LOCUS       NM_033328               1070 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens capping actin protein of muscle Z-line subunit alpha 3
            (CAPZA3), mRNA.
ACCESSION   NM_033328
VERSION     NM_033328.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Kim,H.N., Roh,S.J., Sung,Y.A., Chung,H.W., Lee,J.Y., Cho,J.,
            Shin,H. and Kim,H.L.
  TITLE     Genome-wide association study of the five-factor model of
            personality in young Korean women
  JOURNAL   J Hum Genet 58 (10), 667-674 (2013)
   PUBMED   23903073
  REMARK    Erratum:[J Hum Genet. 2015 Aug;60(8):463. doi:
            10.1038/jhg.2015.67.. PMID: 26303433]
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Miyagawa,Y., Tanaka,H., Iguchi,N., Kitamura,K., Nakamura,Y.,
            Takahashi,T., Matsumiya,K., Okuyama,A. and Nishimune,Y.
  TITLE     Molecular cloning and characterization of the human orthologue of
            male germ cell-specific actin capping protein alpha3 (cpalpha3)
  JOURNAL   Mol Hum Reprod 8 (6), 531-539 (2002)
   PUBMED   12029070
  REMARK    GeneRIF: Capping protein alpha3 may play a physiologically
            important role in sperm architecture as well as in fertility of the
            human male.
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Yoshimura,Y., Tanaka,H., Nozaki,M., Yomogida,K., Shimamura,K.,
            Yasunaga,T. and Nishimune,Y.
  TITLE     Genomic analysis of male germ cell-specific actin capping protein
            alpha
  JOURNAL   Gene 237 (1), 193-199 (1999)
   PUBMED   10524250
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Tanaka,H., Yoshimura,Y., Nishina,Y., Nozaki,M., Nojima,H. and
            Nishimune,Y.
  TITLE     Isolation and characterization of cDNA clones specifically
            expressed in testicular germ cells
  JOURNAL   FEBS Lett 355 (1), 4-10 (1994)
   PUBMED   7957958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG772483.1 and AB053259.1.
            
            On May 17, 2019 this sequence version replaced NM_033328.2.
            
            Summary: This gene encodes an actin capping protein, one of the
            F-actin capping protein alpha subunit family. The encoded protein
            is predominantly localized to the neck region of ejaculated sperm,
            other immunohistochemical signals were found in the tail and
            postacrosomal regions. The encoded protein may also form
            heterodimers of alpha and beta subunits. This protein may be
            important in determining sperm architecture and male fertility.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: GQ472212.1, BC016745.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317658.5/ ENSP00000326238.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BG772483.1         18-36
            20-1070             AB053259.1         3-1053
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..1070
                     /gene="CAPZA3"
                     /gene_synonym="CAPPA3; Gsg3; HEL-S-86"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 3"
                     /db_xref="GeneID:93661"
                     /db_xref="HGNC:HGNC:24205"
                     /db_xref="MIM:608722"
     exon            1..1070
                     /gene="CAPZA3"
                     /gene_synonym="CAPPA3; Gsg3; HEL-S-86"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1050
                     /gene="CAPZA3"
                     /gene_synonym="CAPPA3; Gsg3; HEL-S-86"
                     /note="CapZ alpha-3; F-actin capping protein alpha-3
                     subunit; CP-alpha-3; germ cell-specific protein 3; capping
                     protein (actin filament) muscle Z-line, alpha 3;
                     epididymis secretory protein Li 86; testis tissue
                     sperm-binding protein Li 73n; capping actin protein of
                     muscle Z-line alpha subunit 3"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-3"
                     /protein_id="NP_201585.1"
                     /db_xref="CCDS:CCDS8681.1"
                     /db_xref="GeneID:93661"
                     /db_xref="HGNC:HGNC:24205"
                     /db_xref="MIM:608722"
                     /translation="MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLM
                     HHQGECAGHQHCQKYSVPLCIDGNPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLK
                     DIQSHGIIQNEAEYLRVVLLCALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNY
                     ETGECWNGLWKSKWIFQVNPFLTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQ
                     AQLALSFARLVEEQENKFQAAVLEELQELSNEALRKILRRDLPVTRTLIDWHRILSDL
                     NLVMYPKLGYVIYSRSVLCNWII"
     regulatory      1046..1051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZA3"
                     /gene_synonym="CAPPA3; Gsg3; HEL-S-86"
                     /note="hexamer: TATAAA"
     polyA_site      1070
                     /gene="CAPZA3"
                     /gene_synonym="CAPPA3; Gsg3; HEL-S-86"
                     /note="major polyA site"
ORIGIN      
        1 agaccttgcc agactgcctg ctttcatgga tagacataaa aaccttcagc ttgaatgtta
       61 acaccttgat gggaaaggtg gctcatggaa tgttttctta tcctttgaac actcctcatt
      121 tcagaagctt tgcttctgtt gcaaccaaac atgacactta gcgtgctgag caggaaggac
      181 aaggaaagag taattcgcag actgttatta caggcccctc caggggaatt tgtaaatgcc
      241 tttgatgatc tctgtctgct tatccgtgat gaaaaactta tgcaccacca aggtgagtgt
      301 gcaggccacc aacactgcca aaaatattct gtaccactct gcatcgatgg aaatccagta
      361 ctcttgtctc accacaatgt aatgggcgac taccgatttt ttgaccatca aagcaaactt
      421 tctttcaaat atgacctgct tcaaaatcag ctgaaagaca tccaaagtca tggtatcatt
      481 cagaatgagg cagaatacct gagagttgtt cttctgtgcg ccttaaaact gtatgtgaat
      541 gaccactatc caaaaggaaa ttgcaacatg ctgagaaaaa ctgtcaaaag taaggagtac
      601 ttgatagctt gcattgaaga tcacaactat gaaacaggag agtgctggaa cggactttgg
      661 aaatctaaat ggattttcca agttaaccca tttctaaccc aagtaacggg aagaatattt
      721 gtgcaagctc acttcttcag gtgtgtcaac cttcatattg aaatatccaa ggacctgaaa
      781 gaaagcttgg aaatagttaa ccaagctcaa ctggctctaa gttttgcaag gcttgtggaa
      841 gagcaagaga acaaatttca agctgcagtc ttggaagaat tacaggagtt atccaatgaa
      901 gccctgagaa aaattctacg aagggatctt ccagtgaccc gcactcttat tgactggcac
      961 aggatactct ctgacttgaa tctggtgatg tatcctaaat taggatatgt catttattca
     1021 agaagtgtgt tgtgcaactg gataatataa agaattgctc ctggtaacta
//
