LOCUS       NM_052813               2111 bp    mRNA    linear   PRI 17-MAR-2025
DEFINITION  Homo sapiens caspase recruitment domain family member 9 (CARD9),
            transcript variant 1, mRNA.
ACCESSION   NM_052813
VERSION     NM_052813.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Dantas,M.D.S., Cintra,M.E.C., Lucini,F., Venturini,J., de
            Souza,G.H.A. and Rossato,L.
  TITLE     CARD9 mutations in patients with fungal infections: An update from
            the last 5 years
  JOURNAL   Mycoses 67 (3), e13712 (2024)
   PUBMED   38483073
  REMARK    GeneRIF: CARD9 mutations in patients with fungal infections: An
            update from the last 5 years.
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Lee,J.S. and Kim,C.
  TITLE     Role of CARD9 in Cell- and Organ-Specific Immune Responses in
            Various Infections
  JOURNAL   Int J Mol Sci 25 (5), 2598 (2024)
   PUBMED   38473845
  REMARK    GeneRIF: Role of CARD9 in Cell- and Organ-Specific Immune Responses
            in Various Infections.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Kowluru,A.
  TITLE     Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet
            beta-cell function in health and metabolic stress: Is there room
            for MALT1?
  JOURNAL   Biochem Pharmacol 218, 115889 (2023)
   PUBMED   37991197
  REMARK    GeneRIF: Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in
            islet beta-cell function in health and metabolic stress: Is there
            room for MALT1?
            Review article
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Xu,X., Lu,H., Li,J., Duan,J., Wang,Z., Yang,J., Gu,S., Luo,R.,
            Liang,S., Tang,W., Zhang,F., Hang,J., Ge,J., Lin,X., Qu,J., Jia,X.
            and Xu,J.
  TITLE     Heterozygous CARD9 mutation favors the development of allergic
            bronchopulmonary aspergillosis
  JOURNAL   Chin Med J (Engl) 136 (16), 1949-1958 (2023)
   PUBMED   37461235
  REMARK    GeneRIF: Heterozygous CARD9 mutation favors the development of
            allergic bronchopulmonary aspergillosis.
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Fang,N., Ding,Y. and Yang,W.
  TITLE     Expression of mir-25-3p, CARD9 and Surviving in Acute Pancreatitis
            and Predictive Value for Patient Outcome
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (1), 30-35 (2023)
   PUBMED   37213160
  REMARK    GeneRIF: Expression of mir-25-3p, CARD9 and Surviving in Acute
            Pancreatitis and Predictive Value for Patient Outcome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2111)
  AUTHORS   Yang,H., Minamishima,Y.A., Yan,Q., Schlisio,S., Ebert,B.L.,
            Zhang,X., Zhang,L., Kim,W.Y., Olumi,A.F. and Kaelin,W.G. Jr.
  TITLE     pVHL acts as an adaptor to promote the inhibitory phosphorylation
            of the NF-kappaB agonist Card9 by CK2
  JOURNAL   Mol Cell 28 (1), 15-27 (2007)
   PUBMED   17936701
  REMARK    GeneRIF: Data show that pVHL acts as an adaptor to promote the
            inhibitory phosphorylation of the NF-kappaB agonist Card9 by casein
            kinase 2.
REFERENCE   7  (bases 1 to 2111)
  AUTHORS   Hsu,Y.M., Zhang,Y., You,Y., Wang,D., Li,H., Duramad,O., Qin,X.F.,
            Dong,C. and Lin,X.
  TITLE     The adaptor protein CARD9 is required for innate immune responses
            to intracellular pathogens
  JOURNAL   Nat Immunol 8 (2), 198-205 (2007)
   PUBMED   17187069
REFERENCE   8  (bases 1 to 2111)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 2111)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
REFERENCE   10 (bases 1 to 2111)
  AUTHORS   Bertin,J., Guo,Y., Wang,L., Srinivasula,S.M., Jacobson,M.D.,
            Poyet,J.L., Merriam,S., Du,M.Q., Dyer,M.J., Robison,K.E.,
            DiStefano,P.S. and Alnemri,E.S.
  TITLE     CARD9 is a novel caspase recruitment domain-containing protein that
            interacts with BCL10/CLAP and activates NF-kappa B
  JOURNAL   J Biol Chem 275 (52), 41082-41086 (2000)
   PUBMED   11053425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM148244.1, AK292081.1,
            AL592301.14 and AF311287.1.
            
            On Aug 31, 2019 this sequence version replaced NM_052813.4.
            
            Summary: The protein encoded by this gene is a member of the CARD
            protein family, which is defined by the presence of a
            characteristic caspase-associated recruitment domain (CARD). CARD
            is a protein interaction domain known to participate in activation
            or suppression of CARD containing members of the caspase family,
            and thus plays an important regulatory role in cell apoptosis. This
            protein was identified by its selective association with the CARD
            domain of BCL10, a postive regulator of apoptosis and NF-kappaB
            activation, and is thought to function as a molecular scaffold for
            the assembly of a BCL10 signaling complex that activates NF-kappaB.
