LOCUS       NM_032310                857 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 19 (CARD19),
            transcript variant 1, mRNA.
ACCESSION   NM_032310
VERSION     NM_032310.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 857)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 857)
  AUTHORS   Rios,K.E., Kashyap,A.K., Maynard,S.K., Washington,M., Paul,S. and
            Schaefer,B.C.
  TITLE     CARD19, the protein formerly known as BinCARD, is a mitochondrial
            protein that does not regulate Bcl10-dependent NF-kappaB activation
            after TCR engagement
  JOURNAL   Cell Immunol 356, 104179 (2020)
   PUBMED   32763502
  REMARK    GeneRIF: CARD19, the protein formerly known as BinCARD, is a
            mitochondrial protein that does not regulate Bcl10-dependent
            NF-kappaB activation after TCR engagement.
REFERENCE   3  (bases 1 to 857)
  AUTHORS   Suzuki,H., Kameyama,T. and Takaoka,A.
  TITLE     BinCARD2 as a positive regulator of interferon response in innate
            immunity
  JOURNAL   Biochem Biophys Res Commun 511 (2), 287-293 (2019)
   PUBMED   30795865
  REMARK    GeneRIF: BinCARD isoform2 (BinCARD2) is a one of CARD proteins
            involved in apoptosis and inflammation. BinCARD2 knock down
            suppresses innate immune responses induced by 3pRNA, poly(I:C) and
            vesicular stomatitis virus (VSV).
REFERENCE   4  (bases 1 to 857)
  AUTHORS   Chen,K.E., Richards,A.A., Caradoc-Davies,T.T., Vajjhala,P.R.,
            Robin,G., Lua,L.H., Hill,J.M., Schroder,K., Sweet,M.J., Kellie,S.,
            Kobe,B. and Martin,J.
  TITLE     The structure of the caspase recruitment domain of BinCARD reveals
            that all three cysteines can be oxidized
  JOURNAL   Acta Crystallogr D Biol Crystallogr 69 (Pt 5), 774-784 (2013)
   PUBMED   23633586
  REMARK    GeneRIF: the crystal structure of BinCARD reveals that all three
            cysteines were oxidized
REFERENCE   5  (bases 1 to 857)
  AUTHORS   Woo,H.N., Hong,G.S., Jun,J.I., Cho,D.H., Choi,H.W., Lee,H.J.,
            Chung,C.W., Kim,I.K., Jo,D.G., Pyo,J.O., Bertin,J. and Jung,Y.K.
  TITLE     Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a
            Bcl10-interacting CARD protein
  JOURNAL   FEBS Lett 578 (3), 239-244 (2004)
   PUBMED   15637807
  REMARK    GeneRIF: BinCard inhibits BCL10-mediated activation of NF-kappa B.
REFERENCE   6  (bases 1 to 857)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY005780.1, BC004500.2, AL451065.13 and DB550397.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032310.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX339725.2, SRR1163657.414009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375464.7/ ENSP00000364613.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                HY005780.1         96-180
            86-314              BC004500.2         49-277
            315-315             AL451065.13        129559-129559
            316-738             BC004500.2         279-701
            739-851             DB550397.1         329-441
            852-852             AL451065.13        132234-132234
            853-857             DB550397.1         443-447
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..857
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /note="caspase recruitment domain family member 19"
                     /db_xref="GeneID:84270"
                     /db_xref="HGNC:HGNC:28148"
                     /db_xref="MIM:617726"
     exon            1..136
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..681
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Bcl10-interacting protein with CARD; bcl10-interacting
                     CARD protein; caspase recruitment domain-containing
                     protein 19"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 19
                     isoform 1"
                     /protein_id="NP_115686.3"
                     /db_xref="CCDS:CCDS6702.2"
                     /db_xref="GeneID:84270"
                     /db_xref="HGNC:HGNC:28148"
                     /db_xref="MIM:617726"
                     /translation="MTDQTYCDRLVQDTPFLTGHGRLSEQQVDRIILQLNRYYPQILT
                     NKEAEKFRNPKASLRVRLCDLLSHLQRSGERDCQEFYRALYIHAQPLHSRLPSRHALQ
                     NSDCTELDSGSQSGELSNRGPMSFLAGLGLAVGLALLLYCYPPDPKGLPGTRRVLGFS
                     PVIIDRHVSRYLLAFLADDLGGL"
     exon            137..279
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            280..433
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            434..493
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            494..565
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            566..857
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      836..841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /note="hexamer: ATTAAA"
     polyA_site      857
                     /gene="CARD19"
                     /gene_synonym="BinCARD; C9orf89"
                     /note="major polyA site"
ORIGIN      
        1 caaaaggggc gggcgagcac ggcccgcggg cggcgttcgc tggagctggt ggaccgggcg
       61 gctgaccgag gggcggacgc gcggcggggc agaccgctgg ggactgcggg cggcgctgtg
      121 tccgtcgcca tgacagatca gacctattgt gaccgcctgg tgcaggacac gcctttcctg
      181 acaggccatg ggcgcttgag tgagcagcag gtggacagga tcatcctcca gctgaaccgt
      241 tactacccac agatccttac caacaaggag gcggaaaagt tccggaaccc caaggcatcc
      301 ttgcgtgtgc ggctctgtga cctcctgagc cacctgcagc ggagcggtga gcgggactgc
      361 caggagttct accgagccct gtatatccat gcccagcccc tgcacagccg cctgcccagc
      421 cgccacgctc tgcagaactc agattgcaca gagctagact cgggcagcca gagcggcgag
      481 ctgagtaaca ggggacccat gagcttcctg gctggcctgg gccttgctgt gggactggcc
      541 ctgctcctgt actgctatcc gccagacccc aagggcctgc cagggacccg gcgcgtcctc
      601 ggtttctcgc ctgtcatcat cgacagacat gtcagccgct acctgctggc cttcctggca
      661 gatgacctag gggggctctg acagaccctg gacccagggc ctcacctgcc actcaaccaa
      721 agagtcctcg agccggcccg ccaaggggac tgctgcttct ttttctaaat gcatattttt
      781 cattatttat aatttgtgta aaaaacacac cttcacctta caaggtgctg accatattaa
      841 atgttcaggt tctctca
//
