LOCUS       NM_001159773            3287 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript
            variant 3, mRNA.
ACCESSION   NM_001159773
VERSION     NM_001159773.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3287)
  AUTHORS   Yang,W., Liu,Z. and Liu,T.
  TITLE     Pan-cancer analysis predicts CANT1 as a potential prognostic,
            immunologic biomarker
  JOURNAL   Cell Signal 117, 111107 (2024)
   PUBMED   38369265
  REMARK    GeneRIF: Pan-cancer analysis predicts CANT1 as a potential
            prognostic, immunologic biomarker.
REFERENCE   2  (bases 1 to 3287)
  AUTHORS   Liu,T., Li,Z.Z., Sun,L., Yang,K., Chen,J.M., Han,X.Y., Qi,L.M.,
            Zhou,X.G. and Wang,P.
  TITLE     Upregulated CANT1 is correlated with poor prognosis in
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 23 (1), 1007 (2023)
   PUBMED   37858061
  REMARK    GeneRIF: Upregulated CANT1 is correlated with poor prognosis in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3287)
  AUTHORS   Gao,F., Hu,X., Liu,W., Wu,H., Mu,Y. and Zhao,Y.
  TITLE     Calcium-activated nucleotides 1 (CANT1)-driven nuclear
            factor-k-gene binding (NF-kB) signaling pathway facilitates the
            lung cancer progression
  JOURNAL   Bioengineered 13 (2), 3183-3193 (2022)
   PUBMED   35068336
  REMARK    GeneRIF: Calcium-activated nucleotides 1 (CANT1)-driven nuclear
            factor-k-gene binding (NF-kB) signaling pathway facilitates the
            lung cancer progression.
REFERENCE   4  (bases 1 to 3287)
  AUTHORS   Wang,H.D., Guo,L.J., Feng,Z.Q., Zhang,D.W., Zhang,M.T., Gao,Y.,
            Chen,C.L. and Zhu,B.F.
  TITLE     Cloning, expression and enzyme activity delineation of two novel
            CANT1 mutations: the disappearance of dimerization may indicate the
            change of protein conformation and even function
  JOURNAL   Orphanet J Rare Dis 15 (1), 240 (2020)
   PUBMED   32907608
  REMARK    GeneRIF: Cloning, expression and enzyme activity delineation of two
            novel CANT1 mutations: the disappearance of dimerization may
            indicate the change of protein conformation and even function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3287)
  AUTHORS   Dai,J., Liu,J., Deng,Y., Smith,T.M. and Lu,M.
  TITLE     Structure and protein design of a human platelet function inhibitor
  JOURNAL   Cell 116 (5), 649-659 (2004)
   PUBMED   15006348
  REMARK    Erratum:[Cell. 2004 Apr 30;117(3):413]
REFERENCE   6  (bases 1 to 3287)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 3287)
  AUTHORS   Faivre,L., Le Merrer,M., Al-Gazali,L.I., Ausems,M.G., Bitoun,P.,
            Bacq,D., Maroteaux,P., Munnich,A. and Cormier-Daire,V.
  TITLE     Homozygosity mapping of a Desbuquois dysplasia locus to chromosome
            17q25.3
  JOURNAL   J Med Genet 40 (4), 282-284 (2003)
   PUBMED   12676900
REFERENCE   8  (bases 1 to 3287)
  AUTHORS   Murphy,D.M., Ivanenkov,V.V. and Kirley,T.L.
  TITLE     Bacterial expression and characterization of a novel, soluble,
            calcium-binding, and calcium-activated human nucleotidase
  JOURNAL   Biochemistry 42 (8), 2412-2421 (2003)
   PUBMED   12600208
  REMARK    GeneRIF: This soluble apyrase is a calcium-binding protein, as
            evident from saturable Ca2+-dependent changes in intrinsic
            tryptophan fluorescence, UV difference absorption spectra, and
            Ca2+-triggered transition from enzymatically inactive form to
            active enzyme.
REFERENCE   9  (bases 1 to 3287)
  AUTHORS   Failer,B.U., Braun,N. and Zimmermann,H.
  TITLE     Cloning, expression, and functional characterization of a
            Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase
  JOURNAL   J Biol Chem 277 (40), 36978-36986 (2002)
   PUBMED   12167635
REFERENCE   10 (bases 1 to 3287)
  AUTHORS   Smith,T.M., Hicks-Berger,C.A., Kim,S. and Kirley,T.L.
