LOCUS       NM_007359               3890 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CASC3 exon junction complex subunit (CASC3), mRNA.
ACCESSION   NM_007359
VERSION     NM_007359.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3890)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3890)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3890)
  AUTHORS   Gerbracht,J.V., Boehm,V., Britto-Borges,T., Kallabis,S.,
            Wiederstein,J.L., Ciriello,S., Aschemeier,D.U., Kruger,M.,
            Frese,C.K., Altmuller,J., Dieterich,C. and Gehring,N.H.
  TITLE     CASC3 promotes transcriptome-wide activation of nonsense-mediated
            decay by the exon junction complex
  JOURNAL   Nucleic Acids Res 48 (15), 8626-8644 (2020)
   PUBMED   32621609
  REMARK    GeneRIF: CASC3 promotes transcriptome-wide activation of
            nonsense-mediated decay by the exon junction complex.
REFERENCE   4  (bases 1 to 3890)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3890)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   6  (bases 1 to 3890)
  AUTHORS   Macchi,P., Kroening,S., Palacios,I.M., Baldassa,S., Grunewald,B.,
            Ambrosino,C., Goetze,B., Lupas,A., St Johnston,D. and Kiebler,M.
  TITLE     Barentsz, a new component of the Staufen-containing
            ribonucleoprotein particles in mammalian cells, interacts with
            Staufen in an RNA-dependent manner
  JOURNAL   J Neurosci 23 (13), 5778-5788 (2003)
   PUBMED   12843282
REFERENCE   7  (bases 1 to 3890)
  AUTHORS   Degot,S., Regnier,C.H., Wendling,C., Chenard,M.P., Rio,M.C. and
            Tomasetto,C.
  TITLE     Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein
            overexpressed in breast cancer
  JOURNAL   Oncogene 21 (28), 4422-4434 (2002)
   PUBMED   12080473
REFERENCE   8  (bases 1 to 3890)
  AUTHORS   Varis,A., Wolf,M., Monni,O., Vakkari,M.L., Kokkola,A., Moskaluk,C.,
            Frierson,H. Jr., Powell,S.M., Knuutila,S., Kallioniemi,A. and
            El-Rifai,W.
  TITLE     Targets of gene amplification and overexpression at 17q in gastric
            cancer
  JOURNAL   Cancer Res 62 (9), 2625-2629 (2002)
   PUBMED   11980659
REFERENCE   9  (bases 1 to 3890)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   10 (bases 1 to 3890)
  AUTHORS   Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
            Lidereau,R., Basset,P. and Rio,M.C.
  TITLE     Identification of four novel human genes amplified and
            overexpressed in breast carcinoma and localized to the q11-q21.3
            region of chromosome 17
  JOURNAL   Genomics 28 (3), 367-376 (1995)
   PUBMED   7490069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X80199.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007359.4.
            
            Summary: The product of this gene is a core component of the exon
            junction complex (EJC), a protein complex that is deposited on
            spliced mRNAs at exon-exon junctions and functions in
            nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA
            and interacts with two other EJC core components. It is
            predominantly located in the cytoplasm, but shuttles into the
            nucleus where it localizes to nuclear speckles. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050526.1, X80199.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264645.12/ ENSP00000264645.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3890              X80199.2           222-4111
FEATURES             Location/Qualifiers
     source          1..3890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..3890
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /note="CASC3 exon junction complex subunit"
                     /db_xref="GeneID:22794"
                     /db_xref="HGNC:HGNC:17040"
                     /db_xref="MIM:606504"
