LOCUS       NM_001366385            4717 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 14 (CARD14),
            transcript variant 5, mRNA.
ACCESSION   NM_001366385
VERSION     NM_001366385.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4717)
  AUTHORS   Iliaki,S., Kreike,M., Ferreras Moreno,N., De Meyer,F., Aidarova,A.,
            Braun,H., Libert,C., Afonina,I.S. and Beyaert,R.
  TITLE     Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in
            keratinocytes
  JOURNAL   Biochem Pharmacol 228, 116316 (2024)
   PUBMED   38797267
  REMARK    GeneRIF: Polo-like kinase 1 (PLK1) is a novel CARD14-binding
            protein in keratinocytes.
REFERENCE   2  (bases 1 to 4717)
  AUTHORS   DeVore,S.B., Schuetz,M., Alvey,L., Lujan,H., Ochayon,D.E.,
            Williams,L., Chang,W.C., Filuta,A., Ruff,B., Kothari,A., Hahn,J.M.,
            Brandt,E., Satish,L., Roskin,K., Herr,A.B., Biagini,J.M.,
            Martin,L.J., Cagdas,D., Keles,S., Milner,J.D., Supp,D.M. and
            Khurana Hershey,G.K.
  TITLE     Regulation of MYC by CARD14 in human epithelium is a determinant of
            epidermal homeostasis and disease
  JOURNAL   Cell Rep 43 (8), 114589 (2024)
   PUBMED   39110589
  REMARK    GeneRIF: Regulation of MYC by CARD14 in human epithelium is a
            determinant of epidermal homeostasis and disease.
REFERENCE   3  (bases 1 to 4717)
  AUTHORS   Li,N., Tao,J., Zhang,J., Liu,Z. and Yu,P.
  TITLE     A novel mutation in a CARD14-associated papulosquamous eruption
  JOURNAL   Pediatr Dermatol 40 (4), 706-709 (2023)
   PUBMED   36724903
  REMARK    GeneRIF: A novel mutation in a CARD14-associated papulosquamous
            eruption.
REFERENCE   4  (bases 1 to 4717)
  AUTHORS   Trai,N.N., Van Em,D., Van,B.T., My,L.H., Van Tro,C., Hao,N.T.,
            Vu,H.A., Tram,D.B., Van Thuong,N. and Doanh,L.H.
  TITLE     Correlation of IL36RN and CARD14 mutations with clinical
            manifestations and laboratory findings in patients with generalised
            pustular psoriasis
  JOURNAL   Indian J Dermatol Venereol Leprol 89 (3), 378-384 (2023)
   PUBMED   36331855
  REMARK    GeneRIF: Correlation of IL36RN and CARD14 mutations with clinical
            manifestations and laboratory findings in patients with generalised
            pustular psoriasis.
REFERENCE   5  (bases 1 to 4717)
  AUTHORS   Msafiri Makene,A. and Liu,J.L.
  TITLE     Association between CARD14 gene polymorphisms and psoriasis
            vulgaris in Hainan Han population based on exon sequencing: A
            case-control study
  JOURNAL   Medicine (Baltimore) 101 (40), e30890 (2022)
   PUBMED   36221432
  REMARK    GeneRIF: Association between CARD14 gene polymorphisms and
            psoriasis vulgaris in Hainan Han population based on exon
            sequencing: A case-control study.
REFERENCE   6  (bases 1 to 4717)
  AUTHORS   Speckman,R.A., Wright Daw,J.A., Helms,C., Duan,S., Cao,L.,
            Taillon-Miller,P., Kwok,P.Y., Menter,A. and Bowcock,A.M.
  TITLE     Novel immunoglobulin superfamily gene cluster, mapping to a region
            of human chromosome 17q25, linked to psoriasis susceptibility
  JOURNAL   Hum Genet 112 (1), 34-41 (2003)
   PUBMED   12483297
  REMARK    GeneRIF: Chromosome 17q25 harbors a susceptibility locus for
            psoriasis. Non-parametric linkage analysis revealed a linkage peak
            lying close to a novel cluster of genes from the immunoglobulin
            (Ig) superfamily.
REFERENCE   7  (bases 1 to 4717)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
REFERENCE   8  (bases 1 to 4717)
  AUTHORS   Gaide,O., Martinon,F., Micheau,O., Bonnet,D., Thome,M. and
            Tschopp,J.