  TITLE     Cloning, expression, and characterization of a soluble
            calcium-activated nucleotidase, a human enzyme belonging to a new
            family of extracellular nucleotidases
  JOURNAL   Arch Biochem Biophys 406 (1), 105-115 (2002)
   PUBMED   12234496
  REMARK    GeneRIF: Cloning, expression, and characterization of this
            calcium-acdtivated enzyme, a human enzyme belonging to a new family
            of extracellular nucleotidases.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC355691.1 and BC017655.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001159773.1.
            
            Summary: This protein encoded by this gene belongs to the apyrase
            family. It functions as a calcium-dependent nucleotidase with a
            preference for UDP. Mutations in this gene are associated with
            Desbuquois dysplasia with hand anomalies. Alternatively spliced
            transcript variants have been noted for this gene.[provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.291521.1,
                                           SRR3476690.988982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392446.10/ ENSP00000376241.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DC355691.1         54-87
            35-3287             BC017655.1         1-3253
FEATURES             Location/Qualifiers
     source          1..3287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3287
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="calcium activated nucleotidase 1"
                     /db_xref="GeneID:124583"
                     /db_xref="HGNC:HGNC:19721"
                     /db_xref="MIM:613165"
     exon            1..101
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            102..225
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            226..878
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1453
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /EC_number="3.6.1.6"
                     /note="Ca2+-dependent endoplasmic reticulum nucleoside
                     diphosphatase; micromelic dwarfism with vertebral and
                     metaphyseal abnormalities and advanced carpotarsal
                     ossification; soluble calcium-activated nucleotidase
                     SCAN-1; soluble Ca-activated nucleotidase, isozyme 1;
                     apyrase homolog; putative MAPK-activating protein PM09;
                     putative NF-kappa-B-activating protein 107; apyrase 1
                     homolog (C. lectularius)"
                     /codon_start=1
                     /product="soluble calcium-activated nucleotidase 1"
                     /protein_id="NP_001153245.1"
                     /db_xref="CCDS:CCDS11760.1"
                     /db_xref="GeneID:124583"
                     /db_xref="HGNC:HGNC:19721"
                     /db_xref="MIM:613165"
                     /translation="MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWK
                     VILTFFVGAAILWLLCSHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAG
                     IRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAE
                     KGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLA
                     VKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQ
                     PPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSH
                     VGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGS
                     VKYEGIEFI"
     exon            879..1082
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..3287
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3265..3270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="hexamer: AATAAA"
     polyA_site      3287
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="major polyA site"
ORIGIN      
        1 agtcggccac cttcctccgt cccggccgtt agcccagcca agcccagcca agcccagcca
       61 agccccgccg atcgcgggca ccggagccag ccccgcagcg gagggaccac agagcaccag
