LOCUS       NM_001363995            5055 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calnexin (CANX), transcript variant 5, mRNA.
ACCESSION   NM_001363995
VERSION     NM_001363995.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5055)
  AUTHORS   Ye,Y., Zhang,J., Guo,Y., Zhu,J., Tang,B. and Fan,P.
  TITLE     PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting
            the CANX/NOX4 signaling pathway
  JOURNAL   Immun Inflamm Dis 11 (2), e765 (2023)
   PUBMED   36840500
  REMARK    GeneRIF: PON2 ameliorates Ang II-induced cardiomyocyte injury by
            targeting the CANX/NOX4 signaling pathway.
REFERENCE   2  (bases 1 to 5055)
  AUTHORS   Yan,G., Li,X., Zheng,Z., Gao,W., Chen,C., Wang,X., Cheng,Z., Yu,J.,
            Zou,G., Farooq,M.Z., Zhu,X., Zhu,W., Zhong,Q. and Yan,X.
  TITLE     KAT7-mediated CANX (calnexin) crotonylation regulates
            leucine-stimulated MTORC1 activity
  JOURNAL   Autophagy 18 (12), 2799-2816 (2022)
   PUBMED   35266843
  REMARK    GeneRIF: KAT7-mediated CANX (calnexin) crotonylation regulates
            leucine-stimulated MTORC1 activity.
REFERENCE   3  (bases 1 to 5055)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5055)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5055)
  AUTHORS   Watanabe,A., Mizoguchi,I., Hasegawa,H., Katahira,Y., Inoue,S.,
            Sakamoto,E., Furusaka,Y., Sekine,A., Miyakawa,S., Murakami,F.,
            Xu,M., Yoneto,T. and Yoshimoto,T.
  TITLE     A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under
            Inflammatory Conditions
  JOURNAL   Front Immunol 12, 757669 (2021)
   PUBMED   34603342
  REMARK    GeneRIF: A Chaperone-Like Role for EBI3 in Collaboration With
            Calnexin Under Inflammatory Conditions.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5055)
  AUTHORS   Lenter,M. and Vestweber,D.
  TITLE     The integrin chains beta 1 and alpha 6 associate with the chaperone
            calnexin prior to integrin assembly
  JOURNAL   J Biol Chem 269 (16), 12263-12268 (1994)
   PUBMED   8163531
REFERENCE   7  (bases 1 to 5055)
  AUTHORS   Tjoelker,L.W., Seyfried,C.E., Eddy,R.L. Jr., Byers,M.G.,
            Shows,T.B., Calderon,J., Schreiber,R.B. and Gray,P.W.
  TITLE     Human, mouse, and rat calnexin cDNA cloning: identification of
            potential calcium binding motifs and gene localization to human
            chromosome 5
  JOURNAL   Biochemistry 33 (11), 3229-3236 (1994)
   PUBMED   8136357
REFERENCE   8  (bases 1 to 5055)
  AUTHORS   Honore,B., Rasmussen,H.H., Celis,A., Leffers,H., Madsen,P. and
            Celis,J.E.
  TITLE     The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin
            exhibit strikingly different levels in quiescent keratinocytes as
            compared to their proliferating normal and transformed
            counterparts: cDNA cloning and expression of calnexin
  JOURNAL   Electrophoresis 15 (3-4), 482-490 (1994)
   PUBMED   8055875
REFERENCE   9  (bases 1 to 5055)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 5055)
  AUTHORS   Galvin,K., Krishna,S., Ponchel,F., Frohlich,M., Cummings,D.E.,
            Carlson,R., Wands,J.R., Isselbacher,K.J., Pillai,S. and Ozturk,M.
  TITLE     The major histocompatibility complex class I antigen-binding
            protein p88 is the product of the calnexin gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8452-8456 (1992)
   PUBMED   1326756
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113426.2.
