LOCUS       NM_001355024            5072 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens calcyphosine 2 (CAPS2), transcript variant 6, mRNA.
ACCESSION   NM_001355024
VERSION     NM_001355024.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5072)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
REFERENCE   2  (bases 1 to 5072)
  AUTHORS   Wang,S., Chen,J.Z., Zhang,Z., Huang,Q., Gu,S., Ying,K., Xie,Y. and
            Mao,Y.
  TITLE     Cloning, characterization, and expression of calcyphosine 2, a
            novel human gene encoding an EF-hand Ca(2+)-binding protein
  JOURNAL   Biochem Biophys Res Commun 291 (2), 414-420 (2002)
   PUBMED   11846421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092552.10 and AC091534.7.
            
            On Nov 19, 2021 this sequence version replaced NM_001355024.3.
            
            Summary: Calcyphosine-2 is a calcium-binding protein with 2 EF-hand
            motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar
            2008].
            
            Sequence Note: s.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.151425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000699294.1/
                                                ENSP00000514274.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AC092552.10        1530-1987
            459-568             AC092552.10        5327-5436
            569-618             AC092552.10        6566-6615
            619-664             AC092552.10        8632-8677
            665-841             AC092552.10        10278-10454
            842-964             AC092552.10        15420-15542
            965-1032            AC092552.10        18939-19006
            1033-1152           AC092552.10        26978-27097
            1153-1227           AC092552.10        31943-32017
            1228-1323           AC092552.10        32888-32983
            1324-1417           AC092552.10        33074-33167
            1418-1536           AC092552.10        38487-38605
            1537-1613           AC092552.10        40034-40110
            1614-1768           AC092552.10        42079-42233
            1769-1829           AC092552.10        46774-46834
            1830-1888           AC091534.7         185518-185576       c
            1889-1985           AC091534.7         182808-182904       c
            1986-5072           AC091534.7         176536-179622       c
FEATURES             Location/Qualifiers
     source          1..5072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.1-q21.2"
     gene            1..5072
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /note="calcyphosine 2"
                     /db_xref="GeneID:84698"
                     /db_xref="HGNC:HGNC:16471"
                     /db_xref="MIM:607724"
     exon            1..458
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            459..568
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..2161
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /note="isoform 6 is encoded by transcript variant 6;
                     calcyphosphine 2; calcyphosin-2"
                     /codon_start=1
                     /product="calcyphosin-2 isoform 6"
                     /protein_id="NP_001341953.2"
                     /db_xref="CCDS:CCDS91727.1"
                     /db_xref="GeneID:84698"
                     /db_xref="HGNC:HGNC:16471"
                     /db_xref="MIM:607724"
                     /translation="MDLEVKGVAATSRSQIQPFFGRKKPLQQRWTSESWTNQNSCPPV
                     VPRLDLGSLVDSDDEDQNIIPENLPAPTDKCKLKYQQCKTEIKEGYKQYSQRNAENTK
                     SNVTHKQSPRNKIDEKCVQDEEANTDDLTTLDRKAILQQGYADNSCDKQQRARKLDAE
                     IVAAEKKKQIVAEQVMIDHLSRAVISDPEQNLAIEQKESDHILPDSKMTPLRFRKRTL
                     HETKIRTHSTLTENVLSHKLQFDGRIVSRNGRDACRELIGFFFTHDQSLTIYEYRQFG
                     KNRTNVLPFIQKSIYSHQCGRRKGKQYRLGDFYVGATLTFLSSDHLSLPESIKENTLL
