LOCUS       NM_032587               4038 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 6 (CARD6),
            mRNA.
ACCESSION   NM_032587
VERSION     NM_032587.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4038)
  AUTHORS   Liu,Y., Chen,T. and Zheng,G.
  TITLE     Exosome-transmitted circ-CARD6 facilitates posterior capsule
            opacification development by miR-31/FGF7 axis
  JOURNAL   Exp Eye Res 207, 108572 (2021)
   PUBMED   33844960
  REMARK    GeneRIF: Exosome-transmitted circ-CARD6 facilitates posterior
            capsule opacification development by miR-31/FGF7 axis.
REFERENCE   2  (bases 1 to 4038)
  AUTHORS   Sun,P., Zeng,Q., Cheng,D., Zhang,K., Zheng,J., Liu,Y., Yuan,Y.F.
            and Tang,Y.D.
  TITLE     Caspase Recruitment Domain Protein 6 Protects Against Hepatic
            Steatosis and Insulin Resistance by Suppressing Apoptosis
            Signal-Regulating Kinase 1
  JOURNAL   Hepatology 68 (6), 2212-2229 (2018)
   PUBMED   29729191
  REMARK    GeneRIF: expression markedly reduced in nonalcoholic fatty liver
            disease livers
REFERENCE   3  (bases 1 to 4038)
  AUTHORS   Tervaniemi,M.H., Katayama,S., Skoog,T., Siitonen,H.A., Vuola,J.,
            Nuutila,K., Sormunen,R., Johnsson,A., Linnarsson,S., Suomela,S.,
            Kankuri,E., Kere,J. and Elomaa,O.
  TITLE     NOD-like receptor signaling and inflammasome-related pathways are
            highlighted in psoriatic epidermis
  JOURNAL   Sci Rep 6, 22745 (2016)
   PUBMED   26976200
  REMARK    GeneRIF: Data show that NOD-like receptor signaling genes NOD2,
            PYCARD, CARD6, and IFI16 are upregulated in psoriatic epidermis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4038)
  AUTHORS   Kim,S.S., Ahn,C.H., Kang,M.R., Kim,Y.R., Kim,H.S., Yoo,N.J. and
            Lee,S.H.
  TITLE     Expression of CARD6, an NF-kappaB activator, in gastric, colorectal
            and oesophageal cancers
  JOURNAL   Pathology 42 (1), 50-53 (2010)
   PUBMED   20025480
  REMARK    GeneRIF: The increased expression of CARD6 in esophageal squamous
            cell carcinoma,gastric and colorectal adenocarcinoma suggested that
            neoexpression of CARD6 might be related to activation of NF-kappaB
            pathway.
REFERENCE   5  (bases 1 to 4038)
  AUTHORS   Dufner,A. and Mak,T.W.
  TITLE     CARD tricks: controlling the interactions of CARD6 with RICK and
            microtubules
  JOURNAL   Cell Cycle 5 (8), 797-800 (2006)
   PUBMED   16582588
  REMARK    GeneRIF: review of the regulation of interactions of CARD6 with
            RICK and microtubules [review]
            Review article
REFERENCE   6  (bases 1 to 4038)
  AUTHORS   Dufner,A., Pownall,S. and Mak,T.W.
  TITLE     Caspase recruitment domain protein 6 is a microtubule-interacting
            protein that positively modulates NF-kappaB activation
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 988-993 (2006)
   PUBMED   16418290
  REMARK    GeneRIF: CARD6 is a regulator of NF-kappaB activation that
            modulates the functions of RICK protein
REFERENCE   7  (bases 1 to 4038)
  AUTHORS   Stehlik,C., Hayashi,H., Pio,F., Godzik,A. and Reed,J.C.
  TITLE     CARD6 is a modulator of NF-kappa B activation by Nod1- and
            Cardiak-mediated pathways
  JOURNAL   J Biol Chem 278 (34), 31941-31949 (2003)
   PUBMED   12775719
  REMARK    GeneRIF: identification as a modulator of NF-kappa B activation by
            Nod1- and Cardiak-mediated pathways
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC093825.1 and AC026732.5.
