LOCUS       NM_006135               2358 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens capping actin protein of muscle Z-line subunit alpha 1
            (CAPZA1), mRNA.
ACCESSION   NM_006135
VERSION     NM_006135.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Zhang,C., Wei,G., Zhu,X., Chen,X., Ma,X., Hu,P., Liu,W., Yang,W.,
            Ruan,T., Zhang,W., Wu,C. and Tao,K.
  TITLE     Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric
            Cancer by Targeting the miR-589/CAPZA1 Axis
  JOURNAL   Int J Nanomedicine 18, 127-142 (2023)
   PUBMED   36643863
  REMARK    GeneRIF: Exosome-Delivered circSTAU2 Inhibits the Progression of
            Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Wang,D., Ye,Z., Wei,W., Yu,J., Huang,L., Zhang,H. and Yue,J.
  TITLE     Capping protein regulates endosomal trafficking by controlling
            F-actin density around endocytic vesicles and recruiting RAB5
            effectors
  JOURNAL   Elife 10, e65910 (2021)
   PUBMED   34796874
  REMARK    GeneRIF: Capping protein regulates endosomal trafficking by
            controlling F-actin density around endocytic vesicles and
            recruiting RAB5 effectors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Funk,J., Merino,F., Schaks,M., Rottner,K., Raunser,S. and
            Bieling,P.
  TITLE     A barbed end interference mechanism reveals how capping protein
            promotes nucleation in branched actin networks
  JOURNAL   Nat Commun 12 (1), 5329 (2021)
   PUBMED   34504078
  REMARK    GeneRIF: A barbed end interference mechanism reveals how capping
            protein promotes nucleation in branched actin networks.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Mapping of the mouse actin capping protein alpha subunit genes and
            pseudogenes
  JOURNAL   Genomics 39 (3), 264-270 (1997)
   PUBMED   9119363
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Vertebrates have conserved capping protein alpha isoforms with
            specific expression patterns
  JOURNAL   Cell Motil Cytoskeleton 38 (2), 120-132 (1997)
   PUBMED   9331217
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   Maun,N.A., Speicher,D.W., DiNubile,M.J. and Southwick,F.S.
  TITLE     Purification and properties of a Ca(2+)-independent barbed-end
            actin filament capping protein, CapZ, from human polymorphonuclear
            leukocytes
  JOURNAL   Biochemistry 35 (11), 3518-3524 (1996)
   PUBMED   8639502
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Barron-Casella,E.A., Torres,M.A., Scherer,S.W., Heng,H.H.,
            Tsui,L.C. and Casella,J.F.
  TITLE     Sequence analysis and chromosomal localization of human Cap Z.
            Conserved residues within the actin-binding domain may link Cap Z
            to gelsolin/severin and profilin protein families
  JOURNAL   J Biol Chem 270 (37), 21472-21479 (1995)
   PUBMED   7665558
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000144.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006135.2.
            
            Summary: CAPZA1 is a member of the F-actin capping protein alpha
            subunit family. This gene encodes the alpha subunit of the
            barbed-end actin binding protein.  The protein regulates growth of
            the actin filament by capping the barbed end of growing actin
            filaments. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648738.1, SRR1803613.213307.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263168.4/ ENSP00000263168.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2358              BC000144.1         5-2362
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..2358
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 1"
                     /db_xref="GeneID:829"
                     /db_xref="HGNC:HGNC:1488"
                     /db_xref="MIM:601580"
     exon            1..52
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..874
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /note="Cap Z; capZ alpha-1; capping protein (actin
                     filament) muscle Z-line, alpha 1; capping actin protein of
                     muscle Z-line alpha subunit 1"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-1"
                     /protein_id="NP_006126.1"
                     /db_xref="CCDS:CCDS30805.1"