                     KLRITNIDQIALDSLKTASMEQEDDIIIQETNDRLVFKAIQDVLKEKLHKRGVRILTG
                     LGKYFQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNGKVDYGEFK
                     RGIIGEMNEYRKSYVRKAFMKLDFNKSGSVPIINIRKCYCAKKHSQVISGHSTEEEIK
                     SSFLETLKVACSKSDEVSYGEFEDYYEGLSIGIVDDEDFVNILRTPWGI"
     exon            569..618
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            619..664
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            665..841
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            842..964
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1032
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1152
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1227
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1323
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1417
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1536
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1613
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1768
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1888
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1985
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..5072
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5046..5051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /note="hexamer: AATAAA"
     polyA_site      5072
                     /gene="CAPS2"
                     /gene_synonym="UG0636c06"
                     /note="major polyA site"
ORIGIN      
        1 gccggttccc tgggaggctg cggcggctgt agctgaggtt tcaccccttt gggttttcca
       61 gccagcaagt acttctgaga gcgtggcggg gtctccggcc acaagctcag ttccggtcag
      121 ccaggcagcg gaactgagga ggcagattgg cgggggcggg aggtggcgta gaacgaacaa
      181 gggacttggg ccgacgacct tttcgtccct ggaggtcaga gtgtaatcag aagccctgcg
      241 ctgcggcgcc tgttgccggg caacctgcag acgcgggcct ggactgtcta gactgtcctg
      301 tctaaagctt tctgaatgcg gtttttggag gaatcgcgct agtttatacc ttttccaact
      361 cttctaactc tggacctctt cttaccgagc ttgttaggtg aaatcaggct gactgtctct
      421 tgtgcccctc gcctgtcctg tccaggaatc ccagttagta tactgcatga taaacacagg
      481 aactcaaatg gatttagagg ttaaaggagt tgctgccact tctaggagcc aaattcagcc
      541 attctttgga agaaagaagc ctctacaaca aaggtggact tctgagtcat ggacaaacca
      601 gaattcttgc ccaccagtgg tcccacgact tgatttggga agccttgttg actctgatga
      661 tgaggatcag aacataatac ctgaaaattt gccagcacca acagacaaat gtaaactaaa
      721 atatcagcaa tgtaaaactg aaattaaaga gggctataag cagtatagtc agagaaatgc
      781 agaaaataca aaatcaaatg ttacacataa acagtctcca agaaacaaga tagatgaaaa
      841 gtgtgtgcaa gatgaagaag ccaacacaga tgaccttacg actctggata ggaaagccat
      901 cttacagcaa ggttatgcag acaactcttg cgataaacaa cagagggcaa gaaaattgga
      961 tgcagaaatt gtggctgcag agaagaagaa acagattgtt gcagagcaag tgatgataga
     1021 ccacttatct agggctgtca tcagtgatcc agagcaaaat ttagccattg agcaaaaaga
     1081 aagtgatcat atccttccag attcaaagat gacacctctt cgatttagaa aaagaacact
     1141 acatgaaaca aagataagaa ctcattctac attaactgaa aatgtgcttt ctcataaatt
     1201 acagtttgat ggtaggatcg tatcacgtaa tggacgtgat gcttgcagag agctcattgg
     1261 gttctttttc actcatgacc aatcccttac aatttatgaa tatcgacaat ttgggaaaaa
     1321 tagaacaaat gtgcttcctt ttattcaaaa aagcatttat agtcatcagt gtggacgaag
     1381 aaaaggaaaa caataccgac ttggtgattt ttatgttggt gcaaccttga catttttgag
     1441 ttctgatcat ctcagccttc cagaaagcat caaagaaaac acattactta aactccgaat
     1501 cacaaatatt gatcaaatag ctttggattc tctcaaaact gcttctatgg aacaggagga
     1561 tgatataatc attcaagaaa ccaatgatag gctggtcttc aaagcaattc aagatgtgct
     1621 aaaagaaaaa ctacataaaa gaggtgttcg tattttgact ggattgggaa aatattttca
     1681 acagttggac aaggaaggaa atggactttt agataaggca gattttaagc aagctctaaa
     1741 agtgtttcac ttagaagtgt ctgaaaagga ttttgagtct gcatggctaa ttctgaatga
     1801 caatggcaat ggcaaggttg attatggaga attcaaacgt ggtattattg gtgaaatgaa
     1861 tgaatacagg aaatcatatg ttcgaaaggc ctttatgaaa ctggatttca acaaaagtgg