            
            On Nov 22, 2018 this sequence version replaced NM_032587.3.
            
            Summary: This gene encodes a protein that contains a caspase
            recruitment domain (CARD), an antiparallel six-helical bundle that
            mediates homotypic protein-protein interactions. The encoded
            protein is a microtubule-associated protein that has been shown to
            interact with receptor-interacting protein kinases and positively
            modulate signal transduction pathways converging on activation of
            the inducible transcription factor NF-kB. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF356193.1, SRR1660807.65126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254691.10/ ENSP00000254691.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3179              BC093825.1         7-3185
            3180-4038           AC026732.5         91758-92616         c
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..4038
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /note="caspase recruitment domain family member 6"
                     /db_xref="GeneID:84674"
                     /db_xref="HGNC:HGNC:16394"
                     /db_xref="MIM:609986"
     exon            1..299
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3130
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /note="caspase recruitment domain protein 6;
                     CARD-containing inhibitor of Nod1 and Cardiak-induced
                     NF-kB activation"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 6"
                     /protein_id="NP_115976.2"
                     /db_xref="CCDS:CCDS3935.1"
                     /db_xref="GeneID:84674"
                     /db_xref="HGNC:HGNC:16394"
                     /db_xref="MIM:609986"
                     /translation="MATESTPSEIIERERKKLLEILQHDPDSILDTLTSRRLISEEEY
                     ETLENVTDLLKKSRKLLILVQKKGEATCQHFLKCLFSTFPQSAAICGLRHEVLKHENT
                     VPPQSMGASSNSEDAFSPGIKQPEAPEITVFFSEKEHLDLETSEFFRDKKTSYRETAL
                     SARKNEKEYDTPEVTLSYSVEKVGCEVPATITYIKDGQRYEELDDSLYLGKEEYLGSV
                     DTPEDAEATVEEEVYDDPEHVGYDGEEDFENSETTEFSGEEPSYEGSETSLSLEEEQE
                     KSIEERKKVFKDVLLCLNMDRSRKVLPDFVKQFSLDRGCKWTPESPGDLAWNFLMKVQ
                     ARDVTARDSILSHKVLDEDSKEDLLAGVENLEIRDIQTINPLDVLCATMLCSDSSLQR
                     QVMSNMYQCQFALPLLLPDAENNKSILMLGAMKDIVKKQSTQFSGGPTEDTEKFLTLM
                     KMPVISFVRLGYCSFSKSRILNTLLSPAQLKLHKIFLHQDLPLLVLPRQISDGLVEIT
                     WCFPDSDDRKENPFFQKPVALANLRGNLESFWTQFGFLMEVSSAVFFFTDCLGEKEWD
                     LLMFLGEAAIERCYFVLSSQARESEEAQIFQRILNLKPAQLLFWERGDAGDRRKNMEG
                     LQAALQEVMFSSCLRCVSVEDMAALARELGIQVDEDFENTQRIQVSSGENMAGTAEGE
                     GQQRHSQLKSSSKSQALMPIQEPGTQCELSQNLQNLYGTPVFRPVLENSWLFPTRIGG
                     NFNHVSLKASWVMGRPFGSEQRPKWFHPLPFQNAGAQGRGKSFGIQSFHPQIFYSGER
