LOCUS       NM_015099               4515 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calmodulin binding transcription activator 2 (CAMTA2),
            transcript variant 1, mRNA.
ACCESSION   NM_015099
VERSION     NM_015099.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4515)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4515)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4515)
  AUTHORS   Monies,D., Abou Al-Shaar,H., Goljan,E.A., Al-Younes,B.,
            Al-Breacan,M.M.A., Al-Saif,M.M., Wakil,S.M., Meyer,B.F.,
            Khabar,K.S.A. and Bohlega,S.
  TITLE     Identification of a novel genetic locus underlying tremor and
            dystonia
  JOURNAL   Hum Genomics 11 (1), 25 (2017)
   PUBMED   29110692
  REMARK    GeneRIF: Mutation of CAMTA2 resulting in post-transcriptional
            inhibition of its own gene activity likely underlies a novel
            syndromic tremulous dystonia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4515)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 4515)
  AUTHORS   Finkler,A., Ashery-Padan,R. and Fromm,H.
  TITLE     CAMTAs: calmodulin-binding transcription activators from plants to
            human
  JOURNAL   FEBS Lett 581 (21), 3893-3898 (2007)
   PUBMED   17689537
  REMARK    Review article
REFERENCE   6  (bases 1 to 4515)
  AUTHORS   Liu,N. and Olson,E.N.
  TITLE     Coactivator control of cardiovascular growth and remodeling
  JOURNAL   Curr Opin Cell Biol 18 (6), 715-722 (2006)
   PUBMED   17046230
  REMARK    Review article
REFERENCE   7  (bases 1 to 4515)
  AUTHORS   Song,K., Backs,J., McAnally,J., Qi,X., Gerard,R.D.,
            Richardson,J.A., Hill,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     The transcriptional coactivator CAMTA2 stimulates cardiac growth by
            opposing class II histone deacetylases
  JOURNAL   Cell 125 (3), 453-466 (2006)
   PUBMED   16678093
REFERENCE   8  (bases 1 to 4515)
  AUTHORS   Schwartz,R.J. and Schneider,M.D.
  TITLE     CAMTA in cardiac hypertrophy
  JOURNAL   Cell 125 (3), 427-429 (2006)
   PUBMED   16678087
  REMARK    Review article
REFERENCE   9  (bases 1 to 4515)
  AUTHORS   Bouche,N., Scharlat,A., Snedden,W., Bouchez,D. and Fromm,H.
  TITLE     A novel family of calmodulin-binding transcription activators in
            multicellular organisms
  JOURNAL   J Biol Chem 277 (24), 21851-21861 (2002)
   PUBMED   11925432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004771.1, DB275145.1 and AB020716.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015099.3.
            
            Summary: The protein encoded by this gene is a member of the
            calmodulin-binding transcription activator protein family. Members
            of this family share a common domain structure that consists of a
            transcription activation domain, a DNA-binding domain, and a
            calmodulin-binding domain. The encoded protein may be a
            transcriptional coactivator of genes involved in cardiac growth.
            Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142695.1, AB020716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348066.8/ ENSP00000321813.7
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC004771.1         57328-57337         c
            11-49               DB275145.1         1-39
            50-945              AB020716.1         1-896
            946-946             AC004771.1         50185-50185         c
            947-2853            AB020716.1         898-2804
            2854-2854           AC004771.1         41995-41995         c
            2855-4288           AB020716.1         2806-4239
            4289-4515           AC004771.1         37659-37885         c
FEATURES             Location/Qualifiers
     source          1..4515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..4515
                     /gene="CAMTA2"
                     /note="calmodulin binding transcription activator 2"
                     /db_xref="GeneID:23125"
                     /db_xref="HGNC:HGNC:18807"
                     /db_xref="MIM:611508"
     exon            1..83
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..178
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..3756
                     /gene="CAMTA2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="calmodulin-binding transcription activator 2
                     isoform 1"
                     /protein_id="NP_055914.2"
                     /db_xref="CCDS:CCDS11063.1"
                     /db_xref="GeneID:23125"
                     /db_xref="HGNC:HGNC:18807"
