LOCUS       NM_199141               3295 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens coactivator associated arginine methyltransferase 1
            (CARM1), transcript variant 1, mRNA.
ACCESSION   NM_199141 XM_032719
VERSION     NM_199141.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Cho,Y. and Kim,Y.K.
  TITLE     CARM1 phosphorylation at S595 by p38gamma MAPK drives ROS-mediated
            cellular senescence
  JOURNAL   Redox Biol 76, 103344 (2024)
   PUBMED   39265499
  REMARK    GeneRIF: CARM1 phosphorylation at S595 by p38gamma MAPK drives
            ROS-mediated cellular senescence.
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Chen,X., Huang,M.F., Fan,D.M., He,Y.H., Zhang,W.J., Ding,J.C.,
            Peng,B.L., Pan,X., Liu,Y., Du,J., Li,Y., Liu,Z.Y., Xie,B.L.,
            Kuang,Z.J., Yi,J. and Liu,W.
  TITLE     CARM1 hypermethylates the NuRD chromatin remodeling complex to
            promote cell cycle gene expression and breast cancer development
  JOURNAL   Nucleic Acids Res 52 (12), 6811-6829 (2024)
   PUBMED   38676947
  REMARK    GeneRIF: CARM1 hypermethylates the NuRD chromatin remodeling
            complex to promote cell cycle gene expression and breast cancer
            development.
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Bacabac,M., Liu,P. and Xu,W.
  TITLE     Protein Arginine Methyltransferase CARM1 in Human Breast Cancer
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38878278
  REMARK    GeneRIF: Protein Arginine Methyltransferase CARM1 in Human Breast
            Cancer.
            Review article
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   Hayati,R.F., Nakajima,R., Zhou,Y., Shirasawa,M., Zhao,L.,
            Fikriyanti,M., Iwanaga,R., Bradford,A.P., Kurayoshi,K., Araki,K.
            and Ohtani,K.
  TITLE     Trans-Activation of the Coactivator-Associated Arginine
            Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of
            Human T-Cell Leukemia Virus Type 1
  JOURNAL   Genes (Basel) 15 (6), 698 (2024)
   PUBMED   38927636
  REMARK    GeneRIF: Trans-Activation of the Coactivator-Associated Arginine
            Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of
            Human T-Cell Leukemia Virus Type 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Itonaga,H., Mookhtiar,A.K., Greenblatt,S.M., Liu,F., Martinez,C.,
            Bilbao,D., Rains,M., Hamard,P.J., Sun,J., Umeano,A.C., Duffort,S.,
            Chen,C., Man,N., Mas,G., Tottone,L., Totiger,T., Bradley,T.,
            Taylor,J., Schurer,S. and Nimer,S.D.
  TITLE     Tyrosine phosphorylation of CARM1 promotes its enzymatic activity
            and alters its target specificity
  JOURNAL   Nat Commun 15 (1), 3415 (2024)
   PUBMED   38649367
  REMARK    GeneRIF: Tyrosine phosphorylation of CARM1 promotes its enzymatic
            activity and alters its target specificity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Blanc,R.S. and Richard,S.
  TITLE     Regenerating muscle with arginine methylation
  JOURNAL   Transcription 8 (3), 175-178 (2017)
   PUBMED   28301308
  REMARK    Review article
REFERENCE   7  (bases 1 to 3295)
  AUTHORS   Lee,J. and Bedford,M.T.
  TITLE     PABP1 identified as an arginine methyltransferase substrate using
            high-density protein arrays
  JOURNAL   EMBO Rep 3 (3), 268-273 (2002)
   PUBMED   11850402
  REMARK    GeneRIF: Methylates PAB1 and TARPP, suggesting a role in regulating
            transcription/translation.
REFERENCE   8  (bases 1 to 3295)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
REFERENCE   9  (bases 1 to 3295)
  AUTHORS   Bauer,U.M., Daujat,S., Nielsen,S.J., Nightingale,K. and
            Kouzarides,T.
  TITLE     Methylation at arginine 17 of histone H3 is linked to gene
            activation
  JOURNAL   EMBO Rep 3 (1), 39-44 (2002)
   PUBMED   11751582
REFERENCE   10 (bases 1 to 3295)
  AUTHORS   Chen,D., Ma,H., Hong,H., Koh,S.S., Huang,S.M., Schurter,B.T.,
            Aswad,D.W. and Stallcup,M.R.
  TITLE     Regulation of transcription by a protein methyltransferase
  JOURNAL   Science 284 (5423), 2174-2177 (1999)
   PUBMED   10381882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007565.1 and AC011442.5.
