LOCUS       NM_001159772            3426 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript
            variant 2, mRNA.
ACCESSION   NM_001159772
VERSION     NM_001159772.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Yang,W., Liu,Z. and Liu,T.
  TITLE     Pan-cancer analysis predicts CANT1 as a potential prognostic,
            immunologic biomarker
  JOURNAL   Cell Signal 117, 111107 (2024)
   PUBMED   38369265
  REMARK    GeneRIF: Pan-cancer analysis predicts CANT1 as a potential
            prognostic, immunologic biomarker.
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Liu,T., Li,Z.Z., Sun,L., Yang,K., Chen,J.M., Han,X.Y., Qi,L.M.,
            Zhou,X.G. and Wang,P.
  TITLE     Upregulated CANT1 is correlated with poor prognosis in
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 23 (1), 1007 (2023)
   PUBMED   37858061
  REMARK    GeneRIF: Upregulated CANT1 is correlated with poor prognosis in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Gao,F., Hu,X., Liu,W., Wu,H., Mu,Y. and Zhao,Y.
  TITLE     Calcium-activated nucleotides 1 (CANT1)-driven nuclear
            factor-k-gene binding (NF-kB) signaling pathway facilitates the
            lung cancer progression
  JOURNAL   Bioengineered 13 (2), 3183-3193 (2022)
   PUBMED   35068336
  REMARK    GeneRIF: Calcium-activated nucleotides 1 (CANT1)-driven nuclear
            factor-k-gene binding (NF-kB) signaling pathway facilitates the
            lung cancer progression.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Wang,H.D., Guo,L.J., Feng,Z.Q., Zhang,D.W., Zhang,M.T., Gao,Y.,
            Chen,C.L. and Zhu,B.F.
  TITLE     Cloning, expression and enzyme activity delineation of two novel
            CANT1 mutations: the disappearance of dimerization may indicate the
            change of protein conformation and even function
  JOURNAL   Orphanet J Rare Dis 15 (1), 240 (2020)
   PUBMED   32907608
  REMARK    GeneRIF: Cloning, expression and enzyme activity delineation of two
            novel CANT1 mutations: the disappearance of dimerization may
            indicate the change of protein conformation and even function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Dai,J., Liu,J., Deng,Y., Smith,T.M. and Lu,M.
  TITLE     Structure and protein design of a human platelet function inhibitor
  JOURNAL   Cell 116 (5), 649-659 (2004)
   PUBMED   15006348
  REMARK    Erratum:[Cell. 2004 Apr 30;117(3):413]
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Faivre,L., Le Merrer,M., Al-Gazali,L.I., Ausems,M.G., Bitoun,P.,
            Bacq,D., Maroteaux,P., Munnich,A. and Cormier-Daire,V.
  TITLE     Homozygosity mapping of a Desbuquois dysplasia locus to chromosome
            17q25.3
  JOURNAL   J Med Genet 40 (4), 282-284 (2003)
   PUBMED   12676900
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Murphy,D.M., Ivanenkov,V.V. and Kirley,T.L.
  TITLE     Bacterial expression and characterization of a novel, soluble,
            calcium-binding, and calcium-activated human nucleotidase
  JOURNAL   Biochemistry 42 (8), 2412-2421 (2003)
   PUBMED   12600208
  REMARK    GeneRIF: This soluble apyrase is a calcium-binding protein, as
            evident from saturable Ca2+-dependent changes in intrinsic
            tryptophan fluorescence, UV difference absorption spectra, and
            Ca2+-triggered transition from enzymatically inactive form to
            active enzyme.
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Failer,B.U., Braun,N. and Zimmermann,H.
  TITLE     Cloning, expression, and functional characterization of a
            Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase
  JOURNAL   J Biol Chem 277 (40), 36978-36986 (2002)
   PUBMED   12167635
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   Smith,T.M., Hicks-Berger,C.A., Kim,S. and Kirley,T.L.
  TITLE     Cloning, expression, and characterization of a soluble
            calcium-activated nucleotidase, a human enzyme belonging to a new
            family of extracellular nucleotidases
  JOURNAL   Arch Biochem Biophys 406 (1), 105-115 (2002)
   PUBMED   12234496
  REMARK    GeneRIF: Cloning, expression, and characterization of this
            calcium-acdtivated enzyme, a human enzyme belonging to a new family
            of extracellular nucleotidases.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF328554.2 and BC017655.1.
