LOCUS       NM_006366               2925 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclase associated actin cytoskeleton regulatory
            protein 2 (CAP2), transcript variant 1, mRNA.
ACCESSION   NM_006366
VERSION     NM_006366.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2925)
  AUTHORS   Li,X., Luo,M., Xu,H., Jia,L., Liang,Y., Xu,Q. and Wang,Y.
  TITLE     CAP2 contributes to Parkinson's disease diagnosed by neutrophil
            extracellular trap-related immune activity
  JOURNAL   Front Immunol 15, 1377409 (2024)
   PUBMED   38846945
  REMARK    GeneRIF: CAP2 contributes to Parkinson's disease diagnosed by
            neutrophil extracellular trap-related immune activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2925)
  AUTHORS   Pelucchi,S., Macchi,C., D'Andrea,L., Rossi,P.D., Speciani,M.C.,
            Stringhi,R., Ruscica,M., Arosio,B., Di Luca,M., Cesari,M.,
            Edefonti,V. and Marcello,E.
  TITLE     An association study of cyclase-associated protein 2 and frailty
  JOURNAL   Aging Cell 22 (9), e13918 (2023)
   PUBMED   37537790
  REMARK    GeneRIF: An association study of cyclase-associated protein 2 and
            frailty.
REFERENCE   3  (bases 1 to 2925)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2925)
  AUTHORS   Di Maio,A., De Rosa,A., Pelucchi,S., Garofalo,M., Marciano,B.,
            Nuzzo,T., Gardoni,F., Isidori,A.M., Di Luca,M., Errico,F., De
            Bartolomeis,A., Marcello,E. and Usiello,A.
  TITLE     Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes
            in Post-Mortem Brain of Schizophrenia, Parkinson's and Alzheimer's
            Disease Patients
  JOURNAL   Int J Mol Sci 23 (3), 1539 (2022)
   PUBMED   35163460
  REMARK    GeneRIF: Analysis of mRNA and Protein Levels of CAP2, DLG1 and
            ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson's and
            Alzheimer's Disease Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2925)
  AUTHORS   Yoon,S., Shin,B. and Woo,H.G.
  TITLE     Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting
            Epithelial-Mesenchymal Transition in Liver Cancer Cells
  JOURNAL   Mol Cells 44 (8), 569-579 (2021)
   PUBMED   34294609
  REMARK    GeneRIF: Endoplasmic Reticulum Stress Induces CAP2 Expression
            Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells.
REFERENCE   6  (bases 1 to 2925)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   7  (bases 1 to 2925)
  AUTHORS   Shibata,R., Mori,T., Du,W., Chuma,M., Gotoh,M., Shimazu,M.,
            Ueda,M., Hirohashi,S. and Sakamoto,M.
  TITLE     Overexpression of cyclase-associated protein 2 in multistage
            hepatocarcinogenesis
  JOURNAL   Clin Cancer Res 12 (18), 5363-5368 (2006)
   PUBMED   17000669
  REMARK    GeneRIF: CAP2 is up-regulated in human cancers and that is possibly
            related to multistage hepatocarcinogenesis.
REFERENCE   8  (bases 1 to 2925)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 2925)
  AUTHORS   Hubberstey,A., Yu,G., Loewith,R., Lakusta,C. and Young,D.
  TITLE     Mammalian CAP interacts with CAP, CAP2, and actin
  JOURNAL   J Cell Biochem 61 (3), 459-466 (1996)
   PUBMED   8761950
REFERENCE   10 (bases 1 to 2925)
  AUTHORS   Yu,G., Swiston,J. and Young,D.
  TITLE     Comparison of human CAP and CAP2, homologs of the yeast adenylyl
            cyclase-associated proteins
  JOURNAL   J Cell Sci 107 (Pt 6), 1671-1678 (1994)
   PUBMED   7962207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL832154.1, BC008481.1,
            AI928000.1 and BF791244.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006366.2.
            
            Summary: This gene was identified by its similarity to the gene for
            human adenylyl cyclase-associated protein. The function of the
            protein encoded by this gene is unknown. However, the protein
            appears to be able to interact with adenylyl cyclase-associated
            protein and actin. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.135347.1,
                                           SRR1660807.44434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229922.7/ ENSP00000229922.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-597               AL832154.1         2-598
            598-1289            BC008481.1         481-1172
            1290-1840           AI928000.1         1-551               c
            1841-2141           AL832154.1         1593-1893
            2142-2316           AL832154.1         1896-2070
            2317-2545           BF791244.1         231-459
            2546-2925           AL832154.1         2299-2678
FEATURES             Location/Qualifiers
     source          1..2925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..2925
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /note="cyclase associated actin cytoskeleton regulatory
                     protein 2"
                     /db_xref="GeneID:10486"
                     /db_xref="HGNC:HGNC:20039"
                     /db_xref="MIM:618385"
     exon            1..152
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            153..274
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1587
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2810452G09Rik; adenylyl cyclase-associated protein 2; CAP
                     2; CAP, adenylate cyclase-associated protein, 2"
                     /codon_start=1
                     /product="adenylyl cyclase-associated protein 2 isoform 1"
