LOCUS       NM_001349627             607 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calmodulin binding transcription activator 1 (CAMTA1),
            transcript variant 23, mRNA.
ACCESSION   NM_001349627
VERSION     NM_001349627.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Al-Kateb,H., Au,P.Y.B., Berland,S., Cogne,B., Demurger,F.,
            Fluss,J., Isidor,B., Frank,L.M., Varvagiannis,K., Koolen,D.A.,
            McDonald,M., Montgomery,S., Moortgat,S., Deprez,M., Karadurmus,D.,
            Paulsen,J., Reis,A., Rieger,M., Vasileiou,G., Willing,M. and
            Shinawi,M.
  TITLE     CAMTA1-related disorder: Phenotypic and molecular characterization
            of 26 new individuals and literature review
  JOURNAL   Clin Genet 105 (3), 294-301 (2024)
   PUBMED   38044714
  REMARK    GeneRIF: CAMTA1-related disorder: Phenotypic and molecular
            characterization of 26 new individuals and literature review.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Alves,G., Ornellas,M.H. and Liehr,T.
  TITLE     The role of Calmodulin Binding Transcription Activator 1 (CAMTA1)
            gene and its putative genetic partners in the human nervous system
  JOURNAL   Psychogeriatrics 22 (6), 869-878 (2022)
   PUBMED   35949142
  REMARK    GeneRIF: The role of Calmodulin Binding Transcription Activator 1
            (CAMTA1) gene and its putative genetic partners in the human
            nervous system.
            Review article
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Dzinovic,I., Serranova,T., Prouteau,C., Colin,E., Ziegler,A.,
            Winkelmann,J., Jech,R. and Zech,M.
  TITLE     Myoclonic dystonia phenotype related to a novel calmodulin-binding
            transcription activator 1 sequence variant
  JOURNAL   Neurogenetics 22 (2), 137-141 (2021)
   PUBMED   33677721
  REMARK    GeneRIF: Myoclonic dystonia phenotype related to a novel
            calmodulin-binding transcription activator 1 sequence variant.
            Erratum:[Neurogenetics. 2022 Jan;23(1):77. doi:
            10.1007/s10048-021-00641-w.. PMID: 34859314]
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Merritt,N., Garcia,K., Rajendran,D., Lin,Z.Y., Zhang,X.,
            Mitchell,K.A., Borcherding,N., Fullenkamp,C., Chimenti,M.S.,
            Gingras,A.C., Harvey,K.F. and Tanas,M.R.
  TITLE     TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex
  JOURNAL   Elife 10, e62857 (2021)
   PUBMED   33913810
  REMARK    GeneRIF: TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Henrich,K.O., Claas,A., Praml,C., Benner,A., Mollenhauer,J.,
            Poustka,A., Schwab,M. and Westermann,F.
  TITLE     Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted
            region at 1p36 in neuroblastoma
  JOURNAL   Eur J Cancer 43 (3), 607-616 (2007)
   PUBMED   17222547
  REMARK    GeneRIF: no evidence for somatic mutations in FLJ10737 in
            neuroblastoma
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Barbashina,V., Salazar,P., Holland,E.C., Rosenblum,M.K. and
            Ladanyi,M.
  TITLE     Allelic losses at 1p36 and 19q13 in gliomas: correlation with
            histologic classification, definition of a 150-kb minimal deleted
            region on 1p36, and evaluation of CAMTA1 as a candidate tumor
            suppressor gene
  JOURNAL   Clin Cancer Res 11 (3), 1119-1128 (2005)
   PUBMED   15709179
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Nakatani,K., Nishioka,J., Itakura,T., Nakanishi,Y., Horinouchi,J.,
            Abe,Y., Wada,H. and Nobori,T.
  TITLE     Cell cycle-dependent transcriptional regulation of
            calmodulin-binding transcription activator 1 in neuroblastoma cells
  JOURNAL   Int J Oncol 24 (6), 1407-1412 (2004)
   PUBMED   15138581
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FLJ10737 and CAMTA1 genes on
            the commonly deleted region of neuroblastoma at human chromosome
            1p36.31-p36.23
  JOURNAL   Int J Oncol 23 (4), 1219-1224 (2003)
   PUBMED   12964007
  REMARK    GeneRIF: FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate
            tumor suppressor genes of neuroblastoma
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Bouche,N., Scharlat,A., Snedden,W., Bouchez,D. and Fromm,H.
  TITLE     A novel family of calmodulin-binding transcription activators in
            multicellular organisms
  JOURNAL   J Biol Chem 277 (24), 21851-21861 (2002)
   PUBMED   11925432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590128.11.
            
            On May 31, 2019 this sequence version replaced NM_001349627.1.
            
            Summary: The protein encoded by this gene contains a CG1
            DNA-binding domain, a transcription factor immunoglobulin domain,
            ankyrin repeats, and calmodulin-binding IQ motifs. The encoded
            protein is thought to be a transcription factor and may be a tumor
            suppressor. However, a translocation event is sometimes observed
            between this gene and the WWTR1 gene, with the resulting
            WWTR1-CAMTA1 oncoprotein leading to epithelioid
            hemangioendothelioma, a malignant vascular cancer. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (23) encodes isoform p.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU941906.1, ERR3218374.842028.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL590128.11        8839-8960
            123-228             AL590128.11        30368-30473
            229-347             AL590128.11        48477-48595
            348-607             AL590128.11        95142-95401
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31-p36.23"
     gene            1..607
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="calmodulin binding transcription activator 1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
     exon            1..122
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..356
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="isoform p is encoded by transcript variant 23"
                     /codon_start=1
                     /product="calmodulin-binding transcription activator 1
                     isoform p"
                     /protein_id="NP_001336556.1"
                     /db_xref="CCDS:CCDS85922.1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
                     /translation="MWRAEGKWLPKTSRKAQGRTDPVSVLMELRGRRTLIKMPYEISA
                     GTQCCEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNERS"
     exon            123..228
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            229..347
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            348..607
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      607
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgggg tggctgggcc ggcggcggcg gcggtacgag gcgcgcgctc ggggtcccgg
       61 tcgcgaggag gaggaggatg tggcgcgcgg aggggaaatg gctgccgaaa acaagccgga
      121 aggcacaagg aaggacagac ccagtctctg tccttatgga gctaaggggg agacggacat
      181 taatcaagat gccatatgaa atttcagctg ggactcagtg ctgtgaagat gatcatggga
      241 acagcaatag tagtcatgta aaaatctttt taccgaaaaa gctgcttgaa tgtctgccga
      301 aatgttcaag tttaccaaaa gagaggcacc gctggaacac taatgagaga tcatgatgca
      361 gccgtccttt tggatttctt tttaataatg tgtgaccctt cacctttgat cccctgacct
      421 gcattacctt ggtaaccatt tcatttttta atttaatttc attttttaat tttggtgtac
      481 aagctgtaac atttcatctt tcaaagtgta acacgctgat ttcctcaaat agagataccc
      541 ctttgagtga taaatttgca aaatgctgtc ttcattttct gtattaaaat tcatttcagt
      601 tttaaaa
//
