LOCUS       NM_001162499            4573 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cullin associated and neddylation dissociated 2
            (putative) (CAND2), transcript variant 1, mRNA.
ACCESSION   NM_001162499
VERSION     NM_001162499.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4573)
  AUTHORS   Gorska,A.A., Sandmann,C., Riechert,E., Hofmann,C., Malovrh,E.,
            Varma,E., Kmietczyk,V., Olschlager,J., Jurgensen,L.,
            Kamuf-Schenk,V., Stroh,C., Furkel,J., Konstandin,M.H., Sticht,C.,
            Boileau,E., Dieterich,C., Frey,N., Katus,H.A., Doroudgar,S. and
            Volkers,M.
  TITLE     Muscle-specific Cand2 is translationally upregulated by mTORC1 and
            promotes adverse cardiac remodeling
  JOURNAL   EMBO Rep 22 (12), e52170 (2021)
   PUBMED   34605609
  REMARK    GeneRIF: Muscle-specific Cand2 is translationally upregulated by
            mTORC1 and promotes adverse cardiac remodeling.
REFERENCE   2  (bases 1 to 4573)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4573)
  AUTHORS   Dong,S.S., Yao,S., Chen,Y.X., Guo,Y., Zhang,Y.J., Niu,H.M.,
            Hao,R.H., Shen,H., Tian,Q., Deng,H.W. and Yang,T.L.
  TITLE     Detecting epistasis within chromatin regulatory circuitry reveals
            CAND2 as a novel susceptibility gene for obesity
  JOURNAL   Int J Obes (Lond) 43 (3), 450-456 (2019)
   PUBMED   29717274
  REMARK    GeneRIF: The work developed the tool and performed 'interaction
            analyses within chromatin regulatory circuitry' (IACRC); analysis
            found CAND2 may be a novel obesity susceptibility gene.
REFERENCE   4  (bases 1 to 4573)
  AUTHORS   Wei,T., Song,J., Xu,M., Lv,L., Liu,C., Shen,J. and Huang,Y.
  TITLE     NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative
            atrial fibrillation: a prospective study among Chinese population
  JOURNAL   Oncotarget 7 (27), 42617-42624 (2016)
   PUBMED   27203392
  REMARK    GeneRIF: NEURL rs12415501 and CAND2 rs4642101 are significantly
            associated with postoperative atrial fibrillation susceptibility
            after coronary artery bypass grafting among Chinese population
REFERENCE   5  (bases 1 to 4573)
  AUTHORS   Suzuki,H., Suzuki,A., Maekawa,Y., Shiraishi,S. and Tamura,T.A.
  TITLE     Interplay between two myogenesis-related proteins: TBP-interacting
            protein 120B and MyoD
  JOURNAL   Gene 504 (2), 213-219 (2012)
   PUBMED   22613845
  REMARK    GeneRIF: results suggest that MyoD and TIP120B potentiate each
            other at gene expression and post-translation levels, respectively,
            which may promote myogenesis cooperatively
REFERENCE   6  (bases 1 to 4573)
  AUTHORS   Shyy,W., Dietz,F., Dobbs,M.B., Sheffield,V.C. and Morcuende,J.A.
  TITLE     Evaluation of CAND2 and WNT7a as candidate genes for congenital
            idiopathic clubfoot
  JOURNAL   Clin Orthop Relat Res 467 (5), 1201-1205 (2009)
   PUBMED   19159115
  REMARK    GeneRIF: Based on these results it is unlikely CAND2 and WNT7a are
            the major genes that causes clubfoot.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4573)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   8  (bases 1 to 4573)
  AUTHORS   You,J., Wang,M., Aoki,T., Tamura,T.A. and Pickart,C.M.
  TITLE     Proteolytic targeting of transcriptional regulator TIP120B by a
            HECT domain E3 ligase
  JOURNAL   J Biol Chem 278 (26), 23369-23375 (2003)
   PUBMED   12692129
  REMARK    GeneRIF: TIP120B is a specific substrate of KIAA10; both are highly
            expressed in human skeletal muscle, suggesting that KIAA10 may
            regulate TIP120B homeostasis specifically in this tissue.
REFERENCE   9  (bases 1 to 4573)
  AUTHORS   Aoki,T., Okada,N., Wakamatsu,T. and Tamura,T.A.
