LOCUS       NM_001746               4915 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calnexin (CANX), transcript variant 1, mRNA.
ACCESSION   NM_001746
VERSION     NM_001746.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4915)
  AUTHORS   Ye,Y., Zhang,J., Guo,Y., Zhu,J., Tang,B. and Fan,P.
  TITLE     PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting
            the CANX/NOX4 signaling pathway
  JOURNAL   Immun Inflamm Dis 11 (2), e765 (2023)
   PUBMED   36840500
  REMARK    GeneRIF: PON2 ameliorates Ang II-induced cardiomyocyte injury by
            targeting the CANX/NOX4 signaling pathway.
REFERENCE   2  (bases 1 to 4915)
  AUTHORS   Yan,G., Li,X., Zheng,Z., Gao,W., Chen,C., Wang,X., Cheng,Z., Yu,J.,
            Zou,G., Farooq,M.Z., Zhu,X., Zhu,W., Zhong,Q. and Yan,X.
  TITLE     KAT7-mediated CANX (calnexin) crotonylation regulates
            leucine-stimulated MTORC1 activity
  JOURNAL   Autophagy 18 (12), 2799-2816 (2022)
   PUBMED   35266843
  REMARK    GeneRIF: KAT7-mediated CANX (calnexin) crotonylation regulates
            leucine-stimulated MTORC1 activity.
REFERENCE   3  (bases 1 to 4915)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4915)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4915)
  AUTHORS   Watanabe,A., Mizoguchi,I., Hasegawa,H., Katahira,Y., Inoue,S.,
            Sakamoto,E., Furusaka,Y., Sekine,A., Miyakawa,S., Murakami,F.,
            Xu,M., Yoneto,T. and Yoshimoto,T.
  TITLE     A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under
            Inflammatory Conditions
  JOURNAL   Front Immunol 12, 757669 (2021)
   PUBMED   34603342
  REMARK    GeneRIF: A Chaperone-Like Role for EBI3 in Collaboration With
            Calnexin Under Inflammatory Conditions.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4915)
  AUTHORS   Lenter,M. and Vestweber,D.
  TITLE     The integrin chains beta 1 and alpha 6 associate with the chaperone
            calnexin prior to integrin assembly
  JOURNAL   J Biol Chem 269 (16), 12263-12268 (1994)
   PUBMED   8163531
REFERENCE   7  (bases 1 to 4915)
  AUTHORS   Tjoelker,L.W., Seyfried,C.E., Eddy,R.L. Jr., Byers,M.G.,
            Shows,T.B., Calderon,J., Schreiber,R.B. and Gray,P.W.
  TITLE     Human, mouse, and rat calnexin cDNA cloning: identification of
            potential calcium binding motifs and gene localization to human
            chromosome 5
  JOURNAL   Biochemistry 33 (11), 3229-3236 (1994)
   PUBMED   8136357
REFERENCE   8  (bases 1 to 4915)
  AUTHORS   Honore,B., Rasmussen,H.H., Celis,A., Leffers,H., Madsen,P. and
            Celis,J.E.
  TITLE     The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin
            exhibit strikingly different levels in quiescent keratinocytes as
            compared to their proliferating normal and transformed
            counterparts: cDNA cloning and expression of calnexin
  JOURNAL   Electrophoresis 15 (3-4), 482-490 (1994)
   PUBMED   8055875
REFERENCE   9  (bases 1 to 4915)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 4915)
  AUTHORS   Galvin,K., Krishna,S., Ponchel,F., Frohlich,M., Cummings,D.E.,
            Carlson,R., Wands,J.R., Isselbacher,K.J., Pillai,S. and Ozturk,M.
  TITLE     The major histocompatibility complex class I antigen-binding
            protein p88 is the product of the calnexin gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8452-8456 (1992)
   PUBMED   1326756
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113426.2 and BC003552.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001746.3.
