LOCUS       NM_004291                800 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CART prepropeptide (CARTPT), mRNA.
ACCESSION   NM_004291
VERSION     NM_004291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 800)
  AUTHORS   Weaver,C., Antony,M., Fite,J., Murugan,P., Nelson,A.C. and
            Manivel,J.C.
  TITLE     Cocaine and amphetamine regulated transcript (CART): a newly
            characterized neuropeptide in human prostate
  JOURNAL   Biotech Histochem 98 (7), 508-522 (2023)
   PUBMED   37615074
  REMARK    GeneRIF: Cocaine and amphetamine regulated transcript (CART): a
            newly characterized neuropeptide in human prostate.
REFERENCE   2  (bases 1 to 800)
  AUTHORS   Khodarahmi,M., Siri,G., Erahimzadeh,F., Farhangi,M.A. and
            Shanehbandi,D.
  TITLE     Dietary glycemic index and glycemic load mediate the effect of
            CARTPT rs2239670 gene polymorphism on metabolic syndrome and
            metabolic risk factors among adults with obesity
  JOURNAL   BMC Endocr Disord 22 (1), 288 (2022)
   PUBMED   36404325
  REMARK    GeneRIF: Dietary glycemic index and glycemic load mediate the
            effect of CARTPT rs2239670 gene polymorphism on metabolic syndrome
            and metabolic risk factors among adults with obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 800)
  AUTHORS   Mahmoudinezhad,M., Abbasalizad-Farhangi,M. and Kahroba,H.
  TITLE     Hypothalamic-pituitary hormones will be affected by the interaction
            between 5q13-14-rs2239670 (CARTPT) gene variants and diet in
            different obesity phenotypes
  JOURNAL   BMC Res Notes 14 (1), 443 (2021)
   PUBMED   34876220
  REMARK    GeneRIF: Hypothalamic-pituitary hormones will be affected by the
            interaction between 5q13-14-rs2239670 (CARTPT) gene variants and
            diet in different obesity phenotypes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 800)
  AUTHORS   Samson,W.K., Salvemini,D. and Yosten,G.L.C.
  TITLE     Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise
  JOURNAL   Endocrinology 162 (8) (2021)
   PUBMED   34043767
  REMARK    GeneRIF: Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise.
            Review article
REFERENCE   5  (bases 1 to 800)
  AUTHORS   Lau,J. and Herzog,H.
  TITLE     CART in the regulation of appetite and energy homeostasis
  JOURNAL   Front Neurosci 8, 313 (2014)
   PUBMED   25352770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 800)
  AUTHORS   Stein,J., Steiner,D.F. and Dey,A.
  TITLE     Processing of cocaine- and amphetamine-regulated transcript (CART)
            precursor proteins by prohormone convertases (PCs) and its
            implications
  JOURNAL   Peptides 27 (8), 1919-1925 (2006)
   PUBMED   16784796
  REMARK    Review article
REFERENCE   7  (bases 1 to 800)
  AUTHORS   Challis,B.G., Yeo,G.S., Farooqi,I.S., Luan,J., Aminian,S.,
            Halsall,D.J., Keogh,J.M., Wareham,N.J. and O'Rahilly,S.
  TITLE     The CART gene and human obesity: mutational analysis and population
            genetics
  JOURNAL   Diabetes 49 (5), 872-875 (2000)
   PUBMED   10905499
REFERENCE   8  (bases 1 to 800)
  AUTHORS   Smith,Y., Kieval,J., Couceyro,P.R. and Kuhar,M.J.
  TITLE     CART peptide-immunoreactive neurones in the nucleus accumbens in
            monkeys: ultrastructural analysis, colocalization studies, and
            synaptic interactions with dopaminergic afferents
  JOURNAL   J Comp Neurol 407 (4), 491-511 (1999)
   PUBMED   10235641
  REMARK    GeneRIF: Medium-sized CART-positive neurons are common in the
            medial division of the shell of nucleus accumbens in monkeys. CART
            may be involved in neuronal and behavioural changes that underlie
            addiction to psychomotor stimulants and feeding.