     exon            1..243
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2124
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /note="metastatic lymph node 51; barentsz; cancer
                     susceptibility candidate 3; MLN 51; protein barentsz;
                     metastatic lymph node gene 51 protein; cancer
                     susceptibility candidate gene 3 protein; cancer
                     susceptibility 3"
                     /codon_start=1
                     /product="protein CASC3"
                     /protein_id="NP_031385.2"
                     /db_xref="CCDS:CCDS11362.1"
                     /db_xref="GeneID:22794"
                     /db_xref="HGNC:HGNC:17040"
                     /db_xref="MIM:606504"
                     /translation="MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGG
                     SGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEE
                     GEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVEN
                     KVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRW
                     EHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGE
                     RLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQ
                     HGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAP
                     PPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGT
                     WEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNR
                     MEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAP
                     LPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSA
                     PGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPR
                     RTPQPVTIKPPPPEVVSRGSS"
     exon            244..271
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            272..309
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            310..468
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            469..620
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            621..797
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1483
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1548
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1663
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1762
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1977
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2100
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2165
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..3890
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3867..3872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /note="hexamer: AATAAA"
     polyA_site      3890
                     /gene="CASC3"
                     /gene_synonym="BTZ; MLN51"
                     /note="major polyA site"
ORIGIN      
        1 gttctccgta agatggcgga ccggcggcgg cagcgcgctt cgcaagacac cgaggacgag
       61 gaatctggtg cttcgggctc cgacagcggc ggctccccgt tgcggggagg cgggagctgc
      121 agcggtagcg ccggaggcgg cggcagcggc tctctgcctt cacagcgcgg aggccgaacc
      181 ggggcccttc atctgcggcg ggtggagagc gggggcgcca agagtgctga ggagtcggag
      241 tgtgagagtg aagatggcat tgaaggtgat gctgttctct cggattatga aagtgcagaa
      301 gactcggaag gtgaagaagg tgaatacagt gaagaggaaa actccaaagt ggagctgaaa
      361 tcagaagcta atgatgctgt taattcttca acaaaagaag agaagggaga agaaaagcct
      421 gacaccaaaa gcactgtgac tggagagagg caaagtgggg acggacagga gagcacagag
      481 cctgtggaga acaaagtggg taaaaagggc cctaagcatt tggatgatga tgaagatcgg
      541 aagaatccag catacatacc tcggaaaggg ctcttctttg agcatgatct tcgagggcaa
      601 actcaggagg aggaagtcag acccaagggg cgtcagcgaa agctatggaa ggatgagggt
      661 cgctgggagc atgacaagtt ccgggaagat gagcaggccc caaagtcccg acaggagctc
      721 attgctcttt atggttatga cattcgctca gctcataatc ctgatgacat caaacctcga
      781 agaatccgga aaccccgata tgggagtcct ccacaaagag atccaaactg gaacggtgag