                     FMKFSRVARGCHSNGTFGRLPRPICQHVQACPERPQMMGTLERSRAVASKIGHSYSLD
                     SQPARAVGKPWPQQACTRVTELTEATGKLIRTSHIGKPHPQSFQPAAATQKLRPASQQ
                     GVQMKTQGGASNPALQIGSHPMCKSSQFKSDQSNPSTVKHSQPKPFHSVPSQPKSSQT
                     KSCQSQPSQTKPSPCKSTQPKPSQPWPPQSKPSQPRPPQPKSSSTNPSQAKAHHSKAG
                     QKRGGKH"
     exon            300..857
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..4038
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /note="hexamer: AATAAA"
     polyA_site      4038
                     /gene="CARD6"
                     /gene_synonym="CINCIN1"
                     /note="major polyA site"
ORIGIN      
        1 agaggaaaca ggaacaatgg ctaccgagag tactccctca gagatcatag aaagagaaag
       61 aaaaaagttg cttgaaatcc ttcaacatga tcctgattct atcttagaca cgttaacttc
      121 tcggaggctg atttctgagg aagagtatga gactctggag aatgttacag atctcctgaa
      181 gaaaagtcgg aagctgttaa ttttggtaca gaaaaaggga gaggcgacct gtcagcattt
      241 tctcaagtgt ttatttagta cttttccaca gtcagctgcc atttgcggct taaggcatga
      301 agttttaaaa catgagaata cagtacctcc tcaatctatg ggggcaagca gtaattcaga
      361 agatgctttt tctcctggaa taaaacagcc tgaagcccct gagatcacag tgttcttcag
      421 tgagaaggaa cacttggatt tggaaacctc tgagtttttc agggacaaga aaactagtta
      481 tagggaaaca gctttgtctg ccaggaagaa tgagaaggaa tatgacacac cagaagtcac
      541 attatcatat tcagttgaga aagttggatg tgaagttcca gcaactatta catatataaa
      601 agatggacag agatatgagg agctagatga ttctttatac ttaggaaaag aggaatatct
      661 aggatctgtt gacacccctg aagatgcaga agccactgtg gaagaggagg tttatgatga
      721 cccagagcac gttggatatg atggtgaaga ggacttcgag aattcagaaa ccacagagtt
      781 ctctggtgaa gaaccaagtt atgagggatc agaaaccagc ctttcattgg aggaggaaca
      841 ggagaaaagt atagaagaaa gaaaaaaggt gtttaaagat gtcctgttat gtttgaacat
      901 ggatagaagc agaaaggttc tgccagattt tgttaaacaa ttctccttag atcgaggatg
      961 taagtggacc cctgagagtc caggagactt agcctggaat ttcctgatga aagttcaagc
     1021 acgagatgtg acggctaggg attcaatcct cagtcacaag gttctggatg aagatagcaa
     1081 ggaggatttg ctggctggag tggagaattt ggaaattcga gacatacaaa ccattaatcc
     1141 ccttgacgtg ctttgtgcca ccatgctgtg ttcagatagc tctttgcaac gccaagtcat
     1201 gtcaaacatg tatcagtgcc agtttgctct tcccctgcta ctgccagatg cagaaaacaa
     1261 caaaagcatc ttaatgctgg gggccatgaa agacattgtg aagaagcagt caacacagtt
     1321 ttcagggggg cctacagagg atacagaaaa gtttctgact ctcatgaaga tgcctgtcat
     1381 ctcttttgtg cgtctaggat actgtagctt ctctaagtcc agaatcctca acacacttct
     1441 cagccctgcc cagttgaaat tacacaaaat ctttcttcat caagatttgc ctcttttggt
     1501 gcttccccgg caaatctctg atggcctggt tgagataaca tggtgttttc ctgatagcga
     1561 tgatagaaag gaaaacccct ttttccaaaa gcctgttgct ctggctaatc tccgtggaaa
     1621 tctagaaagc ttttggactc agtttggttt tttgatggaa gtttcttcag ctgtgttttt
     1681 tttcactgac tgtttaggtg agaaggaatg ggacttgcta atgtttttag gagaggctgc
