LOCUS       NM_004930               1675 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens capping actin protein of muscle Z-line subunit beta
            (CAPZB), transcript variant 1, mRNA.
ACCESSION   NM_004930
VERSION     NM_004930.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Wang,D., Ye,Z., Wei,W., Yu,J., Huang,L., Zhang,H. and Yue,J.
  TITLE     Capping protein regulates endosomal trafficking by controlling
            F-actin density around endocytic vesicles and recruiting RAB5
            effectors
  JOURNAL   Elife 10, e65910 (2021)
   PUBMED   34796874
  REMARK    GeneRIF: Capping protein regulates endosomal trafficking by
            controlling F-actin density around endocytic vesicles and
            recruiting RAB5 effectors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Wells,C.D., Fawcett,J.P., Traweger,A., Yamanaka,Y., Goudreault,M.,
            Elder,K., Kulkarni,S., Gish,G., Virag,C., Lim,C., Colwill,K.,
            Starostine,A., Metalnikov,P. and Pawson,T.
  TITLE     A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity
            proteins in epithelial cells
  JOURNAL   Cell 125 (3), 535-548 (2006)
   PUBMED   16678097
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Yang,C., Pring,M., Wear,M.A., Huang,M., Cooper,J.A., Svitkina,T.M.
            and Zigmond,S.H.
  TITLE     Mammalian CARMIL inhibits actin filament capping by capping protein
  JOURNAL   Dev Cell 9 (2), 209-221 (2005)
   PUBMED   16054028
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Olavesen,M.G., Bentley,E., Mason,R.V., Stephens,R.J. and
            Ragoussis,J.
  TITLE     Fine mapping of 39 ESTs on human chromosome 6p23-p25
  JOURNAL   Genomics 46 (2), 303-306 (1997)
   PUBMED   9417921
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Kuhlman,P.A. and Fowler,V.M.
  TITLE     Purification and characterization of an alpha 1 beta 2 isoform of
            CapZ from human erythrocytes: cytosolic location and inability to
            bind to Mg2+ ghosts suggest that erythrocyte actin filaments are
            capped by adducin
  JOURNAL   Biochemistry 36 (44), 13461-13472 (1997)
   PUBMED   9354614
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Vertebrates have conserved capping protein alpha isoforms with
            specific expression patterns
  JOURNAL   Cell Motil Cytoskeleton 38 (2), 120-132 (1997)
   PUBMED   9331217
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Barron-Casella,E.A., Torres,M.A., Scherer,S.W., Heng,H.H.,
            Tsui,L.C. and Casella,J.F.
  TITLE     Sequence analysis and chromosomal localization of human Cap Z.
            Conserved residues within the actin-binding domain may link Cap Z
            to gelsolin/severin and profilin protein families
  JOURNAL   J Biol Chem 270 (37), 21472-21479 (1995)
   PUBMED   7665558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY021163.1, BC107752.1,
            BC008095.1 and BQ773230.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004930.4.