            
            Summary: This gene encodes a member of the calnexin family of
            molecular chaperones. The encoded protein is a calcium-binding,
            endoplasmic reticulum (ER)-associated protein that interacts
            transiently with newly synthesized N-linked glycoproteins,
            facilitating protein folding and assembly. It may also play a
            central role in the quality control of protein folding by retaining
            incorrectly folded protein subunits within the ER for degradation.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jun 2018].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.273705.1,
                                           SRR1660809.233914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC113426.2         88288-88461
            175-348             AC113426.2         95038-95211
            349-422             AC113426.2         95617-95690
            423-481             AC113426.2         96491-96549
            482-623             AC113426.2         97598-97739
            624-705             AC113426.2         98337-98418
            706-898             AC113426.2         99232-99424
            899-1000            AC113426.2         105258-105359
            1001-1190           AC113426.2         105464-105653
            1191-1304           AC113426.2         109027-109140
            1305-1461           AC113426.2         109763-109919
            1462-1677           AC113426.2         112163-112378
            1678-1797           AC113426.2         113019-113138
            1798-1924           AC113426.2         114016-114142
            1925-2004           AC113426.2         116039-116118
            2005-5055           AC113426.2         117950-121000
FEATURES             Location/Qualifiers
     source          1..5055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..5055
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="calnexin"
                     /db_xref="GeneID:821"
                     /db_xref="HGNC:HGNC:1473"
                     /db_xref="MIM:114217"
     exon            1..174
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            175..348
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2058
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="isoform c precursor is encoded by transcript
                     variant 5; major histocompatibility complex class I
                     antigen-binding protein p88; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="calnexin isoform c precursor"
                     /protein_id="NP_001350924.1"
                     /db_xref="CCDS:CCDS93837.1"
                     /db_xref="GeneID:821"
                     /db_xref="HGNC:HGNC:1473"
                     /db_xref="MIM:114217"
                     /translation="MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVED
                     SKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDG
                     KWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIEC
                     GGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKH
                     AKRPDADLKTYFTDKKTHLYTLKSRGTNHLCFVHKEMGVSFPKTPGARHCSYPKASVL
                     NPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVK
                     PDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANP
                     RCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRM
                     TPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMI
                     EAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKE
                     EEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPR
                     RE"
     exon            349..422
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            423..481
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            482..623