      841 cggctaaaca agtctcatcg ccaccagggt cttgggggca ccctaccacc aaggacattt
      901 attaacagga atgctgcagg taccggccgt atgtctgcac ccaggaatta ttctcgatct
      961 gggggcttca aggaaggtcg tgctggtttt aggcctgtgg aagctggtgg gcagcatggt
     1021 ggccggtctg gtgagactgt taagcatgag attagttacc ggtcacggcg cctagagcag
     1081 acttctgtga gggatccatc tccagaagca gatgctccag tgcttggcag tcctgagaag
     1141 gaagaggcag cctcagagcc accagctgct gctcctgatg ctgcaccacc accccctgat
     1201 aggcccattg agaagaaatc ctattcccgg gcaagaagaa ctcgaaccaa agttggagat
     1261 gcagtcaagc ttgcagagga ggtgccccct cctcctgaag gactgattcc agcacctcca
     1321 gtcccagaaa ccaccccaac tccacctact aagactggga cctgggaagc tccggtggat
     1381 tctagtacaa gtggacttga gcaagatgtg gcacaactaa atatagcaga acagaattgg
     1441 agtccggggc agccttcttt cctgcaacca cgggaacttc gaggtatgcc caaccatata
     1501 cacatgggag caggacctcc acctcagttt aaccggatgg aagaaatggg tgtccagggt
     1561 ggtcgagcca aacgctattc atcccagcgg caaagacctg tgccagagcc ccccgcccct
     1621 ccagtgcata tcagtatcat ggagggacat tactatgatc cactgcagtt ccagggacca
     1681 atctataccc atggtgacag ccctgccccg ctgcctccac agggcatgct tgtgcagcca
     1741 ggaatgaacc ttccccaccc aggtttacat ccccaccaga caccagctcc tctgcccaat
     1801 ccaggcctct atcccccacc agtgtccatg tctccaggac agccaccacc tcagcagttg
     1861 cttgctccta cttacttttc tgctccaggc gtcatgaact ttggtaatcc cagttaccct
     1921 tatgctccag gggcactgcc tcccccacca ccgcctcatc tgtatcctaa tacacaggcc
     1981 ccatcacagg tatatggagg agtgacctac tataaccccg cccagcagca ggtgcagcca
     2041 aagccctccc caccccggag gactccccag ccagtcacca tcaagccccc tccacctgag
     2101 gttgtaagca ggggttccag ttaatacaag tttctgaata ttttaaatct taacatcata
     2161 taaaaagcag cagaggtgag aactcagaag agaaatacag ctggctatct actaccagaa
     2221 gggcttcaaa gatatagggt gtggctccta ccagcaaaca gctgaaagag gaggacccct
     2281 gccttcctct gaggacaggc tctagagaga gggagaaaca agtggacctc gtcccatctt
     2341 cactcttcac ttgagttggc tgtgttcggg ggagcagaga gagccagaca gccccaagct
     2401 tctgagtcta gatacagaag cccatgtctt ctgctgttct tcacttctgg gaaattgaag
     2461 tgtcttctgt tcccaaggaa gctccttcct gtttgttttg ttttctaaga tgttcatttt
     2521 taaagcctgg cttcttatcc ttaatattat tttaattttt tctctttgtt tctgtttctt
     2581 gctctctctc cctgccttta aatgaaacaa gtctagtctt ctggttttct agcccctctg
     2641 gattcccttt tgactcttcc gtgcatccca gataatggag aatgtatcag ccagccttcc
     2701 ccaccaagtc taaaaagacc tggcctttca cttttagttg gcatttgtta tcctcttgta
     2761 tacttgtatt cccttaactc taaccctgtg gaagcatggc tgtctgcaca gagggtccca
     2821 ttgtgcagaa aagctcagag taggtgggta ggagcccttc tctttgactt aggtttttag
     2881 gagtctgagc atccatcaat acctgtacta tgatgggctt ctgttctctg ctgagggcca
     2941 ataccctact gtggggagag atggcacacc agatgctttt gtgagaaagg gatggtggag
     3001 tgagagcctt tgcctttagg ggtgtgtatt cacatagtcc tcagggctca gtcttttgag
     3061 gtaagtggaa ttagagggcc ttgcttctct tctttccatt cttcttgcta cacccctttt
     3121 ccagttgctg tggaccaatg catctcttta aaggcaaata ttatccagca agcagtctac
     3181 cctgtccttt gcaattgctc ttctccacgt ctttcctgct acaagtgttt tagatgttac
     3241 taccttattt tccccgaatt ctatttttgt ccttgcagac agaatataaa aactcctggg
     3301 cttaaggcct aaggaagcca gtcaccttct gggcaagggc tcctatcttt cctccctatc
     3361 catggcacta aaccacttct ctgctgcctc tgtggaagag attcctatta ctgcagtaca
     3421 tacgtctgcc aggggtaacc tggccactgt ccctgtcctt ctacagaacc tgagggcaaa
     3481 gatggtggct gtgtctctcc ccggtaatgt cactgttttt attccttcca tctagcagct
     3541 ggcctaatca ctctgagtca caggtgtggg atggagagtg gggagaggca cttaatctgt
     3601 aacccccaag gaggaaataa ctaagagatt cttctagggg tagctggtgg ttgtgccttt
     3661 tgtaggctgt tccctttgcc ttaaacctga agatgtctcc tcaagcctgt gggcagcatg
     3721 cccagattcc cagaccttaa gacactgtga gagttgtctc tgttggtcca ctgtgtttag
     3781 ttgcaaggat ttttccatgt gtggtggtgt tttttgttac tgttttaaag ggtgcccatt
     3841 tgtgatcagc attgtgactt ggagataata aaatttagac tataaacttg
//