                     /db_xref="MIM:611508"
                     /translation="MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTN
                     EEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDGKTTRE
                     DHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPALEDCGKGCS
                     PIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQQILDTHPT
                     KPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEPPPLI
                     APLPPELPKAHTSPSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQR
                     AGGLTPTRHLAPQADPRPSMSLAVVVGTEPSAPPAPPSPAFDPDRFLNSPQRGQTYGG
                     GQGVSPDFPEAEAAHTPCSALEPAAALEPQAAARGPPPQSVAGGRRGNCFFIQDDDSG
                     EELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFGGPVGASELEPFSLSSFPD
                     LMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITGPWTEAAEHYSC
                     VFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPS
                     TQLDWLSLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEGQGPGFEA
                     RVVVLVESMIPRSTWKGPERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGS
                     LDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFRWNRQALSIPDSLGRLPLSVAH
                     SRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTGLSSVSSPSELSDGTFSVTSAY
                     SSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSLPALP
                     PASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRER
                     TGAVGLSETMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGK
                     MESDFALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQL
                     TWIALKFALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPH
                     RTSATLPARNKGSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT"
     exon            179..282
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..350
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..486
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..558
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..712
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..847
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1785
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1912
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2047
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2163
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2348
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2427
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2650
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2955
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3152
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3336
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3408
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3429
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3617
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3692
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..4515
                     /gene="CAMTA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4497..4502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMTA2"
                     /note="hexamer: ATTAAA"
     polyA_site      4515
                     /gene="CAMTA2"
                     /note="major polyA site"
ORIGIN      
        1 agacgccgct gtcagccggc gctggggggg gtcggtgtgg ggtagaatgg ccgctgccgc
       61 cgtcacccgc gggaccccgg gagcacagac tccccctccc cccggcccct caggccgggg
      121 gtgaccttgc cccctggagc cctcaccatg aataccaagg acaccaccga ggttgctgaa
      181 aacagccacc acctgaagat ctttctcccc aagaagctgc tggagtgtct tcctcgctgc
      241 ccgctgctgc ctccagagag gctacggtgg aatacaaatg aggagattgc atcctacctg
      301 atcacctttg agaagcatga tgagtggctg tcttgtgccc caaagacaag gcctcagaat
      361 ggctccatca tcctctacaa tcgcaagaag gtgaaatatc ggaaggatgg ttacctctgg
      421 aagaagcgga aggatgggaa gaccacccga gaggaccaca tgaagctgaa ggtccagggc
      481 atggagtgtc tctatggctg ctacgttcac tcttccatcg tccccacatt ccatcggcgc
      541 tgctactggc tgctccagaa ccctgacatc gtccttgtgc actacctgaa cgtcccagcc
      601 ctggaggact gtggaaaggg ctgcagcccc atcttttgtt ccatcagcag cgaccgtcga
      661 gagtggctga agtggtcccg ggaggagttg ttgggacagc tgaagcccat gtttcatggc
      721 atcaagtgga gctgcgggaa tggaacagaa gagttctctg tagaacacct ggtgcagcag
      781 attttggaca cccacccaac caagcctgct ccccgaaccc acgcctgtct ctgcagtggg
      841 gggcttggtt ctgggagcct tacccacaaa tgcagcagca cgaaacaccg catcatctct
