LOCUS       NM_032415               4287 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 11 (CARD11),
            transcript variant 2, mRNA.
ACCESSION   NM_032415
VERSION     NM_032415.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4287)
  AUTHORS   Hu,Y., Han,L., Xu,W., Li,T., Zhao,Q., Lu,W., Sun,J. and Wang,Y.
  TITLE     CARD11 regulates the thymic Treg development in an
            NF-kappaB-independent manner
  JOURNAL   Front Immunol 15, 1364957 (2024)
   PUBMED   38650932
  REMARK    GeneRIF: CARD11 regulates the thymic Treg development in an
            NF-kappaB-independent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4287)
  AUTHORS   Decombis,S., Bellanger,C., Le Bris,Y., Madiot,C., Jardine,J.,
            Santos,J.C., Boulet,D., Dousset,C., Menard,A., Kervoelen,C.,
            Douillard,E., Moreau,P., Minvielle,S., Moreau-Aubry,A.,
            Tessoulin,B., Roue,G., Bidere,N., Le Gouill,S.,
            Pellat-Deceunynck,C. and Chiron,D.
  TITLE     CARD11 gain of function upregulates BCL2A1 expression and promotes
            resistance to targeted therapies combination in B-cell lymphoma
  JOURNAL   Blood 142 (18), 1543-1555 (2023)
   PUBMED   37562004
  REMARK    GeneRIF: CARD11 gain of function upregulates BCL2A1 expression and
            promotes resistance to targeted therapies combination in B-cell
            lymphoma.
REFERENCE   3  (bases 1 to 4287)
  AUTHORS   Loh,J.T., Teo,J.K.H., Kannan,S., Verma,C.S., Andiappan,A.K.,
            Lim,H.H. and Lam,K.P.
  TITLE     DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to
            inhibit the T cell signaling mediator CARD11
  JOURNAL   Sci Signal 16 (809), eadg5171 (2023)
   PUBMED   37906628
  REMARK    GeneRIF: DOK3 promotes atopic dermatitis by enabling the
            phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
REFERENCE   4  (bases 1 to 4287)
  AUTHORS   Cros,G., Chapdelaine,H., Teira,P., Fernandez,I., Pastore,Y.,
            Haddad,E. and Touzot,F.
  TITLE     A novel variant in caspase recruitment domain family member 11
            highlights the variability of clinical manifestations and
            management in a three generation family
  JOURNAL   J Allergy Clin Immunol Pract 11 (10), 3265-3268 (2023)
   PUBMED   37385446
  REMARK    GeneRIF: A novel variant in caspase recruitment domain family
            member 11 highlights the variability of clinical manifestations and
            management in a three generation family.
REFERENCE   5  (bases 1 to 4287)
  AUTHORS   Baronio,M., Gazzurelli,L., Rezzola,S., Rossi,S., Tessarin,G.,
            Marinoni,M., Salpietro,A., Fiore,M., Moratto,D., Chiarini,M.,
            Badolato,R., Parolini,S., Tabellini,G. and Lougaris,V.
  TITLE     CARD11 dominant negative mutation leads to altered human Natural
            Killer cell homeostasis
  JOURNAL   Immunobiology 228 (3), 152381 (2023)
   PUBMED   37086690
  REMARK    GeneRIF: CARD11 dominant negative mutation leads to altered human
            Natural Killer cell homeostasis.
REFERENCE   6  (bases 1 to 4287)
  AUTHORS   Gaide,O., Favier,B., Legler,D.F., Bonnet,D., Brissoni,B.,
            Valitutti,S., Bron,C., Tschopp,J. and Thome,M.
  TITLE     CARMA1 is a critical lipid raft-associated regulator of TCR-induced
            NF-kappa B activation
  JOURNAL   Nat Immunol 3 (9), 836-843 (2002)
   PUBMED   12154360
  REMARK    GeneRIF: CARMA1 is a critical lipid raft-associated regulator of
            TCR-induced NF-kappa B activation and CD28 costimulation-dependent
            Jnk activation.
