LOCUS       NM_006367               2626 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cyclase associated actin cytoskeleton regulatory
            protein 1 (CAP1), transcript variant 1, mRNA.
ACCESSION   NM_006367
VERSION     NM_006367.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Zeng,J., Li,X., Liang,L., Duan,H., Xie,S. and Wang,C.
  TITLE     Phosphorylation of CAP1 regulates lung cancer proliferation,
            migration, and invasion
  JOURNAL   J Cancer Res Clin Oncol 148 (1), 137-153 (2022)
   PUBMED   34636991
  REMARK    GeneRIF: Phosphorylation of CAP1 regulates lung cancer
            proliferation, migration, and invasion.
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Kakurina,G.V., Cheremisina,O.V., Sereda,E.E., Kolegova,E.S.,
            Kondakova,I.V. and Choinzonov,E.L.
  TITLE     Serum levels of cytoskeleton remodeling proteins and their mRNA
            expression in tumor tissue of metastatic laryngeal and
            hypopharyngeal cancers
  JOURNAL   Mol Biol Rep 48 (6), 5135-5142 (2021)
   PUBMED   34231097
  REMARK    GeneRIF: Serum levels of cytoskeleton remodeling proteins and their
            mRNA expression in tumor tissue of metastatic laryngeal and
            hypopharyngeal cancers.
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Moriyama,K. and Yahara,I.
  TITLE     Human CAP1 is a key factor in the recycling of cofilin and actin
            for rapid actin turnover
  JOURNAL   J Cell Sci 115 (Pt 8), 1591-1601 (2002)
   PUBMED   11950878
  REMARK    GeneRIF: plays a key role in speeding up the turnover of actin
            filaments by effectively recycling cofilin and actin and through
            its effect on both ends of actin filament
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Hubberstey,A., Yu,G., Loewith,R., Lakusta,C. and Young,D.
  TITLE     Mammalian CAP interacts with CAP, CAP2, and actin
  JOURNAL   J Cell Biochem 61 (3), 459-466 (1996)
   PUBMED   8761950
REFERENCE   9  (bases 1 to 2626)
  AUTHORS   Yu,G., Swiston,J. and Young,D.
  TITLE     Comparison of human CAP and CAP2, homologs of the yeast adenylyl
            cyclase-associated proteins
  JOURNAL   J Cell Sci 107 (Pt 6), 1671-1678 (1994)
   PUBMED   7962207
REFERENCE   10 (bases 1 to 2626)
  AUTHORS   Matviw,H., Yu,G. and Young,D.
  TITLE     Identification of a human cDNA encoding a protein that is
            structurally and functionally related to the yeast adenylyl
            cyclase-associated CAP proteins
  JOURNAL   Mol Cell Biol 12 (11), 5033-5040 (1992)
   PUBMED   1406678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512599.33.
            
            On May 21, 2020 this sequence version replaced NM_006367.3.
            
            Summary: The protein encoded by this gene is related to the S.
            cerevisiae CAP protein, which is involved in the cyclic AMP
            pathway. The human protein is able to interact with other molecules
            of the same protein, as well as with CAP2 and actin. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2, and 4-10 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013963.2, SRR11853565.690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372805.8/ ENSP00000361891.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL512599.33        3719-3791
            74-195              AL512599.33        22327-22448
            196-299             AL512599.33        23057-23160
            300-377             AL512599.33        24725-24802
            378-521             AL512599.33        27217-27360
            522-607             AL512599.33        27464-27549
            608-713             AL512599.33        29205-29310
            714-891             AL512599.33        30530-30707
            892-1076            AL512599.33        32680-32864
            1077-1200           AL512599.33        33149-33272
            1201-1283           AL512599.33        33420-33502
            1284-1427           AL512599.33        33826-33969
            1428-2626           AL512599.33        34440-35638
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..2626
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /note="cyclase associated actin cytoskeleton regulatory
                     protein 1"
                     /db_xref="GeneID:10487"
                     /db_xref="HGNC:HGNC:20040"
                     /db_xref="MIM:617801"
     exon            1..73
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            74..195
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1511
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /note="isoform a is encoded by transcript variant 1;
                     adenylyl cyclase-associated protein 1; testis secretory
                     sperm-binding protein Li 218p; CAP, adenylate
                     cyclase-associated protein 1; adenylate cyclase associated
                     protein 1"
                     /codon_start=1
                     /product="adenylyl cyclase-associated protein 1 isoform a"
                     /protein_id="NP_006358.2"
                     /db_xref="CCDS:CCDS41309.1"
                     /db_xref="GeneID:10487"