  TITLE     TBP-interacting protein 120B, which is induced in relation to
            myogenesis, binds to NOT3
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1097-1103 (2002)
   PUBMED   12207886
  REMARK    GeneRIF: TIP120B was induced in C2C12 myoblasts when these cells
            differentiated into myotubes (TIP120B).
REFERENCE   10 (bases 1 to 4573)
  AUTHORS   Aoki,T., Okada,N., Ishida,M., Yogosawa,S., Makino,Y. and
            Tamura,T.A.
  TITLE     TIP120B: a novel TIP120-family protein that is expressed
            specifically in muscle tissues
  JOURNAL   Biochem Biophys Res Commun 261 (3), 911-916 (1999)
   PUBMED   10441524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR001490.1, BC136592.1, BX502783.1, AB014567.1 and W44800.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001162499.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.187710.1,
                                           SRR1803615.203844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456430.6/ ENSP00000387641.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               DR001490.1         9-261
            254-2613            BC136592.1         201-2560
            2614-2982           BX502783.1         257-625
            2983-3713           BC136592.1         2930-3660
            3714-4572           AB014567.1         3299-4157
            4573-4573           W44800.1           19-19               c
FEATURES             Location/Qualifiers
     source          1..4573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.2"
     gene            1..4573
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /note="cullin associated and neddylation dissociated 2
                     (putative)"
                     /db_xref="GeneID:23066"
                     /db_xref="HGNC:HGNC:30689"
                     /db_xref="MIM:610403"
     exon            1..109
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..3752
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /note="isoform 1 is encoded by transcript variant 1; TBP
                     interacting protein; cullin-associated NEDD8-dissociated
                     protein 2; epididymis tissue protein Li 169; p120 CAND2;
                     TBP-interacting protein 120B; TBP-interacting protein of
                     120 kDa B; cullin-associated and neddylation-dissociated
                     protein 2; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="cullin-associated NEDD8-dissociated protein 2
                     isoform 1"
                     /protein_id="NP_001155971.1"
                     /db_xref="CCDS:CCDS54554.1"
                     /db_xref="GeneID:23066"
                     /db_xref="HGNC:HGNC:30689"
                     /db_xref="MIM:610403"
                     /translation="MSTAAFHISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDED
                     SERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVVKVKEYQVETIVDTLCTNMRSDKEQL
                     RDIAGIGLKTVLSELPPAATGSGLATNVCRKITGQLTSAIAQQEDVAVQLEALDILSD
                     MLSRLGVPLGAFHASLLHCLLPQLSSPRLAVRKRAVGALGHLAAACSTDLFVELADHL
                     LDRLPGPRVPTSPTAIRTLIQCLGSVGRQAGHRLGAHLDRLVPLVEDFCNLDDDELRE
                     SCLQAFEAFLRKCPKEMGPHVPNVTSLCLQYIKHDPNYNYDSDEDEEQMETEDSEFSE
                     QESEDEYSDDDDMSWKVRRAAAKCIAALISSRPDLLPDFHCTLAPVLIRRFKEREENV
                     KADVFTAYIVLLRQTQPPKGWLEAMEEPTQTGSNLHMLRGQVPLVVKALQRQLKDRSV
                     RARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSSTIRMDALAFLQGLLG
                     TEPAEAFHPHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPY
                     VGEMSAVTLARLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRLRNE
                     ITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKNQRALRLATLAALDALAQS
                     QGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQAQPASLVEVSGPVLSEL
                     LRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAPVYEQAVDGGPGLHK
                     QVFHSLARCVAALSAACPQEAASTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAGP
                     GHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPFLLEQIEAEPRRQYLL
                     LHSLREALGAAQPDSLKPYAEDIWALLFQRCEGAEEGTRGVVAECIGKLVLVNPSFLL
                     PRLRKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSFIGEFMESLQDPDLNVRRA
                     TLAFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRK
                     AAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMVARLATLCPAPVLQR
                     VDRLIEPLRATCTAKVKAGSVKQEFEKQDELKRSAMRAVAALLTIPEVGKSPIMADFS
                     SQIRSNPELAALFESIQKDSASAPSTDSMELS"
     exon            110..253
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            254..408
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            409..532
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            533..798
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            799..904
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1047
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1340
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1482
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..2985
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3081
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3251
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3416
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3524
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..4573
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /note="hexamer: AATAAA"
     polyA_site      4573
                     /gene="CAND2"
                     /gene_synonym="TIP120B; Tp120b"
                     /note="major polyA site"
ORIGIN      
        1 atattccctc ccgccggccg gctccgcggc gcgcagccac catgagcacc gccgccttcc
       61 acatctccag cctcctggag aagatgacgt ccagcgacaa ggacttcagg ttcatggcca
      121 ccagcgacct gatgtcggag ttgcagaagg actccatcca gctggacgag gacagcgagc
      181 gcaaggtggt gaagatgctg ctccggctcc tggaggacaa gaacggtgag gtgcagaacc
      241 tggctgtcaa gtgcctgggt cctctggtgg tcaaagtgaa ggagtaccag gtggagacca
      301 ttgtggacac cctgtgcacc aacatgcggt cagacaagga gcagctgcga gacattgccg
      361 gcattggcct caagaccgtc ctctcggagc tccctcctgc agccacaggc tccgggctgg
      421 ccaccaacgt gtgccggaag atcacaggcc agctcaccag tgccattgcc cagcaggagg
      481 atgtggctgt gcagctggaa gccctggaca tcctctctga catgctgagc aggctgggtg
      541 tcccgctggg cgccttccac gccagcctcc tgcactgtct gctgccacag ctgagcagcc
      601 cgcgcctggc ggtgcgcaag cgggcggtcg gagcgcttgg ccacctggcg gccgcctgca
      661 gcaccgacct cttcgtcgag ctcgctgacc acctactgga ccggctgccc ggcccgcggg
      721 tgcccaccag cccgactgcc atccgcaccc tgatccaatg tttgggcagc gtcggccgcc
      781 aggccggcca ccgcctcggg gctcacctgg accgcctggt gcccctggtg gaggatttct
      841 gcaacctgga tgatgatgag ctccgggagt cctgcctcca ggcttttgag gccttcttga
      901 ggaagtgccc caaggaaatg ggtcctcacg tgcccaacgt gaccagcctc tgcctccaat
      961 acataaaaca cgaccccaac tacaactacg acagtgatga ggatgaggag cagatggaga
     1021 cagaggatag tgaattcagt gagcaagaga gtgaagacga gtacagcgat gacgatgaca
     1081 tgagctggaa ggtgcgccgg gcagctgcca agtgcatcgc agccttgatc agctcgcggc
     1141 ctgacctgct gcccgatttc cactgcaccc tggcacctgt gctcatccgc cgcttcaaag
     1201 aacgcgagga gaacgtcaag gctgacgtct tcactgctta catcgtgctg ctgcggcaaa
     1261 cacagccccc gaagggatgg ctggaggcca tggaggaacc cacccagacc ggcagcaacc
     1321 tccatatgct acgtggacag gtgccccttg tggtcaaggc cctgcagcgg cagcttaaag
     1381 atcggagcgt cagagcccgc cagggatgct tcagcctcct caccgagctg gcgggtgtcc
     1441 tcccaggcag cctggccgag catatgcctg tgctggtatc aggcatcatc ttctcgctgg