REFERENCE   7  (bases 1 to 4287)
  AUTHORS   Wang,D., You,Y., Case,S.M., McAllister-Lucas,L.M., Wang,L.,
            DiStefano,P.S., Nunez,G., Bertin,J. and Lin,X.
  TITLE     A requirement for CARMA1 in TCR-induced NF-kappa B activation
  JOURNAL   Nat Immunol 3 (9), 830-835 (2002)
   PUBMED   12154356
  REMARK    GeneRIF: CARMA1 is an essential signaling component that mediates
            TCR-induced NF-kappa B activation.
REFERENCE   8  (bases 1 to 4287)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
REFERENCE   9  (bases 1 to 4287)
  AUTHORS   Gaide,O., Martinon,F., Micheau,O., Bonnet,D., Thome,M. and
            Tschopp,J.
  TITLE     Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10
            phosphorylation and NF-kappaB activation
  JOURNAL   FEBS Lett 496 (2-3), 121-127 (2001)
   PUBMED   11356195
REFERENCE   10 (bases 1 to 4287)
  AUTHORS   Bertin,J., Wang,L., Guo,Y., Jacobson,M.D., Poyet,J.L.,
            Srinivasula,S.M., Merriam,S., DiStefano,P.S. and Alnemri,E.S.
  TITLE     CARD11 and CARD14 are novel caspase recruitment domain
            (CARD)/membrane-associated guanylate kinase (MAGUK) family members
            that interact with BCL10 and activate NF-kappa B
  JOURNAL   J Biol Chem 276 (15), 11877-11882 (2001)
   PUBMED   11278692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY086990.1, AK074049.1 and
            AA594170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 30, 2020 this sequence version replaced NM_032415.6.
            
            Summary: The protein encoded by this gene belongs to the
            membrane-associated guanylate kinase (MAGUK) family, a class of
            proteins that functions as molecular scaffolds for the assembly of
            multiprotein complexes at specialized regions of the plasma
            membrane. This protein is also a member of the CARD protein family,
            which is defined by carrying a characteristic caspase-associated
            recruitment domain (CARD). This protein has a domain structure
            similar to that of CARD14 protein. The CARD domains of both
            proteins have been shown to specifically interact with BCL10, a
            protein known to function as a positive regulator of cell apoptosis
            and NF-kappaB activation. When expressed in cells, this protein
            activated NF-kappaB and induced the phosphorylation of BCL10.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074049.1, AF322641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396946.9/ ENSP00000380150.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 HY086990.1         80-81
            3-4281              AK074049.1         1-4279
            4282-4287           AA594170.1         186-191
FEATURES             Location/Qualifiers
     source          1..4287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.2"
     gene            1..4287
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /note="caspase recruitment domain family member 11"
                     /db_xref="GeneID:84433"
                     /db_xref="HGNC:HGNC:16393"
                     /db_xref="MIM:607210"
     exon            1..201
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            202..333
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..3791
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /note="bcl10-interacting maguk protein 3; carma 1;
                     CARD-containing MAGUK protein 1"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     11"
                     /protein_id="NP_115791.3"
                     /db_xref="CCDS:CCDS5336.2"
                     /db_xref="GeneID:84433"
                     /db_xref="HGNC:HGNC:16393"
                     /db_xref="MIM:607210"
                     /translation="MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTP
                     YLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPEL
                     YKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLE
                     DEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMA
                     VMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEML
