LOCUS       NM_001042625             966 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcyphosine like (CAPSL), transcript variant 2, mRNA.
ACCESSION   NM_001042625
VERSION     NM_001042625.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Lindner,A., Marbach,F., Tschernitz,S., Ortner,C., Berneburg,M.,
            Felthaus,O., Prantl,L., Kye,M.J., Rappl,G., Altmuller,J.,
            Thiele,H., Schreml,S. and Schreml,J.
  TITLE     Calcyphosine-like (CAPSL) is regulated in Multiple Symmetric
            Lipomatosis and is involved in Adipogenesis
  JOURNAL   Sci Rep 9 (1), 8444 (2019)
   PUBMED   31186450
  REMARK    GeneRIF: Calcyphosine-like (CAPSL) is regulated in Multiple
            Symmetric Lipomatosis and is involved in Adipogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 966)
  AUTHORS   Santiago,J.L., Alizadeh,B.Z., Martinez,A., Espino,L., de la
            Calle,H., Fernandez-Arquero,M., Figueredo,M.A., de la Concha,E.G.,
            Roep,B.O., Koeleman,B.P. and Urcelay,E.
  TITLE     Study of the association between the CAPSL-IL7R locus and type 1
            diabetes
  JOURNAL   Diabetologia 51 (9), 1653-1658 (2008)
   PUBMED   18563381
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 966)
  AUTHORS   Todd,J.A., Walker,N.M., Cooper,J.D., Smyth,D.J., Downes,K.,
            Plagnol,V., Bailey,R., Nejentsev,S., Field,S.F., Payne,F.,
            Lowe,C.E., Szeszko,J.S., Hafler,J.P., Zeitels,L., Yang,J.H.,
            Vella,A., Nutland,S., Stevens,H.E., Schuilenburg,H., Coleman,G.,
            Maisuria,M., Meadows,W., Smink,L.J., Healy,B., Burren,O.S.,
            Lam,A.A., Ovington,N.R., Allen,J., Adlem,E., Leung,H.T.,
            Wallace,C., Howson,J.M., Guja,C., Ionescu-Tirgoviste,C.,
            Simmonds,M.J., Heward,J.M., Gough,S.C., Dunger,D.B., Wicker,L.S.
            and Clayton,D.G.
  CONSRTM   Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control
            Consortium
  TITLE     Robust associations of four new chromosome regions from genome-wide
            analyses of type 1 diabetes
  JOURNAL   Nat Genet 39 (7), 857-864 (2007)
   PUBMED   17554260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W25222.1, CD687387.1, BM975803.1 and AC112204.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001042625.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.263451.1,
                                           SRR5189652.103475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651391.1/ ENSP00000498465.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               W25222.1           15-201
            188-502             CD687387.1         193-507
            503-959             BM975803.1         16-472              c
            960-966             AC112204.2         114228-114234       c
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..966
                     /gene="CAPSL"
                     /note="calcyphosine like"
                     /db_xref="GeneID:133690"
                     /db_xref="HGNC:HGNC:28375"
                     /db_xref="MIM:618799"
     exon            1..82
                     /gene="CAPSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..709
                     /gene="CAPSL"
                     /codon_start=1
                     /product="calcyphosin-like protein"
                     /protein_id="NP_001036090.1"
                     /db_xref="CCDS:CCDS3912.2"
                     /db_xref="GeneID:133690"
                     /db_xref="HGNC:HGNC:28375"
                     /db_xref="MIM:618799"
                     /translation="MAGTARHDREMAIQAKKKLTTATDPIERLRLQCLARGSAGIKGL
                     GRVFRIMDDDNNRTLDFKEFMKGLNDYAVVMEKEEVEELFRRFDKDGNGTIDFNEFLL
                     TLRPPMSRARKEVIMQAFRKLDKTGDGVITIEDLREVYNAKHHPKYQNGEWSEEQVFR
                     KFLDNFDSPYDKDGLVTPEEFMNYYAGVSASIDTDVYFIIMMRTAWKL"
     exon            83..219
                     /gene="CAPSL"
                     /inference="alignment:Splign:2.1.0"
     exon            220..397
                     /gene="CAPSL"
                     /inference="alignment:Splign:2.1.0"
     exon            398..607
                     /gene="CAPSL"
                     /inference="alignment:Splign:2.1.0"
     exon            608..966
                     /gene="CAPSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPSL"
                     /note="hexamer: AATAAA"
     polyA_site      893
                     /gene="CAPSL"
                     /note="major polyA site"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPSL"
                     /note="hexamer: AATAAA"
     polyA_site      966
                     /gene="CAPSL"
ORIGIN      
        1 agggaccagt tttcctagat gcaggagaca gcgtccatag tttcagttcg aagcaactgg
       61 tggcaaaagg ttagcattta agatggcagg gacagcgcgc catgaccgag agatggcgat
      121 ccaggccaag aaaaagctca ccacggccac cgaccccatt gaaagactcc gactgcagtg
      181 cctggccagg ggctctgctg ggatcaaagg acttggcaga gtgtttagaa ttatggatga
      241 cgataataat cgaacccttg attttaaaga atttatgaaa gggttaaatg attatgctgt
      301 ggtcatggaa aaagaagagg tggaagaact tttccggagg tttgataaag atggaaatgg
      361 aacaatagac ttcaatgaat ttcttctcac attaagacct ccaatgtcca gagccagaaa
      421 agaggtaatc atgcaagctt ttagaaagtt agacaagact ggagatggtg ttataacaat
      481 cgaagacctt cgtgaagtat ataatgcaaa acaccaccca aagtaccaga atggggaatg
      541 gagtgaggaa caagtattta ggaaatttct ggataacttt gattcaccct atgacaaaga
      601 tggattggtg acccctgagg agttcatgaa ctactatgca ggtgtgagcg catccattga
      661 cactgatgtg tacttcatca tcatgatgag aaccgcctgg aagctttaag cacatgacct
      721 ggggaccagg ccctgggaca gccatgtggc tccaaatgac taaatgtcag ctcaaaaacc
      781 agaatcgtat ttgatttcac actcatccta atgttttttt ctgtgtcaaa atattgcatt
      841 ttctggggcc aaaaaacagg cagaaataaa agacattgag tagccaactg tgagtttgcc
      901 ttgcctaaga ctgtttcctt tgttctaaaa taggacttaa ataaaatgag ctctgtaaag
      961 ctccta
//