     1741 cattgaaaga tgctactttg ttctcagttc ccaagccagg gagagtgaag aggctcaaat
     1801 ttttcagagg atactgaact tgaagccagc acagctactg ttttgggaga ggggagatgc
     1861 tggggataga aggaagaaca tggagggcct tcaagctgcc ctccaggaag tgatgttctc
     1921 ttcttgcctc agatgtgtgt ctgtggagga tatggccgcc ctggccaggg agctggggat
     1981 tcaggtagat gaagactttg aaaacactca gagaattcaa gtttcctctg gagaaaacat
     2041 ggctgggaca gctgaaggtg agggtcagca aagacacagt cagctaaaaa gctcatctaa
     2101 aagccaggct ctaatgccaa ttcaagagcc tgggactcaa tgtgagctca gccagaatct
     2161 tcagaatctc tatggtaccc cagtattcag gcctgttcta gagaactcct ggctctttcc
     2221 aaccagaatt ggaggtaact ttaaccatgt ttccttgaaa gcctcctggg ttatgggccg
     2281 cccctttggg tcagagcaga ggcctaagtg gttccatcct ttgccttttc agaatgcagg
     2341 ggcccagggc cgaggtaaaa gttttggtat tcaatccttc catccccaga tattttattc
     2401 aggtgaaaga ttcatgaaat tttccagagt tgctcgggga tgtcactcga atggaacatt
     2461 tgggagactg ccaagaccca tttgtcagca tgtacaggcc tgccctgaga gaccacaaat
     2521 gatgggaact cttgaaaggt ctagggcagt agcctccaag ataggtcact cctattccct
     2581 ggattcacag ccagcaagag cagtagggaa gccatggcct cagcaagctt gcaccagggt
     2641 aacagagtta actgaagcaa ctggaaaact gataagaaca tcccatattg gaaagcctca
     2701 ccctcagtcc tttcaaccag cagcagccac acaaaaacta agacctgctt ctcagcaagg
     2761 agtccagatg aagacacaag gtggggcttc aaatccagct ctccaaatag ggtcccatcc
     2821 catgtgcaag agctctcagt tcaaatccga tcagtccaac ccatccacag tcaaacactc
     2881 ccagcctaaa cccttccatt ctgtgccctc tcaacctaaa tcctctcaga caaaatcctg
     2941 tcagtcccag ccctcccaaa ctaaaccttc tccatgcaaa tctactcagc ctaagccaag
     3001 ccagccctgg cctccccagt ctaagccttc tcagcccaga ccccctcaac ctaagtcatc
     3061 ctcaaccaat ccttcacaag ctaaggcaca ccactcaaaa gcagggcaga agaggggagg
     3121 gaagcattaa agagctaact ccagagatct ataaagcata tcctttaccc aggccattcc
     3181 tatcatatag taagcagaag agttgccatg aaagtaaaag actactgtca ttagcatgta
     3241 aaacaaagaa agatatacat gactgaattg gatatctttg tttgtttgtt tgagacagag
     3301 tttcactctt gttgcccagg ctggagtgca atggcacgat ctcggctcac cgcaacctct
     3361 gcttcctggc ttaaagtgat tctcctgcct cagcctctcg agtagctggg attacaggca
     3421 tgcaccacca cacccagcta attttgtatt tttagtagag gcagggtttc tccatgttgg
     3481 tcaggctggt cttgaactcc cgacctcagg tgatccgccc acctaggcct ctcaaagtgt
     3541 tgggattacg tgtgtaagcc acagtgccca gcccgaattg gatatcttta agatatctgt
     3601 aagtgttata tccctaacca agaagaaaaa tatgaaaata attaagacta gaatcaagca
     3661 gtagataatt gaatccaatc ttgggtatta ttagataatg tataacttgc acccagggaa
     3721 tgggggtcta tgagacaacc ccacttggag aagaatgggg ttagggtctc taattgcaaa
     3781 gtgactgtac aataggacga aagttgcctc tgtgtctgag aaagtatctt agttgttggc
     3841 tgctccagag gtatctttgt caaaagcttc tggttcaata tcagccactg agcagataac
     3901 cctgcttatt tggtgtggtt aaatcaacta gcttctgcta atagccccaa tttgcttgaa
     3961 tgggaaaact ctctcatttg acccttatag gtagaaataa tgaattaaca accaataaaa
     4021 ttaatcattt ggcattaa
//
