LOCUS       NM_015215               8314 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calmodulin binding transcription activator 1 (CAMTA1),
            transcript variant 1, mRNA.
ACCESSION   NM_015215 XM_042323
VERSION     NM_015215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8314)
  AUTHORS   Al-Kateb,H., Au,P.Y.B., Berland,S., Cogne,B., Demurger,F.,
            Fluss,J., Isidor,B., Frank,L.M., Varvagiannis,K., Koolen,D.A.,
            McDonald,M., Montgomery,S., Moortgat,S., Deprez,M., Karadurmus,D.,
            Paulsen,J., Reis,A., Rieger,M., Vasileiou,G., Willing,M. and
            Shinawi,M.
  TITLE     CAMTA1-related disorder: Phenotypic and molecular characterization
            of 26 new individuals and literature review
  JOURNAL   Clin Genet 105 (3), 294-301 (2024)
   PUBMED   38044714
  REMARK    GeneRIF: CAMTA1-related disorder: Phenotypic and molecular
            characterization of 26 new individuals and literature review.
REFERENCE   2  (bases 1 to 8314)
  AUTHORS   Alves,G., Ornellas,M.H. and Liehr,T.
  TITLE     The role of Calmodulin Binding Transcription Activator 1 (CAMTA1)
            gene and its putative genetic partners in the human nervous system
  JOURNAL   Psychogeriatrics 22 (6), 869-878 (2022)
   PUBMED   35949142
  REMARK    GeneRIF: The role of Calmodulin Binding Transcription Activator 1
            (CAMTA1) gene and its putative genetic partners in the human
            nervous system.
            Review article
REFERENCE   3  (bases 1 to 8314)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 8314)
  AUTHORS   Dzinovic,I., Serranova,T., Prouteau,C., Colin,E., Ziegler,A.,
            Winkelmann,J., Jech,R. and Zech,M.
  TITLE     Myoclonic dystonia phenotype related to a novel calmodulin-binding
            transcription activator 1 sequence variant
  JOURNAL   Neurogenetics 22 (2), 137-141 (2021)
   PUBMED   33677721
  REMARK    GeneRIF: Myoclonic dystonia phenotype related to a novel
            calmodulin-binding transcription activator 1 sequence variant.
            Erratum:[Neurogenetics. 2022 Jan;23(1):77. doi:
            10.1007/s10048-021-00641-w.. PMID: 34859314]
REFERENCE   5  (bases 1 to 8314)
  AUTHORS   Merritt,N., Garcia,K., Rajendran,D., Lin,Z.Y., Zhang,X.,
            Mitchell,K.A., Borcherding,N., Fullenkamp,C., Chimenti,M.S.,
            Gingras,A.C., Harvey,K.F. and Tanas,M.R.
  TITLE     TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex
  JOURNAL   Elife 10, e62857 (2021)
   PUBMED   33913810
  REMARK    GeneRIF: TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8314)
  AUTHORS   Henrich,K.O., Claas,A., Praml,C., Benner,A., Mollenhauer,J.,
            Poustka,A., Schwab,M. and Westermann,F.
  TITLE     Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted
            region at 1p36 in neuroblastoma
  JOURNAL   Eur J Cancer 43 (3), 607-616 (2007)
   PUBMED   17222547
  REMARK    GeneRIF: no evidence for somatic mutations in FLJ10737 in
            neuroblastoma
REFERENCE   7  (bases 1 to 8314)
  AUTHORS   Barbashina,V., Salazar,P., Holland,E.C., Rosenblum,M.K. and
            Ladanyi,M.
  TITLE     Allelic losses at 1p36 and 19q13 in gliomas: correlation with
            histologic classification, definition of a 150-kb minimal deleted
            region on 1p36, and evaluation of CAMTA1 as a candidate tumor
            suppressor gene
  JOURNAL   Clin Cancer Res 11 (3), 1119-1128 (2005)
   PUBMED   15709179
REFERENCE   8  (bases 1 to 8314)
  AUTHORS   Nakatani,K., Nishioka,J., Itakura,T., Nakanishi,Y., Horinouchi,J.,
            Abe,Y., Wada,H. and Nobori,T.