  TITLE     Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10
            phosphorylation and NF-kappaB activation
  JOURNAL   FEBS Lett 496 (2-3), 121-127 (2001)
   PUBMED   11356195
REFERENCE   9  (bases 1 to 4717)
  AUTHORS   Bertin,J., Wang,L., Guo,Y., Jacobson,M.D., Poyet,J.L.,
            Srinivasula,S.M., Merriam,S., DiStefano,P.S. and Alnemri,E.S.
  TITLE     CARD11 and CARD14 are novel caspase recruitment domain
            (CARD)/membrane-associated guanylate kinase (MAGUK) family members
            that interact with BCL10 and activate NF-kappa B
  JOURNAL   J Biol Chem 276 (15), 11877-11882 (2001)
   PUBMED   11278692
REFERENCE   10 (bases 1 to 4717)
  AUTHORS   Tomfohrde,J., Silverman,A., Barnes,R., Fernandez-Vina,M.A.,
            Young,M., Lory,D., Morris,L., Wuepper,K.D., Stastny,P., Menter,A.
            et al.
  TITLE     Gene for familial psoriasis susceptibility mapped to the distal end
            of human chromosome 17q
  JOURNAL   Science 264 (5162), 1141-1145 (1994)
   PUBMED   8178173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087741.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a caspase recruitment domain-containing
            protein that is a member of the membrane-associated guanylate
            kinase (MAGUK) family of proteins. Members of this protein family
            are scaffold proteins that are involved in a diverse array of
            cellular processes including cellular adhesion, signal transduction
            and cell polarity control. This protein has been shown to
            specifically interact with BCL10, a protein known to function as a
            positive regulator of cell apoptosis and NF-kappaB activation.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY032927.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000648509.2/ ENSP00000498071.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC087741.18        40117-40143         c
            28-350              AC087741.18        36945-37267         c
            351-498             AC087741.18        31518-31665         c
            499-696             AC087741.18        30872-31069         c
            697-927             AC087741.18        28524-28754         c
            928-1065            AC087741.18        27383-27520         c
            1066-1391           AC087741.18        25935-26260         c
            1392-1559           AC087741.18        21629-21796         c
            1560-1679           AC087741.18        20301-20420         c
            1680-1805           AC087741.18        19274-19399         c
            1806-1955           AC087741.18        18701-18850         c
            1956-2072           AC087741.18        17554-17670         c
            2073-2215           AC087741.18        14840-14982         c
            2216-2310           AC087741.18        14521-14615         c
            2311-2374           AC087741.18        12011-12074         c
            2375-2567           AC087741.18        11582-11774         c
            2568-2694           AC087741.18        8303-8429           c
            2695-2935           AC087741.18        7753-7993           c
            2936-2999           AC087741.18        6288-6351           c
            3000-3114           AC087741.18        5832-5946           c
            3115-3285           AC087741.18        4968-5138           c
            3286-3407           AC087741.18        4521-4642           c
            3408-3523           AC087741.18        3088-3203           c
            3524-4717           AC087741.18        842-2035            c
FEATURES             Location/Qualifiers
     source          1..4717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..4717
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="caspase recruitment domain family member 14"
                     /db_xref="GeneID:79092"
                     /db_xref="HGNC:HGNC:16446"
                     /db_xref="MIM:607211"
     exon            1..27
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            28..350
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..498
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..696
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..927
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             717..3731
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="isoform 1 is encoded by transcript variant 5;
                     bcl10-interacting maguk protein 2; caspase recruitment
                     domain-containing protein 14; CARD-containing MAGUK
                     protein 2"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 14
