LOCUS       NM_021571                702 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 18 (CARD18),
            mRNA.
ACCESSION   NM_021571
VERSION     NM_021571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 702)
  AUTHORS   Qin,H., Jin,J., Fischer,H., Mildner,M., Gschwandtner,M., Mlitz,V.,
            Eckhart,L. and Tschachler,E.
  TITLE     The caspase-1 inhibitor CARD18 is specifically expressed during
            late differentiation of keratinocytes and its expression is lost in
            lichen planus
  JOURNAL   J Dermatol Sci 87 (2), 176-182 (2017)
   PUBMED   28506683
  REMARK    GeneRIF: In lesional epidermis of patients with lichen planus,
            CARD18 expression was either greatly diminished or entirely absent
            whereas in non-lesional areas expression was comparable to normal
            skin.
REFERENCE   2  (bases 1 to 702)
  AUTHORS   Lu,A., Li,Y., Schmidt,F.I., Yin,Q., Chen,S., Fu,T.M., Tong,A.B.,
            Ploegh,H.L., Mao,Y. and Wu,H.
  TITLE     Molecular basis of caspase-1 polymerization and its inhibition by a
            new capping mechanism
  JOURNAL   Nat Struct Mol Biol 23 (5), 416-425 (2016)
   PUBMED   27043298
REFERENCE   3  (bases 1 to 702)
  AUTHORS   Goblos,A., Danis,J., Vas,K., Bata-Csorgo,Z., Kemeny,L. and Szell,M.
  TITLE     Keratinocytes express functional CARD18, a negative regulator of
            inflammasome activation, and its altered expression in psoriasis
            may contribute to disease pathogenesis
  JOURNAL   Mol Immunol 73, 10-18 (2016)
   PUBMED   27023378
  REMARK    GeneRIF: CARD18 expression differs in healthy and psoriatic skin;
            moreover, CARD18 demonstrated altered response under inflammatory
            conditions in healthy and psoriatic skin
REFERENCE   4  (bases 1 to 702)
  AUTHORS   Tan,C., Liu,S. and Xiang,Z.
  TITLE     [The expression of CARD18 in apoptin-transfected gastric cancer
            cells and gastric adenocarcinoma tissues]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29 (8), 858-861 (2013)
   PUBMED   23948415
  REMARK    GeneRIF: CARD18 may be both a promising marker for prognosis and a
            target protein for treatment of gastric cancer.
REFERENCE   5  (bases 1 to 702)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 702)
  AUTHORS   Lamkanfi,M., Denecker,G., Kalai,M., D'hondt,K., Meeus,A.,
            Declercq,W., Saelens,X. and Vandenabeele,P.
  TITLE     INCA, a novel human caspase recruitment domain protein that
            inhibits interleukin-1beta generation
  JOURNAL   J Biol Chem 279 (50), 51729-51738 (2004)
   PUBMED   15383541
REFERENCE   7  (bases 1 to 702)
  AUTHORS   Razmara,M., Srinivasula,S.M., Wang,L., Poyet,J.L., Geddes,B.J.,
            DiStefano,P.S., Bertin,J. and Alnemri,E.S.
  TITLE     CARD-8 protein, a new CARD family member that regulates caspase-1
            activation and apoptosis
  JOURNAL   J Biol Chem 277 (16), 13952-13958 (2002)
   PUBMED   11821383
REFERENCE   8  (bases 1 to 702)
  AUTHORS   Druilhe,A., Srinivasula,S.M., Razmara,M., Ahmad,M. and Alnemri,E.S.
  TITLE     Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two
            dominant negative caspase recruitment domain proteins
  JOURNAL   Cell Death Differ 8 (6), 649-657 (2001)
   PUBMED   11536016
REFERENCE   9  (bases 1 to 702)
  AUTHORS   Humke,E.W., Shriver,S.K., Starovasnik,M.A., Fairbrother,W.J. and
            Dixit,V.M.
  TITLE     ICEBERG: a novel inhibitor of interleukin-1beta generation
  JOURNAL   Cell 103 (1), 99-111 (2000)
   PUBMED   11051551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003181.2, AY358231.1 and AW295205.1.
            
            On May 17, 2019 this sequence version replaced NM_021571.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358231.1, AA257158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530950.2/ ENSP00000436691.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AP003181.2         7247-7281           c
            36-39               AY358231.1         6-9
            40-40               AP003181.2         7242-7242           c
            41-473              AY358231.1         10-442
            474-695             AW295205.1         14-235              c
            696-702             AP003181.2         5226-5232           c
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..702
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /note="caspase recruitment domain family member 18"
                     /db_xref="GeneID:59082"
                     /db_xref="HGNC:HGNC:28861"
                     /db_xref="MIM:605354"
     exon            1..50
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..316
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /note="ICEBERG caspase-1 inhibitor; caspase-1 inhibitor
                     Iceberg"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     18"
                     /protein_id="NP_067546.1"
                     /db_xref="CCDS:CCDS53705.1"
                     /db_xref="GeneID:59082"
                     /db_xref="HGNC:HGNC:28861"
                     /db_xref="MIM:605354"
                     /translation="MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVR
                     DENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH"
     exon            51..317
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /inference="alignment:Splign:2.1.0"
     exon            318..702
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /inference="alignment:Splign:2.1.0"
     regulatory      452..457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /note="hexamer: AATAAA"
     polyA_site      474
                     /gene="CARD18"
                     /gene_synonym="ICEBERG; pseudo-ICE; UNQ5804"
                     /note="major polyA site"
ORIGIN      
        1 attgcaagtg taacacacat tgcaagtgcc aacgtgagga gccatggctg accaactctt
       61 gcgtaaaaag agaagaattt ttatccattc agtgggtgca ggcacaataa atgccttgct
      121 ggattgccta ttagaggatg aagttattag ccaggaagac atgaacaaag tgagagatga
      181 aaatgacact gtcatggata aggctcgagt cttgattgac cttgttactg gaaaaggacc
      241 caagtcttgc tgcaaattta tcaagcatct ctgtgaagaa gaccctcaac ttgcctcaaa
      301 gatgggtttg cactaagaga gaagatggaa ctctggagca cttcagagac ttcccagagc
      361 ttcttccaag ggagaagata ttctcgtgaa agaaaaaaac aaaacaaaac aacagtgctt
      421 ttttcaaacc tgattaattt catcaatttc caataaatct ttcattctct catattactt
      481 tcttcttatt ctttctctcc tcataccaac agaggataat tcatcaataa taatgaaggt
      541 catgatgatt gtaatgtaat taagaaagtc cctccctttc ccttcctttc tgtttagttc
      601 ctttgcaatc ctgtagagac atgtacagct tactttggtg cttttagcac tgagagtctg
      661 ctgtgatggg aataaaatga agtcccagct cagaatttta aa
//