  TITLE     Cell cycle-dependent transcriptional regulation of
            calmodulin-binding transcription activator 1 in neuroblastoma cells
  JOURNAL   Int J Oncol 24 (6), 1407-1412 (2004)
   PUBMED   15138581
REFERENCE   9  (bases 1 to 8314)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FLJ10737 and CAMTA1 genes on
            the commonly deleted region of neuroblastoma at human chromosome
            1p36.31-p36.23
  JOURNAL   Int J Oncol 23 (4), 1219-1224 (2003)
   PUBMED   12964007
  REMARK    GeneRIF: FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate
            tumor suppressor genes of neuroblastoma
REFERENCE   10 (bases 1 to 8314)
  AUTHORS   Bouche,N., Scharlat,A., Snedden,W., Bouchez,D. and Fromm,H.
  TITLE     A novel family of calmodulin-binding transcription activators in
            multicellular organisms
  JOURNAL   J Biol Chem 277 (24), 21851-21861 (2002)
   PUBMED   11925432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC151835.1, AL359881.28,
            Z98884.11 and KF495855.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015215.3.
            
            Summary: The protein encoded by this gene contains a CG1
            DNA-binding domain, a transcription factor immunoglobulin domain,
            ankyrin repeats, and calmodulin-binding IQ motifs. The encoded
            protein is thought to be a transcription factor and may be a tumor
            suppressor. However, a translocation event is sometimes observed
            between this gene and the WWTR1 gene, with the resulting
            WWTR1-CAMTA1 oncoprotein leading to epithelioid
            hemangioendothelioma, a malignant vascular cancer. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151835.1, AB020640.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303635.12/ ENSP00000306522.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1426              BC151835.1         131-1556
            1427-2729           AL359881.28        5038-6340
            2730-5530           BC151835.1         2860-5660
            5531-7624           Z98884.11          44142-46235
            7625-7915           KF495855.1         1-291
            7916-8314           Z98884.11          46527-46925
FEATURES             Location/Qualifiers
     source          1..8314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31-p36.23"
     gene            1..8314
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="calmodulin binding transcription activator 1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
     exon            1..122
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..5099
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="calmodulin-binding transcription activator 1
                     isoform a"
                     /protein_id="NP_056030.1"
                     /db_xref="CCDS:CCDS30576.1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
                     /translation="MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNS
                     NSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRP
                     QNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPT
                     FHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQL
                     KPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHH
                     KCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPV
                     LLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGS
                     LSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSS
                     ESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMV
                     SSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGS
                     SLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKP
                     LPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQ
                     AMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNV
                     VQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSG
                     DSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAAS
                     AQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPAS
                     LIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDD
                     NQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGAL
                     GSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWR
                     TKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRL
                     PLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISS
                     PEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLP
                     TALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGK
                     WNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYR
                     DSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISST
                     MSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAAD
                     WSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAA
                     VIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKC
                     GKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIE
                     KGQGT"
     exon            123..192
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            193..311
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            312..379
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            380..515
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            516..587
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            588..741
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            742..882
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            883..2729
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2856
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2991
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3143
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3340
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3419
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3735
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..4259
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4447
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4448..4694
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4766
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..4960
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..5035
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..5066
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            5067..8314
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8288..8293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="hexamer: ATTAAA"
     polyA_site      8314
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgggg tggctgggcc ggcggcggcg gcggtacgag gcgcgcgctc ggggtcccgg
       61 tcgcgaggag gaggaggatg tggcgcgcgg aggggaaatg gctgccgaaa acaagccgga
      121 agagcgtttc ccaaagtgta ttctgcggaa ctagcaccta ctgtgttctc aacaccgtgc
      181 cacctataga agatgatcat gggaacagca atagtagtca tgtaaaaatc tttttaccga
      241 aaaagctgct tgaatgtctg ccgaaatgtt caagtttacc aaaagagagg caccgctgga
      301 acactaatga ggaaattgca gcttatttaa taacatttga gaaacacgaa gaatggctaa
      361 ccacctcccc taagacaaga ccacagaatg gctcaatgat actctacaac aggaagaaag
      421 tgaaatacag gaaagatggg tattgctgga aaaagaggaa agatgggaaa acgaccagag
      481 aggaccacat gaaactcaag gtccagggag tggagtgctt gtacggctgc tatgtccatt
      541 cctccatcat ccccaccttc caccggaggt gctactggct ccttcagaac cccgacatcg
      601 tcctggtgca ctacctgaac gtgccggcca tcgaggactg cggcaagcct tgcggcccca
      661 tcctctgctc catcaacacc gacaagaagg agtgggcgaa atggacgaaa gaagagctca
      721 tcgggcagct gaaacccatg ttccatggca tcaagtggac ctgcagcaat gggaacagca
      781 gctcaggctt ctcggtggaa cagctggtgc agcagatcct cgacagccac cagaccaagc
      841 cccagccgcg gacccacaac tgcctctgca ccggcagcct gggagctggc ggcagcgtgc
      901 atcacaagtg taacagcgcc aaacaccgca tcatctcgcc caaggtggag ccacggacag
      961 gggggtacgg gagccactcg gaggtgcagc acaatgacgt gtcggagggc aagcacgagc
     1021 acagccacag caagggctcc agccgtgaga agaggaacgg caaggtggcc aagcccgtgc
     1081 tcctgcacca gagcagcacc gaggtctcct ccaccaacca ggtggaagtc cccgacacca
     1141 cccagagctc ccctgtgtcc atcagcagcg ggctcaacag cgacccggac atggtggaca
     1201 gcccggtggt cacaggtgtg tccggtatgg cggtggcctc tgtgatgggg agcttgtccc
     1261 agagcgccac ggtgttcatg tcagaggtca ccaatgaggc cgtgtacacc atgtccccca
     1321 ccgctggccc caaccaccac ctcctctcac ctgacgcctc tcagggcctc gtcctggccg
     1381 tgagctctga tggccacaag ttcgcctttc ccaccacggg cagctcggag agcctgtcca
     1441 tgctgcccac caacgtgtcc gaagagctgg tcctctccac caccctcgac ggtggccgga
     1501 agattccaga aaccaccatg aactttgacc ccgactgttt ccttaataac ccaaagcagg
     1561 gccagacgta cgggggtgga ggcctgaaag ccgagatggt cagctccaac atccggcact
     1621 cgccacccgg ggagcggagc ttcagcttta ccaccgtcct caccaaggag atcaagaccg
     1681 aggacacctc cttcgagcag cagatggcca aagaagcgta ctcctcctcc gcggcggctg
     1741 tggcagccag ctccctcacc ctgaccgccg gctccagcct cctgccgtcg ggcggcggcc
     1801 tgagtcccag caccaccctg gagcagatgg acttcagcgc catcgactcc aacaaggact
     1861 acacgtccag cttcagccag acgggccaca gcccccacat ccaccagacc ccctccccga
     1921 gcttcttcct gcaggacgcc agcaaacccc tccccgtcga gcagaacacc cacagcagcc
     1981 tgagtgactc tgggggcacc ttcgtgatgc ccacggtgaa aacggaggcc tcgtcccaaa
     2041 ccagctcctg cagcggtcac gtggagacgc ggatcgagtc cacttcctcc ctccacctca
     2101 tgcagttcca ggccaacttc caggccatga cggcagaagg ggaggtcacc atggagacct
     2161 cgcaggcggc ggaagggagc gaggtcctgc tcaagtctgg ggagctgcag gcttgcagct
     2221 ctgagcacta cctgcagccg gagaccaacg gggtaatccg aagcgccggc ggcgtcccca
     2281 tcctcccggg caacgtggtg cagggactct accccgtggc ccagcccagc ctcggcaacg
     2341 cctccaacat ggagctcagc ctggaccact ttgacatctc cttcagcaac cagttctccg
     2401 acctgatcaa cgacttcatc tccgtggagg ggggcagcag caccatctat gggcaccagc
     2461 tggtgtcggg ggacagcacg gcgctctcac agtcagagga cggggcgcgg gcccccttca
     2521 cccaggcaga gatgtgcctc ccctgctgta gcccccagca gggtagcctg cagctgagca
     2581 gctcggaggg cggggccagc accatggcct acatgcacgt cgccgaggtg gtctcggccg
     2641 cctcggccca gggcacccta ggcatgctgc agcagagcgg acgggtgttc atggtgaccg
     2701 actactcccc agagtggtct tacccagagg gaggagtgaa ggtcctcatc acaggcccgt
     2761 ggcaagaagc cagcaataac tacagctgcc tgtttgacca gatctcagtg cctgcatccc