REFERENCE   9  (bases 1 to 800)
  AUTHORS   Kristensen,P., Judge,M.E., Thim,L., Ribel,U., Christjansen,K.N.,
            Wulff,B.S., Clausen,J.T., Jensen,P.B., Madsen,O.D., Vrang,N.,
            Larsen,P.J. and Hastrup,S.
  TITLE     Hypothalamic CART is a new anorectic peptide regulated by leptin
  JOURNAL   Nature 393 (6680), 72-76 (1998)
   PUBMED   9590691
REFERENCE   10 (bases 1 to 800)
  AUTHORS   Douglass,J. and Daoud,S.
  TITLE     Characterization of the human cDNA and genomic DNA encoding CART: a
            cocaine- and amphetamine-regulated transcript
  JOURNAL   Gene 169 (2), 241-245 (1996)
   PUBMED   8647455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029882.1 and AI417979.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004291.3.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate multiple biologically active peptides. These
            peptides play a role in appetite, energy balance, maintenance of
            body weight, reward and addiction, and the stress response.
            Expression of a similar gene transcript in rodents is upregulated
            following administration of cocaine and amphetamine. Mutations in
            this gene are associated with susceptibility to obesity in humans.
            [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16826.1, SRR5189652.169127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296777.5/ ENSP00000296777.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               BC029882.1         109-641
            534-800             AI417979.1         4-270               c
FEATURES             Location/Qualifiers
     source          1..800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..800
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /note="CART prepropeptide"
                     /db_xref="GeneID:9607"
                     /db_xref="HGNC:HGNC:24323"
                     /db_xref="MIM:602606"
     exon            1..178
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..370
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /note="cocaine- and amphetamine-regulated transcript
                     protein"
                     /codon_start=1
                     /product="cocaine- and amphetamine-regulated transcript
                     protein preproprotein"
                     /protein_id="NP_004282.1"
                     /db_xref="CCDS:CCDS4011.1"
                     /db_xref="GeneID:9607"
                     /db_xref="HGNC:HGNC:24323"
                     /db_xref="MIM:602606"
                     /translation="MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAV
                     DDASHEKELIEALQEVLKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDC
                     PRGTSCNSFLLKCL"
     exon            179..262
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /inference="alignment:Splign:2.1.0"
     exon            263..800
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /inference="alignment:Splign:2.1.0"
     regulatory      780..785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /note="hexamer: AATAAA"
     polyA_site      800
                     /gene="CARTPT"
                     /gene_synonym="CART"
                     /note="major polyA site"
ORIGIN      
        1 aacgacgagt ttcagaacga tggagagctc ccgcgtgagg ctgctgcccc tcctgggcgc
       61 cgccctgctg ctgatgctac ctctgttggg tacccgtgcc caggaggacg ccgagctcca
      121 gccccgagcc ctggacatct actctgccgt ggatgatgcc tcccacgaga aggagctgat
      181 cgaagcgctg caagaagtct tgaagaagct caagagtaaa cgtgttccca tctatgagaa
      241 gaagtatggc caagtcccca tgtgtgacgc cggtgagcag tgtgcagtga ggaaaggggc
      301 aaggatcggg aagctgtgtg actgtccccg aggaacctcc tgcaattcct tcctcctgaa
      361 gtgcttatga aggggcgtcc attctcctcc atacatcccc atccctctac tttccccaga
      421 ggaccacacc ttcctccctg gagtttggct taagcaacag ataaagtttt tattttcctc
      481 tgaagggaaa gggctctttt cctgctgttt caaaaataaa agaacacatt agatgttact
      541 gtgtgaagaa taatgccttg tatggtgttg atacgtgtgt gaagtattct tattttattt
      601 gtctgacaaa ctcttgtgta cctttgtgta aagaagggaa gctttgtttg aaaattgtat
      661 ttttgtatgt ggcatggcag aatgaaaatt agatctagct aatctcggta gatgtcatta
      721 caacctggaa aataaatcac cctaagtgac acaaattgaa gcatgtacaa attatacata
      781 ataaagtgtt tttaataatt
//