                     /db_xref="HGNC:HGNC:20040"
                     /db_xref="MIM:617801"
                     /translation="MADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYV
                     QAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLS
                     DLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDA
                     AMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELS
                     GLPSGPSAGSCPPPPPPCPPPPPVSTISCSYESASRSSLFAQINQGESITHALKHVSD
                     DMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEPAVLELEGKKWRVENQ
                     ENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEII
                     NSKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNE
                     FPVPEQFKTLWNGQKLVTTVTEIAG"
     exon            196..299
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            300..377
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            378..521
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            522..607
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            608..713
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            714..891
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1076
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1200
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1283
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1427
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2626
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /note="hexamer: AATAAA"
     polyA_site      2596
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
     regulatory      2605..2610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="CAP1"
                     /gene_synonym="CAP; CAP1-PEN"
                     /note="major polyA site"
ORIGIN      
        1 gagattgctg ggcggttctt gccggaagcg gagagcggct gatcgcagtc cggaggtgag
       61 gcggaactct gaggtggtcc attatggctg acatgcaaaa tctggtagaa agattggaga
      121 gggcagtggg ccgcctggag gcagtatctc atacctctga catgcaccgt gggtatgcag
      181 acagtccttc aaaagcagga gcagctccat atgtgcaggc atttgactcg ctgcttgctg
      241 gtcctgtggc agagtacttg aagatcagta aagagattgg gggagacgtg cagaaacatg
      301 cggagatggt ccacacaggt ttgaagttgg agcgagctct gttggttaca gcttctcagt
      361 gtcaacagcc agcagaaaat aagctttccg atttgttggc acccatctca gagcagatca
      421 aagaagtgat aacctttcgg gagaagaacc gaggcagcaa gttgtttaat cacctgtcag
      481 ctgtcagcga aagtatccag gccctgggct gggtggctat ggctcccaag cctggccctt
      541 atgtgaaaga aatgaatgat gccgccatgt tttatacaaa ccgagtcctc aaagagtaca
      601 aagatgtgga taagaagcat gtagactggg tcaaagctta tttaagtata tggacagagc
      661 tgcaggctta cattaaggag ttccatacca ccggactggc ctggagcaaa acggggcctg
      721 tggcaaaaga actgagcgga ctgccatctg gaccctctgc cggatcatgt cctcctcccc
      781 ctccaccatg cccccctcct cccccagtct ctaccatttc atgctcatat gagtctgctt
      841 cccgctcatc actgttcgcg cagattaatc agggggagag cattacacat gccctgaaac
      901 atgtatctga tgacatgaag actcacaaga accctgccct gaaggctcag agtggtccag
      961 tacgcagtgg ccccaaacca ttctctgcac ctaaacccca aaccagccca tcccccaaac
     1021 gagccacaaa gaaggagcca gctgtacttg aactggaggg caagaagtgg agagtggaaa
     1081 atcaggaaaa tgtttccaac ctggtgattg aggacacaga gctgaaacag gtggcttaca
     1141 tatacaagtg tgtcaacacg acattgcaaa tcaagggcaa aattaactcc attacagtag
     1201 ataactgtaa gaaacttggc ctggtattcg atgacgtggt gggcattgtg gagataatca
     1261 acagtaagga tgtcaaagtt caggtaatgg gtaaagtgcc aaccatatcc atcaacaaaa
     1321 cagatggctg ccatgcttac ctgagcaaga attccctgga ttgtgaaata gtcagtgcca
     1381 aatcttccga gatgaatgtc ctcattccta cagaaggcgg tgactttaat gaattcccag
     1441 ttcctgagca gttcaagacc ctatggaacg ggcagaagtt ggtcaccaca gtgacagaaa
     1501 ttgctggata agcgaagtgc cactgggttc tttgccctcc cttcacacca tgggataaat
     1561 ctgtatcaag acggttcttt tctagatttc ctctaccttt ttgctcttaa aactgcttct
     1621 ctgctctgag aagcacagct acctgccttc actgaaatat acctcaggct gaaatttggg
     1681 gtgggatagc aggtcagttg atcttctgca ggaaggtgca gcttttccat atcagctcaa
     1741 ccacgccgcc agtccattct taaggaactg ccgactagga ctgatgatgc attttagctt
     1801 tgagcttttg ggggttattc taccaacaaa cagtccattg gaaagaaaac agtccctgga
     1861 attaacagat cagaatgttc acactggtta atcttttttt aacaatgagc atgaaggtag
     1921 cagaagctgg tgtgtttcca gatggttctt ctaaccaaac taatttttca ctgttgacaa
     1981 gcgaggcaag ggttgcactg gaccaaaggc tgaggcttgg ccatctagca ttccatacaa
     2041 aattgtttcc tataagcatt ccttttattc tctattctat cctgggtctg cctcaaccgt
     2101 gagataggag agtctctggt actagctgct gtagcagtgc ccttcatcca gggcagttaa
     2161 tggagtcttg gaccctttct ttctctggga tccctgccca gcaccttcct atagagatga
     2221 ctttaaaagg aaaaaaaaaa aaaaaaaaac ccacatgatt tcaaggagtc tggcattcct
     2281 gaatccttct tccctgccag gtgcctgtca cctgtcttca ctgcctcctt ttccctgtca
     2341 tgctcatcag cttatggctt ctgtctaagc acctgaacag aggactgaaa cctccactgc
     2401 aggctggttt taggtcttga attatgtaag aatcttgcac agcactgcta atgtaaattt
     2461 cagttgtttt tccctctagg acaaacactt accaaaatat gcaacttttt tttggtggga
     2521 agagagattg tcctgtgatt tctacccatt tcctgaggcc tgtggaaata aacctttatg
     2581 tacttaaagt tatacagaaa atagaataaa gttaatacca aacttg
//