     2821 tgattcagcc tggggtgctg cgctgctact gcccagccca tgacactggt cttgtgaccc
     2881 tacaagttgc cttcaacaac cagatcatct ccaactcggt ggtgtttgag tacaaagccc
     2941 gggctctgcc cacgctccct tcctcccagc acgactggct gtcgttggac gataaccagt
     3001 tcaggatgtc catcctggaa cgactggagc agatggagag gaggatggcc gagatgacgg
     3061 ggtcccagca gcacaaacag gcgagcggag gcggcagcag tggaggcggc agcgggagcg
     3121 ggaatggagg gagccaggca cagtgtgctt ctgggactgg ggccttgggg agctgctttg
     3181 agagccgtgt ggtcgtggta tgcgagaaga tgatgagccg agcctgctgg gcgaagtcca
     3241 agcacttgat ccactcaaag actttccgcg gaatgaccct actccacctg gccgctgccc
     3301 agggctatgc caccctaatc cagaccctca tcaaatggcg tacaaagcac gcggatagca
     3361 ttgacctgga actggaagtt gaccccttga atgtggacca cttctcctgt actcctctga
     3421 tgtgggcgtg tgccctaggg cacttggaag ctgccgtcgt gctgtacaag tgggaccgtc
     3481 gggccatctc gattcccgac tctctaggaa ggctgccttt gggaattgcc aggtcacggg
     3541 gtcatgtgaa attagcagag tgtctggagc acctgcagag agatgagcag gctcagctgg
     3601 gacagaaccc cagaatccac tgtcctgcaa gcgaagagcc cagcacagag agctggatgg
     3661 cccagtggca cagcgaagcc atcagctctc cagaaatacc caagggagtc actgttattg
     3721 caagcaccaa cccagagctg agaagacctc gttctgaacc ctctaattac tacagcagtg
     3781 agagccacaa agattatccg gctcccaaaa agcataaatt gaaccctgag tacttccaga
     3841 caaggcagga gaagctgctt cccactgcac tgagtctgga agagccaaat atcaggaagc
     3901 aaagccctag ttctaagcag tctgtccccg agacactcag ccccagtgaa ggagtgaggg
     3961 acttcagccg ggaactctcc cctcccactc cagagactgc agcatttcaa gcctctggat
     4021 ctcagcctgt aggaaagtgg aattccaaag atctttacat tggtgtgtct acagtacagg
     4081 tgactggaaa tccgaagggg accagtgtag gaaaggaggc agcaccttca caggtgcgtc
     4141 cacgggaacc aatgagtgtc ctgatgatgg ctaacagaga ggtggtgaat acagagctgg
     4201 ggtcctaccg tgatagtgca gaaaatgaag aatgcggcca gcccatggat gacatacagg
     4261 tgaacatgat gaccttggca gaacacatta ttgaagccac acctgaccga atcaagcagg
     4321 agaattttgt gcccatggag tcctcaggat tggaaagaac agaccctgcc accattagca
     4381 gtacaatgag ctggctggcc agttatctag cggatgctga ctgccttccc agtgctgccc
     4441 agatccgaag tgcatataac gagcctctaa ccccttcttc taataccagc ttgagccctg
     4501 ttggctctcc cgtcagtgaa atcgctttcg agaaacctaa ccttccctcc gccgcggatt
     4561 ggtcagaatt cctgagtgca tctaccagtg agaaggtaga gaatgagttt gctcagctca
     4621 ctctgtctga tcatgaacag agagaactct atgaggctgc caggcttgtc cagacagctt
     4681 tccggaaata caagggccga cccttgcggg aacagcaaga agtagctgct gctgttattc
     4741 agcgttgtta cagaaaatat aaacagtacg cactttataa aaagatgaca caggctgcca
     4801 tccttatcca gagcaaattc cgaagttact atgaacaaaa aaaattccag cagagccgac
     4861 gggctgctgt gctcatccaa aagtactacc gaagttataa gaaatgtggc aaaagacggc
     4921 aggctcgccg gacggctgtg attgtacaac agaaactcag gagcagtttg ctaaccaaaa
     4981 agcaggatca agctgctcga aaaataatga ggtttcttcg ccgctgtcgc cacagccccc
     5041 tggtggacca taggctgtac aaaaggagtg aaagaattga aaaaggccaa ggaacttgaa
     5101 gacatacagc agcatccctt agcaatgtga cattgctttt cagactgttt tcatttctgt
     5161 ttttagcaga gacatgcaac aacaacacac acgcacacac gcacacacac acacgtacac
     5221 acacatacaa aatccctctg cagttttggg gagatcagct gcaggatttt aacaggaatg
     5281 ttttggtcat tgcatttgca ctttcatgga caacttttaa tttgatcagc aagacatctt
     5341 ggaactcaat cttctgttgg atcacgggaa atcaagacac ccaggaggaa ttgaaagagg
     5401 cttcctcttc tcaggaagaa gccatttcct tctcatatag ggctgtattc aaacatcgtg
     5461 tggaactgta caaatattta taccaaaaat atagataaga aaaggtgggg ctatactagc
     5521 aacaaaaaaa gaatgctgtt cctgcacctg ccggttattt ccaagaagct gaatctttgg