     1921 cagtgtgcct attataaaca taagaaaatg ttactgtgca aagaagcatt ctcaagtaat
     1981 ttcaggccat tcaacagagg aagaaatcaa atcatccttt ctagaaacat taaaagttgc
     2041 ctgcagcaag tctgatgaag tgtcatatgg tgaatttgaa gattactatg aaggtttaag
     2101 tataggaata gtagatgatg aagactttgt taacatctta cgtactccat gggggattta
     2161 gtctttaata atacatatgt catcaacact aagcatttta ttggagagat gatatcaatg
     2221 taaaggatga tcaaacactg gaatatattt tcctaggact tcctttattc tggtttcttg
     2281 tttgtttgtt ttgttttgtt ttgttttctc aaaaatgttg aatttggaaa gagaactatc
     2341 cagaaagata gatgtagggg tgtgttagtg tttgtgcatg tgtatgcctg ttcacatgtc
     2401 cttacatttg taaagatatc tttttggttt attacttatc ttgcgtatat tttagaggtc
     2461 attttttatt aacttcagta ggaaagttac atctgcatca aacaatatgg caacatctat
     2521 ttattaacca agtttcctgt cctttcacat tgttttttgc tacctcttcc tcagaatata
     2581 tttgccacca tggtcaattt gataaattag aattgggccc aaagccagtg agataattca
     2641 atgtgttttt aacacatgaa aatattaaag gatatgcaag agaaattttt caagcagtgt
     2701 gattatagat gttttctgta tatagaatat ttcaaatgat ggaggtttac cccatgatgc
     2761 tcatttaaat actgacttgt cttttaaatc tgtcttctaa attatgtact gttgttggtt
     2821 aaatagagca caatgtagtt attctaatgc ccagttgtat ttgttctttt attctgcttt
     2881 ttaactgtaa tcctttttac cagcatacga ttgttattga gcaatatgaa agggaaatgt
     2941 tctttattaa aatcaataca ttatcttatt aaacaaagat cctaaaagta tattgttgca
     3001 tatatgaatc caaggaatag ttcagtaatt attgcctaaa atgtgaaagc atattttgta
     3061 tcctaaaatg aatgtatgat attctaaaca tctgttttag tataacaaac aattgaaaca
     3121 tttccttcta aatatatgtt atttaatagt tacatgtatt ataatcattc tttctaaatt
     3181 ctttgctagt catttcttcc tgggaataca gagaaaagag acaactttat gagttgtttt
     3241 caacttcata attttaaatt ttctatgtta atataacata aattagaaaa aataagtgat
     3301 tcaaaatgaa aatatttact ttgtagaata tgactttaga catatcactg tatccatcta
     3361 tacttggcag caacatgaga agtgtgatac atgtgaaccc aacaaattca aagttgcact
     3421 tttcaagatg tgagaaggta ctaaaactta atactaaaac atgagaggga aaatatgtgt
     3481 aaacctctag tgctattttc actggctaaa ttctttattt cttgattttt ttaaaaatta
     3541 ggttattaaa attaaaacaa tatgctagaa gacattttgg cagaaataag tctataacac
     3601 tatttttgtc acatatcttt ttcttggaaa aatttatcca actatagaca tcttaaaccc
     3661 tacaaattgt tcttgttaaa aatgactaat actgggggtg ctcaatatgc atatagtgtt
     3721 tttcattgat aatttttatt tagttcttaa gaaacctgtt cttaatgttg gcatgtcaca
     3781 tttttctgtt actataatca gaaaatgtat agtctgttat actgtaaaaa aaaaaaaaaa
     3841 gggaagctac ttttggaatg taacgtgtta acatgacagc atactcttag tattaatctt
     3901 aatcttccta acataagcat tcacatgtgg ttatttgtag gaaatagctc tatttatgag
     3961 attttttttg gtgtattttg ttagaattgg tgacacagta aatcattctg cttttggatt
     4021 tgcctgactg cctgcattct tctttgattt tggtatagta aaatctgtta tttagtgtta
     4081 aacttaataa aagagcattt aagagaagtg acatttcaaa catccacaac acaactgact
     4141 tttgaaatcc tatgcttaat agtctttgta attctaaaag accttttgaa aatgttaaaa
     4201 tattaaatta tatgttgtaa tgctgttaca tgaattttat agttatgtat attttataga
     4261 tctctatgtc tttgtaagtt acttgcttgt atgctatata attgctttct cagttaacca
     4321 tactgtttat ggaattgtat atactgattt ttctgttttt atattttaaa aataaaagtt
     4381 gagaatttta aggaaaaaca ttttattaaa aagacaaggt atattatata ggaattttaa
     4441 gctaactttt aatggaaagg acatacatat ttgcatgatg gagcaatcac attatagtta
     4501 aacatgtatg tccctgtttt aaattttata gtatataaat atatgtgcta atgaaccagc
     4561 gactctgcat agaggcagtc acttagagta attaataatc ttgatacagc tgtagatcat
     4621 atcttatttt acatattact tttgacttcc agtttaagtt gtttgttatc aagtatttca
     4681 ggagagaatt gtgtacatta ggctatgttt actgcagatt atgtaacatg cttttatgag
     4741 attatagttt gtagtgcttg caaatataaa acatgtaccc tgataaacta taatcactac
     4801 taggttgacc agcaaggaca aacatgaaaa tgcttaaaaa aaagaaagcg cttaaaacaa
     4861 agaaatagaa ggtaatgggc atatataaaa taagccaagc aagagaagag caaagacaat
     4921 ctgcagggtg gacatggatg tattcgtttc tgatcatgag aagaggctct tgtcatacat
     4981 atcgttccat ttttatttta aagttctata aacttctgag gtaaactgat ttcttggatg
     5041 tacttaataa agaataaatg tttcatattg ga
//