                     /protein_id="NP_006357.1"
                     /db_xref="CCDS:CCDS4539.1"
                     /db_xref="GeneID:10486"
                     /db_xref="HGNC:HGNC:20039"
                     /db_xref="MIM:618385"
                     /translation="MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAP
                     SVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHEND
                     VAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMN
                     DAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVAST
                     VSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKG
                     LRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRV
                     EYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIV
                     EVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDY
                     REFPIPEQFKTAWDGSKLITEPAEIMA"
     exon            275..375
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            376..453
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            454..597
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            598..683
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            684..789
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            790..979
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1155
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1279
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1362
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1503
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2925
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /note="hexamer: AGTAAA"
     polyA_site      2925
                     /gene="CAP2"
                     /gene_synonym="CMD2I"
                     /note="major polyA site"
ORIGIN      
        1 gactctcccc tggagcagcg tgactgacac cggctcctat tcagctggga ggagggagag
       61 gggaggagaa ggggagggcc gcgggaggag ggtacgagtg gccgaccacg gatttgcatt
      121 gccgaggacg ggaccccagg gcagcgaagc agaatggcca acatgcaggg actggtggaa
      181 agactggaac gagctgtcag ccgcctggag tcgctgtctg cagagtccca caggccccct
      241 gggaactgcg gggaagtcaa tggtgtcatt gcaggtgtgg caccctccgt ggaagccttt
      301 gacaagctga tggacagtat ggtggccgag tttttaaaga acagtaggat ccttgctggg
      361 gacgtggaga cccatgcaga aatggtgcac agtgctttcc aggcccagcg ggctttcctt
      421 ctgatggcct ctcagtacca acaaccccac gagaatgacg tggccgcact tctgaaaccc
      481 atatcggaaa agattcagga aatccaaact ttcagagaga gaaaccgggg gagtaacatg
      541 tttaatcatc tttcggccgt cagcgaaagc atccctgccc ttggatggat agctgtgtct
      601 cccaaacctg gtccttatgt caaggagatg aatgacgctg ccacctttta cactaacagg
      661 gtcttaaagg actacaaaca cagtgatttg cgtcatgtgg attgggtgaa gtcatatttg
      721 aacatttgga gtgaacttca agcatacatc aaggaacacc acaccacggg cctcacatgg
      781 agcaaaacag gtcctgtagc atccacagta tcagcgtttt ctgtcctctc ctctgggcct
      841 ggccttcctc caccccctcc tcctctgcct cctccagggc cacctccact tttcgagaat
      901 gaaggcaaaa aagaggaatc ttctccttca cgctcagctt tatttgccca acttaaccag
      961 ggagaagcaa ttacaaaagg gctccgccat gtcacagatg accagaagac atacaaaaat
     1021 cccagcctgc gggctcaagg agggcaaact caatctccca ccaaaagtca cactccaagt
     1081 cccacatctc ctaaatctta tccttctcaa aaacatgccc cagtgttgga gttggaagga
     1141 aagaaatgga gagtggagta ccaagaggac aggaatgacc ttgtgatttc agagactgag
     1201 ctgaaacaag tggcttacat tttcaaatgc gaaaaatcaa ctattcagat aaaagggaaa
     1261 gtaaactcca ttataattga caactgtaaa aaactcggcc tggtgtttga caatgtggtg
     1321 ggcattgtgg aagtgatcaa ctcccaggac attcaaatcc aggtaatggg gagagtgcca
     1381 acaatttcca ttaataagac agaaggttgc cacatatacc tcagtgaaga tgcattagac
     1441 tgtgagatcg tgagcgccaa gtcatctgaa atgaacatac ttatccctca ggatggtgat
     1501 tatagagaat ttcccattcc tgaacagttc aagacagcat gggatggatc caagttaatc
     1561 actgaacctg cagaaattat ggcctaactt cctgagagac cgaaccccct cacctgaatc
     1621 cccctctatc aaacaaacaa aaaagcagca gtaaagagct agaagttgca gtagccccta
     1681 ctgctttagc tttggcctcc aacgattctg tgctatagat acagcactgt ttctggcacg
     1741 cctcgtgggc attttgaaat atttaacgtt tcctcatgat ttgcctttgt gtgtgatttt
     1801 agttccacat gatgacttgt gaacattagg gatttaaagg aaaaaaaaaa agaattctgt
     1861 tcccctcata tcatgaacac agtaactgat aggtaaaaag actgcatgat tcacttttac
     1921 acttatattt cattgctagt taaaaaataa aacctttgag aatctaagat gtacattttt
     1981 accttttagg caatttcaat ataatgtaga agtagtagtg tgccctgaaa aatgtacacg
     2041 ttttttctta ttgttaccac atgttcacct ttatcagcgt ggatactgtc agcatgagta
     2101 catatttcaa cccacgcttg taaaagacat aagagtttat aaaggaccaa attcagttcc
     2161 ttggtccttg gaagacctat attctctgta gttactgaaa accgaaagtc aattctaatt
     2221 attcatctta catatttttc caccatgtca tttgaaaact tgcttttctt ctgcataaga
     2281 gattcttatg ccaaaaacat taaacagaag aaatcatttt ttttgctatg taatacctcg
     2341 caactttgct ctaaaatcaa gctcagttat tattttccaa gtttgaacat gttaaatatc
     2401 agatgccttg taaattatgt ctttaacgtt ttcttataga ctaatttcct cttttccacc
     2461 tgccagactt gctaaccaag ctcgaaaatg aacatgaaaa agccatacat gtattatttc
     2521 tcctaaaacc taaggcatta tctgttggtt tggcttgctg ctcctatttt gtagtcttga
     2581 tagtagatgc ttcttcagcg taagagtagc tatgatattc ctttttatct tttcagtaca
     2641 tagtgctgaa aaatctgcaa cttcttggat catatttaat gaattatagt ataatgcttg
     2701 caggcccagt acaagcatat atattgtgcc tcttacagcc tttggaatac attgtttcca
     2761 ttttttaaat atcttctata tccatatagt attcaaatta ttaatgctca tgtaccaagg
     2821 ttttgctata aaagttttgt ctgtatgaat aatgtggctt tagtaaataa tcatttttca
     2881 actgtaaact tattctgaaa taaagtaaaa ttctaattgt ttaaa
//