                     KTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAE
                     ELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQ
                     YSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLP
                     RNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQ
                     RAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAE
                     PPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQ
                     SEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTL
                     LGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTI
                     QRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCD
                     DVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSRE
                     EVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSENKYKRMN
                     SNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCE
                     RRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKN
                     PNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKRFRK
                     LLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQRKT
                     IWVDEDQL"
     exon            334..546
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            547..684
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1010
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1190
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1343
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1469
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1667
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1844
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1896
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1979
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2080
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2133
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2266
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2468
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2595
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2836
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2933
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3029
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3165
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3345
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3470
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3586
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..4287
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4265..4270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /note="hexamer: ATTAAA"
     polyA_site      4287
                     /gene="CARD11"
                     /gene_synonym="BENTA; BIMP3; CARMA1; IMD11; IMD11A; PPBL"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgcctc ctctggcctt cggactcctg cccgcgccgc ccgcagcccc ctcccggccc
       61 tgcagcccct gggcgggcgg cgcccctcgg aggacggctc cgggcccggg gggacggagg
      121 gcctggtcgc ctggaggaag ccggaggcct gcgtggagga ggcgccccgc gcagctggct
      181 ggcggagcat gagcgcccca gatcccaagc actgcaagtc cagatgcaac gggagcctgg
      241 ctcaagggac gacaagatcc agccggaaag tgtagaagtc acaccccaat ggcgggatag
      301 cagcccctgt gtgtgagcac ccctccatgc caggaggagg gccagagatg gatgactaca
      361 tggagacgct gaaggatgaa gaggacgcct tgtgggagaa tgtggagtgt aaccggcaca
      421 tgctcagccg ctatatcaac cctgccaagc tcacgcccta cctgcgtcag tgtaaggtca
      481 ttgatgagca ggatgaagat gaagtgctta atgcccctat gctgccatcc aagatcaacc
      541 gagcaggccg gctgttggac attctacata ccaaggggca aaggggctat gtggtcttct
      601 tggagagcct agaattttat tacccagaac tgtacaaact ggtgactggg aaagagccca
      661 ctcggagatt ctccaccatt gtggtggagg aaggccacga gggcctcacg cacttcctga
      721 tgaacgaggt catcaagctg cagcagcaga tgaaggccaa ggacctgcaa cgctgcgagc
      781 tgctggccag gttgcggcag ctggaggatg agaagaagca gatgacgctg acgcgcgtgg
      841 agctgctaac cttccaggag cggtactaca agatgaagga agagcgggac agctacaatg
      901 acgagctggt caaggtgaag gacgacaact acaacttagc catgcgctac gcacagctca
      961 gtgaggagaa gaacatggcg gtcatgagga gccgagacct ccaactcgag atcgatcagc