      901 cccaaagtgg agccccgagc tttaaccctg acctctatcc cccacgctca ccccccagag
      961 cctcctccac tgatagcccc acttccccca gagctcccca aggcacacac ctccccatct
     1021 tcttcctctt cttcctcctc atcaggtttt gcagagcccc tagaaatcag acctagccct
     1081 cccacttctc gagggggttc ttcaagagga ggcactgcta tcctcctcct gacaggactg
     1141 gagcagcggg ctggaggctt gacgcccacc aggcacttgg ctccacaggc tgatcctagg
     1201 ccttccatga gtttggcagt ggttgtaggc actgagcctt ctgccccacc agctcctccc
     1261 agtcctgcct ttgaccctga tcgttttctc aacagccccc agaggggcca gacatatgga
     1321 ggggggcagg gagtaagccc agacttcccc gaggcagagg ccgctcatac cccctgttct
     1381 gccctagagc ctgctgctgc cctggagccc caggcagctg ctcggggtcc cccaccacag
     1441 tcagtagcag gtgggagaag aggaaactgc ttcttcatcc aagatgatga cagtggggag
     1501 gagctcaagg gtcacggggc tgccccaccc ataccttcac cccctccctc acccccaccc
     1561 tcacctgccc ccttggagcc gtcaagcagg gtaggaagag gagaggcctt gtttggagga
     1621 cctgttgggg ccagtgaact ggagcccttc agtctttcat cattcccaga ccttatggga
     1681 gaactcatca gtgacgaagc tccaagcatc cctgctccga ccccccagct gtctcctgct
     1741 cttagcacca tcacagactt ctccccagag tggtcctacc cagagggtgg ggtcaaggtg
     1801 ctcatcacag gtccttggac cgaagccgcc gagcattact cctgtgtctt tgatcacatc
     1861 gcagtgccag cctcacttgt ccagcctggt gtcttacgct gctactgtcc cgcccatgag
     1921 gtagggctgg tgtctttgca ggtggcaggg cgggaggggc ccctttctgc ttctgtgctc
     1981 tttgagtatc gagcccgccg attcctgtct ctgcctagta ctcaacttga ctggctgtca
     2041 ctggacgaca accagttccg gatgtccata ctagagcgac tggagcagat ggagaagcgg
     2101 atggcagaga tcgcagcagc tgggcaggtg ccttgccagg gtcctgatgc tcctccagtt
     2161 caggatgaag gccaggggcc tgggttcgaa gcacgggtag tggtcttggt agaaagcatg
     2221 atcccacgct ccacctggaa gggtcctgaa cgtctggccc atggaagccc cttccggggc
     2281 atgagccttc tgcacctggc tgctgcccag ggctatgccc gcctcatcga gaccctgagc
     2341 cagtggcgga gtgtggagac tggaagcttg gacttagagc aggaggttga cccgctcaac
     2401 gtggatcatt tctcttgcac ccctctgatg tgggcttgtg ccctgggaca cctggaagct
     2461 gctgtgctcc ttttccgttg gaaccgacag gcactgagca ttcccgactc tctgggccgt
     2521 ctgccattgt ctgtggctca ttcccggggt catgtgcgcc ttgcccgctg ccttgaggaa
     2581 ctacagagac aggagccttc ggtggagccc ccatttgccc tatcgccacc ctcctccagc
     2641 ccagacactg gtctgagcag cgtctcctcg ccctcggagc tgtcggatgg caccttttcc
     2701 gtcacgtcag cctattctag tgccccagat ggcagtcccc cccctgcacc tctgccagcc
     2761 tctgagatga ctatggagga catggcccca ggccagcttt cctctggtgt cccagaagcc
     2821 cccctactcc tcatggacta tgaggctacc aactccaagg ggcccctctc ctcccttcct
     2881 gccctcccac cagcttcaga tgatggggct gctccagagg acgctgacag cccacaggct
     2941 gtggatgtga tcccggtgga catgatctca ctagccaagc agatcatcga agccacaccg
     3001 gagcggatta aacgagagga cttcgtgggg ctgcccgagg ctggagcctc aatgcgggag
     3061 cggacagggg ctgtggggct cagtgagacc atgtcctggc tggccagcta cctggagaat
     3121 gtggaccatt tccccagctc aacccctccc agcgaactgc cctttgagcg aggtcgcctg
     3181 gctgtccctt cagcaccctc ctgggcagag tttctctctg catccaccag tggcaagatg
     3241 gaaagtgatt ttgccctgct gacactatca gatcacgagc agcgggaact gtatgaggct
     3301 gcccgagtca tccagacggc cttccgaaag tacaagggcc ggcggctgaa ggagcagcag
     3361 gaggtagcag cagctgtaat ccagcgctgt taccggaagt acaagcagct gacctggatt
     3421 gcacttaagt ttgcactcta taagaagatg acccaggcgg ccatcctgat ccagagcaag
     3481 ttccgaagct actatgaaca gaagcgattt cagcagagcc gccgagcggc tgtgctcatc
     3541 cagcagcact accgctccta ccgccgcagg cccggccctc cccaccggac ttcggccacc
     3601 ctgcctgccc gcaacaaagg ctcctttctc accaagaagc aggaccaggc agcccggaag
     3661 atcatgagat tcctgcggcg ctgccgacac aggatgaggg aactgaagca gaaccaggag
     3721 ctggaagggc ttccccagcc gggactggcc acatgacctg gccaccgcct ttctcaccac
     3781 cctgggggcg cctcgtgcag tcttaacagg gagagggctt tctggggcag ggggagcccc
     3841 tgtcggcagc tttcctgttc acctttgttg gagccctctg taggcctcct ccctcctccc
     3901 cacgccttgc tcccacaccc ctctcctcgt ccctcctggt cgtgccccgt ctcttttggt
     3961 cctggctcca gaaaacccgc gccccacata cctgcatctt ccgctgtgac ctccggagcc
     4021 ctgcctgccc ctgctcccca gctcctcctg cctgcacccg actcggcccc ctcctgactt
     4081 gccttattta tttgttcgac gcgtctctga atgtatccgc ctcggttccc accactgcct
     4141 tcgctgcgca cgcccctcgt gtttcagggc tgaccgtgtc cccacccgac tccgcatgtt
     4201 tgcgtctgtt tcctccctct ctggccctgt cttaccccat cacccgactc tggccactga
     4261 cctcagggcc gaaggggagg tggtgtacat aggaacgcgt tgcggagtcc gccccgtccc
     4321 ccgaggggag gggtcttgta catactgtaa catacagagt atagtgaaga atctatttaa
     4381 ggcgccgcgg ggagggctgc acggccgggc ttgtggttct ctagcgcggc gggggcctcc
     4441 tgccggctcc acgggcactt tctacttgtg catgggcttg gtttatacga attgccatta
     4501 aacatcgctg cacca
//