            
            On Apr 26, 2019 this sequence version replaced NM_199141.1.
            
            Summary: This gene belongs to the protein arginine
            methyltransferase (PRMT) family. The encoded enzyme catalyzes the
            methylation of guanidino nitrogens of arginyl residues of proteins.
            The enzyme acts specifically on histones and other
            chromatin-associated proteins and is involved in regulation of gene
            expression. The enzyme may act in association with other proteins
            or within multi-protein complexes and may play a role in cell
            type-specific functions and cell lineage specification. A related
            pseudogene is located on chromosome 9. [provided by RefSeq, Aug
            2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304716.468425.1,
                                           SRR1163657.143069.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327064.9/ ENSP00000325690.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AC007565.1         30799-31168
            371-496             AC011442.5         26646-26771
            497-603             AC011442.5         29734-29840
            604-708             AC011442.5         30798-30902
            709-819             AC011442.5         33879-33989
            820-997             AC011442.5         35572-35749
            998-1088            AC011442.5         38102-38192
            1089-1170           AC011442.5         38391-38472
            1171-1256           AC011442.5         41290-41375
            1257-1346           AC011442.5         41572-41661
            1347-1484           AC011442.5         42131-42268
            1485-1574           AC011442.5         42354-42443
            1575-1687           AC011442.5         42529-42641
            1688-1765           AC011442.5         42745-42822
            1766-1834           AC011442.5         43070-43138
            1835-3295           AC011442.5         43310-44770
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3295
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /note="coactivator associated arginine methyltransferase
                     1"
                     /db_xref="GeneID:10498"
                     /db_xref="HGNC:HGNC:23393"
                     /db_xref="MIM:603934"
     exon            1..370
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1977
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /EC_number="2.1.1.319"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein arginine N-methyltransferase 4; histone-arginine
                     methyltransferase CARM1"
                     /codon_start=1
                     /product="histone-arginine methyltransferase CARM1 isoform
                     1"
                     /protein_id="NP_954592.1"
                     /db_xref="CCDS:CCDS12250.1"
                     /db_xref="GeneID:10498"
                     /db_xref="HGNC:HGNC:23393"
                     /db_xref="MIM:603934"
                     /translation="MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDAN
                     GEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITL
                     GCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQ
                     NMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTM
                     AQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAK
                     KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY
                     FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFD
                     VAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDI
                     SIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSG
                     MAVAGMPTAYDLSSVIASGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGA
                     QGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIPTNTMHYGS"
     exon            371..496
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            497..603
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            604..708
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            709..819
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            820..997
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1088
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1170
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1256
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1346
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1484
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1574
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1687