     1021 taaagcaccg gttgaataag atggaggagg aatgtaagct ggagagaaat cagtctctaa
     1081 aactgaagaa tgacattgaa aatcggccca agaaggagca ggttctggaa ctggagcggg
     1141 agaatgaaat gctgaagacc aaaaaccagg agctgcagtc catcatccag gccgggaagc
     1201 gcagcctgcc agactcagac aaggccatcc tggacatctt ggaacacgac cgcaaggagg
     1261 ccctggagga caggcaggag ctggtcaaca ggatctacaa cctgcaggag gaggcccgcc
     1321 aggcagagga gctgcgagac aagtacctgg aggagaagga ggacctggag ctcaagtgct
     1381 cgaccctggg aaaggactgt gaaatgtaca agcaccgcat gaacacggtc atgctgcagc
     1441 tggaggaggt ggagcgggag cgggaccagg ccttccactc ccgagatgaa gctcagacac
     1501 agtactcgca gtgcttaatc gaaaaggaca agtacaggaa gcagatccgc gagctggagg
     1561 agaagaacga cgagatgagg atcgagatgg tgcggcggga ggcctgcatc gtcaacctgg
     1621 agagcaagct gcggcgcctc tccaaggaca gcaacaacct ggaccagagt ctgcccagga
     1681 acctgccagt aaccatcatc tctcaggact ttggggatgc cagccccagg accaatggtc
     1741 aagaagctga cgattcttcc acctcggagg agtcacctga agacagcaag tacttcctgc
     1801 cctaccatcc gccccagcgc aggatgaacc tgaagggcat ccagctgcag agagccaaat
     1861 cccccatcag cctgaagcga acatcagatt ttcaagccaa ggggcacgag gaagaaggca
     1921 cggacgccag ccctagctcc tgcggatctc tgcccatcac caactccttc accaagatgc
     1981 agcccccccg gagccgcagc agcatcatgt caatcaccgc cgagcccccg ggaaacgact
     2041 ccatcgtcag acgctacaag gaggacgcgc cccatcgcag cacagtcgaa gaagacaatg
     2101 acagcggcgg gtttgacgcc ttagatctgg atgatgacag tcacgaacgc tactccttcg
     2161 gaccctcctc catccactcc tcctcctcct cccaccaatc cgagggcctg gatgcctacg
     2221 acctggagca ggtcaacctc atgttcagga agttctctct ggaaagaccc ttccggcctt
     2281 cggtcacctc tgtggggcac gtgcggggcc cagggccctc ggtgcagcac acgacgctga
     2341 atggcgacag cctcacctcc cagctcaccc tgctgggggg caacgcgcga gggagcttcg
     2401 tgcactcggt caagcctggc tctctggccg agaaagccgg cctccgtgag ggccaccagc
     2461 tgctgctgct agaaggctgc atccgaggcg agaggcagag tgtcccgttg gacacatgca
     2521 ccaaagagga agcccactgg accatccaga ggtgcagcgg ccccgtcacg ctgcactaca
     2581 aggtcaacca cgaagggtac cggaagctgg tgaaggacat ggaggacggc ctgatcacat
     2641 cgggggactc gttctacatc cggctgaacc tgaacatctc cagccagctg gacgcctgca
     2701 ccatgtccct gaagtgtgac gatgttgtgc acgtccgtga caccatgtac caggacaggc
     2761 acgagtggct gtgcgcgcgg gtcgaccctt tcacagacca tgacctggat atgggcacca
     2821 tacccagcta cagccgagcc cagcagctcc tcctggtgaa actgcagcgc ctgatgcacc
     2881 gaggcagccg ggaggaggta gacggcaccc accacaccct gcgggcactc cggaacaccc
     2941 tgcagccaga agaagcgctt tcaacaagcg acccccgggt cagcccccgt ctctcgcgag
     3001 caagcttcct ttttggccag ctccttcagt tcgtcagcag gtccgagaac aagtataagc
     3061 ggatgaacag caacgagcgg gtccgcatca tctcggggag tccgctaggg agcctggccc
     3121 ggtcctcgct ggacgccacc aagctcttga ctgagaagca ggaagagctg gaccctgaga
     3181 gcgagctggg caagaacctc agcctcatcc cctacagcct ggtacgcgcc ttctactgcg
     3241 agcgccgccg gcccgtgctc ttcacaccca ccgtgctggc caagacgctg gtgcagaggc
     3301 tgctcaactc gggaggtgcc atggagttca ccatctgcaa gtcagatatc gtcacaagag
     3361 atgagttcct cagaaggcag aagacggaga ccatcatcta ctcccgagag aagaacccca
     3421 acgcgttcga atgcatcgcc cctgccaaca ttgaagctgt ggccgccaag aacaagcact
     3481 gcctgctgga ggctgggatc ggctgcacaa gagacttgat caagtccaac atctacccca
     3541 tcgtgctctt catccgggtg tgtgagaaga acatcaagag gttcagaaag ctgctgcccc
     3601 gacctgagac ggaggaggag ttcctgcgcg tgtgccggct gaaggagaag gagctggagg
     3661 ccctgccgtg cctgtacgcc acggtggaac ctgacatgtg gggcagcgta gaggagctgc
     3721 tccgcgttgt caaggacaag atcggcgagg agcagcgcaa gaccatctgg gtggacgagg
     3781 accagctgtg aggcgggcgc cctgggcaga gagactctgt ggcgcggggc atcctatgag
     3841 gcaggcaccc tgggcagaga gatgcagtgg gtgcgggggg atcctgtggc ccacagagct
     3901 gccccagcag acgctccgcc ccacccggtg atggagcccc ggggggacag tcgtgcctgg
     3961 ggaggagcag ggtacagccc attcccccag ccctggctga cctggcctag cagtttggcc
     4021 ctgctggcct tagcagggag acaggggagc aaagaacgcc aagccggagg cccgaggcca
     4081 gccggcctct cgagagccag agcagcagtt gaatgtaatg ctggggacag gcatgctgcc
     4141 gccagtaggg cggggacccg gacagccagg tgactaccag tcctggggac acactcacca
     4201 taaacacatc cccaggcagg acagatcggg gaaggggtgt gtaccaggct atgatttctc
     4261 ttgcattaaa atgtattatt atttctt
//
