LOCUS       NM_052889                532 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 16 (CARD16),
            transcript variant 2, mRNA.
ACCESSION   NM_052889
VERSION     NM_052889.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 532)
  AUTHORS   Rousset,F., Hazane-Puch,F., Pinosa,C., Nguyen,M.V., Grange,L.,
            Soldini,A., Rubens-Duval,B., Dupuy,C., Morel,F. and Lardy,B.
  TITLE     IL-1beta mediates MMP secretion and IL-1beta neosynthesis via
            upregulation of p22(phox) and NOX4 activity in human articular
            chondrocytes
  JOURNAL   Osteoarthritis Cartilage 23 (11), 1972-1980 (2015)
   PUBMED   26521743
  REMARK    GeneRIF: Expression of NOX4/p22(phox) as well as ROS production is
            enhanced by IL-1beta. On the other hand, the use of NOX4 inhibitors
            decreased IL-1beta-induced collagenase synthesis by chondrocytes.
REFERENCE   2  (bases 1 to 532)
  AUTHORS   Shelton,R.C., Claiborne,J., Sidoryk-Wegrzynowicz,M., Reddy,R.,
            Aschner,M., Lewis,D.A. and Mirnics,K.
  TITLE     Altered expression of genes involved in inflammation and apoptosis
            in frontal cortex in major depression
  JOURNAL   Mol Psychiatry 16 (7), 751-762 (2011)
   PUBMED   20479761
REFERENCE   3  (bases 1 to 532)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 532)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 532)
  AUTHORS   Wang,X., Narayanan,M., Bruey,J.M., Rigamonti,D., Cattaneo,E.,
            Reed,J.C. and Friedlander,R.M.
  TITLE     Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa
            cell death
  JOURNAL   Biochim Biophys Acta 1762 (8), 742-754 (2006)
   PUBMED   16920334
  REMARK    GeneRIF: Cop inhibition of cell death, at least to a certain
            extent, results from its interference with the activation of
            caspase-1 and caspase-4.
REFERENCE   6  (bases 1 to 532)
  AUTHORS   Wang,X., Wang,H., Figueroa,B.E., Zhang,W.H., Huo,C., Guan,Y.,
            Zhang,Y., Bruey,J.M., Reed,J.C. and Friedlander,R.M.
  TITLE     Dysregulation of receptor interacting protein-2 and caspase
            recruitment domain only protein mediates aberrant caspase-1
            activation in Huntington's disease
  JOURNAL   J Neurosci 25 (50), 11645-11654 (2005)
   PUBMED   16354923
  REMARK    GeneRIF: Caspase-1-mediated cell death is regulated, at least in
            part, by the balance of Rip2 and Cop; alterations of this balance
            may contribute to aberrant caspase-1-mediated pathogenesis in
            Huntington's disease.
REFERENCE   7  (bases 1 to 532)
  AUTHORS   Lamkanfi,M., Denecker,G., Kalai,M., D'hondt,K., Meeus,A.,
            Declercq,W., Saelens,X. and Vandenabeele,P.
  TITLE     INCA, a novel human caspase recruitment domain protein that
            inhibits interleukin-1beta generation
  JOURNAL   J Biol Chem 279 (50), 51729-51738 (2004)
   PUBMED   15383541
REFERENCE   8  (bases 1 to 532)
  AUTHORS   Razmara,M., Srinivasula,S.M., Wang,L., Poyet,J.L., Geddes,B.J.,
            DiStefano,P.S., Bertin,J. and Alnemri,E.S.
  TITLE     CARD-8 protein, a new CARD family member that regulates caspase-1
            activation and apoptosis
  JOURNAL   J Biol Chem 277 (16), 13952-13958 (2002)
   PUBMED   11821383
REFERENCE   9  (bases 1 to 532)
  AUTHORS   Lee,S.H., Stehlik,C. and Reed,J.C.
  TITLE     Cop, a caspase recruitment domain-containing protein and inhibitor
            of caspase-1 activation processing
  JOURNAL   J Biol Chem 276 (37), 34495-34500 (2001)
   PUBMED   11432859
REFERENCE   10 (bases 1 to 532)
  AUTHORS   Druilhe,A., Srinivasula,S.M., Razmara,M., Ahmad,M. and Alnemri,E.S.
  TITLE     Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two
            dominant negative caspase recruitment domain proteins
  JOURNAL   Cell Death Differ 8 (6), 649-657 (2001)
   PUBMED   11536016
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001153.5.
            
            On Apr 27, 2021 this sequence version replaced NM_052889.3.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA960387.1, BC070196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673097.2/ ENSP00000509408.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AP001153.5         83230-83274         c
            46-312              AP001153.5         82331-82597         c
            313-375             AP001153.5         81422-81484         c
            376-532             AP001153.5         79502-79658         c
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..532
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /note="caspase recruitment domain family member 16"
                     /db_xref="GeneID:114769"
                     /db_xref="HGNC:HGNC:33701"
                     /db_xref="MIM:615680"
     exon            1..45
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..332
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /note="isoform 2 is encoded by transcript variant 2; CARD
                     only protein; caspase recruitment domain-containing
                     protein 16; caspase-1 dominant-negative inhibitor
                     pseudo-ICE; pseudo interleukin-1beta converting enzyme;
                     caspase-1 inhibitor COP; CARD only domain-containing
                     protein 1; CARD-only protein 1; pseudo-IL1B-converting
                     enzyme; pseudo interleukin-1 beta converting enzyme;
                     caspase recruitment domain-only protein 1"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 16
                     isoform 2"
                     /protein_id="NP_443121.1"
                     /db_xref="CCDS:CCDS41705.1"
                     /db_xref="GeneID:114769"
                     /db_xref="HGNC:HGNC:33701"
                     /db_xref="MIM:615680"
                     /translation="MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVK
                     RENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN"
     exon            46..312
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            313..375
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            376..532
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      512..517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /note="hexamer: AATAAA"
     polyA_site      532
                     /gene="CARD16"
                     /gene_synonym="COP; COP1; LLID-114769; PSEUDO-ICE"
                     /note="major polyA site"
ORIGIN      
        1 agtttcagcc cacacaagaa gggtaggaga gaaaagccat ggccgacaag gtcctgaagg
       61 agaagagaaa gctgtttatc cattccatgg gtgaaggtac aataaatggc ttactggatg
      121 aattattaca gacaagggtg ctgaaccagg aagagatgga gaaagtaaaa cgtgaaaatg
      181 ctacagttat ggataagacc cgagctttga ttgactccgt tattccgaaa ggggcacagg
      241 catgccaaat ttgcatcaca tacatttgtg aagaagacag ttacctggca gagacgctgg
      301 gactctcagc aggtccgata cctggaaatt agcttagtac acaagactcc caattactat
      361 tttcttcctt cccagctctt caggcagtgc aggacaaccc agctatgccc acatgctcaa
      421 gcccagaagg cagaatcaag ctttgctttc tagaagacgc tcaaaggata tggaaacaaa
      481 agttgcagag gtgccatgtt cagaatacaa taataaagtg gagtgaaaga ta
//