            
            Summary: This gene encodes the beta subunit of the barbed-end actin
            binding protein, which belongs to the F-actin capping protein
            family. The capping protein is a heterodimeric actin capping
            protein that blocks actin filament assembly and disassembly at the
            fast growing (barbed) filament ends and functions in regulating
            actin filament dynamics as well as in stabilizing actin filament
            lengths in muscle and nonmuscle cells. A pseudogene of this gene is
            located on the long arm of chromosome 2. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            found.[provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.352082.1,
                                           SRR3476690.1160401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264202.8/ ENSP00000264202.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                HY021163.1         105-156
            53-1090             BC107752.1         1-1038
            1091-1671           BC008095.1         416-996
            1672-1675           BQ773230.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1675
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:832"
                     /db_xref="HGNC:HGNC:1491"
                     /db_xref="MIM:601572"
     exon            1..104
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..920
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-actin-capping protein subunit beta; capZ beta;
                     epididymis secretory sperm binding protein; capping
                     protein (actin filament) muscle Z-line, beta; capping
                     actin protein of muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 1"
                     /protein_id="NP_004921.1"
                     /db_xref="CCDS:CCDS41277.1"
                     /db_xref="GeneID:832"
                     /db_xref="HGNC:HGNC:1491"
                     /db_xref="MIM:601572"
                     /translation="MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVD
                     QPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANN
                     AFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKS
                     SGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE
                     DMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC"
     exon            105..194
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            195..316
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            317..430
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            431..572
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            573..689
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            690..755
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            756..832
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1675
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="major polyA site"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="hexamer: AAGAAA"
     polyA_site      1347
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
     regulatory      1637..1642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="hexamer: AAGAAA"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
                     /note="hexamer: AATAAA"
     polyA_site      1657
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
     polyA_site      1675
                     /gene="CAPZB"
                     /gene_synonym="CAPB; CAPPB; CAPZ"
ORIGIN      
        1 atgttcactc ctgggcaccc ggggaagtgg aagcgccggg ccctgctgcg ggggggagag
       61 ccactgacgc cgggaccggg accgccgccg ccgccgccac catgagtgat cagcagctgg
      121 actgtgcctt ggacctaatg aggcgcctgc ctccccagca aatcgagaaa aacctcagcg
      181 acctgatcga cctggtcccc agtctatgtg aggatctcct gtcttctgtt gaccagccac
      241 tgaaaattgc cagagacaag gtggtgggaa aggattacct tttgtgtgac tacaacagag
      301 atggggactc ctataggtca ccatggagta acaagtatga ccctcccttg gaggatgggg
      361 ccatgccgtc agctcggctg agaaagctgg aggtggaagc caacaatgcc tttgaccagt
      421 atcgagacct gtattttgaa ggtggcgtct catctgtcta cctctgggat ctggatcatg
      481 gctttgctgg agtgatcctc ataaagaagg ctggagatgg atcaaagaag atcaaaggct
      541 gctgggattc catccacgtg gtagaagtgc aggagaaatc cagcggtcgc accgcccatt
      601 acaagttgac ctccacggtg atgctgtggc tgcagaccaa caaatctggc tctggcacca
      661 tgaacctcgg aggcagcctt accagacaga tggagaagga tgaaactgtg agtgactgct
      721 ccccacacat agccaacatc gggcgcctgg tagaggacat ggaaaataaa atcagaagta
      781 cgctgaacga gatctacttt ggaaaaacaa aggatatcgt caatgggctg aggtctgtgc
      841 agacttttgc agacaaatca aaacaagaag ctctgaagaa tgacctggtg gaggctttga
      901 agagaaagca gcaatgctaa acctctgttt catgctaacc agacacgccg tgcactcgtt
      961 agattccttt cttagaaaac tcgttttctg ctcccttccc tcgtcccttc cctccccgac
     1021 aggtcacata acagctgcat cattgaccgc acagcgccat ctctccctga gaataaagcc
     1081 gatagccacc ctcctccggc tccgagcctg cttctgccac acctcgctct cagttctctc
     1141 cacatttcca tagagaccgt gtggtttttg ttcacccggg ccccccgtct tcctccctgt
     1201 ccccccattt ataggcataa aatccactgt ctgccagcct cccttccctc ccaccttttt
     1261 ggtacattgg tgtaaaaaat gtaaaacaaa aaaattttat gaactaactg tggtgtgtga
     1321 aagagagaag aaaaactgga aatcttattc cgtgtgtgtt tgggagttgc ttggggttgg
     1381 gggtcgtggg gacaggggac agctctggga gcagaggtgg ccctcggtgc cgtcctgcgc
     1441 agactctccc gtcccacgga ggccgcgggg tgggggctgg ggggggtgcc gccgaccgtt
     1501 ccgctcttcc ggccaggtgc ttttctgtca atttctatgg aatgcaaaag gaggtttttg
     1561 ttttattttg tttttttgta aagcttaaga aaaaaatcta catcttatac ttgagcctcc
     1621 atacttaaaa aaagaaaaga aaagaaatca ataaaaagaa actggggcgc agtta
//