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            624..705
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            706..898
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1000
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1190
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1304
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1461
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1677
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1797
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1924
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2004
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..5055
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: AGTAAA"
     polyA_site      4070
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="major polyA site"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: ATTAAA"
     polyA_site      4339
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="major polyA site"
     regulatory      5028..5033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
                     /note="hexamer: AATAAA"
     polyA_site      5055
                     /gene="CANX"
                     /gene_synonym="CNX; IP90; P90"
ORIGIN      
        1 agggccgggc ttcgtgcggt ggggctcgct cgcgcggcag cggtggccga ggcctcttgg
       61 ttctgcggca cgtgacggtc gggccgcctc cgcctctctc tttactgcgg cgcggggcaa
      121 ggtgtgcggg cgggaagggg cacgggcacc cccgcggtcc ccgggaggct agagatcatg
      181 gaagggaagt ggttgctgtg tatgttactg gtgcttggaa ctgctattgt tgaggctcat
      241 gatggacatg atgatgatgt gattgatatt gaggatgacc ttgacgatgt cattgaagag
      301 gtagaagact caaaaccaga taccactgct cctccttcat ctcccaaggt tacttacaaa
      361 gctccagttc caacagggga agtatatttt gctgattctt ttgacagagg aactctgtca
      421 gggtggattt tatccaaagc caagaaagac gataccgatg atgaaattgc caaatatgat
      481 ggaaagtggg aggtagagga aatgaaggag tcaaagcttc caggtgataa aggacttgtg
      541 ttgatgtctc gggccaagca tcatgccatc tctgctaaac tgaacaagcc cttcctgttt
      601 gacaccaagc ctctcattgt tcagtatgag gttaatttcc aaaatggaat agaatgtggt
      661 ggtgcctatg tgaaactgct ttctaaaaca ccagaactca acctggatca gttccatgac
      721 aagacccctt atacgattat gtttggtcca gataaatgtg gagaggacta taaactgcac
      781 ttcatcttcc gacacaaaaa ccccaaaacg ggtatctatg aagaaaaaca tgctaagagg
      841 ccagatgcag atctgaagac ctattttact gataagaaaa cacatcttta cacactaaaa
      901 agccgaggga ctaatcattt atgtttcgtg cataaggaaa tgggcgttag cttccccaag
      961 accccaggag ccaggcattg ttcttacccc aaagcctcag tcttgaatcc agataatagt
     1021 tttgaaatac tggttgacca atctgtggtg aatagtggaa atctgctcaa tgacatgact
     1081 cctcctgtaa atccttcacg tgaaattgag gacccagaag accggaagcc cgaggattgg
     1141 gatgaaagac caaaaatccc agatccagaa gctgtcaagc cagatgactg ggatgaagat
     1201 gcccctgcta agattccaga tgaagaggcc acaaaacccg aaggctggtt agatgatgag
     1261 cctgagtacg tacctgatcc agacgcagag aaacctgagg attgggatga agacatggat
     1321 ggagaatggg aggctcctca gattgccaac cctagatgtg agtcagctcc tggatgtggt
     1381 gtctggcagc gacctgtgat tgacaacccc aattataaag gcaaatggaa gcctcctatg
     1441 attgacaatc ccagttacca gggaatctgg aaacccagga aaataccaaa tccagatttc
     1501 tttgaagatc tggaaccttt cagaatgact ccttttagtg ctattggttt ggagctgtgg
     1561 tccatgacct ctgacatttt ttttgacaac tttatcattt gtgctgatcg aagaatagtt
     1621 gatgattggg ccaatgatgg atggggcctg aagaaagctg ctgatggggc tgctgagcca
     1681 ggcgttgtgg ggcagatgat cgaggcagct gaagagcgcc cgtggctgtg ggtagtctat
     1741 attctaactg tagcccttcc tgtgttcctg gttatcctct tctgctgttc tggaaagaaa
     1801 cagaccagtg gtatggagta taagaaaact gatgcacctc aaccggatgt gaaggaagag
     1861 gaagaagaga aggaagagga aaaggacaag ggagatgagg aggaggaagg agaagagaaa
     1921 cttgaagaga aacagaaaag tgatgctgaa gaagatggtg gcactgtcag tcaagaggag
     1981 gaagacagaa aacctaaagc agaggaggat gaaattttga acagatcacc aagaaacaga
