LOCUS       NM_005898               5514 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript
            variant 1, mRNA.
ACCESSION   NM_005898
VERSION     NM_005898.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5514)
  AUTHORS   Qin,M., Fan,W., Chen,F., Ruan,K. and Liu,D.
  TITLE     Caprin1 Bridges PRMT1 to G3BP1 and Spaces Them to Ensure Proper
            Stress Granule Formation
  JOURNAL   J Mol Biol 436 (19), 168727 (2024)
   PUBMED   39079611
  REMARK    GeneRIF: Caprin1 Bridges PRMT1 to G3BP1 and Spaces Them to Ensure
            Proper Stress Granule Formation.
REFERENCE   2  (bases 1 to 5514)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5514)
  AUTHORS   Yang,W., Chen,H., Li,G., Zhang,T., Sui,Y., Liu,L., Hu,J., Wang,G.,
            Chen,H., Wang,Y., Li,X., Tan,H., Kong,R., Sun,B. and Li,L.
  TITLE     Caprin-1 influences autophagy-induced tumor growth and immune
            modulation in pancreatic cancer
  JOURNAL   J Transl Med 21 (1), 903 (2023)
   PUBMED   38082307
  REMARK    GeneRIF: Caprin-1 influences autophagy-induced tumor growth and
            immune modulation in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5514)
  AUTHORS   Kurhade,C., Kang,S., Biering,S.B., Hwang,S. and Randall,G.
  TITLE     CAPRIN1 Is Required for Control of Viral Replication Complexes by
            Interferon Gamma
  JOURNAL   mBio 14 (3), e0017223 (2023)
   PUBMED   37052473
  REMARK    GeneRIF: CAPRIN1 Is Required for Control of Viral Replication
            Complexes by Interferon Gamma.
REFERENCE   5  (bases 1 to 5514)
  AUTHORS   Schulte,T., Panas,M.D., Han,X., Williams,L., Kedersha,N.,
            Fleck,J.S., Tan,T.J.C., Dopico,X.C., Olsson,A., Morro,A.M.,
            Hanke,L., Nilvebrant,J., Giang,K.A., Nygren,P.A., Anderson,P.,
            Achour,A. and McInerney,G.M.
  TITLE     Caprin-1 binding to the critical stress granule protein G3BP1 is
            influenced by pH
  JOURNAL   Open Biol 13 (5), 220369 (2023)
   PUBMED   37161291
  REMARK    GeneRIF: Caprin-1 binding to the critical stress granule protein
            G3BP1 is influenced by pH.
REFERENCE   6  (bases 1 to 5514)
  AUTHORS   Katsafanas,G.C. and Moss,B.
  TITLE     Vaccinia virus intermediate stage transcription is complemented by
            Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and
            cytoplasmic activation/proliferation-associated protein (p137)
            individually or as a heterodimer
  JOURNAL   J Biol Chem 279 (50), 52210-52217 (2004)
   PUBMED   15471883
  REMARK    GeneRIF: involvement of cellular protein p137 in transcription of
            intermediate stage genes may regulate the transition between early
            and late phases of vaccinia virus replication
REFERENCE   7  (bases 1 to 5514)
  AUTHORS   Grill,B., Wilson,G.M., Zhang,K.X., Wang,B., Doyonnas,R.,
            Quadroni,M. and Schrader,J.W.
  TITLE     Activation/division of lymphocytes results in increased levels of
            cytoplasmic activation/proliferation-associated protein-1:
            prototype of a new family of proteins
  JOURNAL   J Immunol 172 (4), 2389-2400 (2004)
   PUBMED   14764709
  REMARK    GeneRIF: Homologous region-1 (HR-1) is a novel protein domain that
            has been identified near the N-terminus of human caprin-1; highly
            conserved in vertebrates and insects, it is also present in the
            human caprin-2 paralog.
REFERENCE   8  (bases 1 to 5514)
  AUTHORS   de Vries,H., Ruegsegger,U., Hubner,W., Friedlein,A., Langen,H. and
            Keller,W.
  TITLE     Human pre-mRNA cleavage factor II(m) contains homologs of yeast
            proteins and bridges two other cleavage factors
  JOURNAL   EMBO J 19 (21), 5895-5904 (2000)
   PUBMED   11060040
REFERENCE   9  (bases 1 to 5514)
  AUTHORS   Gessler,M., Klamt,B., Tsaoussidou,S., Ellis,J.A. and Luzio,J.P.
  TITLE     The gene encoding the GPI-anchored membrane protein p137GPI (M11S1)
            maps to human chromosome 11p13 and is highly conserved in the mouse
  JOURNAL   Genomics 32 (1), 169-170 (1996)
   PUBMED   8786113
REFERENCE   10 (bases 1 to 5514)
  AUTHORS   Ellis,J.A. and Luzio,J.P.
