LOCUS       NM_032330               1004 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calpain small subunit 2 (CAPNS2), mRNA.
ACCESSION   NM_032330
VERSION     NM_032330.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1004)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet 9 (2), e1003266 (2013)
   PUBMED   23408906
REFERENCE   3  (bases 1 to 1004)
  AUTHORS   Bralic,M. and Stemberga,V.
  TITLE     Calpain expression in the brain cortex after traumatic brain injury
  JOURNAL   Coll Antropol 36 (4), 1319-1323 (2012)
   PUBMED   23390828
  REMARK    GeneRIF: Our results indicate that prolonged calpain expression in
            resident brain cells (neurons, glial and endothelial cells) plays
            an important role in neuronal degeneration following traumatic
            brain injury.
REFERENCE   4  (bases 1 to 1004)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1004)
  AUTHORS   Hata,S., Doi,N., Kitamura,F. and Sorimachi,H.
  TITLE     Stomach-specific calpain, nCL-2/calpain 8, is active without
            calpain regulatory subunit and oligomerizes through C2-like domains
  JOURNAL   J Biol Chem 282 (38), 27847-27856 (2007)
   PUBMED   17646163
REFERENCE   6  (bases 1 to 1004)
  AUTHORS   Ma,H., Nakajima,E., Shih,M., Azuma,M. and Shearer,T.R.
  TITLE     Expression of calpain small subunit 2 in mammalian tissues
  JOURNAL   Curr Eye Res 29 (4-5), 337-347 (2004)
   PUBMED   15590481
REFERENCE   7  (bases 1 to 1004)
  AUTHORS   Schad,E., Farkas,A., Jekely,G., Tompa,P. and Friedrich,P.
  TITLE     A novel human small subunit of calpains
  JOURNAL   Biochem J 362 (Pt 2), 383-388 (2002)
   PUBMED   11853546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006000.1 and BC005397.1.
            
            On May 17, 2019 this sequence version replaced NM_032330.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC005397.1, BM914235.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457326.3/ ENSP00000400882.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-997               BC006000.1         13-1009
            998-1004            BC005397.1         998-1004
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..1004
                     /gene="CAPNS2"
                     /gene_synonym="CSS2"
                     /note="calpain small subunit 2"
                     /db_xref="GeneID:84290"
                     /db_xref="HGNC:HGNC:16371"
                     /db_xref="MIM:616767"
     exon            1..1004
                     /gene="CAPNS2"
                     /gene_synonym="CSS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..820
                     /gene="CAPNS2"
                     /gene_synonym="CSS2"
                     /EC_number="3.4.22.17"
                     /note="calcium-dependent protease small subunit 2"
                     /codon_start=1
                     /product="calpain small subunit 2"
                     /protein_id="NP_115706.1"
                     /db_xref="CCDS:CCDS54010.1"
                     /db_xref="GeneID:84290"
                     /db_xref="HGNC:HGNC:16371"
                     /db_xref="MIM:616767"
                     /translation="MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGI
                     VNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMN
                     ILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQ
                     YDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDA
                     MFRAFKSLDRDRDGLIQVSIKEWLQLTMYS"
     regulatory      980..985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPNS2"
                     /gene_synonym="CSS2"
                     /note="hexamer: ATTAAA"
     polyA_site      1004
                     /gene="CAPNS2"
                     /gene_synonym="CSS2"
                     /note="major polyA site"
ORIGIN      
        1 acttgaactc catttcatct tttttcatac catctctaag attgctgccg catttgcttg
       61 ttaaactgaa agcatgtttc ttgcaaaggc tctattggaa ggagcagatc gaggtcttgg
      121 agaagctctt ggaggcctct ttggaggagg tggtcagaga agagaaggag gaggaagaaa
      181 tattggaggg atagttggag gaattgtgaa ttttatcagt gaggctgcag cagctcagta
      241 tactccagaa ccgcctccca ctcagcagca tttcaccagt gtggaggcct cagaaagtga
      301 ggaagttagg cgatttcggc aacaatttac acagctggct ggaccagaca tggaggtggg
      361 tgccactgat ctgatgaata ttctcaacaa agtcctttct aagcacaaag atcttaagac
      421 tgacggtttt agtcttgaca cctgccggag cattgtgtct gtcatggaca gtgacacgac
      481 tggtaagctg ggctttgaag aatttaagta tctgtggaac aacatcaaga aatggcagtg
      541 tgtttataag cagtatgaca gggaccattc tgggtctctg ggaagttctc agctgcgggg
      601 agctctgcag gccgcaggct tccagctaaa tgaacaactt taccaaatga ttgtccgccg
      661 gtatgctaat gaagatggag atatggattt taacaatttc atcagctgct tggtccgcct
      721 ggatgccatg tttcgtgcct tcaagtctct ggatagagat agagatggcc tgattcaagt
      781 gtctatcaaa gaatggctgc agttgaccat gtattcctga agtgggaact gagaagtcaa
      841 gatcctccct ggaggacagg actgaaaacc ttgccaagct gtacacagtt gctgataccc
      901 tgtgcaacag ctctcatttc ctggcaagct ctttcacaac cctacatatt tctgatcatg
      961 tgctgccttt tactgctgaa ttaaaacaga tatttcacga aaaa
//