                     isoform 1"
                     /protein_id="NP_001353314.1"
                     /db_xref="CCDS:CCDS11768.1"
                     /db_xref="GeneID:79092"
                     /db_xref="HGNC:HGNC:16446"
                     /db_xref="MIM:607211"
                     /translation="MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLR
                     QAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTL
                     VTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHL
                     GLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASR
                     CRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRS
                     LTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQ
                     KSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFEL
                     TDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSS
                     TESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEG
                     DPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRIL
                     SQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASE
                     PLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIR
                     VNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSR
                     AQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRM
                     EGSSTCFWAESCLTLVPYTLVRPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLA
                     EYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLH
                     RMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAP
                     DGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR"
     exon            928..1065
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1391
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1559
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1679
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1805
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1955
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2072
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2215
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2310
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2374
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2567
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2694
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2935
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..2999
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3114
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3285
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3407
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3523
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..4717
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4329..4334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="hexamer: AATAAA"
     polyA_site      4350
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="major polyA site"
     regulatory      4698..4703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="hexamer: AATAAA"
     polyA_site      4717
                     /gene="CARD14"
                     /gene_synonym="BIMP2; CARMA2; PRP; PSORS2; PSS1"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgct tccctgggag ggggaagagt ttcactctgg ctcctaggct ggaatgcagt
       61 ggcaccatct cagctctctg caacctccac ttcccaggtt caagcgattc tcctgcctca
      121 ccctcctgag tagctgggac tacaggcgag caccaccaca gccggctaat ttttctattt
      181 ctagtagaaa tggggtttca ccatgttggc aggctggtct cgaactctga cctcaagtga
      241 tctgcctgcc tcagcctctg aaagtgctgg attgcaggcg tgagccaccg caccaggcct
      301 aaacagattt ctttacaatc taccaccatg aacagcaagc attagcattg gctcttcctt
      361 ctgcccagct ccgtcccacc cagcagcccg cagagaaagg aggcagctgg caccacactg
      421 ggctttggag acactgcggg gactgtggac cccaccctgc tgcacggagc tcctgcaaaa
      481 gcaaacctga gaaccttgca tacagatccc tgcaagaggc atctgtctcc agtggtccag
      541 cctctccttc caaatgaaaa gaatcaagtc acaggaattc atgggtctgt aaggaatcgc
      601 tcccatctgt gcccaggaga ttaacaaagg cggtggctgc agctctgtga gcagtggaga
      661 aaaattaggc acaacctgat atcctcccac aggagcggtc ctcccagcgc ccagccatgg
      721 gggaactgtg ccgcagggac tccgcactca cggcactgga cgaggagaca ctgtgggaga
      781 tgatggagag ccaccgccac aggatcgtac gctgcatctg ccccagccgc ctcaccccct
      841 acctgcgcca ggccaaggtg ctgtgccagc tggacgagga ggaggtgctg cacagccccc
      901 ggctcaccaa cagcgccatg cgggccgggc acttgctgga tttgctgaag actcgaggga
      961 agaacggggc catcgccttc ctggagagcc tgaagttcca caaccctgac gtctacaccc