  TITLE     Identification and characterization of a novel protein (p137) which
            transcytoses bidirectionally in Caco-2 cells
  JOURNAL   J Biol Chem 270 (35), 20717-20723 (1995)
   PUBMED   7657653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090469.9.
            
            On Nov 23, 2018 this sequence version replaced NM_005898.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.81371.1,
                                           SRR1660809.169250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341394.9/ ENSP00000340329.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC090469.9         184467-184607       c
            142-357             AC090469.9         183702-183917       c
            358-420             AC090469.9         164550-164612       c
            421-507             AC090469.9         164351-164437       c
            508-746             AC090469.9         159864-160102       c
            747-829             AC090469.9         159696-159778       c
            830-967             AC090469.9         156573-156710       c
            968-1020            AC090469.9         153461-153513       c
            1021-1107           AC090469.9         153297-153383       c
            1108-1263           AC090469.9         150119-150274       c
            1264-1372           AC090469.9         149925-150033       c
            1373-1434           AC090469.9         146882-146943       c
            1435-1545           AC090469.9         146049-146159       c
            1546-1695           AC090469.9         145660-145809       c
            1696-1846           AC090469.9         144282-144432       c
            1847-2041           AC090469.9         139665-139859       c
            2042-2142           AC090469.9         139042-139142       c
            2143-2206           AC090469.9         138577-138640       c
            2207-5514           AC090469.9         133728-137035       c
FEATURES             Location/Qualifiers
     source          1..5514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..5514
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="cell cycle associated protein 1"
                     /db_xref="GeneID:4076"
                     /db_xref="HGNC:HGNC:6743"
                     /db_xref="MIM:601178"
     exon            1..141
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2271
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GPI-anchored membrane protein 1; cytoplasmic
                     activation/proliferation-associated protein-1;
                     GPI-anchored protein p137; RNA granule protein 105;
                     activation/proliferation-associated protein 1; caprin 1;
                     GPI-p137; membrane component chromosome 11 surface marker
                     1; cytoplasmic activation- and proliferation-associated
                     protein 1"
                     /codon_start=1
                     /product="caprin-1 isoform 1"
                     /protein_id="NP_005889.3"
                     /db_xref="CCDS:CCDS31453.1"
                     /db_xref="GeneID:4076"
                     /db_xref="HGNC:HGNC:6743"
                     /db_xref="MIM:601178"
                     /translation="MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPAT
                     GTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEV
                     TNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLG
                     DDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLL
                     EGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAE
                     PEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAA
                     SPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSA
                     QPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQ
                     PSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINV
                     NAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQL
                     QTVVGTYHGSPDQSHQVTGNHQQPPQQNTGFPRSNQPYYNSRGVSRGGSRGARGLMNG
                     YRGPANGFRGGYDGYRPSFSNTPNSGYTQSQFSAPRDYSGYQRDGYQQNFKRGSGQSG
                     PRGAPRGRGGPPRPNRGMPQMNTQQVN"
     exon            142..357
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            358..420
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            421..507
