggcttgat tggctttgcc
     7441 tgtgcacaca cacatcagtt tgccttaaac ttggagctat ggggagtccc agattttcca
     7501 gcttagtggg tgaagtttag ctgtcaccta catccaggaa gtgggggaaa agggaaaaaa
     7561 agaggatatt caccaccatg ttcccatccg gtctttcccc tgccttgctt tgtgcagcag
     7621 gtgggcagac agagcccaca gaaacagaag tagaaagagg gccgcaccat ctctggggcc
     7681 agcactccta agtcttagct ctttgtggga atagaaaatc ctgagctccc accacctctc
     7741 gtctgaccct ccatcaactc cctcgaacct gtgcaaatgg actgagcaaa agaaaatgga
     7801 aagagatgtt tgtcaccaca caggagacct cctttctggc cccaagcaca actccatctc
     7861 tgcgtatgct cagaaactca gaatttagct gctacttatg tgttagctcc attctctctg
     7921 gtgtgtgact gagagaacac gccagtgttc ttactgacag aggcttaggg gtgaccctct
     7981 ctggacccag aggaagtaca acctctgtag cgagaattgt ccttgggaac agaaacaggc
     8041 attcctccac agtgagtggc tccccctatt ttttttttat ttggaagaga ccaagaattg
     8101 ggggaattga tttccagtct tagctgtttc ccggaatgtc atctgtgcag gcaggtaggc
     8161 ggctgccggg tgcagcaggc agcgtgactg atgtgaaggc cgcccaatcc tcacgtgcta
     8221 agacccgagt atcgtgttta attgcagtgt aggcacgtcg ccattcaaac tcagttctgg
     8281 ggtggttttg cataaagttt tgccaacgtg ttcttttttc tgtatgtatt attgcctttt
     8341 tataaaaggt gttgaagtat tgtctcagtg ataaaaagag agagatgtta atggttgttg
     8401 tatatttcac cgtatccaat tgtaagtatt tgcagggtac agcagagcct tagcttgcaa
     8461 gagcgtttgt gcaggaggtg tccctcaaca cccaggagct gaagggattg gaaaggtttg
     8521 gattctttgt aaatgtcctg cttttctttc tctctgtgtg tatctattta catgccttag
     8581 cacacgccct cccatcctga tccctttgcc ctgtcgccgg aacaaccaga atgctggtgc
     8641 gctgccggca cagtacaagt tgatgaaacc ctaatcagtt atcttgtgtg acaggggaag
     8701 aagagaaact ccatagtatt ccttgtagaa tatacatacc tgtaggatgc tgtgtaatgg
     8761 gaaaccatag aattgggctt ttgtcatttc aaagttggag aaatgtatga ataaaatgta
     8821 taaaacatga aaa
//