            
            On May 31, 2019 this sequence version replaced NM_001159772.1.
            
            Summary: This protein encoded by this gene belongs to the apyrase
            family. It functions as a calcium-dependent nucleotidase with a
            preference for UDP. Mutations in this gene are associated with
            Desbuquois dysplasia with hand anomalies. Alternatively spliced
            transcript variants have been noted for this gene.[provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6380202.7830.5, SRR6380202.7830.7
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1656              AF328554.2         16-1671
            1657-3426           BC017655.1         1484-3253
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3426
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="calcium activated nucleotidase 1"
                     /db_xref="GeneID:124583"
                     /db_xref="HGNC:HGNC:19721"
                     /db_xref="MIM:613165"
     exon            1..101
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            102..240
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            241..364
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            365..1017
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1592
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /EC_number="3.6.1.6"
                     /note="Ca2+-dependent endoplasmic reticulum nucleoside
                     diphosphatase; micromelic dwarfism with vertebral and
                     metaphyseal abnormalities and advanced carpotarsal
                     ossification; soluble calcium-activated nucleotidase
                     SCAN-1; soluble Ca-activated nucleotidase, isozyme 1;
                     apyrase homolog; putative MAPK-activating protein PM09;
                     putative NF-kappa-B-activating protein 107; apyrase 1
                     homolog (C. lectularius)"
                     /codon_start=1
                     /product="soluble calcium-activated nucleotidase 1"
                     /protein_id="NP_001153244.1"
                     /db_xref="CCDS:CCDS11760.1"
                     /db_xref="GeneID:124583"
                     /db_xref="HGNC:HGNC:19721"
                     /db_xref="MIM:613165"
                     /translation="MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWK
                     VILTFFVGAAILWLLCSHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAG
                     IRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAE
                     KGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLA
                     VKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQ
                     PPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSH
                     VGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGS
                     VKYEGIEFI"
     exon            1018..1221
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..3426
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3404..3409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="hexamer: AATAAA"
     polyA_site      3426
                     /gene="CANT1"
                     /gene_synonym="DBQD; DBQD1; EDM7; SCAN-1; SCAN1; SHAPY"
                     /note="major polyA site"
ORIGIN      
        1 agtcggccac cttcctccgt cccggccgtt agcccagcca agcccagcca agcccagcca
       61 agccccgccg atcgcgggca ccggagccag ccccgcagcg ggagcctaac ccagaggaag
      121 tggagactcc tttactgcac atctgtctgc tccaggccag gcactgttct aggagccagg
      181 atacagaggt ggagacagaa acaaacaaac cgataactgt atacaatact ctaacgtcag
      241 agggaccaca gagcaccagc ctgcatggaa cttccttcct cactcagctt cccacgttgc
      301 cagctgggac aggggagatg gagtaatttt gctgtggaaa gacttcacgt cttgccgaat
      361 gaaagtcccg cctgtctgtc acgctgatgc ccgtgcagct gtctgagcac ccggaatgga