            Several alternatively spliced transcript variants have been
            observed, but their full-length nature is not clearly defined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF311287.1, SRR14038195.929001.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371732.10/ ENSP00000360797.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BM148244.1         13-48
            37-1897             AK292081.1         1-1861
            1898-1898           AL592301.14        7793-7793           c
            1899-2110           AK292081.1         1863-2074
            2111-2111           AF311287.1         2081-2081
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2111
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /note="caspase recruitment domain family member 9"
                     /db_xref="GeneID:64170"
                     /db_xref="HGNC:HGNC:16391"
                     /db_xref="MIM:607212"
     exon            1..138
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            139..338
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1765
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caspase recruitment domain-containing protein 9; caspase
                     recruitment domain protein 9"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 9
                     isoform 1"
                     /protein_id="NP_434700.2"
                     /db_xref="CCDS:CCDS6997.1"
                     /db_xref="GeneID:64170"
                     /db_xref="HGNC:HGNC:16391"
                     /db_xref="MIM:607212"
                     /translation="MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDD
                     EEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARV
                     FSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQER
                     VQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLM
                     KAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRS
                     SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRK
                     DSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKA
                     DELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLS
                     DKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRAL
                     RKMQKGWRQGEEDRENTTGSDNTDTEGS"
     exon            339..476
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            477..781
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            782..961
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1105
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1231
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1423
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1465
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1511
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1588
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1665
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..2111
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="CARD9"
                     /gene_synonym="CANDF2; hCARD9; IMD103"
                     /note="major polyA site"
ORIGIN      
        1 aagcagaacc catcaggaag tgcacaggcg tccggcgtgc tcctccctcc ctgcagcccc
       61 gggcagcatc tcccagaggc tccgcggccc aggctcctgg tgtgtctgca gtgcaggtgg
      121 ctcctggaag accctcagcc tgcctgctga ggccatgtcg gactacgaga acgatgacga
      181 gtgctggagc gtcctggagg gcttccgggt gacgctcacc tcggtcatcg acccctcacg
      241 catcacacct tacctgcggc agtgcaaggt cctgaacccc gatgatgagg agcaggtgct
      301 cagcgacccc aacctggtca tccgcaaacg gaaagtgggt gtgctcctgg acatcctgca
      361 gcggaccggc cacaagggct acgtggcctt cctcgagagc ctggagctct actacccgca
      421 gctgtacaag aaggtcacag gcaaggagcc ggcccgcgtc ttctccatga tcatcgacgc
      481 gtccggggag tcaggcctga ctcagctgct gatgactgag gtcatgaagc tgcagaagaa
      541 ggtgcaggac ctgaccgcgc tgctgagctc caaagatgac ttcatcaagg agctgcgggt
      601 gaaggacagc ctgctgcgca agcaccagga gcgtgtgcag aggctcaagg aggagtgcga
      661 ggccggcagc cgcgagctca agcgctgcaa ggaggagaac tacgacctgg ccatgcgcct
      721 ggcgcaccag agtgaggaga agggcgccgc gctcatgcgg aaccgtgacc tgcagctgga
      781 gattgaccag ctcaagcaca gcctcatgaa ggccgaggac gactgcaagg tggagcgcaa
      841 gcacacgctg aagctcaggc acgccatgga gcagcggccc agccaggagc tgctgtggga
      901 gctgcagcag gagaaggccc tgctccaggc ccgggtgcag gagctggagg cctccgtcca
      961 ggaggggaag ctggacagga gcagccccta catccaggta ctggaggagg actggcggca
     1021 ggcgctgcgg gaccaccagg agcaggccaa caccatcttc tccctgcgca aggacctccg
     1081 ccagggcgag gcccgacgcc tccggtgcat ggaggagaag gagatgttcg agctgcagtg
     1141 cctggcacta cgtaaggact ccaagatgta caaggaccgc atcgaggcca tcctgctgca
     1201 gatggaggag gtcgccattg agcgggacca ggccatagcc acgcgggagg agctgcacgc
     1261 acagcacgcc cggggcctgc aggagaagga cgcgctgcgc aagcaggtgc gggagctggg
     1321 cgagaaggcg gatgagctgc agctgcaggt gttccagtgt gaggcgcagc tactggccgt
     1381 ggagggcagg ctcaggcggc agcagctgga gacgctcgtc ctgagctccg acctggaaga
     1441 tggctcaccc aggaggtccc aggagctctc actcccccag gacctggagg acacccagct
     1501 ctcagacaaa ggctgccttg ccggcggggg gagcccgaaa cagccctttg cagctctgca
     1561 ccaggagcag gttttgcgga acccccatga cgcaggcctg agcagcgggg agccgcccga
     1621 gaaggagcgg cggcgcctca aagagagttt tgagaactac cgcaggaagc gcgccctcag
     1681 gaagatgcag aaaggatggc ggcaggggga ggaggaccgg gagaacacca cgggcagcga
     1741 caacaccgac actgagggct cctagccgca gcagcgcagg ccccgaccag ggcacaccca
     1801 ccggcccggc ctcctgccac ccgggggtgc cgacgccctg gggcgcagac ttccccgagc
     1861 cgtcgctgac ttggcctgga acgaggaatc tggtgccctg aaaggcccag ccggactgcc
     1921 gggcattggg gccgtttgtt aagcggcact cattttgcgg aggccatgcg ggtgctcacc
     1981 acccccatgc acacgccatc tgtgtaactt caggatctgt tctgtttcac catgtaacac
     2041 acaatacatg catgcattgt attagtgtta gaaaacacag ctgcgtaaat aaacagcacg
     2101 ggtgacccgc a
//