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1765
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1834
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..3295
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3269..3274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /note="hexamer: AATAAA"
     polyA_site      3295
                     /gene="CARM1"
                     /gene_synonym="PRMT4"
                     /note="major polyA site"
ORIGIN      
        1 ctcggcctgc acggcggctg cggcggcggt agcggcagcg gcggcggcgg cggcggcggc
       61 ggcggcggcg gcggcggcgg cggcggcagc ggcggcggcc tgggcccggg cgcagcggcg
      121 gcggcggcgg ggcctggagc cggatctaag atggcagcgg cggcggcggc ggtggggccg
      181 ggcgcgggcg gcgcggggtc ggcggtcccg ggcggcgcgg ggccctgcgc taccgtgtcg
      241 gtgttccccg gcgcccgcct cctcaccatc ggcgacgcga acggcgagat ccagcggcac
      301 gcggagcagc aggcgctgcg cctcgaggtg cgcgccggcc cggactcggc gggcatcgcc
      361 ctctacagcc atgaagatgt gtgtgtcttt aagtgctcag tgtcccgaga gacagagtgc
      421 agccgtgtgg gcaagcagtc cttcatcatc accctgggct gcaacagcgt cctcatccag
      481 ttcgccacac ccaacgattt ctgttccttc tacaacatcc tgaaaacctg ccggggccac
      541 accctggagc ggtctgtgtt cagcgagcgg acggaggagt cttctgccgt gcagtacttc
      601 cagttttatg gctacctgtc ccagcagcag aacatgatgc aggactacgt gcggacaggc
      661 acctaccagc gcgccatcct gcaaaaccac accgacttca aggacaagat cgttcttgat
      721 gttggctgtg gctctgggat cctgtcgttt tttgccgccc aagctggagc acggaaaatc
      781 tacgcggtgg aggccagcac catggcccag cacgctgagg tcttggtgaa gagtaacaac
      841 ctgacggacc gcatcgtggt catcccgggc aaggtggagg aggtgtcact ccccgagcag
      901 gtggacatca tcatctcgga gcccatgggc tacatgctct tcaacgagcg catgctggag
      961 agctacctcc acgccaagaa gtacctgaag cccagcggaa acatgtttcc taccattggt
     1021 gacgtccacc ttgcaccctt cacggatgaa cagctctaca tggagcagtt caccaaggcc
     1081 aacttctggt accagccatc tttccatgga gtggacctgt cggccctccg aggtgccgcg
     1141 gtggatgagt atttccggca gcctgtggtg gacacatttg acatccggat cctgatggcc
     1201 aagtctgtca agtacacggt gaacttctta gaagccaaag aaggagattt gcacaggata
     1261 gaaatcccat tcaaattcca catgctgcat tcagggctgg tccacggcct ggctttctgg
     1321 tttgacgttg ctttcatcgg ctccataatg accgtgtggc tgtccacagc cccgacagag
     1381 cccctgaccc actggtacca ggtgcggtgc ctgttccagt caccactgtt cgccaaggca
     1441 ggggacacgc tctcagggac atgtctgctt attgccaaca aaagacagag ctacgacatc
     1501 agtattgtgg cccaggtgga ccagaccggc tccaagtcca gtaacctcct ggatctgaaa
     1561 aaccccttct ttagatacac gggcacaacg ccctcacccc cacccggctc ccactacaca
     1621 tctccctcgg aaaacatgtg gaacacgggc agcacctaca acctcagcag cgggatggcc
     1681 gtggcaggga tgccgaccgc ctatgacttg agcagtgtta ttgccagtgg ctccagcgtg
     1741 ggccacaaca acctgattcc tttagccaac acggggattg tcaatcacac ccactcccgg
     1801 atgggctcca taatgagcac ggggattgtc caagggtcct ccggcgccca gggcagtggt
     1861 ggtggcagca cgagtgccca ctatgcagtc aacagccagt tcaccatggg cggccccgcc
     1921 atctccatgg cgtcgcccat gtccatcccg accaacacca tgcactacgg gagctagggg
     1981 cccgccccgc ggactgacag caccaggaaa ccaaatgatg tccctgcccg ccgcccccgc
     2041 cgggcggctt tcccccttgt actggagaag ctcgaacacc cggtcacagc tctctttgct
     2101 atgggaactg ggacactttt ttacacgatg ttgccgccgt ccccacccta acccccacct
     2161 cccggccctg agcgtgtgtc gctgccatat tttacacaaa atcatgttgt gggagccctc
     2221 gtcccccctc ctgcccgctc taccctgacc tgggcttgtc atctgctgga acaggcgcca
     2281 tggggcctgc cagccctgcc tgccaggtcc cttagcacct gtccccctgc ctgtctccag
     2341 tgggaaggta gcctggccag gcggggcctc cccttcgacg accaggcctc ggtcacaacg
     2401 gacgtgacat gctgcttttt ttaattttat ttttttatga aaagaaccag tgtcaatccg
     2461 cagaccctct gtgaagccag gccggccggg ccgagccagc agcccctctc cctagactca
     2521 gaggcgccgc ggggaggggt ggccccgccg aggcttcagg ggccccctcc ccaccaaagg
     2581 gttcacctca cacttgaatg tacaacccac cccactgtcg ggaaggcctc cgtcctcggc
     2641 ccctgcctct tgctgctgtc ctgtccccga gcccctgcag gtcccccccc gcccccccac
     2701 tcaagagtta gagcaggtgg ctgcaggcct tgggcccgga gggaaggcca ctgccggcca
     2761 cttggggcag acacagacac ctcaaggatc tgtcacggaa ggcgtccttt ttccttgtag
     2821 ctaacgttag gcctgagtag ctcccctcca tccttgtaga cgctccagtc cctactactg
     2881 tgacggcatt tccatccctc ccctgcccgg gaagggacct tgcagggacc tctccctcca
     2941 aaaaaagaaa aaaagaaaaa gaaagaaaaa ataaatgagg aaacgtgttg cagcacaggc
     3001 agttttcttc tccttctgct cccctgtttc tcataccccc aaactcagat gctggagctc
     3061 aggcccgccg tgtgtgcacc caggcaggag cgggcgctgt ccaggctggg ccgccccctt
     3121 ggctctccct cctgttccag gggagccata ggagggaaag caggtggccc gggggggata
     3181 tgggggcccc agccctgtcc caaagctccc tgctcggctg cccctcgccc gcctttatat
     3241 aaattctctg aatcaccttt gcatagaaaa taaaagtgtt tgctttgtaa gaaaa
//
