LOCUS       NM_014316               2709 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcium regulated heat stable protein 1 (CARHSP1),
            transcript variant 1, mRNA.
ACCESSION   NM_014316
VERSION     NM_014316.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Zhu,G.D., Yu,J., Sun,Z.Y., Chen,Y., Zheng,H.M., Lin,M.L.,
            Ou-Yang,S., Liu,G.L., Zhang,J.W. and Shao,F.M.
  TITLE     Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible
            for radiation resistance in glioblastoma
  JOURNAL   Cell Death Dis 12 (8), 724 (2021)
   PUBMED   34290231
  REMARK    GeneRIF: Genome-wide CRISPR/Cas9 screening identifies CARHSP1
            responsible for radiation resistance in glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2709)
  AUTHORS   Li,X., Kong,D., Chen,H., Liu,S., Hu,H., Wu,T., Wang,J., Chen,W.,
            Ning,Y., Li,Y. and Lu,Z.
  TITLE     miR-155 acts as an anti-inflammatory factor in
            atherosclerosis-associated foam cell formation by repressing
            calcium-regulated heat stable protein 1
  JOURNAL   Sci Rep 6, 21789 (2016)
   PUBMED   26899994
  REMARK    GeneRIF: Increased miR-155 relieves chronic inflammation by a
            negative feedback loop and plays a protective role during
            atherosclerosis-associated foam cell formation by signaling through
            the miR-155-CARHSP1-TNF-alpha pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2709)
  AUTHORS   Fan,Y., Guo,Y., Hamblin,M., Chang,L., Zhang,J. and Chen,Y.E.
  TITLE     Inhibition of gluconeogenic genes by calcium-regulated heat-stable
            protein 1 via repression of peroxisome proliferator-activated
            receptor alpha
  JOURNAL   J Biol Chem 286 (47), 40584-40594 (2011)
   PUBMED   21990353
  REMARK    GeneRIF: CARHSP1 inhibits hepatic gluconeogenic gene expression via
            repression of PPARalpha
REFERENCE   5  (bases 1 to 2709)
  AUTHORS   Hou,H., Wang,F., Zhang,W., Wang,D., Li,X., Bartlam,M., Yao,X. and
            Rao,Z.
  TITLE     Structure-functional analyses of CRHSP-24 plasticity and dynamics
            in oxidative stress response
  JOURNAL   J Biol Chem 286 (11), 9623-9635 (2011)
   PUBMED   21177848
  REMARK    GeneRIF: CRHSP-24 participates in oxidative stress response via a
            dynamic and temporal association between stress granules and
            processing bodies.
REFERENCE   6  (bases 1 to 2709)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2709)
  AUTHORS   Schafer,C., Steffen,H., Krzykowski,K.J., Goke,B. and
            Groblewski,G.E.
  TITLE     CRHSP-24 phosphorylation is regulated by multiple signaling
            pathways in pancreatic acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (4), G726-G734 (2003)
   PUBMED   12801884
REFERENCE   8  (bases 1 to 2709)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2709)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     The archetype STYX/dead-phosphatase complexes with a spermatid
            mRNA-binding protein and is essential for normal sperm production
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2112-2117 (2002)
   PUBMED   11842224
REFERENCE   10 (bases 1 to 2709)
  AUTHORS   Groblewski,G.E., Yoshida,M., Bragado,M.J., Ernst,S.A., Leykam,J.
            and Williams,J.A.
  TITLE     Purification and characterization of a novel physiological
            substrate for calcineurin in mammalian cells
  JOURNAL   J Biol Chem 273 (35), 22738-22744 (1998)
   PUBMED   9712905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022167.7.