      421 atgagtctat gcactccctc cggatcagtg tggggggcct tcctgtgctg gcgtccatga
      481 ccaaggccgc ggacccccgc ttccgccccc gctggaaggt gatcctgacg ttctttgtgg
      541 gtgctgccat cctctggctg ctctgctccc accgcccggc ccccggcagg ccccccaccc
      601 acaatgcaca caactggagg ctcggccagg cgcccgccaa ctggtacaat gacacctacc
      661 ccctgtctcc cccacaaagg acaccggctg ggattcggta tcgaatcgca gttatcgcag
      721 acctggacac agagtcaagg gcccaagagg aaaacacctg gttcagttac ctgaaaaagg
      781 gctacctgac cctgtcagac agtggggaca aggtggccgt ggaatgggac aaagaccatg
      841 gggtcctgga gtcccacctg gcggagaagg ggagaggcat ggagctatcc gacctgattg
      901 ttttcaatgg gaaactctac tccgtggatg accggacggg ggtcgtctac cagatcgaag
      961 gcagcaaagc cgtgccctgg gtgattctgt ccgacggcga cggcaccgtg gagaaaggct
     1021 tcaaggccga atggctggca gtgaaggacg agcgtctgta cgtgggcggc ctgggcaagg
     1081 agtggacgac cactacgggt gatgtggtga acgagaaccc ggagtgggtg aaggtggtgg
     1141 gctacaaggg cagcgtggac cacgagaact gggtgtccaa ctacaacgcc ctgcgggctg
     1201 ctgccggcat ccagccgcca ggctacctca tccatgagtc tgcctgctgg agtgacacgc
     1261 tgcagcgctg gttcttcctg ccgcgccgcg ccagccagga gcgctacagc gagaaggacg
     1321 acgagcgcaa gggcgccaac ctgctgctga gcgcctcccc tgacttcggc gacatcgctg
     1381 tgagccacgt cggggcggtg gtccccactc acggcttctc gtccttcaag ttcatcccca
     1441 acaccgacga ccagatcatt gtggccctca aatccgagga ggacagcggc agagtcgcct
     1501 cctacatcat ggccttcacg ctggacgggc gcttcctgtt gccggagacc aagatcggaa
     1561 gcgtgaaata cgaaggcatc gagttcattt aactcaaaac ggaaacactg agcaaggcca
     1621 tcaggactca gcttttataa aaacaagagg agtgcacttt tgttttgttt tgttcttttt
     1681 ggaactgtgc ctgggttgga ggtctggaca gggagcccag tcccgggccc catagtggtg
     1741 cgggcactgg acccccgggc cccacggagg ccgcggtctg aactgctttc catgctgcca
     1801 tctggtggtg atttcggtca cttcaggcat tgactcaagg cctgcctaac tggctgggtc
     1861 gtttcttcca tccgacctcg tttcttttct ttcctatgtt cttttgttca gtgaatatcc
     1921 ctagagctcc taccatatgt caggccctat gcctcaccct gagaacgcag tgagcatgag
     1981 gtggacctgt ttgctgggaa ccccaggtca cccccttttc ttcctactct gtgcctggag
     2041 catcatgtcc acccctgcag atccttggaa aagaaaatgt ttatgttgca gggtattgca
     2101 tggtcacgag tgagggcagg cccctgggga cacatctgcc cacagctgca caggccaggg
     2161 cgcaggcaca tctgttggtt ctcaggcctc agataaaacc atctccgcat catatggcca
     2221 gtgaccgctt tctcccttca agaaaattct gtggctgtgc agtactttga agttttaatt
     2281 attaacctgc tttaattaaa gcagtttcct ttcttataaa gtggaatcac caaatcttat
     2341 cacacagagc acagtcctgt agttacccag cccgctccag cagtgcggga gattgtaagg
     2401 aagcggtggc ggctggtgaa gcaagtctca catgtcggcg ttcttggcca atggatacaa
     2461 agataaagaa aatgttgcct ttttctagga actgtcagaa atcctcatgc ctttcaagac
     2521 ttctgtgaat gacttgaatt ttttattccc tgcctagggt ctgtgaacga ggcctgtctc
     2581 ttccctgggg tttctttcca tggcctttat ttctcctctt ccagtgggag ttttgcaggc
     2641 tcttctctgt ggaaacttca cgagcgttgg ctgggcctcg gcttcgctgg agtgtactcc
     2701 agggtgaagg cagagtggga tttgagaccc aggttaggca cgacccaggc tgagaaggga
     2761 cgtttccatc attcacagtg ccctccccac agcactacct caccccgacc cccaccctca
     2821 ctcctacccc accccgcgat cgtcaggggt gccacggtgg gccggagggt gccggctctg
     2881 gctgtccctg tgccggtccc tcacaaacct ctcccccttt gaaactcaag cacagctgcg
     2941 aggagggcag cgaggaggga cccctctctc atggttgtct ctttcccccg ctatgtcata
     3001 ggtagtggag gaagcgaagg aagtgaacgc tgaatgtgac gcatttctga agagctcagc
     3061 tgtcaccggg catagcctgg aagccccaag tctgttctga ctttgcctgg ctgtctcctt
     3121 gacccgcctc ctagatcatt gtccttgatg tccaggctgg gtcatttaaa atagagatgc
     3181 aatcaggaag gttgggggac ttgggactgt ggctgaattg agaccttgct gatgtattca
     3241 tgtcagcacc tgagtcacag cccaggtgcc cggaagcagc ctcttcgcat aggcagtgat
     3301 ttgcgattac tttaaagctc accttttttc ttcccctctc tgttcgctgc tgtcagcata
     3361 atgattgtgt tccttcccta tgggatccat ctgttttgta aacaataaag cgtctgaggg
     3421 agtgta
//
