LOCUS       NM_007058               2718 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens calpain 11 (CAPN11), mRNA.
ACCESSION   NM_007058
VERSION     NM_007058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2718)
  AUTHORS   Ben-Aharon,I., Brown,P.R., Shalgi,R. and Eddy,E.M.
  TITLE     Calpain 11 is unique to mouse spermatogenic cells
  JOURNAL   Mol Reprod Dev 73 (6), 767-773 (2006)
   PUBMED   16541461
  REMARK    GeneRIF: Characterization of a related mouse gene and comparison of
            the protein to the human protein.
REFERENCE   2  (bases 1 to 2718)
  AUTHORS   Dear,T.N., Moller,A. and Boehm,T.
  TITLE     CAPN11: A calpain with high mRNA levels in testis and located on
            chromosome 6
  JOURNAL   Genomics 59 (2), 243-247 (1999)
   PUBMED   10409436
REFERENCE   3  (bases 1 to 2718)
  AUTHORS   Rojas,F.J., Brush,M. and Moretti-Rojas,I.
  TITLE     Calpain-calpastatin: a novel, complete calcium-dependent protease
            system in human spermatozoa
  JOURNAL   Mol Hum Reprod 5 (6), 520-526 (1999)
   PUBMED   10340998
REFERENCE   4  (bases 1 to 2718)
  AUTHORS   Saido,T.C., Sorimachi,H. and Suzuki,K.
  TITLE     Calpain: new perspectives in molecular diversity and
            physiological-pathological involvement
  JOURNAL   FASEB J 8 (11), 814-822 (1994)
   PUBMED   8070630
  REMARK    Review article
REFERENCE   5  (bases 1 to 2718)
  AUTHORS   Melloni,E. and Pontremoli,S.
  TITLE     The calpains
  JOURNAL   Trends Neurosci 12 (11), 438-444 (1989)
   PUBMED   2479145
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB052011.1, BC033733.1 and
            AJ242832.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007058.3.
            
            Summary: Calpains constitute a family of intracellular
            calcium-dependent cysteine proteases. There are eight members in
            this superfamily. They consist of a variable 80 kDa subunit and an
            invariant 30 kDa subunit. This calpain protein appears to have
            protease activity and calcium-binding ability. A similar mouse
            protein may play a functional role in spermatogenesis and in the
            regulation of calcium-dependent signal transduction events during
            meiosis. [provided by RefSeq, Dec 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033733.1, AK314054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398776.2/ ENSP00000381758.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB052011.1         10-29
            21-1350             BC033733.1         1-1330
            1351-2344           AJ242832.1         1314-2307
            2345-2718           BC033733.1         2325-2698
FEATURES             Location/Qualifiers
     source          1..2718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2718
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /note="calpain 11"
                     /db_xref="GeneID:11131"
                     /db_xref="HGNC:HGNC:1478"
                     /db_xref="MIM:604822"
     exon            1..45
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2249
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /EC_number="3.4.22.17"
                     /note="calcium-activated neutral proteinase 11; CANP 11"
                     /codon_start=1
                     /product="calpain-11"
                     /protein_id="NP_008989.2"
                     /db_xref="CCDS:CCDS47436.1"
                     /db_xref="GeneID:11131"
                     /db_xref="HGNC:HGNC:1478"
                     /db_xref="MIM:604822"
                     /translation="MLYSPGPSLPESAESLDGSQEDKPRGSCAEPTFTDTGMVAHINN
                     SRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSK
                     NVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVP
                     RGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKA
                     YAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSI
                     EVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDS
                     AREWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHT
                     TFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQ
                     KNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREV
                     SSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSED
                     DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDK
                     DGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQ
                     VLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMWG"
     exon            46..117
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            118..368
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            369..438