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            508..746
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            747..829
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            830..967
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1020
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1107
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1263
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1372
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1434
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1545
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1695
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1846
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2041
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2142
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2206
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..5514
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="hexamer: AATAAG"
     polyA_site      4061
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="major polyA site"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="hexamer: TATAAA"
     polyA_site      4839
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
     regulatory      4972..4977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="hexamer: ATTAAA"
     regulatory      4977..4982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="hexamer: AACAAA"
     polyA_site      4995
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
     polyA_site      5002
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
                     /note="hexamer: ATTAAA"
     polyA_site      5514
                     /gene="CAPRIN1"
                     /gene_synonym="CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1;
                     NEDLAAD; p137GPI; RNG105"
ORIGIN      
        1 cactaggagc ggctctcggt gcagcgggac agggcgaagc ggcctgcgcc cacggagcgc
       61 gcgacactgc ccggaaggga ccaccaccct tgccccctca gctgcccact cgtgatttcc
      121 agcggcctcc gcgcgcgcac gatgccctcg gccaccagcc acagcgggag cggcagcaag
      181 tcgtccggac cgccaccgcc gtcgggttcc tccgggagtg aggcggccgc gggagccggg
      241 gccgccgcgc cggcttctca gcaccccgca accggcaccg gcgctgtcca gaccgaggcc
      301 atgaagcaga ttctcggggt gatcgacaag aaacttcgga acctggagaa gaaaaagggt
      361 aagcttgatg attaccagga acgaatgaac aaaggggaaa ggcttaatca agatcagctg
      421 gatgccgttt ctaagtacca ggaagtcaca aataatttgg agtttgcaaa agaattacag
      481 aggagtttca tggcactaag tcaagatatt cagaaaacaa taaagaagac agcacgtcgg
      541 gagcagctta tgagagaaga agctgaacag aaacgtttaa aaactgtact tgagctacag
      601 tatgttttgg acaaattggg agatgatgaa gtgcggactg acctgaaaca aggtttgaat
      661 ggagtgccaa tattgtccga agaggagttg tcattgttgg atgaattcta taagctagta
      721 gaccctgaac gggacatgag cttgaggttg aatgaacagt atgaacatgc ctccattcac
      781 ctgtgggacc tgctggaagg gaaggaaaaa cctgtatgtg gaaccaccta taaagttcta
      841 aaggaaattg ttgagcgtgt ttttcagtca aactactttg acagcaccca caaccaccag
      901 aatgggctgt gtgaggaaga agaggcagcc tcagcacctg cagttgaaga ccaggtacct
      961 gaagctgaac ctgagccagc agaagagtac actgagcaaa gtgaagttga atcaacagag
     1021 tatgtaaata gacagttcat ggcagaaaca cagttcacca gtggtgaaaa ggagcaggta
     1081 gatgagtgga cagttgaaac ggttgaggtg gtaaattcac tccagcagca acctcaggct
     1141 gcatcccctt cagtaccaga gccccactct ttgactccag tggctcaggc agatcccctt
     1201 gtgagaagac agcgagtaca agaccttatg gcacaaatgc agggtcccta taatttcata
     1261 caggattcaa tgctggattt tgaaaatcag acacttgatc ctgccattgt atctgcacag
     1321 cctatgaatc caacacaaaa catggacatg ccccagctgg tttgccctcc agttcattct
     1381 gaatctagac ttgctcagcc taatcaagtt cctgtacaac cagaagcgac acaggttcct
     1441 ttggtatcat ccacaagtga ggggtacaca gcatctcaac ccttgtacca gccttctcat
     1501 gctacagagc aacgaccaca gaaggaacca attgatcaga ttcaggcaac aatctcttta
     1561 aatacagacc agactacagc atcatcatcc cttcctgctg cgtctcagcc tcaagtattt
     1621 caggctggga caagcaaacc tttacatagc agtggaatca atgtaaatgc agctccattc
     1681 caatccatgc aaacggtgtt caatatgaat gccccagttc ctcctgttaa tgaaccagaa
     1741 actttaaaac agcaaaatca gtaccaggcc agttataacc agagcttttc tagtcagcct
     1801 caccaagtag aacaaacaga gcttcagcaa gaacagcttc aaacagtggt tggcacttac
     1861 catggttccc cagaccagtc ccatcaagtg actggtaacc accagcagcc tcctcagcag
     1921 aacactggat ttccacgtag caatcagccc tattacaata gtcgtggtgt gtctcgtgga
     1981 ggctcccgtg gtgctagagg cttgatgaat ggataccggg gccctgccaa tggattcaga