                     /db_xref="GeneID:829"
                     /db_xref="HGNC:HGNC:1488"
                     /db_xref="MIM:601580"
                     /translation="MADFDDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDN
                     LLREGAAHAFAQYNMDQFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLR
                     KEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIES
                     HQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTV
                     SNEAQTAKEFIKIIENAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILS
                     YKIGKEMQNA"
     exon            53..116
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..168
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..232
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..439
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..519
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..598
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..670
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..733
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..2358
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /note="hexamer: AATATA"
     polyA_site      2358
                     /gene="CAPZA1"
                     /gene_synonym="CAPPA1; CAPZ; CAZ1"
                     /note="major polyA site"
ORIGIN      
        1 agaacagccc aagatggccg acttcgatga tcgtgtgtcg gatgaggaga aggtacgcat
       61 agctgctaaa ttcatcactc atgcaccccc aggggaattt aatgaagtat tcaatgacgt
      121 tcggctacta cttaataatg acaatctcct cagggaaggg gcagcacatg catttgccca
      181 gtataacatg gatcagttca cgcctgtgaa gatagaagga tatgaagatc aggtcttaat
      241 tacagagcac ggtgacctgg gtaatagcag atttttagat ccaagaaaca aaatttcctt
      301 taaatttgac cacttacgga aagaagcaag tgacccccag ccagaagaag cagatggagg
      361 tctgaagtct tggagagaat cctgtgacag tgctttaaga gcctatgtga aagaccatta
      421 ttccaacggc ttctgtactg tttatgctaa aactatcgat gggcaacaga ctattattgc
      481 atgtattgaa agccaccagt ttcagcctaa aaacttctgg aatggtcgtt ggagatcaga
      541 gtggaagttc accatcacac cacctacagc ccaggtggtt ggcgtgctta agattcaggt
      601 tcactattat gaagatggca atgttcagtt ggttagtcat aaagatgtac aggattcact
      661 aactgtttcg aatgaagccc aaactgccaa ggagtttatt aaaatcatag agaatgcaga
      721 aaatgagtat cagacagcaa ttagtgaaaa ctatcaaaca atgtcagata ccacattcaa
      781 ggccttgcgc cggcagcttc cagttacccg caccaaaatc gactggaaca agatactcag
      841 ctacaagatt ggcaaagaaa tgcagaatgc ttaaaggctg aatgtaggat tcttcagtat
      901 gtggaaagac aaggattcaa cgtgtggtca tatgataaat aagtgattta taaacaagag
      961 tgatattttg ctagggcttt caaagttaac cggttttcta gcctcatgga atactgttga
     1021 acctatagcg ttgtcttgat tcttttgtgt tctctgcctt gtaattttct gttactgcta
     1081 tatctacgtg taaatctttt tttctttttt tttttttttt tttggttaat tctgccacat
     1141 ttaatgttgg tgagagagtg atctatccta atgacatttt actgtttaaa aaagtttcct
     1201 agccatgaag ccctgctact gatttagaca aggtattatg gtcattactt tgtaccccta
     1261 tccttccaag cacttctggt acttcagtcg tttttactga tccaccaaca cctaaagagg
     1321 ctatgctaca gtctctagct aaatggaaga cacattcatc cttctccctc tgactgcttt
     1381 gatcatcatt tattgcatct cataactaat tttctaaagt ttggattggg acttttcagg
     1441 tcctttttgg agggcaaagg aagtgccagc ttctctgggg aacttgtttt taaatccaaa
     1501 gacttgaacc acattccctg cacatgaaca tgtttgcttt tatcccttct ctcattgtct
     1561 ccttcccatc ttagtaccat tgtagttata aacatctgca ttttttagaa gcattttacc
     1621 catttatttt tttaaacatt caagaactgc tgacgtactg tggatgtaga gtataaaact
     1681 tgaaaaatgc agatgttgaa ggaataatag gtatcttgtg ctttaatact ttatggcagg
     1741 attgtactat aagcaaatga attaaacagc tatgtaaatc ataaagaaaa actaaaaatg
     1801 aaccaaagtg aaaggataac ttccaggcag tatctttcta ttgtaacctg ttatttaagg
     1861 aaatactagt gatttcttct aaataggatg taaaacttct ttcaaattac tcttcctcag
     1921 tcctgcctgc caagaactca agtgtaactg tgataaaata acctttccca ggtatattgg
     1981 caggtatgtg tgtaatctca gaatacacag gtgacataga tatgatatga caactggtaa
     2041 tggtggattc atttacattg tttacacttc tatgaccagg ccttaaggga aggtcagttt
     2101 tttaaaaaac caagtagtgt cttcctacct atctccagat acatgtcaaa aaaagaaagg
     2161 tgtttgtgct tccgttttgt ttctgctcag taatatagtc aagcaagttt gttccaggtg
     2221 acccattgag ctgtgtatgc atttttgttt atttcaataa aatatatttg tattatttgt
     2281 ccttcatact atccatccat accacactat cttctgtatc aggtagtcta atagaaatat
     2341 acctgttttg ttctaaaa
//