            
            On Nov 23, 2018 this sequence version replaced NM_014316.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1-9 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.824613.1,
                                           SRR3476690.910325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311052.10/ ENSP00000311847.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC022167.7         158153-158193
            42-206              AC022167.7         167824-167988
            207-329             AC022167.7         168687-168809
            330-2709            AC022167.7         171833-174212
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.2"
     gene            1..2709
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /note="calcium regulated heat stable protein 1"
                     /db_xref="GeneID:23589"
                     /db_xref="HGNC:HGNC:17150"
                     /db_xref="MIM:616885"
     exon            1..41
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..206
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..492
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /note="calcium-regulated heat-stable protein (24kD);
                     calcium-regulated heat-stable protein of 24 kDa; calcium
                     regulated heat stable protein 1, 24kDa"
                     /codon_start=1
                     /product="calcium-regulated heat-stable protein 1"
                     /protein_id="NP_055131.2"
                     /db_xref="CCDS:CCDS10537.1"
                     /db_xref="GeneID:23589"
                     /db_xref="HGNC:HGNC:17150"
                     /db_xref="MIM:616885"
                     /translation="MSSEPPPPPQPPTHQASVGLLDTPRSRERSPSPLRGNVVPSPLP
                     TRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPV
                     EGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKHETWSGHVISS"
     exon            207..329
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..2709
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      743
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /note="major polyA site"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
                     /note="hexamer: AATAAA"
     polyA_site      2709
                     /gene="CARHSP1"
                     /gene_synonym="CRHSP-24; CRHSP24; CSDC1"
ORIGIN      
        1 agtcggagcg aagcggctgg cggagcagaa cggattgcag ggtcagccat gtcatctgag
       61 cctcccccac caccacagcc ccccacccat caagcttcag tcgggctgct ggacacccct
      121 cggagccgtg agcgctcacc atcccctctg cggggcaacg tggtcccaag cccactgccc
      181 actcgccgga cgaggacctt ctcggcgacg gtgcgggctt cacagggccc cgtctacaaa
      241 ggagtctgca aatgcttctg ccggtccaag ggccatggct tcattactcc agctgatggc
      301 ggccccgaca tcttcctgca catctctgat gtggaagggg agtatgtccc agtggaaggc
      361 gacgaggtca cctataaaat gtgctccatc ccacccaaga atgagaagct gcaggccgtg
      421 gaggtcgtca tcactcacct ggcaccaggc accaagcatg agacctggtc tggacatgtc
      481 atcagctcct aggagatggt ggaagcaccc cttgtcctgt gcttgtggga gactttgcag
      541 ggaggaggca gcagacactg gagatgacat tcttccacac gagacggggc ttcagccggg
      601 catggtccct ctcaagtatc tcctggagga aggggtatgg ggggcaggtg tggggtgtgg
      661 ggtgttcccg gccatcagca cagcctatga ccattgcaac aacctctcac catctgaaga
      721 gcattaaaag catttaaaaa ggagaggtgc ccactggtgg ctgagtggag gttccaaccc
      781 catcccaggg agtggatcaa gggtggtatt tctccagctg ctcagacaca tgggctcaac
      841 ccacagaatc cctcttcctc ctggagctgg aggccccaga ttcccagatc tggccccctg
      901 gcagcctgac agggaccttg cgtgacttct ccaaggcaaa tttccaccta agtgcccctt
      961 gcgcctctcc tggggcctgg gcaaagcagt tttctaattc ttggcttggt tggttctagg
     1021 ggagctggct tgaagtgggt ggggaaaggc gggggtggcg gtctttggat tggacggatg
     1081 ttgccttttg gtgcctttgc agtgggaggc ggcatagctg cctgtctggg gaagacagtt
     1141 ctcccagcac tcccacccct gggcacagca ggctggtact gggaggctga acccctctta
     1201 gagcctgacc ttttcatctg ccttctggtt gtgtgaccat cactcaacag ccatttcaca
     1261 gcccctgtaa ttatggcggc ggggggctgg ggtggtggtg gtgggaaggg cttgtggaga
     1321 ggacacagtc tttgtttaaa aactttgtcc cgatccatcc agaaaagagt aggtagcttg
     1381 catcctgaca gcctggcaaa gtcaagaaag ttgaaggaga aacatacctt tggagagggg
     1441 gttttcttta aaactagtgt taagaaatgc ttagggattt tttttttctt atttttcata
     1501 actaaagctt tcacccagag ccggctctgt ttgcactttg ctgccgacat tgcaaacttt
     1561 ttggcagggt gggagactga gtctcattct gtcacccagg ctggagtgca gtggcccgat
     1621 ctcagcttac tgcaacctct gccctccagg gttctggcaa ttccgcctca gtctcctgag
     1681 tagctgggat tacaggcatg cgccaccaca cccggttaat ttttgtattt ttagtagaga
     1741 ccaggtttca tcatgttggg caggatggtc ttgaacccct gacctcagat gatctgccca
     1801 tctcggcctc tcaaagtgct gggattacaa gtgtgagcca tcgcgcccgg cctgcaaact
     1861 tttttgtagg tatttctggt aaacaaatcc ttaggttatc tttgctgtgg ttgtggtttg
     1921 gctttagtca tgatttcaaa gtagaaatag ctaggcatta ttttttgaaa tatatgacct
     1981 atatgtagtc aagaatccac tgaacagagg caagcaaacc ttttggaaac tggcttttgg
     2041 gcagacagta aacgtccagt ttgatgctgg aagcatgaac agcttcatca ggtaggtact
     2101 cctcaactct gatgagtttg tcctttcagc ctaagggggt ggaagggagt tgtttgagaa
     2161 tagcaaatac gcatgttgat tgcgagtgtg tggagacaaa ggcagttccc accacagtta
     2221 ggtcctggcc attgtttcct cgcctgcgat gctccttgta catcctcacc ctcctctccc
     2281 gcctctgcct tctgctgggt caaaggtggc cttttctctc cagccttgaa ttgttccctg
     2341 ttggcttccc aagggcccat ctgctggtac agtccacact tccacagcca agacccgaga
     2401 gggctttcac tgccccaagc ctctctcctg tgaccctggg attctgtctt ggcagaatcc
     2461 tttgtcagcg gctcttactc tgtccttcct gtttggccac agctctttca atcaatgggt
     2521 attctagaac cgcaggatgt cagagctgga agggacgcga taccggttta cacaagggga
     2581 aactcctcga ggctctggga gggacggagg gttttggtga cagagcgaga gctaaaattg
     2641 aggattcctg aatccagatc ttgcctccca tcagccatct ttctcccaat aaatttttgt
     2701 tttgtgcaa
//