     1021 tggtcaccgg gctgcagcct gatgttgact tcagtaactt tagcggtctc atggagacat
     1081 ccaagctgac cgagtgcctg gctggggcca tcggcagcct gcaggaggag ctgaaccagg
     1141 aaaaggggca gaaggaggtg ctgctgcggc ggtgccagca gctgcaggag cacctgggcc
     1201 tggccgagac ccgtgccgag ggcctgcacc agctggaggc tgaccacagc cgcatgaagc
     1261 gtgaggttag cgcacacttc catgaggtgc tgaggctgaa ggacgagatg ctcagcctct
     1321 cgctgcacta tagcaatgcg ctgcaggaga aggagctggc cgcctcacgc tgccgcagcc
     1381 tgcaggagga gctgtatcta ctgaagcagg agctgcagcg agccaacatg gtttcctcct
     1441 gtgagctgga attgcaagag cagtccctga ggacagccag cgaccaggag tccggggatg
     1501 aggagctgaa ccgcctgaag gaggagaatg agaaactgcg ctcgctgact ttcagcctgg
     1561 cggagaagga cattctggag cagagcctgg acgaggcgcg ggggagccga caggagctgg
     1621 tggagcgcat ccactcgctg cgggagcggg ccgtggctgc cgagaggcag cgagagcagt
     1681 actgggaaga gaaggaacag accctgctgc agttccagaa gagtaagatg gcctgccaac
     1741 tctacaggga gaaggtgaat gcgctgcagg cccaggtgtg cgagctgcag aaggagcgag
     1801 accaggcgta ctccgcgagg gacagtgctc agagggagat ttcccagagc ctggtggaga
     1861 aggactccct ccgcaggcag gtgttcgagc tgacggacca ggtctgcgag ctgcgcacac
     1921 agcttcgcca gctgcaggca gagcctccgg gtgtgctcaa gcaggaagcc aggaccaggg
     1981 agccctgtcc acgggagaag cagcggctgg tgcggatgca tgccatctgc cccagagacg
     2041 acagcgactg cagcctcgtc agctccacag agtctcagct cttgtcggac ctgagtgcca
     2101 cgtccagccg cgagctggtg gacagcttcc gctccagcag ccccgcgccc cccagccagc
     2161 agtccctgta caagcgggtg gccgaggact tcggggaaga accctggtct ttcagcagct
     2221 gcctggagat cccggaggga gacccgggag ccctgccggg agctaaggca ggcgacccac
     2281 acctggatta tgagctccta gacacggcag accttccgca gctggaaagc agcctgcagc
     2341 cagtctcccc tggaaggctt gatgtctcgg agagcggcgt cctcatgcgg cggaggccag
     2401 cccgcaggat cctgagccag gtcaccatgc tggcgttcca gggggatgca ttgctggagc
     2461 agatcagcgt catcggcggg aacctcacgg gcatcttcat ccaccgggtc accccgggct
     2521 cggcggcgga ccagatggcc ttgcgcccgg gcacccagat tgtgatggtt gattacgaag
     2581 cctcagagcc cttgttcaag gcagtcctgg aggacacgac cctggaggag gccgtggggc
     2641 ttctcaggag ggtggacggc ttctgctgcc tgtctgtgaa ggtcaacacg gacggttata
     2701 agaggctact ccaggacctg gaggccaaag tggcgacctc gggggactca ttctacatcc
     2761 gggtcaacct ggccatggag ggcagggcca aaggggagct gcaggtgcat tgcaacgagg
     2821 tcctgcacgt caccgacacc atgttccagg gctgcggctg ctggcatgcc caccgcgtga
     2881 actcttacac catgaaggat actgccgcgc acggcaccat ccccaactac tccagggctc
     2941 agcagcagct catagccctc atccaggaca tgactcagca gtgcaccgtg acccgcaagc
     3001 catcttctgg gggaccacag aagctggtcc gcatcgtcag tatggacaaa gccaaggcca
     3061 gccctctgcg tttgtccttt gacaggggcc agttggaccc cagcaggatg gagggctcca
     3121 gcacgtgctt ctgggccgag agctgcctca ccctggtgcc ctataccctg gtgcggcccc
     3181 atcgacccgc ccggccccgg cctgtgctcc tcgtgcccag ggcggttggg aagatcctga
     3241 gcgagaaact gtgcctcctc caagggttta agaagtgcct ggcagagtac ttgagccagg
     3301 aggagtatga ggcctggagc cagagagggg acatcatcca ggagggagag gtgtccgggg
     3361 gccgctgctg ggtgacccgc catgctgtgg agtccctcat ggaaaagaac acccatgccc
     3421 tcctggacgt ccagctggac agtgtctgca ccctgcacag gatggacatc ttccccatcg
     3481 tcatccacgt ctctgtcaac gagaagatgg caaagaagct caagaagggc ctacagcggt
     3541 tgggcacctc agaggagcag ctcctggagg ctgcgaggca ggaggaggga gacctggacc
     3601 gggcgccctg tctatacagc agcctggctc ctgacggctg gagcgacctg gacggcctgc
     3661 tcagctgtgt ccgccaggcc atcgccgacg agcagaagaa ggtggtgtgg acggagcaga
     3721 gcccccgatg atgcaccgtg ccccttcccg ggactgtggg ggcttctgtg tgcctgttaa
     3781 tgcagtcctg ttcctcagcc caggccctct tggcacagct gtgggctcct tggcacatga
     3841 ggccggctct ccccactggc tggggtctaa ccttgaaccc tcaccacgtg caggtcacac
     3901 acagtgaagc cacttgtaac tgcacacttt tctgtggaaa catcttcacc ctttaccagg
     3961 cttggcatgg tctgaactgg aaaccctgag aatgtttctg cagtgggaca ggagggacgt
     4021 cttcccatgc cttccctaga accggaggcc ccggacttct ctggaaaacc gcctgtctgc
     4081 aggcccgatt caaatctatg ggggctgcac ttccctttta cattttgatg tgtcaaaggc
     4141 ttttggagtg accaaaagca cagaggcagc gggtggggcg cctgggtggt ccccaaggtc
     4201 gctgccaccc ttgcccgggg cagaggcaga agcccacata tgctgtgacg ctggccacct
     4261 tttctcagct tctgaggctg cgatgcctca ggaactccag tttacagaga ccagtgtgtt
     4321 tacttgtaaa taaagcctct gcgtggtgga gacggtactt tcagtgggtc tgtgccccgt
     4381 ggcccctgtg cctgttcggt gggggtgtcc cagagaagcc tggcaccagt acccccgtac
     4441 aaggcccagc ggactctgcc ttcccctgac ctggctttgc accccagccc ttcttgggcc
     4501 aaacatcttt actccacctt cagggctcgg ggaggaccca ggtccgccag cacctggcct
     4561 tgcccctgcc tcctggggct gttgcagact gaatgtcatt ttgacagcag tgtccaagaa
     4621 tcaggaagct gttctagaat tcaggttggt atcatcataa atgagttcag aaaaagaact
     4681 tctgtatatt ttactaaaat aaaaagcttt tacaata
//