     2041 ggaggatatg atggttaccg cccttcattc tctaacactc caaacagtgg ttatacacag
     2101 tctcagttca gtgctccccg ggattactct ggctatcaac gggatggata tcagcagaat
     2161 ttcaagcgag gctctgggca gagtggacca cggggagccc cacgaggtcg tggagggccc
     2221 ccaagaccca acagagggat gccgcaaatg aacactcagc aagtgaatta atctgattca
     2281 caggattatg tttaatcgcc aaaaacacac tggccagtgt accataatat gttaccagaa
     2341 gagttattat ctatttgttc tccctttcag gaaacttatt gtaaagggac tgttttcatc
     2401 ccataaagac aggactacaa ttgtcagctt tctattacct ggatatggaa ggaaactatt
     2461 tttactctgc atgttctgtc ctaagcgtca tcttgagcct tgcacatgat actcagattc
     2521 ctcacccttg cttaggagta aaacaatata ctttacaggg tgataataat ctccatagtt
     2581 atttgaagtg gcttgaaaaa ggcaagattg acttttatga cattggataa aatctacaaa
     2641 tcagccctcg agttattcaa tgataactga caaactaaat tatttcccta gaaaggaaga
     2701 tgaaaggagt ggagtgtggt ttggcagaac aactgcattt cacagctttt ccagttaaat
     2761 tggagcactg aacgttcaga tgcataccaa attatgcatg ggtcctaatc acacatataa
     2821 ggctggctac cagctttgac acagcactgt tcatctggcc aaacaactgt ggttaaaaac
     2881 acatgtaaaa tgctttttaa cagctgatac tgtataagac aaagccaaga tgcaaaatta
     2941 ggctttgatt ggcacttttt gaaaaatatg caacaaatat gggatgtaat ccggatggcc
     3001 gcttctgtac ttaatgtgaa atatttagat acctttttga acacttaaca gtttctttga
     3061 gacaatgact tttgtaagga ttggtactat ctatcattcc ttatgacatg tacattgtct
     3121 gtcactaatc cttggatttt gctgtattgt cacctaaatt ggtacaggta ctgatgaaaa
     3181 tctctagtgg ataatcataa cactctcggt cacatgtttt tccttcagct tgaaagcttt
     3241 tttttaaaag gaaaagatac caaatgcctg ctgctaccac ccttttcaat tgctatcttt
     3301 tgaaaggcac cagtatgtgt tttagattga tttccctgtt tcagggaaat cacggacagt
     3361 agtttcagtt ctgatggtat aagcaaaaca aataaaacgt ttataaaagt tgtatcttga
     3421 aacactggtg ttcaacagct agcagcttat gtgattcacc ccatgccacg ttagtgtcac
     3481 aaattttatg gtttatctcc agcaacattt ctctagtact tgcacttatt atcttttgtc
     3541 taatttaacc ttaactgaat tctccgtttc tcctggaggc atttatattc agtgataatt
     3601 ccttccctta gatgcatagg gagagtctct aaatttgatg gaaatggaca cttgagtagt
     3661 gacttagcct tatgtactct gttggaattt gtgctagcag tttgagcact agttctgtgt
     3721 gcctaggaag ttaatgctgc ttattgtctc attctgactt catggagaat taatcccacc
     3781 tttaagcaaa ggctactaag ttaatggtat tttctgtgca gaaattaaat tttattttca
     3841 gcatttagcc caggaattct tccagtaggt gctcagctat ttaaaaacaa aactattctc
     3901 aaacattcat cattagacaa ctggagtttt tgctggtttt gtaacctacc aaaatggata
     3961 ggctgttgaa cattccacat tcaaaagttt tgtagggtgg tgggaaatgg gggatcttca
     4021 atgtttattt taaaataaaa taaaataagt tcttgacttt tctcatgtgt ggttgtggta
     4081 catcatattg gaagggttaa cctgttactt tggcaaatga gtattttttt gctagcacct
     4141 ccccttgcgt gctttaaatg acatctgcct gggatgtacc acaaccatat gttacctgta
     4201 tcttagggga atggataaaa tatttgtggt ttactgggta atccctagat gatgtatgct
     4261 tgcagtccta tataaaacta aatttgctat ctgtgtagaa aataatttca tgacatttac
     4321 aatcaggact gaagtaagtt cttcacacag tgacctctga atcagtttca gagaagggat
     4381 gggggagaaa atgccttcta ggttttgaac ttctatgcat tagtgcagat gttgtgaatg
     4441 tgtaaaggtg ttcatagttt gactgtttct atgtatgttt tttcaaagaa ttgttccttt
     4501 ttttgaacta taatttttct ttttttggtt attttaccat cacagtttaa atgtatatct
     4561 tttatgtctc tactcagacc atatttttaa aggggtgcct cattatgggg cagagaactt
     4621 ttcaataagt ctcattaaga tctgaatctt ggttctaagc attctgtata atatgtgatt
     4681 gcttgtccta gctgcagaag gccttttgtt tggtcaaatg catattttag cagagtttca
     4741 aggaaatgat tgtcacacat gtcactgtag cctcttggtg tagcaagctc acatacaaaa
     4801 tacttttgta tatgcataat ataaatcatc tcatgtggat atgaaacttc ttttttaaaa
     4861 cttaaaaagg tagaatgtta ttgattacct tgattagggc agttttattt ccagatccta
     4921 ataattccta aaaaatatgg aaaagttttt tttcaatcat tgtaccttga tattaaaaca
     4981 aatatccttt aagtatttct aatcagttag cttctacagt tcttttgtct ccttttatat
     5041 gcagctctta cgtgggagac ttttccactt aaaggagaca tagaatgtgt gcttattctc
     5101 agaaggttca ttaactgagg tgatgagtta acaactagtt gagcagtcag cttcctaagt
     5161 gttttaggac atttgttcat tatattttcc gtcatataac tagaggaagt ggaatgcaga
     5221 taagtgccga attcaaaccc ttcattttat gtttaagctc ctgaatctgc attccacttg
     5281 ggttgttttt aagcattcta aattttagtt gattataagt tagatttcac agaatcagta
     5341 ttgcccttga tcttgtcctt tttatggagt taacggggag gaagacccct caggaaaacg
     5401 aaagtaaatt gttaaggctc atcttcatac ctttttccat tttgaatcct acaaaaatac
     5461 tgcaaaagac tagtgaatgt ttaaaattac actagattaa ataatatgaa agtc
//
