LOCUS       NM_014550               4111 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens caspase recruitment domain family member 10 (CARD10),
            mRNA.
ACCESSION   NM_014550
VERSION     NM_014550.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4111)
  AUTHORS   Gui,Z., Zhang,Y., Zhang,A., Xia,W. and Jia,Z.
  TITLE     CARMA3: A potential therapeutic target in non-cancer diseases
  JOURNAL   Front Immunol 13, 1057980 (2022)
   PUBMED   36618379
  REMARK    GeneRIF: CARMA3: A potential therapeutic target in non-cancer
            diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4111)
  AUTHORS   Shi,D., Zhang,Z. and Kong,C.
  TITLE     CARMA3 Transcriptional Regulation of STMN1 by NF-kappaB Promotes
            Renal Cell Carcinoma Proliferation and Invasion
  JOURNAL   Technol Cancer Res Treat 20, 15330338211027915 (2021)
   PUBMED   34190011
  REMARK    GeneRIF: CARMA3 Transcriptional Regulation of STMN1 by NF-kappaB
            Promotes Renal Cell Carcinoma Proliferation and Invasion.
REFERENCE   3  (bases 1 to 4111)
  AUTHORS   Yang,D.H., Guo,T., Yuan,Z.Z., Lei,C., Ding,S.Z., Yang,Y.F.,
            Tan,Z.P. and Luo,H.
  TITLE     Mutant CARD10 in a family with progressive immunodeficiency and
            autoimmunity
  JOURNAL   Cell Mol Immunol 17 (7), 782-784 (2020)
   PUBMED   32238915
  REMARK    GeneRIF: Mutant CARD10 in a family with progressive
            immunodeficiency and autoimmunity.
REFERENCE   4  (bases 1 to 4111)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4111)
  AUTHORS   Peng,L., He,K., Cao,Z., Bi,L., Yu,D., Wang,Q. and Wang,J.
  TITLE     CARD10 promotes the progression of renal cell carcinoma by
            regulating the NF-kappaB signaling pathway
  JOURNAL   Mol Med Rep 21 (1), 329-337 (2020)
   PUBMED   31939627
  REMARK    GeneRIF: CARD10 promotes the progression of renal cell carcinoma by
            regulating the NFkappaB signaling pathway.
REFERENCE   6  (bases 1 to 4111)
  AUTHORS   Sun,L., Deng,L., Ea,C.K., Xia,Z.P. and Chen,Z.J.
  TITLE     The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation
            by BCL10 and MALT1 in T lymphocytes
  JOURNAL   Mol Cell 14 (3), 289-301 (2004)
   PUBMED   15125833
REFERENCE   7  (bases 1 to 4111)
  AUTHORS   McAllister-Lucas,L.M., Inohara,N., Lucas,P.C., Ruland,J.,
            Benito,A., Li,Q., Chen,S., Chen,F.F., Yamaoka,S., Verma,I.M.,
            Mak,T.W. and Nunez,G.
  TITLE     Bimp1, a MAGUK family member linking protein kinase C activation to
            Bcl10-mediated NF-kappaB induction
  JOURNAL   J Biol Chem 276 (33), 30589-30597 (2001)
   PUBMED   11387339
REFERENCE   8  (bases 1 to 4111)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
REFERENCE   9  (bases 1 to 4111)
  AUTHORS   Gaide,O., Martinon,F., Micheau,O., Bonnet,D., Thome,M. and
            Tschopp,J.
  TITLE     Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10
            phosphorylation and NF-kappaB activation
  JOURNAL   FEBS Lett 496 (2-3), 121-127 (2001)
   PUBMED   11356195
REFERENCE   10 (bases 1 to 4111)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022315.1, AY032928.1,
            BC032058.1, AK057334.1 and AY028896.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014550.3.