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            439..557
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            558..691
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            692..860
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            861..944
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1030
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1105
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1266
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1445
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1457
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1669
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1709
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1775
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1833
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1898
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1967
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2046
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2163
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2222
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2718
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="CAPN11"
                     /gene_synonym="calpain11"
                     /note="major polyA site"
ORIGIN      
        1 aactgtcaag caccgagcta gccaccagca tgctgtactc cccagggccg agtcttccgg
       61 agtcagcaga gagcctggat ggatcacagg aggataagcc tcggggctca tgtgcggagc
      121 ccacttttac tgatacggga atggtggctc acataaacaa cagccggctc aaggccaagg
      181 gcgtgggcca gcacgacaac gcccagaact ttggtaacca gagctttgag gagctgcgag
      241 cagcctgtct aagaaagggg gagctcttcg aggacccctt attccctgct gaacccagct
      301 cactgggctt caaggacctg ggccccaact ccaaaaatgt gcagaacatc tcctggcagc
      361 ggcccaagga tatcataaac aaccctctat tcatcatgga tgggatttct ccaacagaca
      421 tctgccaggg gatcctcggg gactgctggc tgctggctgc catcggctcc cttaccacct
      481 gccccaaact gctataccgc gtggtgccca gaggacagag cttcaagaaa aactatgctg
      541 gcatcttcca ttttcagatt tggcagtttg gacagtgggt gaacgtggtg gtagatgacc
      601 ggctgcccac aaagaatgac aagctggtgt ttgtgcactc aaccgaacgc agtgagttct
      661 ggagtgccct gctggagaag gcgtatgcca agctgagtgg gtcctatgaa gcattgtcag
      721 ggggcagtac catggagggc cttgaggact tcacaggagg cgtggcccag agcttccaac
      781 tccagaggcc ccctcagaac ctgctcaggc tccttaggaa ggccgtggag cgatcctccc
      841 tcatgggttg ctccattgaa gtcaccagtg atagtgaact ggaatccatg actgacaaga
      901 tgctggtgag agggcacgct tactctgtga ctggccttca ggatgtccac tacagaggca
      961 aaatggaaac actgattcgg gtccggaatc cctggggccg gattgagtgg aatggagctt
     1021 ggagtgacag tgccagggag tgggaagagg tggcctcaga catccagatg cagctgctgc
     1081 acaagacgga ggacggggag ttctggatgt cctaccaaga tttcctgaac aacttcacgc
     1141 tcctggagat ctgcaacctc acgcctgata cactctctgg ggactacaag agctactggc
     1201 acaccacctt ctacgagggc agctggcgca gaggcagctc cgcagggggc tgcaggaacc
     1261 accctggcac gttctggacc aacccccagt ttaagatctc tcttcctgag ggggatgacc
     1321 cagaggatga cgcagagggc aatgttgtgg tctgcacctg cctggtggcc ctaatgcaga
     1381 agaactggcg gcatgcacgg cagcagggag cccagctgca gaccattggc tttgtcctct
     1441 acgcggtccc aaaagagttt cagaacattc aggatgtcca cttgaagaag gaattcttca
     1501 cgaagtatca ggaccacggc ttctcagaga tcttcaccaa ctcacgggag gtgagcagcc
     1561 aactccggct gcctccgggg gaatatatca ttattccctc cacctttgag ccacacagag
     1621 atgctgactt cctgcttcgg gtcttcaccg agaagcacag cgagtcatgg gaattggatg
     1681 aagtcaacta tgctgagcaa ctccaagagg aaaaggtctc tgaggatgac atggaccagg
     1741 acttcctaca tttgtttaag atagtggcag gagagggcaa ggagataggg gtgtatgagc
     1801 tccagaggct gctcaacagg atggccatca aattcaaaag cttcaagacc aagggctttg
     1861 gcctggatgc ttgccgctgc atgatcaacc tcatggataa agatggctct ggcaagctgg
     1921 ggcttctaga gttcaagatc ctgtggaaaa aactcaagaa atggatggac atcttcagag
     1981 agtgtgacca ggaccattca ggcaccttga actcctatga gatgcgcctg gttattgaga
     2041 aagcaggcat caagctgaac aacaaggtaa tgcaggtcct ggtggccagg tatgcagatg
     2101 atgacctgat catagacttt gacagcttca tcagctgttt cctgaggcta aagaccatgt
     2161 tcacattctt tctaaccatg gaccccaaga atactggcca tatttgcttg agcctggaac
     2221 agtggctgca gatgaccatg tggggataga ggcgctgtag gagcctggtc atctctacca
     2281 gcagcagcag cagcgaggtt ctagcccagg agggtggggt gcttcttgta gccctcagct
     2341 ctccggtctc tgctgatgaa atgggctcca ggtggcagtg cccgggtccc aggtgccgtg
     2401 tttactgcag cagtgggacc tccgtgccca ctcccccagc tcagaggctt tctctttttt
     2461 ccccaacccg gcttctgatg gctggctttc ccccaccatc gctctctcag agtatatttt
     2521 actaaagagt agttgatgct tccccagggt ccccctggct ggggaggcca agaataggga
     2581 agggacttgt agcccgtttc ttaccctcca tgcttgctgt cctgctcaca cctacctgct
     2641 gaccacccat cctggcacag cctctgtttt cctccccatc tgtggatact attctaataa
     2701 atagcacatg ccattggc
//