     1501 ccgaccgctc cagctcctcc accatccgga tggatgccct ggccttcttg caggggctgc
     1561 tgggcaccga accagctgag gccttccacc cacacttgcc tatcctcctg ccacctgtga
     1621 tggcctgtgt ggctgactct ttctacaaga ttgcagccga ggccctggtg gtgctgcagg
     1681 agctggtgcg ggccctgtgg ccgctgcaca ggcctcggat gctggatcct gagccatatg
     1741 ttggagagat gtctgctgtc accctggcgc gacttcgtgc cactgacctg gaccaggagg
     1801 tgaaggagcg ggccatttcc tgcatgggcc accttgtagg ccacctgggt gaccggcttg
     1861 gggatgacct ggagcccacg ttactgctcc tcctggaccg cctgcggaat gagatcaccc
     1921 ggctgcccgc catcaaggcg cttacgctgg tggccgtatc cccactacag cttgacctac
     1981 agcccatcct ggccgaggca ctgcacattc tggcctcatt cctgcggaag aaccagcggg
     2041 ctttgcgact ggccacactg gcagccctgg acgccctggc ccagagccag ggcctcagcc
     2101 tcccaccgtc tgccgtgcag gccgtgctgg ctgagctgcc tgccctggtc aacgagagcg
     2161 acatgcatgt ggcccagctg gctgtggact tccttgccac agtgacccag gcccagccag
     2221 cctctttggt ggaggtcagt ggccctgtgc tctcagagct gctgcggctg ctgcgttcgc
     2281 ccctgttgcc agccggggtt ctggcagctg ctgaaggctt cctgcaggcc ctggtaggga
     2341 cccgtccccc gtgtgtggac tatgccaaac tcatcagcct gctcactgcg cctgtttatg
     2401 agcaggctgt ggatggtggg cctggcctgc acaagcaggt gttccactca ttggcccggt
     2461 gtgtggcagc cctctcagct gcctgtcccc aagaggcggc aagcacagcc agtcgcctgg
     2521 tctgcgatgc caggtcgccc cactccagca cgggggtcaa ggtcctggca ttcttgtcgc
     2581 tggctgaggt gggtcaggtg gctgggccag gccaccagcg ggagctgaag gcggtgctcc
     2641 tggaagcttt ggggtcaccc agtgaggatg tgagggctgc agcctcgtat gcactgggcc
     2701 gtgtgggtgc tggcagcctg cccgacttcc tgcccttcct gctggagcag atcgaggctg
     2761 agccccgacg acagtacctg ctgctgcact cactcaggga ggccctgggg gccgcccagc
     2821 ctgacagcct gaagccctac gccgaggaca tctgggcctt gctgttccag cgctgcgagg
     2881 gtgctgagga gggcacccgg ggggtggtgg ccgagtgcat tgggaagctg gtccttgtga
     2941 acccttcgtt ccttctgccc cgcttgcgga agcagcttgc tgcaggtcgg ccacacaccc
     3001 ggagcaccgt catcacagcg gtcaagttcc ttatctcgga ccagccccat cccattgacc
     3061 ccctcctgaa gagcttcatc ggagagttca tggagagcct gcaggaccca gacctgaacg
     3121 tgcgccgtgc gactctggct ttcttcaact cagctgtgca caacaagccc tcgctagtcc
     3181 gggacctgct ggatgacatc ctgcccctcc tctaccagga gacaaagatc cggcgggacc
     3241 tcatccgaga ggtggagatg gggcccttta aacatacagt ggacgatggg ctggacgtgc
     3301 ggaaggcggc ctttgaatgc atgtattcac tgcttgagag ctgcctgggc cagctggata
     3361 tctgtgagtt cctgaaccat gtggaggacg ggctgaagga ccactacgac atccggatgc
     3421 tgaccttcat catggttgcc cggctggcca ccctgtgtcc tgcacctgtc ctgcagaggg
     3481 tggaccgact cattgagcca ctaagggcca cctgcactgc caaggtcaaa gctggttctg
     3541 tgaagcagga gtttgaaaag caagatgaac tgaagcgctc tgcaatgagg gcagtggctg
     3601 ccctgctgac catccccgag gtggggaaaa gccccatcat ggccgacttc tcttcccaaa
     3661 tcagatccaa ccctgaactt gctgccctct ttgaaagcat ccagaaggat tccgcttcag
     3721 cccccagcac agactcaatg gagctcagct agtcccctca gcaccaaggt gggccctcgc
     3781 ttaagagaaa ggagcccacc caagtccgag gcctccccat cccaccatcg caggtctcta
     3841 cttttgccct tccaccatct cactgggggc cctgtcgctc ctggtcaggg cttacagtgc
     3901 cttctccagg gacccaactc aaaggccccc agcccaagct gtgaggctgc caacagttgg
     3961 gccccttcct taactcagga cagtcatcca aagaaatagg gtgaggaagt tttccagtga
     4021 cttcacactg tacccctcca tagtctgtct ggttccttca gagggtgtct ctgcctcaca
     4081 aactagtagt atttagaaat aggctgtgct gtcagctgta aaagatcagg aggcagcaga
     4141 caccactctg gtttcttcac tgcattcagc aatgcctgaa gttagtgctc aggccgggca
     4201 tctcaaaaga aaagatactt gagttattca cattttaaaa ttcaaaacgg ttcattttta
     4261 agtggcagtg atgaatcaga aatttggaag atgatacggg tttctttttt ccagggagga
     4321 ggaatgggtt gggtagggaa ctggacaggc ttggacctca tgtttcattt ctaatttcaa
     4381 aatacttatt agcaaattgg gcaacaatgg gcatcttcca tgccaccacc caggcataac
     4441 cagttggttt gtttccttct gaggaaggtt tcaaatgtgt ctagtgttca gtattgagga
     4501 caaagaaata caagtggcag gcccaagtat tttctgtgat atcccaggtt aataaagatt
     4561 agattctaag tta
//