            
            Summary: This gene encodes a member of the calnexin family of
            molecular chaperones. The encoded protein is a calcium-binding,
            endoplasmic reticulum (ER)-associated protein that interacts
            transiently with newly synthesized N-linked glycoproteins,
            facilitating protein folding and assembly. It may also play a
            central role in the quality control of protein folding by retaining
            incorrectly folded protein subunits within the ER for degradation.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jun 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.181014.1,
                                           SRR1660805.126186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247461.9/ ENSP00000247461.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC113426.2         88326-88353
            29-2191             BC003552.1         1-2163
            2192-4915           AC113426.2         118277-121000
FEATURES             Location/Qualifiers
     source          1..4915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..4915
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="calnexin"
                     /db_xref="GeneID:821"
                     /db_xref="HGNC:HGNC:1473"
                     /db_xref="MIM:114217"
     exon            1..136
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            137..310
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1918
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="isoform d precursor is encoded by transcript
                     variant 1; major histocompatibility complex class I
                     antigen-binding protein p88; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="calnexin isoform d precursor"
                     /protein_id="NP_001737.1"
                     /db_xref="CCDS:CCDS4447.1"
                     /db_xref="GeneID:821"
                     /db_xref="HGNC:HGNC:1473"
                     /db_xref="MIM:114217"
                     /translation="MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVED
                     SKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDG
                     KWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIEC
                     GGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKH
                     AKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREI
                     EDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDP
                     DAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPS
                     YQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
                     ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQ
                     TSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQE
                     EEDRKPKAEEDEILNRSPRNRKPRRE"
     exon            311..384
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            385..443
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            444..585
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            586..667
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            668..860
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1050
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1164
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1321
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1537
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1657
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1784
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1864
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..4915
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3907..3912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: AGTAAA"
     polyA_site      3930
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="major polyA site"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: ATTAAA"
     polyA_site      4199
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="major polyA site"
     regulatory      4888..4893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: AATAAA"
     polyA_site      4915
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
ORIGIN      
        1 agcggtggcc gaggcctctt ggttctgcgg cacgtgacgg tcgggccgcc tccgcctctc
       61 tctttactgc ggcgcggggc aaggtgtgcg ggcgggaagg ggcacgggca cccccgcggt
      121 ccccgggagg ctagagatca tggaagggaa gtggttgctg tgtatgttac tggtgcttgg
      181 aactgctatt gttgaggctc atgatggaca tgatgatgat gtgattgata ttgaggatga
      241 ccttgacgat gtcattgaag aggtagaaga ctcaaaacca gataccactg ctcctccttc
      301 atctcccaag gttacttaca aagctccagt tccaacaggg gaagtatatt ttgctgattc
      361 ttttgacaga ggaactctgt cagggtggat tttatccaaa gccaagaaag acgataccga
      421 tgatgaaatt gccaaatatg atggaaagtg ggaggtagag gaaatgaagg agtcaaagct
      481 tccaggtgat aaaggacttg tgttgatgtc tcgggccaag catcatgcca tctctgctaa
      541 actgaacaag cccttcctgt ttgacaccaa gcctctcatt gttcagtatg aggttaattt
      601 ccaaaatgga atagaatgtg gtggtgccta tgtgaaactg ctttctaaaa caccagaact
      661 caacctggat cagttccatg acaagacccc ttatacgatt atgtttggtc cagataaatg
      721 tggagaggac tataaactgc acttcatctt ccgacacaaa aaccccaaaa cgggtatcta