            
            Summary: The caspase recruitment domain (CARD) is a protein module
            that consists of 6 or 7 antiparallel alpha helices. It participates
            in apoptosis signaling through highly specific protein-protein
            homophilic interactions. Like several other CARD proteins, CARD10
            belongs to the membrane-associated guanylate kinase (MAGUK) family
            and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM
            603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028896.1, AY032928.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251973.10/ ENSP00000251973.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL022315.1         21565-21776         c
            213-1080            AY032928.1         1-868
            1081-1603           BC032058.1         494-1016
            1604-3009           AY032928.1         1392-2797
            3010-4110           AK057334.1         810-1910
            4111-4111           AY028896.1         3936-3936
FEATURES             Location/Qualifiers
     source          1..4111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4111
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /note="caspase recruitment domain family member 10"
                     /db_xref="GeneID:29775"
                     /db_xref="HGNC:HGNC:16422"
                     /db_xref="MIM:607209"
     exon            1..450
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3314
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /note="CARD-containing MAGUK 3 protein; Bcl10 binding
                     protein and activator of NFKB; carma 3; CARD-containing
                     MAGUK protein 3"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     10"
                     /protein_id="NP_055365.2"
                     /db_xref="CCDS:CCDS13948.1"
                     /db_xref="GeneID:29775"
                     /db_xref="HGNC:HGNC:16422"
                     /db_xref="MIM:607209"
                     /translation="MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNP
                     AKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEF
                     YYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQAR
                     GRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSE
                     EKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDN
                     VDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQE
                     LCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIE
                     KERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQ
                     LQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEE
                     ATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGL
                     SSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFY
                     GDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSL
                     MDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYK
                     RRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALD
                     QLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLA
                     PRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQES
                     VGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQC
                     RGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSS
                     EA"
     exon            451..588
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            589..914
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1124
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1280
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1406
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1598
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1733
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1849
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1878
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2002
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2162
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2274
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2518
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2588
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2691
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2850
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2966
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3079
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..4111
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4091..4096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /note="hexamer: ATTAAA"
     polyA_site      4111
                     /gene="CARD10"
                     /gene_synonym="BIMP1; CARMA3; IMD89"
                     /note="major polyA site"
ORIGIN      
        1 accgcccccc tgcgccggcg gagccgccgc ccgagtgcgg acccgggagc ccgaggcgac
       61 tgtagcgtgc ggggtgagtc gcggggagct cggggcgcgc ccccgacggc gggtctgcgg