      121 cctgcatgga acttccttcc tcactcagct tcccacgttg ccagctggga caggggagat
      181 ggagtaattt tgctgtggaa agacttcacg tcttgccgaa tgaaagtccc gcctgtctgt
      241 cacgctgatg cccgtgcagc tgtctgagca cccggaatgg aatgagtcta tgcactccct
      301 ccggatcagt gtggggggcc ttcctgtgct ggcgtccatg accaaggccg cggacccccg
      361 cttccgcccc cgctggaagg tgatcctgac gttctttgtg ggtgctgcca tcctctggct
      421 gctctgctcc caccgcccgg cccccggcag gccccccacc cacaatgcac acaactggag
      481 gctcggccag gcgcccgcca actggtacaa tgacacctac cccctgtctc ccccacaaag
      541 gacaccggct gggattcggt atcgaatcgc agttatcgca gacctggaca cagagtcaag
      601 ggcccaagag gaaaacacct ggttcagtta cctgaaaaag ggctacctga ccctgtcaga
      661 cagtggggac aaggtggccg tggaatggga caaagaccat ggggtcctgg agtcccacct
      721 ggcggagaag gggagaggca tggagctatc cgacctgatt gttttcaatg ggaaactcta
      781 ctccgtggat gaccggacgg gggtcgtcta ccagatcgaa ggcagcaaag ccgtgccctg
      841 ggtgattctg tccgacggcg acggcaccgt ggagaaaggc ttcaaggccg aatggctggc
      901 agtgaaggac gagcgtctgt acgtgggcgg cctgggcaag gagtggacga ccactacggg
      961 tgatgtggtg aacgagaacc cggagtgggt gaaggtggtg ggctacaagg gcagcgtgga
     1021 ccacgagaac tgggtgtcca actacaacgc cctgcgggct gctgccggca tccagccgcc
     1081 aggctacctc atccatgagt ctgcctgctg gagtgacacg ctgcagcgct ggttcttcct
     1141 gccgcgccgc gccagccagg agcgctacag cgagaaggac gacgagcgca agggcgccaa
     1201 cctgctgctg agcgcctccc ctgacttcgg cgacatcgct gtgagccacg tcggggcggt
     1261 ggtccccact cacggcttct cgtccttcaa gttcatcccc aacaccgacg accagatcat
     1321 tgtggccctc aaatccgagg aggacagcgg cagagtcgcc tcctacatca tggccttcac
     1381 gctggacggg cgcttcctgt tgccggagac caagatcgga agcgtgaaat acgaaggcat
     1441 cgagttcatt taactcaaaa cggaaacact gagcaaggcc atcaggactc agcttttata
     1501 aaaacaagag gagtgcactt ttgttttgtt ttgttctttt tggaactgtg cctgggttgg
     1561 aggtctggac agggagccca gtcccgggcc ccatagtggt gcgggcactg gacccccggg
     1621 ccccacggag gccgcggtct gaactgcttt ccatgctgcc atctggtggt gatttcggtc
     1681 acttcaggca ttgactcaag gcctgcctaa ctggctgggt cgtttcttcc atccgacctc
     1741 gtttcttttc tttcctatgt tcttttgttc agtgaatatc cctagagctc ctaccatatg
     1801 tcaggcccta tgcctcaccc tgagaacgca gtgagcatga ggtggacctg tttgctggga
     1861 accccaggtc accccctttt cttcctactc tgtgcctgga gcatcatgtc cacccctgca
     1921 gatccttgga aaagaaaatg tttatgttgc agggtattgc atggtcacga gtgagggcag
     1981 gcccctgggg acacatctgc ccacagctgc acaggccagg gcgcaggcac atctgttggt
     2041 tctcaggcct cagataaaac catctccgca tcatatggcc agtgaccgct ttctcccttc
     2101 aagaaaattc tgtggctgtg cagtactttg aagttttaat tattaacctg ctttaattaa
     2161 agcagtttcc tttcttataa agtggaatca ccaaatctta tcacacagag cacagtcctg
     2221 tagttaccca gcccgctcca gcagtgcggg agattgtaag gaagcggtgg cggctggtga
     2281 agcaagtctc acatgtcggc gttcttggcc aatggataca aagataaaga aaatgttgcc
     2341 tttttctagg aactgtcaga aatcctcatg cctttcaaga cttctgtgaa tgacttgaat
     2401 tttttattcc ctgcctaggg tctgtgaacg aggcctgtct cttccctggg gtttctttcc
     2461 atggccttta tttctcctct tccagtggga gttttgcagg ctcttctctg tggaaacttc
     2521 acgagcgttg gctgggcctc ggcttcgctg gagtgtactc cagggtgaag gcagagtggg
     2581 atttgagacc caggttaggc acgacccagg ctgagaaggg acgtttccat cattcacagt
     2641 gccctcccca cagcactacc tcaccccgac ccccaccctc actcctaccc caccccgcga
     2701 tcgtcagggg tgccacggtg ggccggaggg tgccggctct ggctgtccct gtgccggtcc
     2761 ctcacaaacc tctccccctt tgaaactcaa gcacagctgc gaggagggca gcgaggaggg
     2821 acccctctct catggttgtc tctttccccc gctatgtcat aggtagtgga ggaagcgaag
     2881 gaagtgaacg ctgaatgtga cgcatttctg aagagctcag ctgtcaccgg gcatagcctg
     2941 gaagccccaa gtctgttctg actttgcctg gctgtctcct tgacccgcct cctagatcat
     3001 tgtccttgat gtccaggctg ggtcatttaa aatagagatg caatcaggaa ggttggggga
     3061 cttgggactg tggctgaatt gagaccttgc tgatgtattc atgtcagcac ctgagtcaca
     3121 gcccaggtgc ccggaagcag cctcttcgca taggcagtga tttgcgatta ctttaaagct
     3181 cacctttttt cttcccctct ctgttcgctg ctgtcagcat aatgattgtg ttccttccct
     3241 atgggatcca tctgttttgt aaacaataaa gcgtctgagg gagtgta
//