      781 tgaagaaaaa catgctaaga ggccagatgc agatctgaag acctatttta ctgataagaa
      841 aacacatctt tacacactaa tcttgaatcc agataatagt tttgaaatac tggttgacca
      901 atctgtggtg aatagtggaa atctgctcaa tgacatgact cctcctgtaa atccttcacg
      961 tgaaattgag gacccagaag accggaagcc cgaggattgg gatgaaagac caaaaatccc
     1021 agatccagaa gctgtcaagc cagatgactg ggatgaagat gcccctgcta agattccaga
     1081 tgaagaggcc acaaaacccg aaggctggtt agatgatgag cctgagtacg tacctgatcc
     1141 agacgcagag aaacctgagg attgggatga agacatggat ggagaatggg aggctcctca
     1201 gattgccaac cctagatgtg agtcagctcc tggatgtggt gtctggcagc gacctgtgat
     1261 tgacaacccc aattataaag gcaaatggaa gcctcctatg attgacaatc ccagttacca
     1321 gggaatctgg aaacccagga aaataccaaa tccagatttc tttgaagatc tggaaccttt
     1381 cagaatgact ccttttagtg ctattggttt ggagctgtgg tccatgacct ctgacatttt
     1441 ttttgacaac tttatcattt gtgctgatcg aagaatagtt gatgattggg ccaatgatgg
     1501 atggggcctg aagaaagctg ctgatggggc tgctgagcca ggcgttgtgg ggcagatgat
     1561 cgaggcagct gaagagcgcc cgtggctgtg ggtagtctat attctaactg tagcccttcc
     1621 tgtgttcctg gttatcctct tctgctgttc tggaaagaaa cagaccagtg gtatggagta
     1681 taagaaaact gatgcacctc aaccggatgt gaaggaagag gaagaagaga aggaagagga
     1741 aaaggacaag ggagatgagg aggaggaagg agaagagaaa cttgaagaga aacagaaaag
     1801 tgatgctgaa gaagatggtg gcactgtcag tcaagaggag gaagacagaa aacctaaagc
     1861 agaggaggat gaaattttga acagatcacc aagaaacaga aagccacgaa gagagtgaaa
     1921 caatcttaag agcttgatct gtgatttctt ctccctcctc ccctgcaaga gtggtcctag
     1981 gagaggacct ggcacacctt aggttgacat tcagaaaact tcaagacatc accatcagca
     2041 ggctccagtt gaacactagt ctgtgtaact ttaaacatct agcagtaaat acttgcagtt
     2101 gtgatataaa ggaccctgtt tctgtagaaa agaaaacatt taacataatg gttgtgaaat
     2161 gtaacatgaa gcaaactaac tttttttttt ttaacatctt tgtttttaaa atagaatgat
     2221 agaactttgc cagtctttaa gatcttggct taatttaatg tattaatctg tttgtgcaaa
     2281 cataatacca ccatttaaaa atgttaggga gatgagttgc agtttttata atagattttt
     2341 tttaaagttt ggtattgtaa aacattcaca cctctgtccc tcaaaattga taattacgtt
     2401 taaagtgcag tcatttgtgg ttagaatctt gttttgtttg cttccattat tgagttcctc
     2461 ctaaggaaat tgaggagagg gactgaatag aagcccaaat tcatataaaa gttgcgttta
     2521 agttgtatta aaaatagata tataagaaaa aattctttca cttgatgttt gttagaccag
     2581 aaagtgtgtg tgttctgtag ctcagttccc agacagcttt ttaggtagtg gaggaggtgg
     2641 cttcatgtgg cacttgggca tttatattcc acttgggagg gtcaggctgt ggccttctgg
     2701 agcaggtggc ttgttaagga atgctagcag ggcatggcac gtgagctccg gaatagatgt
     2761 cttcatcact tcttccactg tgtgttgaca ctgttttcct tacctatttc ctcagatccc
     2821 cagctttctc ctctgctatg cattttcttc acagtgcagc ttgcagtccg ttgctgaaaa
     2881 tgattataag ccctgcataa tgttaagctt tattgtgatt acgtgtatgt ttcttctttc
     2941 ttttaagcag acccatacct ttccagggtc aaagtacaga atagaataca ttgatacaaa
     3001 gtacagaaaa atactttgat ttttatccat ttcttttact ctgtgtaaag acttgagaag
     3061 tctaattcac aggcaaacca atacagaatt gactgcagtt gaacagacta gaagtatttg
     3121 tgggaggagt gacatgaagc atgagttatc tgattttttt tgtagctgct atatatttta
     3181 agccttcatt tgcaattcat gtaacagttg tgtcataaat tacacaataa agcagtcctg
     3241 ttcaaatttt tttttaacgt ggcttgtaga atttttaaaa aagtgatctt aggtttgttt
     3301 tttcatgcgg gatgcagatg ggtgctatca gagcctctcc cacaccacta tagtgtaata
     3361 atgttattat tactctacac tgaaacgtat tcagagttag atattatttt agcttcagtt
     3421 gttctttaga ggctttcaaa tgtaccgatg atactgtttc ttgcactgaa tatataaaca
     3481 ctccacagtg tttatattgg gaagatattg ggaaggaaat atatttgtaa aagatgaagg
     3541 ctgtatctat ttttttttct ttttaaagtt tgttcactta aattcttttg aggatgggat
     3601 gtatttttct tgctgttcag tgctttttcc ttttcatctg ttgttctgtg gtcacagtga
     3661 ccttagctac atagcagact ttcccaaatg tattgattac aaataaacag ttgttactta
     3721 gcaagacctg aaaatatgtc tgcaggtttc tccttgaagc aaatgtgtgg gatcattgca
     3781 tttccagaaa tctgcctcct tcaccctccg ttgacagtat atgtcatgcc tcactttctt
     3841 ctagctgagc tttaaatcat tagagcttaa attgtcagat cgttcattgc ctttccaggg
     3901 ttatttagta aagtttgttg aaaacaaaaa cgccttttct tggttctttt ttcagttatt
     3961 ttgaaggtcc agcatcctga ttaaatgtct gacacattaa tgaatgacca gcagcagctt
     4021 tcagctctta aaaagacact tatattttga ttttacatgc tggttacctg ttccattgtt
     4081 gtcaaatgcc cactctccat cagatgtgtt cctccatttt cttatccaca aagtactcct
     4141 cacttttcaa tttgtcatgt tactaaatgg tgttacatta aagccctgtg ttaagtgtct
     4201 gcttttgact gaatttcttc atagtaacct tcagtgtgtg tgtgtgacta tgttcaatta
     4261 gtgggttgat cttcgtataa ttggccacta tgtgagagtt cactactagg cagaaactat
     4321 tatggacagt gaaataatga cttttatctc accacgtgag tttgatgcag tcttttctgt
     4381 ctagcccttg cctcttcctg cccatgtgat tgcggtgcag tagtttctgt tgtataatag
     4441 tgtggacagc agctcagaaa aggagggaat gctactgata atttgtagat aatattcttt
     4501 aagacttagg ggaaccattg aactttgaaa tttttattag aaaattattt gttcagaatc
     4561 agactccatt attttacata tacttaaata ctttaggggt atttttgaaa gttagcccag
     4621 ttttttatgt gctattaaat ttttagatta catactaaag aaaagtatgt acacagaatg
     4681 tagtgctcct agttactatt ttttctatta agaaatagtt tagttctggt gtaaaatttg
     4741 tttgaatgct aaaaaaaaaa aagcaggact gcattatggc acttttgcct tggtggccca
     4801 ctttctccat ttaaaacatt aggatttgta tttttctgct gcgtttgtat gaagacatat
     4861 ttgattgttg ttttctcttg attttaaaat aaaacctcat gagccctagt aaaaa
//