     2041 aagccacgaa gagagtgaaa caatcttaag agcttgatct gtgatttctt ctccctcctc
     2101 ccctgcaaga gtggtcctag gagaggacct ggcacacctt aggttgacat tcagaaaact
     2161 tcaagacatc accatcagca ggctccagtt gaacactagt ctgtgtaact ttaaacatct
     2221 agcagtaaat acttgcagtt gtgatataaa ggaccctgtt tctgtagaaa agaaaacatt
     2281 taacataatg gttgtgaaat gtaacatgaa gcaaactaac tttttttttt ttaacatctt
     2341 tgtttttaaa atagaatgat agaactttgc cagtctttaa gatcttggct taatttaatg
     2401 tattaatctg tttgtgcaaa cataatacca ccatttaaaa atgttaggga gatgagttgc
     2461 agtttttata atagattttt tttaaagttt ggtattgtaa aacattcaca cctctgtccc
     2521 tcaaaattga taattacgtt taaagtgcag tcatttgtgg ttagaatctt gttttgtttg
     2581 cttccattat tgagttcctc ctaaggaaat tgaggagagg gactgaatag aagcccaaat
     2641 tcatataaaa gttgcgttta agttgtatta aaaatagata tataagaaaa aattctttca
     2701 cttgatgttt gttagaccag aaagtgtgtg tgttctgtag ctcagttccc agacagcttt
     2761 ttaggtagtg gaggaggtgg cttcatgtgg cacttgggca tttatattcc acttgggagg
     2821 gtcaggctgt ggccttctgg agcaggtggc ttgttaagga atgctagcag ggcatggcac
     2881 gtgagctccg gaatagatgt cttcatcact tcttccactg tgtgttgaca ctgttttcct
     2941 tacctatttc ctcagatccc cagctttctc ctctgctatg cattttcttc acagtgcagc
     3001 ttgcagtccg ttgctgaaaa tgattataag ccctgcataa tgttaagctt tattgtgatt
     3061 acgtgtatgt ttcttctttc ttttaagcag acccatacct ttccagggtc aaagtacaga
     3121 atagaataca ttgatacaaa gtacagaaaa atactttgat ttttatccat ttcttttact
     3181 ctgtgtaaag acttgagaag tctaattcac aggcaaacca atacagaatt gactgcagtt
     3241 gaacagacta gaagtatttg tgggaggagt gacatgaagc atgagttatc tgattttttt
     3301 tgtagctgct atatatttta agccttcatt tgcaattcat gtaacagttg tgtcataaat
     3361 tacacaataa agcagtcctg ttcaaatttt tttttaacgt ggcttgtaga atttttaaaa
     3421 aagtgatctt aggtttgttt tttcatgcgg gatgcagatg ggtgctatca gagcctctcc
     3481 cacaccacta tagtgtaata atgttattat tactctacac tgaaacgtat tcagagttag
     3541 atattatttt agcttcagtt gttctttaga ggctttcaaa tgtaccgatg atactgtttc
     3601 ttgcactgaa tatataaaca ctccacagtg tttatattgg gaagatattg ggaaggaaat
     3661 atatttgtaa aagatgaagg ctgtatctat ttttttttct ttttaaagtt tgttcactta
     3721 aattcttttg aggatgggat gtatttttct tgctgttcag tgctttttcc ttttcatctg
     3781 ttgttctgtg gtcacagtga ccttagctac atagcagact ttcccaaatg tattgattac
     3841 aaataaacag ttgttactta gcaagacctg aaaatatgtc tgcaggtttc tccttgaagc
     3901 aaatgtgtgg gatcattgca tttccagaaa tctgcctcct tcaccctccg ttgacagtat
     3961 atgtcatgcc tcactttctt ctagctgagc tttaaatcat tagagcttaa attgtcagat
     4021 cgttcattgc ctttccaggg ttatttagta aagtttgttg aaaacaaaaa cgccttttct
     4081 tggttctttt ttcagttatt ttgaaggtcc agcatcctga ttaaatgtct gacacattaa
     4141 tgaatgacca gcagcagctt tcagctctta aaaagacact tatattttga ttttacatgc
     4201 tggttacctg ttccattgtt gtcaaatgcc cactctccat cagatgtgtt cctccatttt
     4261 cttatccaca aagtactcct cacttttcaa tttgtcatgt tactaaatgg tgttacatta
     4321 aagccctgtg ttaagtgtct gcttttgact gaatttcttc atagtaacct tcagtgtgtg
     4381 tgtgtgacta tgttcaatta gtgggttgat cttcgtataa ttggccacta tgtgagagtt
     4441 cactactagg cagaaactat tatggacagt gaaataatga cttttatctc accacgtgag
     4501 tttgatgcag tcttttctgt ctagcccttg cctcttcctg cccatgtgat tgcggtgcag
     4561 tagtttctgt tgtataatag tgtggacagc agctcagaaa aggagggaat gctactgata
     4621 atttgtagat aatattcttt aagacttagg ggaaccattg aactttgaaa tttttattag
     4681 aaaattattt gttcagaatc agactccatt attttacata tacttaaata ctttaggggt
     4741 atttttgaaa gttagcccag ttttttatgt gctattaaat ttttagatta catactaaag
     4801 aaaagtatgt acacagaatg tagtgctcct agttactatt ttttctatta agaaatagtt
     4861 tagttctggt gtaaaatttg tttgaatgct aaaaaaaaaa aagcaggact gcattatggc
     4921 acttttgcct tggtggccca ctttctccat ttaaaacatt aggatttgta tttttctgct
     4981 gcgtttgtat gaagacatat ttgattgttg ttttctcttg attttaaaat aaaacctcat
     5041 gagccctagt aaaaa
//