      121 acgacgcccc gggggtgctt ggccgcacat ctagccctag ggagccctgg tcgacccccg
      181 tgcgcctctt gcccgcagac cctgaggaca cggccatgcc gggccgggcg gaggcggggg
      241 aggccgagga ggaggccggg gccggctcgg ggtctgaggc ggaggaggac gcgctgtggg
      301 agcgaatcga gggcgtccgg catcggctgg ctcgcgccct gaacccggcc aagctcacgc
      361 cgtatctgcg ccagtgccgg gtcatcgacg agcaggacga ggaggaggtg ctgagcacct
      421 accgcttccc gtgccgcgtc aaccgcaccg ggcgcctgat ggacatcttg cgctgccgtg
      481 gcaagagggg ctatgaggcc ttcctggaag ccctggagtt ctactacccc gaacacttca
      541 cgctgctcac gggccaggaa cccgcccagc gctgctccat gatcctcgat gaggaggggc
      601 ctgagggcct gacccaattc ttgatgacag aggtgcgacg gctgcgggaa gctcgcaaga
      661 gccagctgca gcgggagcag caactgcagg cccggggccg ggtgctcgag gaggagcggg
      721 cagggctgga gcagcggctg cgggaccagc agcaggctca ggagcgctgt caacggctgc
      781 gggaggactg ggaggcgggc agcctggagc tgctgcggct caaggatgag aactacatga
      841 tcgccatgcg cctggcacag ctcagtgagg agaagaactc ggctgtactt cgcagccgtg
      901 acctgcagct ggcggtggat cagctcaagc tcaaagtgag tcggctggag gaagagtgtg
      961 cactgcttcg aagggccagg ggcccgcccc ctggggcaga ggagaaggag aaggagaagg
     1021 agaaggagaa ggagccagac aatgtggacc ttgtctctga gctgcgtgct gagaaccagc
     1081 ggctgacggc gtcactgcgg gagttgcagg agggcctgca gcaggaggcg agccggccgg
     1141 gggccccggg ctccgagcgc atcctgctgg acatcctaga gcatgactgg cgggaggcgc
     1201 aggacagcag gcaggagctg tgccagaagc tgcatgccgt gcagggggag ctgcagtggg
     1261 ccgaggagct gcgcgaccag tacctgcagg agatggaaga cctgcggctc aagcaccgca
     1321 cgctgcagaa ggactgtgac ctgtacaagc accgcatggc cactgtcctg gcccaactgg
     1381 aggagattga gaaggagcga gaccaggcca tccagagccg tgaccggatc cagttgcagt
     1441 actcacagag cctcatcgag aaggaccagt accgcaagca ggtgcggggc ctggaggcgg
     1501 agcgggatga gctgctgaca acgctcacca gcctggaggg caccaaggct ctgctggagg
     1561 ttcagctgca gcgggcccag ggtggcacct gcctcaaggc ctgtgcctcc tcccattccc
     1621 tgtgctccaa cctcagcagc acttggagcc tgagcgagtt cccctcccct ctgggaggcc
     1681 cagaagcaac tggggaggca gctgtcatgg ggggacctga gcctcacaac tcggaggaag
     1741 ccacagacag tgaaaaggag atcaatcggc tctccatcct gcccttcccc cccagtgccg
     1801 gctccatcct ccgccggcag cgtgaggaag accccgcacc ccctaagaga tccttcagca
     1861 gcatgtcaga catcacaggg agtgtgacac ttaagccctg gtcccctggc ctctcttcgt
     1921 cctcatcctc tgacagcgtg tggcctttgg gaaagccgga aggcctcctg gctcggggct
     1981 gtggcctgga cttcctcaac aggtctctgg ctattcgggt gtctggccgg agccccccag
     2041 ggggcccaga gccgcaggac aagggaccag atggactgtc gttttatggg gacagatggt
     2101 ctggggctgt ggtgcgcagg gtgctgtctg ggcctgggtc cgccaggatg gaaccaagag
     2161 agcaaagggt ggaagctgct ggtctggagg gggcgtgcct ggaagccgag gcccagcaga
     2221 gaaccttgct ctggaatcag gggtccacac tcccctccct gatggactcg aaggcctgcc
     2281 agtccttcca cgaggcccta gaagcctggg caaagggacc aggtgccgag cccttctaca
     2341 ttcgtgccaa cctcaccttg cctgagaggg cagatcccca tgccctttgc gtgaaagccc
     2401 aagagatcct tcgactggtg gactcggcat acaagcggag gcaggaatgg ttctgcaccc
     2461 gggttgaccc cctcactctg cgggacctgg accggggcac cgtgcccaat tatcagagag
     2521 cccagcagct cctagaagtt caggagaaat gcctgccctc cagccggcac cgaggccccc
     2581 gcagtaatct gaagaagaga gccctggacc agctgcggct ggtgaggccc aagcccgtgg
     2641 gggcgcctgc aggggactcc ccggatcagc tgctgctgga gccctgtgca gagccggagc
     2701 ggagcctcag accctacagt ttggtgcggc cgctactggt gtctgccctg cggcccgtgg
     2761 tgctgttgcc tgagtgcctg gcgccccggc tcatccgtaa cctgctagac ctgcccagct
     2821 cccggctgga cttccaagtg tgcccagcgg aaagcctctc tggggaggaa ctgtgcccat
     2881 cctcagcgcc tggagccccc aaggctcagc ctgccacccc tgggctaggc agcaggatcc
     2941 gggccatcca ggagtctgtt gggaagaagc actgcctgct ggagctgggt gctcggggtg
     3001 tgcgggagct ggtgcagaac gagatctacc ccatcgtcat ccacgtggag gtgactgaga
     3061 agaatgtccg ggaagtcagg ggtctgctgg gccggccggg ctggcgggac tcagagctgc
     3121 tgcggcagtg ccgtggctca gagcaggtgc tctgggggct gccctgctcc tgggtgcagg
     3181 tgcccgccca tgagtgggga cacgcagagg agctggccaa ggtggtgcgc ggccgcatcc
     3241 tgcaggagca ggcccgcctc gtgtgggtgg agtgcggcag cagcagaggc tgccccagca
     3301 gcagtgaggc ctgaggctca tctgatacct gcaccttctc cccaagccag cgtggaccct
     3361 ggtgtctatg gtgaagctgg gccctcccac cctgagcctt cctagaccct tggactctca
     3421 gatgcagggc ccttggctct ggcctctcac ccccaaggct gtctctggcc ctgccgagcc
     3481 tatgggagtc ccgggacaga gtgcccactc ccctctactt gctgctctgg gcctccccac
     3541 ctttcctggg gtctccacat tcccactagt gggtcttatg tgtgtctgtg tcttctcctt
     3601 aaacactcgc cctggagtct gttctcacac ctgtgcgcag gtttgcacac tcaagttctc
     3661 atgggcaggc tcaggtctgt cccgctgccc tgggcacgag gtctcctgag gacctgggcc
     3721 tgttctgctc ctaggagacc tgagcccgtt accgcgtgac tcccaccatc cagctcgcgc
     3781 tcctcgtgga ttcagccatg catggactgg ggtgttccct ggcccatggt cacctgtgcc
     3841 cctcgtgtct cctcacatgg gtgtctgtgg ttctctcctg tgtaaatgtc acgccccacc
     3901 cctgtttcat gtgggcacta acacgtgtgc gttcctggcg ggcacactca ggaccgtgcc
     3961 tcacagggcc cactccctgc ctatgcctcc ctcttggggg gccgaggagg gcggctgctc
     4021 tgtcatgaga atgtacggcc cgtggatgat taacgggcct ttttcactta gaagctgcac
     4081 attatggagc attaaacact tttgtcatag a
//