     5581 gactgattct cagtggaggg cttagatcat acaaaaatct ttattgggtc cgtgtgttct
     5641 catttccttc actgtttatt tttgtttgtt tgtttgtttg ttttaatctc tacagcacat
     5701 ttaatgcaac ttttgaaatc tgcaggtttt taatgtcttg tggaaatttg cagaggggca
     5761 ggtgtgtggt aaacgggtaa tgcatgggaa ataatgagaa gcagctcaca gagtttaaac
     5821 tattttcttg tccccaccac cttccaagaa cctgcgaggg tagtaatcat cttgtcccct
     5881 ttttcatgtt cagcacttta atttttttgc cttactttca tgtgcaatga gaattactta
     5941 agaattggta acgcatgtag ccttttttag taaccttgga agctgtagta attctaagga
     6001 atcatgaacc ttgcctggac atttgccacc taaacgatca gtgtggtgct gcgttctggc
     6061 cagtaaattc catgtttttg gctatatctc atccaaactg agcagtttct gtgtatatat
     6121 agaaggtaga aatgaaaagt gagaaaatat ttgaaaggga ttatattaat tgctaaatat
     6181 tttattcaca aaggtcaata acatggcaag ataaaattat ttgtatagtt ttgtctgaat
     6241 gagcgagaaa aatgtggatg tactgtttgt atatattgta tatattaaaa cagagatatg
     6301 tgcatgaaat caagaaaaaa gaaatgaaca aaagcaaagc attagtggct atggtctgta
     6361 aaatgaaaca aaaaaacttt atttcactat aagagtactt tattttaaat gttctttagg
     6421 agaacatttt gctaaagcat gactaaactg caaaaaaaaa aaaagagcta ctgtatttag
     6481 acttaggaaa aaaggcagag taacattact taaaaaaaaa aggatatgtt tacatttaat
     6541 tttggctacc aggagtttag tttattttat ttaaaatttt tttgccaatg gtgccaagta
     6601 atgtgaatgc taatactgct taagaaaatt aagttacttt tgcaaaacag ataatcataa
     6661 gatgaatcag tatgtagctt aacaccatcc actcactcca acaaagaaca cttagaatga
     6721 taaaaaaaaa aaaaaaaaac ctgacaaaag aaatagtatg aaaagtagaa aaatgtcacg
     6781 tttccatatc tcctgctgga aatcagaaaa tataataaaa ttgcacaaaa aaaaaaatga
     6841 aaaagatgca gactggtctt ttagagacgg catggtatat tactatttcc acataatgag
     6901 gagccaaaga aatctgatgt ttttaacaat taaactgcta atgttaaatt gagagaataa
     6961 agttcgtatt tgctgatgcc agtttaaaat tcccaggtta cgtctgagga tcagttggtg
     7021 taaagctgag atgttttttc ttggttctgg ctgccaactg tgagttaaaa ctcaaggctt
     7081 gttgtgaagc ctaaaaatat tcacaaataa gcttttaaac tggtgtcttt ggaaggaagg
     7141 tagatacaaa aagattgtgg taaaaactgg ggtcagtgct cttggtgcct tttctataat
     7201 tgtacttgtt ttttaattac ttcctttcac tgccaacctc gaattactgt acagtatatg
     7261 tctttctgct tgtgatcagc tttgacaaca gtgacagccc cacaactagt agccacctgt
     7321 acatttgtaa actgacctga ctccattttg tttttaaatg tgtgggttat gttgcagctg
     7381 ttgcagtccc ccagatacct attattttac acaatttgac ctataggagg acactgagta
     7441 atttacaaac acaactgcat tcataaatgg gaatagaacg tgaaagccag ctctttcaga
     7501 atatcctcta ttaatactga atttagatat ctttattcca tttattatgg tacaaataac
     7561 tgatgtttta accagagtaa tgacctcagt ggatttgctt taaccctcac attttttttt
     7621 taatgtttca catgttacat tattagctga atacgttaga aaatgacaga tggtagagac
     7681 ttccatagaa ttaagagggt tctcatggag gggataggaa gtaggtttaa agcctaccag
     7741 tgtaacctac cagtacaact gtgaatccta ggcgaggcaa aaatgcactt ccactgaaac
     7801 gaagcatttc tgaccgcttt ttcttggtta tgaatcttaa tttcgaatat aagatgatag
     7861 gtaagcgcag ctttcttgga taatctgaat tcccaagtgc caggagtagg atttcattat
     7921 aaaattaata gctaatctta ttctatctcc tgaagattta attgctattg ttacccattc
     7981 gaaatcagct gtactgtgtg aacgaaataa agacaataat acgaacccct ctctggctgc
     8041 acggtcgctt atggcagttc cacacagtag ttggcgccca atggggggtc cctgagactt
     8101 gcatgtaaaa ctagtctaga tgtcttcttt ttttgtaagt tttatttttg taattgtgca
     8161 tgtaaagcat cattgaatca atggatctgt tgaagaactc agctgctgga aaccatgcaa
     8221 aatgttttga attgccctta aaatatggaa aatgttttct gaatgcttta tattctttct
     8281 gctgtaaatt aaaaatgaag aaaatttccc cata
//
